Click here to switch to the map view.

The map label for this gene is gltX

Identifier: 148242765

GI number: 148242765

Start: 1456667

End: 1458094

Strand: Direct

Name: gltX

Synonym: SynRCC307_1666

Alternate gene names: 148242765

Gene position: 1456667-1458094 (Clockwise)

Preceding gene: 148242764

Following gene: 148242768

Centisome position: 65.47

GC content: 63.87

Gene sequence:

>1428_bases
ATGGTGCGTGTTCGTCTGGCCCCCAGCCCAACGGGAACGCTTCATATCGGCACCGCACGCACGGCGGTGTTCAACTGGCT
GTACGCGCGGCGCCATGGCGGCGAGTTTGTGCTGCGCATTGAAGACACCGACAAAGAGCGCAGCAAAAGCGAATACACCA
GCAACATCCTCGATGGCCTGAAGTGGCTGGGTATCGACTGGGATGCCGAGCCCGTCATCCAGAGCGAGCGGGTGGAGCAG
CACCGCCAAGCAATCCAACAACTGCTGGATGCCGGGCTGGCCTACCGCTGTTACGCCTCGGAAGAGGAGCTCAACGCCAT
GCGCGAGGCCCAAATGGCCAACAAGAAAGCGCCGCGTTACGACAACCGCCACCGCAACCTCAGCCACGAGCAGGAAGCCG
ACTATCAAGCCGAGGGACGCCAAGCCACGGTGCGCTTCCGCATCGATGACAGCCGCAACATCCAATGGAACGACCTGGTG
CGCGGCGCGATGAGCTGGAGCGGAGCCGACCTGGGCGGCGACATGGTGATCGCCCGGCGCGCTCCAGCCGATCAAATCGG
CGATCCGCTTTACAACCTCGTGGTGGTGGTCGATGACGCCGCCATGGCCATCACCCATGTGATCCGCGGTGAAGACCACA
TCGCCAACACGGCCAAGCAACTGCTGCTCTACGAAGCCCTGGGGCTGCCGCTGCCTGAGTTCGCCCACACCCCGCTGATC
CTCAACCAAGAGGGCCGCAAGCTCTCCAAGCGCGATGGCGTCACCTCGGTGAGCGACTTCCGCGGCATGGGCTACACCGC
CAGCGCCCTGGCCAACTACATGACCCTGCTGGGCTGGTCGCCGCCGGAGGGCATGGGCGAGCGCTTCTCCTTGGCGGAGG
CCGCCAAGGTGTTCGACTTCCAGCGCGTCAACAAAGCTGGTGCCCGCTTCGATTGGGACAAGCTCAACTGGCTCAATGGC
CAGGTGCTGCATGAGCTTGGTGCCGCAGAACTCAACCGCAAGCTCACCCCGCTTTGGCAGGAGGCAGGCTTTGAGACCAG
CGGCCGCAGCCAAGCTTGGCTGGAGCAACTCTGCGAGCTGCTGGGCCCCTCCCTGACGCTGCTGGCCGATGGCGTCGAGC
AAGCCCGACCGTTTTTTGAAACGCCCTCCCTCAAAGAGGACGCTCAGCAGCAACTGCAACAACCCGGAGCCAAAGAGGCC
CTCAAGGCCCTGCTCAGCTCACTGAGCGACGAGCCGCTGCAGGCCGAACAGGCCAAAGCCCTAATCAGCGATGCCTGCAA
GGCCGCCGATGTGAAAAAAGGCGTGCTGATGAAATCGCTCCGCGGTGCCTTGATGGGGCAACTGCAGGGGCCTGATCTGA
TGGAGAGCTGGCTGCTACTGAACGCGGCCGGGCAAGACCGCGGGCGCATCAGCAGCGCCCTCGGCTGA

Upstream 100 bases:

>100_bases
GGTCATGGGACCGTAGTTCAACCGGTTAGAGCACCGCCCTGTCACGGCGGAAGTTGCGGGTTCGAATCCCGTCGGTCCCG
TTTTCACCTCAACAGCCTCA

Downstream 100 bases:

>100_bases
GCCGGCCTCGGCCTCCAGATCAGGCTGCACCAAGCCCAAGCGGCGCGCCAACCAAGGCGCCGTGAGGCCTTGGAGGCCCA
CGGTCATCAGGATCGTGAGG

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVRVRLAPSPTGTLHIGTARTAVFNWLYARRHGGEFVLRIEDTDKERSKSEYTSNILDGLKWLGIDWDAEPVIQSERVEQ
HRQAIQQLLDAGLAYRCYASEEELNAMREAQMANKKAPRYDNRHRNLSHEQEADYQAEGRQATVRFRIDDSRNIQWNDLV
RGAMSWSGADLGGDMVIARRAPADQIGDPLYNLVVVVDDAAMAITHVIRGEDHIANTAKQLLLYEALGLPLPEFAHTPLI
LNQEGRKLSKRDGVTSVSDFRGMGYTASALANYMTLLGWSPPEGMGERFSLAEAAKVFDFQRVNKAGARFDWDKLNWLNG
QVLHELGAAELNRKLTPLWQEAGFETSGRSQAWLEQLCELLGPSLTLLADGVEQARPFFETPSLKEDAQQQLQQPGAKEA
LKALLSSLSDEPLQAEQAKALISDACKAADVKKGVLMKSLRGALMGQLQGPDLMESWLLLNAAGQDRGRISSALG

Sequences:

>Translated_475_residues
MVRVRLAPSPTGTLHIGTARTAVFNWLYARRHGGEFVLRIEDTDKERSKSEYTSNILDGLKWLGIDWDAEPVIQSERVEQ
HRQAIQQLLDAGLAYRCYASEEELNAMREAQMANKKAPRYDNRHRNLSHEQEADYQAEGRQATVRFRIDDSRNIQWNDLV
RGAMSWSGADLGGDMVIARRAPADQIGDPLYNLVVVVDDAAMAITHVIRGEDHIANTAKQLLLYEALGLPLPEFAHTPLI
LNQEGRKLSKRDGVTSVSDFRGMGYTASALANYMTLLGWSPPEGMGERFSLAEAAKVFDFQRVNKAGARFDWDKLNWLNG
QVLHELGAAELNRKLTPLWQEAGFETSGRSQAWLEQLCELLGPSLTLLADGVEQARPFFETPSLKEDAQQQLQQPGAKEA
LKALLSSLSDEPLQAEQAKALISDACKAADVKKGVLMKSLRGALMGQLQGPDLMESWLLLNAAGQDRGRISSALG
>Mature_475_residues
MVRVRLAPSPTGTLHIGTARTAVFNWLYARRHGGEFVLRIEDTDKERSKSEYTSNILDGLKWLGIDWDAEPVIQSERVEQ
HRQAIQQLLDAGLAYRCYASEEELNAMREAQMANKKAPRYDNRHRNLSHEQEADYQAEGRQATVRFRIDDSRNIQWNDLV
RGAMSWSGADLGGDMVIARRAPADQIGDPLYNLVVVVDDAAMAITHVIRGEDHIANTAKQLLLYEALGLPLPEFAHTPLI
LNQEGRKLSKRDGVTSVSDFRGMGYTASALANYMTLLGWSPPEGMGERFSLAEAAKVFDFQRVNKAGARFDWDKLNWLNG
QVLHELGAAELNRKLTPLWQEAGFETSGRSQAWLEQLCELLGPSLTLLADGVEQARPFFETPSLKEDAQQQLQQPGAKEA
LKALLSSLSDEPLQAEQAKALISDACKAADVKKGVLMKSLRGALMGQLQGPDLMESWLLLNAAGQDRGRISSALG

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI134288884, Length=483, Percent_Identity=36.6459627329193, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI62241042, Length=355, Percent_Identity=23.943661971831, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788743, Length=479, Percent_Identity=39.6659707724426, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI226510925, Length=248, Percent_Identity=33.4677419354839, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786895, Length=316, Percent_Identity=23.7341772151899, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71993394, Length=466, Percent_Identity=30.9012875536481, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17511007, Length=348, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324540, Length=468, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321192, Length=238, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324742, Length=132, Percent_Identity=32.5757575757576, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24665321, Length=485, Percent_Identity=34.020618556701, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYE_SYNR3 (A5GUL0)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227922.1
- ProteinModelPortal:   A5GUL0
- SMR:   A5GUL0
- STRING:   A5GUL0
- GeneID:   5158060
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_1666
- eggNOG:   COG0008
- HOGENOM:   HBG628189
- OMA:   MAHIPLI
- ProtClustDB:   PRK01406
- GO:   GO:0005737
- HAMAP:   MF_00022_B
- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:1.10.1160.10
- Gene3D:   G3DSA:3.40.50.620
- Gene3D:   G3DSA:1.10.10.350
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR00464

Pfam domain/function: PF00749 tRNA-synt_1c; SSF48163 tRNA-synt_bind

EC number: =6.1.1.17

Molecular weight: Translated: 52732; Mature: 52732

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 250-250

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVRLAPSPTGTLHIGTARTAVFNWLYARRHGGEFVLRIEDTDKERSKSEYTSNILDGL
CEEEEECCCCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KWLGIDWDAEPVIQSERVEQHRQAIQQLLDAGLAYRCYASEEELNAMREAQMANKKAPRY
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCC
DNRHRNLSHEQEADYQAEGRQATVRFRIDDSRNIQWNDLVRGAMSWSGADLGGDMVIARR
CCCCCCCCCHHCCCHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEC
APADQIGDPLYNLVVVVDDAAMAITHVIRGEDHIANTAKQLLLYEALGLPLPEFAHTPLI
CCHHHHCCHHEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCEE
LNQEGRKLSKRDGVTSVSDFRGMGYTASALANYMTLLGWSPPEGMGERFSLAEAAKVFDF
ECCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QRVNKAGARFDWDKLNWLNGQVLHELGAAELNRKLTPLWQEAGFETSGRSQAWLEQLCEL
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
LGPSLTLLADGVEQARPFFETPSLKEDAQQQLQQPGAKEALKALLSSLSDEPLQAEQAKA
HCCCHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
LISDACKAADVKKGVLMKSLRGALMGQLQGPDLMESWLLLNAAGQDRGRISSALG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MVRVRLAPSPTGTLHIGTARTAVFNWLYARRHGGEFVLRIEDTDKERSKSEYTSNILDGL
CEEEEECCCCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHH
KWLGIDWDAEPVIQSERVEQHRQAIQQLLDAGLAYRCYASEEELNAMREAQMANKKAPRY
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCC
DNRHRNLSHEQEADYQAEGRQATVRFRIDDSRNIQWNDLVRGAMSWSGADLGGDMVIARR
CCCCCCCCCHHCCCHHCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEC
APADQIGDPLYNLVVVVDDAAMAITHVIRGEDHIANTAKQLLLYEALGLPLPEFAHTPLI
CCHHHHCCHHEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCEE
LNQEGRKLSKRDGVTSVSDFRGMGYTASALANYMTLLGWSPPEGMGERFSLAEAAKVFDF
ECCCCCHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
QRVNKAGARFDWDKLNWLNGQVLHELGAAELNRKLTPLWQEAGFETSGRSQAWLEQLCEL
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
LGPSLTLLADGVEQARPFFETPSLKEDAQQQLQQPGAKEALKALLSSLSDEPLQAEQAKA
HCCCHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
LISDACKAADVKKGVLMKSLRGALMGQLQGPDLMESWLLLNAAGQDRGRISSALG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA