Click here to switch to the map view.

The map label for this gene is cobU [H]

Identifier: 148242333

GI number: 148242333

Start: 1094771

End: 1095340

Strand: Direct

Name: cobU [H]

Synonym: SynRCC307_1234

Alternate gene names: 148242333

Gene position: 1094771-1095340 (Clockwise)

Preceding gene: 148242332

Following gene: 148242334

Centisome position: 49.21

GC content: 62.28

Gene sequence:

>570_bases
ATGGCGGTGGCTAATCACCTGTTGATCACCGGTCCATCGCGCGGCGGCAAAAGTGAATGGGCGGAACAGCGCATCCGCGA
GATGGCTGGTGCAGCCGCAATCACCTATCTCGCCACCGGACCCACACTCCCCGATGACGCTGCCTGGCAACAGCGCCTGA
GCCGTCACCGCCAGCGGCGCCCAGAGCATTGGCGTTTGCTGGAAGCTTCGTCCATTTCAGCGGTGAGCCAGCTGTTGCAG
CAGGGCAGCGACTGCCAGGAGGACTTCGTTTTATTGGACTCCCTCGGTGGACTTGTGGCCTCAGCCCTTGAGCTCGAGGA
GGAGTGCTGGCTGGAGTTGCAGGCTGCCTTTCTGATGGCTCTCGAAAAACGATCAACCCCTGTGGTGTTGGTGGCTGAGG
AAGTGGGCTGGGGCGTGGTTCCGCCAACCGCCATCGGCGGACGCTTTCGCGATCGCAATGGAAGCCTGACCCGGCAGTGT
GAGCAACTCTGCTCGGAAAGTTGGCTCGTGGCAGCTGGACGCGCCTTGCCTCTCCATCAGCTCGCACAACGCCTCAATCC
CGCACCCTGA

Upstream 100 bases:

>100_bases
GCCACCTTCCCGGTGATCCTGGCGACGATCTTCAAGTACTGGATCTTCCGCTACCTCAACCGCGTGTCGCCGTCCTCGGT
GACAACCCTGCGCGGCATGA

Downstream 100 bases:

>100_bases
GTCATGCCTCAGATCGTTTTGGTGGAGCCTGAGATTCCGCCCAATACCGGCAATATCGCCCGCACCTGCGCGGCCACAGA
GACCCCCCTCCACCTGGTGG

Product: bifunctional adenosylcobalamin biosynthesis protein (adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase

Products: NA

Alternate protein names: Adenosylcobinamide kinase; Adenosylcobinamide-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAVANHLLITGPSRGGKSEWAEQRIREMAGAAAITYLATGPTLPDDAAWQQRLSRHRQRRPEHWRLLEASSISAVSQLLQ
QGSDCQEDFVLLDSLGGLVASALELEEECWLELQAAFLMALEKRSTPVVLVAEEVGWGVVPPTAIGGRFRDRNGSLTRQC
EQLCSESWLVAAGRALPLHQLAQRLNPAP

Sequences:

>Translated_189_residues
MAVANHLLITGPSRGGKSEWAEQRIREMAGAAAITYLATGPTLPDDAAWQQRLSRHRQRRPEHWRLLEASSISAVSQLLQ
QGSDCQEDFVLLDSLGGLVASALELEEECWLELQAAFLMALEKRSTPVVLVAEEVGWGVVPPTAIGGRFRDRNGSLTRQC
EQLCSESWLVAAGRALPLHQLAQRLNPAP
>Mature_188_residues
AVANHLLITGPSRGGKSEWAEQRIREMAGAAAITYLATGPTLPDDAAWQQRLSRHRQRRPEHWRLLEASSISAVSQLLQQ
GSDCQEDFVLLDSLGGLVASALELEEECWLELQAAFLMALEKRSTPVVLVAEEVGWGVVPPTAIGGRFRDRNGSLTRQCE
QLCSESWLVAAGRALPLHQLAQRLNPAP

Specific function: ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate [H]

COG id: COG2087

COG function: function code H; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788302, Length=187, Percent_Identity=31.0160427807487, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003203 [H]

Pfam domain/function: PF02283 CobU [H]

EC number: =2.7.1.156; =2.7.7.62 [H]

Molecular weight: Translated: 20729; Mature: 20598

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVANHLLITGPSRGGKSEWAEQRIREMAGAAAITYLATGPTLPDDAAWQQRLSRHRQRR
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
PEHWRLLEASSISAVSQLLQQGSDCQEDFVLLDSLGGLVASALELEEECWLELQAAFLMA
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKRSTPVVLVAEEVGWGVVPPTAIGGRFRDRNGSLTRQCEQLCSESWLVAAGRALPLHQ
HHCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHH
LAQRLNPAP
HHHHCCCCC
>Mature Secondary Structure 
AVANHLLITGPSRGGKSEWAEQRIREMAGAAAITYLATGPTLPDDAAWQQRLSRHRQRR
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
PEHWRLLEASSISAVSQLLQQGSDCQEDFVLLDSLGGLVASALELEEECWLELQAAFLMA
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKRSTPVVLVAEEVGWGVVPPTAIGGRFRDRNGSLTRQCEQLCSESWLVAAGRALPLHQ
HHCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCHHH
LAQRLNPAP
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]