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The map label for this gene is msrA [H]

Identifier: 148242435

GI number: 148242435

Start: 1184933

End: 1185631

Strand: Direct

Name: msrA [H]

Synonym: SynRCC307_1336

Alternate gene names: 148242435

Gene position: 1184933-1185631 (Clockwise)

Preceding gene: 148242434

Following gene: 148242436

Centisome position: 53.26

GC content: 61.95

Gene sequence:

>699_bases
ATGCTGGATTGGCTTCGCGGCGGCACGCCTCCTCAACCCGGTGTGCATGTGGTGTTGGGCACCGCCATTGATGCTCCGCT
CGAGCCAGGGCAGCAGGAGGCCTTGTTTGGTTGCGGCTGTTTCTGGGGCGCCGAAAAAGGGTTTTGGCGCCTACCAGGTG
TGGTGACCACCGCGGTGGGCTATGCGGGCGGCGGCGCTGCCAATCCCAGCTATGAACAGGTCTGCAGCGGCCGCACAGGC
CATGCGGAAGTGGTGCGCGTGGTGTGGGACACCAGCACGATCGGGTTTAGTGATCTGCTCAAGCTGTTTTGGGAATGCCA
CGACCCGACCCAGGGGGACCGGCAAGGCAATGACTGCGGCAGTCAGTACCGCTCAACGATCTACGCCAACGACAGCGCCT
TGATTGAACTGGCCAGCGCCAGTGCCAAGGCTTACCAGGAGCTGCTCAGCGCTGCTGGATTTGCAGCGATCACCACAGAA
ATCCGGCAGGGGGTGCCGTTCTTCGCCGCTGAGAGCTACCACCAGCAGTATTTGGCCAAGCCCGGCAGCCGTCCGTATTG
CTCAGCCATGCCCACCAAGGTGGCGCTAGGCCGTTTCGAGGGCTGTACCTACCAGCTTCCATCGCAGGTGTGGACCAACT
ACGACTGGAGCGTGAGCCACTGTGTGCTGCGTGGTGAGAATGCCCCAATCGCGATTTAA

Upstream 100 bases:

>100_bases
TGGTGTTGTCGCTGCCGTTCTTGCTCTTTGCCTTCACGACCACGCTGCTGAATCACATTGCCCTAGAACCACAGGCAACT
CAGAACGCAGCTGAACTCTG

Downstream 100 bases:

>100_bases
GGCCGCACTCCTCTTGGGATTGTTGGCCCCCACCGCTGCCTGGGCGGGGCCATCCCCTTGGTGGGAGCACTACGACCGCA
GCGATCGCTATCGCTGTGGG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MLDWLRGGTPPQPGVHVVLGTAIDAPLEPGQQEALFGCGCFWGAEKGFWRLPGVVTTAVGYAGGGAANPSYEQVCSGRTG
HAEVVRVVWDTSTIGFSDLLKLFWECHDPTQGDRQGNDCGSQYRSTIYANDSALIELASASAKAYQELLSAAGFAAITTE
IRQGVPFFAAESYHQQYLAKPGSRPYCSAMPTKVALGRFEGCTYQLPSQVWTNYDWSVSHCVLRGENAPIAI

Sequences:

>Translated_232_residues
MLDWLRGGTPPQPGVHVVLGTAIDAPLEPGQQEALFGCGCFWGAEKGFWRLPGVVTTAVGYAGGGAANPSYEQVCSGRTG
HAEVVRVVWDTSTIGFSDLLKLFWECHDPTQGDRQGNDCGSQYRSTIYANDSALIELASASAKAYQELLSAAGFAAITTE
IRQGVPFFAAESYHQQYLAKPGSRPYCSAMPTKVALGRFEGCTYQLPSQVWTNYDWSVSHCVLRGENAPIAI
>Mature_232_residues
MLDWLRGGTPPQPGVHVVLGTAIDAPLEPGQQEALFGCGCFWGAEKGFWRLPGVVTTAVGYAGGGAANPSYEQVCSGRTG
HAEVVRVVWDTSTIGFSDLLKLFWECHDPTQGDRQGNDCGSQYRSTIYANDSALIELASASAKAYQELLSAAGFAAITTE
IRQGVPFFAAESYHQQYLAKPGSRPYCSAMPTKVALGRFEGCTYQLPSQVWTNYDWSVSHCVLRGENAPIAI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=175, Percent_Identity=54.2857142857143, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI208609995, Length=165, Percent_Identity=56.3636363636364, Blast_Score=197, Evalue=7e-51,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=58.252427184466, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1790665, Length=185, Percent_Identity=50.2702702702703, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17533973, Length=173, Percent_Identity=33.5260115606936, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=36.8098159509202, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=38.7755102040816, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=38.0952380952381, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=37.410071942446, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24990; Mature: 24990

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDWLRGGTPPQPGVHVVLGTAIDAPLEPGQQEALFGCGCFWGAEKGFWRLPGVVTTAVG
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHEEECHHHCCCCCCCEECCHHHHHHHC
YAGGGAANPSYEQVCSGRTGHAEVVRVVWDTSTIGFSDLLKLFWECHDPTQGDRQGNDCG
CCCCCCCCCCHHHHHCCCCCHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
SQYRSTIYANDSALIELASASAKAYQELLSAAGFAAITTEIRQGVPFFAAESYHQQYLAK
HHHHHEEEECCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
PGSRPYCSAMPTKVALGRFEGCTYQLPSQVWTNYDWSVSHCVLRGENAPIAI
CCCCCCCCCCCHHHHHHHCCCCCEECCHHHHCCCCCCHHEEEEECCCCCCCC
>Mature Secondary Structure
MLDWLRGGTPPQPGVHVVLGTAIDAPLEPGQQEALFGCGCFWGAEKGFWRLPGVVTTAVG
CCCCCCCCCCCCCCEEEEEEEEECCCCCCCCHHHEEECHHHCCCCCCCEECCHHHHHHHC
YAGGGAANPSYEQVCSGRTGHAEVVRVVWDTSTIGFSDLLKLFWECHDPTQGDRQGNDCG
CCCCCCCCCCHHHHHCCCCCHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCHHH
SQYRSTIYANDSALIELASASAKAYQELLSAAGFAAITTEIRQGVPFFAAESYHQQYLAK
HHHHHEEEECCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
PGSRPYCSAMPTKVALGRFEGCTYQLPSQVWTNYDWSVSHCVLRGENAPIAI
CCCCCCCCCCCHHHHHHHCCCCCEECCHHHHCCCCCCHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA