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The map label for this gene is ribA [H]

Identifier: 148242453

GI number: 148242453

Start: 1200138

End: 1201787

Strand: Direct

Name: ribA [H]

Synonym: SynRCC307_1354

Alternate gene names: 148242453

Gene position: 1200138-1201787 (Clockwise)

Preceding gene: 148242451

Following gene: 148242455

Centisome position: 53.94

GC content: 62.48

Gene sequence:

>1650_bases
ATGAGCTCCCCAGCGGTGACCAGCACCGTCCGTTTCGACCCGATTGAAAAGGCCCTTGAGGCCATTCGGGATGGGGCCTG
CGTGGTGGTGGTCGATGACGAAAACAGGGAAAACGAAGGTGACTTGATCTGCGCGGCGCAATTTGCAACGCCGAAGCAGA
TCAACTTCATGGCCACCGAAGCCCGAGGGTTGATCTGTCTGGCCATGGAAGGCGAGCGGCTCGACGCCCTCGACCTGCCG
CTGATGGTGGGGCAAAACACCGATACCAACCAAACCGCTTTCACCGTCAGCATTGATGCCGGACCTGAGGCTGGGGTCAG
CACAGGCATCTCCGCAGAAGATCGGGCTCGCACCATCCAGGTGGCCTTGCATCCGCAAAGCAAACCCCAAGATCTGCGCC
GCCCGGGCCACATCTTTCCCTTGCGCGCCCGCGATGGGGGAGTGCTGAAACGGGCCGGCCACACCGAAGCCGCCGTGGAT
CTCTCGCGCATGGCGGGGCTGCATCCCTCTGGCGTGATCTGTGAGATCCAAAATCCAGATGGCTCGATGGCGCGGCTACC
GCAGCTGGCGGAGTACGCCGCTGAGCACGGCCTCTACCTGATCTCGATTGCCGATCTCATCCGTTACCGGCTGGAAAACG
AGCGTTTTGTGGTGCGCGAAGCGGAAGCCAAAATCCCCAGCGAATTCGGTGATTTCCGCGCCATTGGCTATCGCAACGTT
CTTGATGGCGGTGAGCATGTGGCGCTGGTCAAGGGCCACCCCGGTCGCCAAAGCGCGCCGGTGATGGTGCGCGTGCACTC
GGAGTGCCTCACCGGGGATGCCTTTGGCTCGCTGCGCTGTGATTGCCGTCCGCAGCTGGAATCGGCGCTGCGCATGATCC
AAGCCGAGGGGGAAGGCGTTGTCGTCTACCTGCGGCAAGAGGGCCGCGGCATCGGACTCATCAACAAGCTCAAGGCCTAC
AGCCTGCAGGAATCTGGCCTCGACACCGTTGAAGCCAATGAACATCTCGGCTTTGGCGCCGATCTGCGCGACTACGGCGT
GGGCGCCCAAATCATTTCCGACCTGGGCATTAAGCGGCTGCGGCTGATCACCAACAACCCCAGAAAAATTGCTGGCCTCG
GTGGCTACGGATTGGAAGTGGTGGACCGGGTTCCCCTGGTGATGGATCCGGGCCAACACAACGCCGACTACCTGCGCACC
AAGGCCCGCAAACTGGGCCATTTACTGCATGGCCCAGGTGCACTGCTGGCCTGGAGCAGCTCCGGCGATGATCCCCGCCA
ACGCGCTCACCAACTCGAAGAGCAACTGGCCAGCAAGCTGCACGCCTTCGGGCTGACGATGGAAGTGGAAGAGCAGCACC
GGGTACTCGCCCTTCTGGGCAAACCGGATCTCACGGTGCGTGTGGGGGCCGCGGAGCGGGGCAGCTTGCAACGCAATTGC
TGGGCCCTGTTGCAGGAATTGGCCCAAGAACCCACAACGCAGCAGCTGCAACTGCTGATTGGCCCGGACCTCGATCGCAG
TGAGCACCCACCGGCTCAGCTCGAGCCCACCGCGCTTGAACTCGAACAGCTACGCCAAGGGGCAGGGGTGGATGCCGTTG
CGGCCATCAACCCTGAGCAATCCCCTTGGACGTTGCTGCGCTGGAGCTAA

Upstream 100 bases:

>100_bases
CGCCACAGGCCTCACCGGCTGCATTGAGGAAGGCTGACTTTAGTGATCGACCCGTTGGCAGCCGCCCGGGCTCTATAAAC
AAGGGACTGAAACGCCCGCA

Downstream 100 bases:

>100_bases
TCAGTCGCTGATGGTGACGGTCTTGATCTTGCTGCCGTTTTTCAACGCCAGCACAACGCCCATGTCACCGGTCAGACCGA
AGACGGTGTGGACGCCATCG

Product: riboflavin biosynthesis protein RibA (3, 4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II)

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSSPAVTSTVRFDPIEKALEAIRDGACVVVVDDENRENEGDLICAAQFATPKQINFMATEARGLICLAMEGERLDALDLP
LMVGQNTDTNQTAFTVSIDAGPEAGVSTGISAEDRARTIQVALHPQSKPQDLRRPGHIFPLRARDGGVLKRAGHTEAAVD
LSRMAGLHPSGVICEIQNPDGSMARLPQLAEYAAEHGLYLISIADLIRYRLENERFVVREAEAKIPSEFGDFRAIGYRNV
LDGGEHVALVKGHPGRQSAPVMVRVHSECLTGDAFGSLRCDCRPQLESALRMIQAEGEGVVVYLRQEGRGIGLINKLKAY
SLQESGLDTVEANEHLGFGADLRDYGVGAQIISDLGIKRLRLITNNPRKIAGLGGYGLEVVDRVPLVMDPGQHNADYLRT
KARKLGHLLHGPGALLAWSSSGDDPRQRAHQLEEQLASKLHAFGLTMEVEEQHRVLALLGKPDLTVRVGAAERGSLQRNC
WALLQELAQEPTTQQLQLLIGPDLDRSEHPPAQLEPTALELEQLRQGAGVDAVAAINPEQSPWTLLRWS

Sequences:

>Translated_549_residues
MSSPAVTSTVRFDPIEKALEAIRDGACVVVVDDENRENEGDLICAAQFATPKQINFMATEARGLICLAMEGERLDALDLP
LMVGQNTDTNQTAFTVSIDAGPEAGVSTGISAEDRARTIQVALHPQSKPQDLRRPGHIFPLRARDGGVLKRAGHTEAAVD
LSRMAGLHPSGVICEIQNPDGSMARLPQLAEYAAEHGLYLISIADLIRYRLENERFVVREAEAKIPSEFGDFRAIGYRNV
LDGGEHVALVKGHPGRQSAPVMVRVHSECLTGDAFGSLRCDCRPQLESALRMIQAEGEGVVVYLRQEGRGIGLINKLKAY
SLQESGLDTVEANEHLGFGADLRDYGVGAQIISDLGIKRLRLITNNPRKIAGLGGYGLEVVDRVPLVMDPGQHNADYLRT
KARKLGHLLHGPGALLAWSSSGDDPRQRAHQLEEQLASKLHAFGLTMEVEEQHRVLALLGKPDLTVRVGAAERGSLQRNC
WALLQELAQEPTTQQLQLLIGPDLDRSEHPPAQLEPTALELEQLRQGAGVDAVAAINPEQSPWTLLRWS
>Mature_548_residues
SSPAVTSTVRFDPIEKALEAIRDGACVVVVDDENRENEGDLICAAQFATPKQINFMATEARGLICLAMEGERLDALDLPL
MVGQNTDTNQTAFTVSIDAGPEAGVSTGISAEDRARTIQVALHPQSKPQDLRRPGHIFPLRARDGGVLKRAGHTEAAVDL
SRMAGLHPSGVICEIQNPDGSMARLPQLAEYAAEHGLYLISIADLIRYRLENERFVVREAEAKIPSEFGDFRAIGYRNVL
DGGEHVALVKGHPGRQSAPVMVRVHSECLTGDAFGSLRCDCRPQLESALRMIQAEGEGVVVYLRQEGRGIGLINKLKAYS
LQESGLDTVEANEHLGFGADLRDYGVGAQIISDLGIKRLRLITNNPRKIAGLGGYGLEVVDRVPLVMDPGQHNADYLRTK
ARKLGHLLHGPGALLAWSSSGDDPRQRAHQLEEQLASKLHAFGLTMEVEEQHRVLALLGKPDLTVRVGAAERGSLQRNCW
ALLQELAQEPTTQQLQLLIGPDLDRSEHPPAQLEPTALELEQLRQGAGVDAVAAINPEQSPWTLLRWS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=49.0196078431373, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=53.125, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=43.6893203883495, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=45.6647398843931, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 59770; Mature: 59639

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPAVTSTVRFDPIEKALEAIRDGACVVVVDDENRENEGDLICAAQFATPKQINFMATE
CCCCCCEEEEEECHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEC
ARGLICLAMEGERLDALDLPLMVGQNTDTNQTAFTVSIDAGPEAGVSTGISAEDRARTIQ
CCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEE
VALHPQSKPQDLRRPGHIFPLRARDGGVLKRAGHTEAAVDLSRMAGLHPSGVICEIQNPD
EEECCCCCCHHHCCCCCEEEEECCCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCC
GSMARLPQLAEYAAEHGLYLISIADLIRYRLENERFVVREAEAKIPSEFGDFRAIGYRNV
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCHHCCEEEECCHHH
LDGGEHVALVKGHPGRQSAPVMVRVHSECLTGDAFGSLRCDCRPQLESALRMIQAEGEGV
CCCCCEEEEEECCCCCCCCCEEEEEECHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCEE
VVYLRQEGRGIGLINKLKAYSLQESGLDTVEANEHLGFGADLRDYGVGAQIISDLGIKRL
EEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHCCHHHHHHHCCCEEE
RLITNNPRKIAGLGGYGLEVVDRVPLVMDPGQHNADYLRTKARKLGHLLHGPGALLAWSS
EEEECCCCEEEECCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SGDDPRQRAHQLEEQLASKLHAFGLTMEVEEQHRVLALLGKPDLTVRVGAAERGSLQRNC
CCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHH
WALLQELAQEPTTQQLQLLIGPDLDRSEHPPAQLEPTALELEQLRQGAGVDAVAAINPEQ
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCC
SPWTLLRWS
CCEEEEEEC
>Mature Secondary Structure 
SSPAVTSTVRFDPIEKALEAIRDGACVVVVDDENRENEGDLICAAQFATPKQINFMATE
CCCCCEEEEEECHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEEC
ARGLICLAMEGERLDALDLPLMVGQNTDTNQTAFTVSIDAGPEAGVSTGISAEDRARTIQ
CCCEEEEEECCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEE
VALHPQSKPQDLRRPGHIFPLRARDGGVLKRAGHTEAAVDLSRMAGLHPSGVICEIQNPD
EEECCCCCCHHHCCCCCEEEEECCCCCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCC
GSMARLPQLAEYAAEHGLYLISIADLIRYRLENERFVVREAEAKIPSEFGDFRAIGYRNV
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCHHCCEEEECCHHH
LDGGEHVALVKGHPGRQSAPVMVRVHSECLTGDAFGSLRCDCRPQLESALRMIQAEGEGV
CCCCCEEEEEECCCCCCCCCEEEEEECHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCEE
VVYLRQEGRGIGLINKLKAYSLQESGLDTVEANEHLGFGADLRDYGVGAQIISDLGIKRL
EEEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHCCHHHHHHHCCCEEE
RLITNNPRKIAGLGGYGLEVVDRVPLVMDPGQHNADYLRTKARKLGHLLHGPGALLAWSS
EEEECCCCEEEECCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
SGDDPRQRAHQLEEQLASKLHAFGLTMEVEEQHRVLALLGKPDLTVRVGAAERGSLQRNC
CCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCHHHH
WALLQELAQEPTTQQLQLLIGPDLDRSEHPPAQLEPTALELEQLRQGAGVDAVAAINPEQ
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCC
SPWTLLRWS
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]