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The map label for this gene is fumC [H]

Identifier: 148243039

GI number: 148243039

Start: 1684415

End: 1685833

Strand: Direct

Name: fumC [H]

Synonym: SynRCC307_1940

Alternate gene names: 148243039

Gene position: 1684415-1685833 (Clockwise)

Preceding gene: 148243035

Following gene: 148243040

Centisome position: 75.71

GC content: 63.57

Gene sequence:

>1419_bases
ATGTCGGATCAGCACAGCCACACCGGTCAAACCTGGCGGCTCGAGCACGACAGCCTTGGCGATGTGCGCGTCCCCGCCGA
CCGTTACTGGGGGGCTCAAACCGAACGGGCCCGGCATCGCTTTCAAATCGGCAACGACCCAATTCCGCTGGAGTTAATCC
ATGCGATCGCTTGCCTCAAGCGCATGGCTGCCCACACCAACCATCAGCTCGGCGTGCTGGATGAGCAGCGCTGCCAATGG
ATCAGCGAGGCGGCCCGCGAGGTGGAAGGGGGAAAGCTGGATGGGGAATTTCCGCTGTCCTGCTGGCAAAGCGGCAGCGG
CACCCAAACGAACATGAACGTCAATGAGGTGATTGCCAATCGGGCCTGCGAACTGGCCGGCCAAGCTCGCGGCTCCAGGG
ACGTGGTGCATCCCAATGACCACGTCAACCGCAGCCAGAGCACCAACGATGTGTTCCCCTGTGCCATCCATTTGGCTGCT
GAGCGGCAGCAACGGCAAGCGCTACTGCCGGCCCTACATCAATTGGTGGAGGCACTGGAGAGCAAAGCCGCCGCCTGGGA
CGGTGTCGTCAAAATTGGCCGCACCCACCTCCAAGACGCCGTTCCCCTGACGGTGGGGCAAGAGGTTGGTGGCTGGGCCG
CCCAACTGCGCAGTGCTGGCGAGCGGCTAGAGCAAGGACTGCTGGAGTTGCGCTCCATTCCCCTTGGCGGAACAGCTGTG
GGCACCGGGATTGGGGCCCCCAAGGGCTATCCGCAAGCCGTATGTGAGCAGCTCAGCAGCTGTGAAGGCGTGGAGTGGCG
CAGTGATGGCAACCGCTTCGCGCTGATGGGAAGCCATGACGCGTTGGTGCAGCAAATGGCCCGGCTGCGGCTCCTGGCTG
GAGCGCTGCACAAGATCGTCAACGACATTCGCCTGTTGGCCTGCGGTCCCAGGGCAGGGCTCGGGGAGCTGCAGTTGCCC
GCCAACGAACCAGGCAGCTCGATCATGCCCGGCAAGGTCAATCCAACCCAATGCGAGGCCGTGGCGATGGCCACGACCCA
AGTGATGGGCATGGATCAAGCGGTGGCGATTGGCGGCAGCGCCGGGCACCTGCAGATGAATGTCTACAAACCCCTGCTCG
GACTCAATCTGCTGCGCAGCGGCGAAATGCTCACCGACAGCTGCCGCAGCCTGGAGGAGCACCTGGTGCGCGGCATGGAC
CTAGACCATTCCAAGGTGGGGCACTTCCGCGACCAATCGCTGATGCTGGTGACGGCCCTGGCACCCGTGATCGGCTACGA
CATGGCCGCCAAAATCGCCCTGCATGCCCACAGTGAAGGGCTGAGCCTGCGGGAAGCGGCACTGGTGCTGAATGCCATCG
AAGCCGACGCCTTCGATGCAGCGGTGAACCCTGGATGGATGGCCAAGCCCCATGACTGA

Upstream 100 bases:

>100_bases
CGGCGGGAGCAAGTGCTCGAGCATCGCCGGACCCCAAGGCACACATGAGTCAGTGGTAAGGGTGAACGATTAAGAACTCG
TCAGGGCACGTTTTTGCTTT

Downstream 100 bases:

>100_bases
GATGGCAAGCAGCGGCTGGCATCCGCACCTCTGGCATCCCTTTACCCAGCCAGGGCGAGGCCCTGCTCCGATTCCGGTGC
GCCGCGGCCAGGGGGTTTGG

Product: fumarase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSDQHSHTGQTWRLEHDSLGDVRVPADRYWGAQTERARHRFQIGNDPIPLELIHAIACLKRMAAHTNHQLGVLDEQRCQW
ISEAAREVEGGKLDGEFPLSCWQSGSGTQTNMNVNEVIANRACELAGQARGSRDVVHPNDHVNRSQSTNDVFPCAIHLAA
ERQQRQALLPALHQLVEALESKAAAWDGVVKIGRTHLQDAVPLTVGQEVGGWAAQLRSAGERLEQGLLELRSIPLGGTAV
GTGIGAPKGYPQAVCEQLSSCEGVEWRSDGNRFALMGSHDALVQQMARLRLLAGALHKIVNDIRLLACGPRAGLGELQLP
ANEPGSSIMPGKVNPTQCEAVAMATTQVMGMDQAVAIGGSAGHLQMNVYKPLLGLNLLRSGEMLTDSCRSLEEHLVRGMD
LDHSKVGHFRDQSLMLVTALAPVIGYDMAAKIALHAHSEGLSLREAALVLNAIEADAFDAAVNPGWMAKPHD

Sequences:

>Translated_472_residues
MSDQHSHTGQTWRLEHDSLGDVRVPADRYWGAQTERARHRFQIGNDPIPLELIHAIACLKRMAAHTNHQLGVLDEQRCQW
ISEAAREVEGGKLDGEFPLSCWQSGSGTQTNMNVNEVIANRACELAGQARGSRDVVHPNDHVNRSQSTNDVFPCAIHLAA
ERQQRQALLPALHQLVEALESKAAAWDGVVKIGRTHLQDAVPLTVGQEVGGWAAQLRSAGERLEQGLLELRSIPLGGTAV
GTGIGAPKGYPQAVCEQLSSCEGVEWRSDGNRFALMGSHDALVQQMARLRLLAGALHKIVNDIRLLACGPRAGLGELQLP
ANEPGSSIMPGKVNPTQCEAVAMATTQVMGMDQAVAIGGSAGHLQMNVYKPLLGLNLLRSGEMLTDSCRSLEEHLVRGMD
LDHSKVGHFRDQSLMLVTALAPVIGYDMAAKIALHAHSEGLSLREAALVLNAIEADAFDAAVNPGWMAKPHD
>Mature_471_residues
SDQHSHTGQTWRLEHDSLGDVRVPADRYWGAQTERARHRFQIGNDPIPLELIHAIACLKRMAAHTNHQLGVLDEQRCQWI
SEAAREVEGGKLDGEFPLSCWQSGSGTQTNMNVNEVIANRACELAGQARGSRDVVHPNDHVNRSQSTNDVFPCAIHLAAE
RQQRQALLPALHQLVEALESKAAAWDGVVKIGRTHLQDAVPLTVGQEVGGWAAQLRSAGERLEQGLLELRSIPLGGTAVG
TGIGAPKGYPQAVCEQLSSCEGVEWRSDGNRFALMGSHDALVQQMARLRLLAGALHKIVNDIRLLACGPRAGLGELQLPA
NEPGSSIMPGKVNPTQCEAVAMATTQVMGMDQAVAIGGSAGHLQMNVYKPLLGLNLLRSGEMLTDSCRSLEEHLVRGMDL
DHSKVGHFRDQSLMLVTALAPVIGYDMAAKIALHAHSEGLSLREAALVLNAIEADAFDAAVNPGWMAKPHD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=463, Percent_Identity=47.9481641468683, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=50.7936507936508, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=48.9082969432314, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI87082375, Length=471, Percent_Identity=36.3057324840764, Blast_Score=275, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=49.7826086956522, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=48.159509202454, Blast_Score=305, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=47.4025974025974, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=47.8448275862069, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=47.8448275862069, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=48.2683982683983, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=47.0842332613391, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=43.9393939393939, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50918; Mature: 50786

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQHSHTGQTWRLEHDSLGDVRVPADRYWGAQTERARHRFQIGNDPIPLELIHAIACLK
CCCCCCCCCCEEEECCCCCCCEECCHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
RMAAHTNHQLGVLDEQRCQWISEAAREVEGGKLDGEFPLSCWQSGSGTQTNMNVNEVIAN
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHH
RACELAGQARGSRDVVHPNDHVNRSQSTNDVFPCAIHLAAERQQRQALLPALHQLVEALE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAAAWDGVVKIGRTHLQDAVPLTVGQEVGGWAAQLRSAGERLEQGLLELRSIPLGGTAV
HHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GTGIGAPKGYPQAVCEQLSSCEGVEWRSDGNRFALMGSHDALVQQMARLRLLAGALHKIV
CCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
NDIRLLACGPRAGLGELQLPANEPGSSIMPGKVNPTQCEAVAMATTQVMGMDQAVAIGGS
HHHEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCC
AGHLQMNVYKPLLGLNLLRSGEMLTDSCRSLEEHLVRGMDLDHSKVGHFRDQSLMLVTAL
CCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHH
APVIGYDMAAKIALHAHSEGLSLREAALVLNAIEADAFDAAVNPGWMAKPHD
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDQHSHTGQTWRLEHDSLGDVRVPADRYWGAQTERARHRFQIGNDPIPLELIHAIACLK
CCCCCCCCCEEEECCCCCCCEECCHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
RMAAHTNHQLGVLDEQRCQWISEAAREVEGGKLDGEFPLSCWQSGSGTQTNMNVNEVIAN
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHH
RACELAGQARGSRDVVHPNDHVNRSQSTNDVFPCAIHLAAERQQRQALLPALHQLVEALE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKAAAWDGVVKIGRTHLQDAVPLTVGQEVGGWAAQLRSAGERLEQGLLELRSIPLGGTAV
HHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GTGIGAPKGYPQAVCEQLSSCEGVEWRSDGNRFALMGSHDALVQQMARLRLLAGALHKIV
CCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
NDIRLLACGPRAGLGELQLPANEPGSSIMPGKVNPTQCEAVAMATTQVMGMDQAVAIGGS
HHHEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCC
AGHLQMNVYKPLLGLNLLRSGEMLTDSCRSLEEHLVRGMDLDHSKVGHFRDQSLMLVTAL
CCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHH
APVIGYDMAAKIALHAHSEGLSLREAALVLNAIEADAFDAAVNPGWMAKPHD
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]