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The map label for this gene is adk

Identifier: 148243234

GI number: 148243234

Start: 1842318

End: 1842866

Strand: Direct

Name: adk

Synonym: SynRCC307_2135

Alternate gene names: 148243234

Gene position: 1842318-1842866 (Clockwise)

Preceding gene: 148243233

Following gene: 148243235

Centisome position: 82.8

GC content: 61.93

Gene sequence:

>549_bases
ATGAGTCATCGACTGCTGTTTGTCGGCCCACCTGGTGCCGGCAAAGGAACCCAAGCAGAACGCCTGGCCGCGAACCATGG
GCTGCTTCATCTCTCCACAGGCGACCTGCTGCGCGCAGAAGTCAAAGCGGGGAGCGAATTGGGCAAAGAAGCCGAAGCGG
TGATGAACCGCGGTGAACTGGTGAGCGATGCGCTGGTGCTGGCGATCGTGCGCTCGCGCTTGCAAAGCCACAGCGGCGGC
TGGCTCCTGGATGGCTTCCCCCGCAACCTGGCCCAGGCCGAAGCCCTCGATGCCCTGCTGAGCGAGCTCAACCAACCGCT
GCAAAGCGTGCTGTTGATGGAGCTGGACGACGACGAGCTCGTGCAACGTCTGCTGGCCCGTGGCCGCGCCGATGACAACG
AAGAGGTAATTCGCCATCGGCTCAGCGTTTACCGGGAGCAAACCGCGCCTTTGATTAACCATTACGAGCAGCGGGGACAG
CTCAAAAGAGTGGTCAGCACTGGCACGATCGAAGCCGTCGCCGAACAGATCACAGCGGCCTTGGCTTAA

Upstream 100 bases:

>100_bases
GTGCCACCTCTCTGCTGATCCTGGTGGGCGTTGCCATTGACACCGCCAAGCAGGTTCAGACCTATGTGATCTCCCAGCGT
TACGAAGGAATGGTGCGTCA

Downstream 100 bases:

>100_bases
GGCGCCGTGATAAGTTGTTTGTTTGTCAATAGGAGAGCCCACCCATGAAGGTGCGCGCCTCAGTGAAGCGCATGTGCGAC
AAGTGCCGGGTGATTCGTCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MSHRLLFVGPPGAGKGTQAERLAANHGLLHLSTGDLLRAEVKAGSELGKEAEAVMNRGELVSDALVLAIVRSRLQSHSGG
WLLDGFPRNLAQAEALDALLSELNQPLQSVLLMELDDDELVQRLLARGRADDNEEVIRHRLSVYREQTAPLINHYEQRGQ
LKRVVSTGTIEAVAEQITAALA

Sequences:

>Translated_182_residues
MSHRLLFVGPPGAGKGTQAERLAANHGLLHLSTGDLLRAEVKAGSELGKEAEAVMNRGELVSDALVLAIVRSRLQSHSGG
WLLDGFPRNLAQAEALDALLSELNQPLQSVLLMELDDDELVQRLLARGRADDNEEVIRHRLSVYREQTAPLINHYEQRGQ
LKRVVSTGTIEAVAEQITAALA
>Mature_181_residues
SHRLLFVGPPGAGKGTQAERLAANHGLLHLSTGDLLRAEVKAGSELGKEAEAVMNRGELVSDALVLAIVRSRLQSHSGGW
LLDGFPRNLAQAEALDALLSELNQPLQSVLLMELDDDELVQRLLARGRADDNEEVIRHRLSVYREQTAPLINHYEQRGQL
KRVVSTGTIEAVAEQITAALA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=38.6792452830189, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=38.6792452830189, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI4502011, Length=186, Percent_Identity=40.3225806451613, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=35.8695652173913, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=36.4130434782609, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=34.6733668341709, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=34.6733668341709, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=34.6733668341709, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=34.6733668341709, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=29.4736842105263, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=31.8181818181818, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=37.5, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17552384, Length=189, Percent_Identity=40.2116402116402, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=38.9189189189189, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17550688, Length=188, Percent_Identity=34.5744680851064, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=177, Percent_Identity=35.0282485875706, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25147457, Length=183, Percent_Identity=25.6830601092896, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537943, Length=207, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=192, Percent_Identity=34.8958333333333, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=34.2245989304813, Blast_Score=120, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=32.9787234042553, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI22026816, Length=187, Percent_Identity=40.1069518716578, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17647141, Length=163, Percent_Identity=38.0368098159509, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24663208, Length=163, Percent_Identity=38.0368098159509, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=32.4468085106383, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=32.4468085106383, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221459597, Length=182, Percent_Identity=34.6153846153846, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356893, Length=182, Percent_Identity=34.6153846153846, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SYNR3 (A5GVX9)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001228391.1
- ProteinModelPortal:   A5GVX9
- SMR:   A5GVX9
- STRING:   A5GVX9
- GeneID:   5156595
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_2135
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK14531
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19797; Mature: 19666

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRLLFVGPPGAGKGTQAERLAANHGLLHLSTGDLLRAEVKAGSELGKEAEAVMNRGEL
CCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VSDALVLAIVRSRLQSHSGGWLLDGFPRNLAQAEALDALLSELNQPLQSVLLMELDDDEL
HHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VQRLLARGRADDNEEVIRHRLSVYREQTAPLINHYEQRGQLKRVVSTGTIEAVAEQITAA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LA
CC
>Mature Secondary Structure 
SHRLLFVGPPGAGKGTQAERLAANHGLLHLSTGDLLRAEVKAGSELGKEAEAVMNRGEL
CCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VSDALVLAIVRSRLQSHSGGWLLDGFPRNLAQAEALDALLSELNQPLQSVLLMELDDDEL
HHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VQRLLARGRADDNEEVIRHRLSVYREQTAPLINHYEQRGQLKRVVSTGTIEAVAEQITAA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA