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The map label for this gene is arlS [H]

Identifier: 148242219

GI number: 148242219

Start: 986558

End: 988066

Strand: Direct

Name: arlS [H]

Synonym: SynRCC307_1120

Alternate gene names: 148242219

Gene position: 986558-988066 (Clockwise)

Preceding gene: 148242215

Following gene: 148242220

Centisome position: 44.34

GC content: 61.03

Gene sequence:

>1509_bases
ATGGCCGCTGGAAGGCTGGCTCTCATCCTGATCAGGTTTTGCCGTTTGCGCTTGAAAGCCAGAGCTGACAACAGCGCCTG
GGCTGTTGACCATGGAGAGATGACAAGCCAGAGACATTGGCGCGATCGCTTGCTGGGCACCCTCCAGGGGCAGCTGCAGC
TGGCCACTTATGTGACGGTGTTTCTGGGCTTCACCGGAGCCTCCTGCGCGGGGCTCTGGGTGAGCGAGCGAAACCTGTTC
CGCCAACACAGCATGGCCGTAGTGCAATCGGCAGCTGGGATTGCTCAGGCCCTGGAGCGGTTGCCGGATCCGCCCAGTCG
TCTACGGGTGCAGCAGCAACTCGAGAGCATCAGCGATAAGCGCACCATTTTTTGGTTTCAACAGAACGATGGCTCGCTGA
TCTTTCCGCGATCGCCGCTGCAGCCCCCCAGCGCCTACCTGCTGGAGCGGGCCCAGGCCCAGCCCTCACAGCAGGTGATC
ACCGATGCCCAACGGCGCTATCTCACCAAAGAGGTGCTGCGCTTGCCCAGTGGGGCCAGTGTTTGGGCTGCTTGTGATGT
GAGCGTTAGCTCGCTGGCCTTCAGCTCCTACATCTCTTGGATGATCCTGATTTGGTCGGTCTGTTTGGTGCTGACCCTCT
TGGTGGTCACTGTGTTGGTGCGGCGCATTGTTCGGCCCTTGCGGCAACTCAGCGAGCTCACCGAAACGGTGACAGCCGAC
ACGTTGCAGAACTCCCACGTGCAGTTCAGCGCTGCCCCTGAAGAGATCAGCCGCCTGGCGGAGAACTATGAGGAGCTGTT
GCAGCGTTTGTCGCTGTCGTGGAGCCATCAACGCCAGTTCGTGAGCGCTGTGAGCCATGAGCTGCGTACACCGCTCACGA
TTGTTGGCGGTTACATCAAGCGCACCCTCCGCACCGGAGACACTCTCGAGGCTTCCCAGCGCAAGGGGTTGCAAACCGCT
GAGCAGGAAACCCTGCGCATGCGCCATTTGCTCGATGATTTGCTCGATTTATCCCGCGGTGATTCAGGTCGGCTCAGCGT
GAGCCAGCAGCCGGTGGCGTTGCTGCCGTTGCTGGAGCAGGTGCAGGAGTTGGCCCAGAGCACGCAGCAGCGCAGCATCG
TTTTGCTGCTGCCAGATTCCGCTGAGCTGATCGCCAATGCCGATCCCGATCGCTTGCAGCAGGTGCTGCTGAATTTGATT
GAAAATGCCTGTAAGTATTCCGGGCCCCAAGCGCCGGTTGAGCTGGCCCTGCTGTCATCCCCCGACGAGCTGACGATCGA
AGTGCGTGATCAGGGCATTGGGGTGCCGCCTGAGGATCAAGAACGCATCTTTGAGCGCTTCCAGCGCGCCACCAATGCCC
CTGCTGGTGAGGGCTCTGGCTTGGGCTTATCGGTGGTGCGATTGTTGGTGGAGGGCATGGGCGGCCAGGTCAGCCTGCGC
AGCCAGCTCGGCAGAGGCAGTGTGTTCAGCCTGCACCTGCGTCCCGTTGAACGCGCCGATCACACCTGA

Upstream 100 bases:

>100_bases
CGATGGCACCACCAGCACATCCCAGGGTGCTGGTGATCCATCGACGTCATCGACATCCGCTGAGAGGCGCTGCTGCAGCT
CCGCAAAGCTCAGGGCTGAC

Downstream 100 bases:

>100_bases
TGCTCGCCTACCTCGTTGCCACATCACTGCTGATCCCGGCCAACCTCTGGGCTGCGATCACCCCGCACCTGCATAGCGAA
GTGTCGATGCGGATCCTGCA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MAAGRLALILIRFCRLRLKARADNSAWAVDHGEMTSQRHWRDRLLGTLQGQLQLATYVTVFLGFTGASCAGLWVSERNLF
RQHSMAVVQSAAGIAQALERLPDPPSRLRVQQQLESISDKRTIFWFQQNDGSLIFPRSPLQPPSAYLLERAQAQPSQQVI
TDAQRRYLTKEVLRLPSGASVWAACDVSVSSLAFSSYISWMILIWSVCLVLTLLVVTVLVRRIVRPLRQLSELTETVTAD
TLQNSHVQFSAAPEEISRLAENYEELLQRLSLSWSHQRQFVSAVSHELRTPLTIVGGYIKRTLRTGDTLEASQRKGLQTA
EQETLRMRHLLDDLLDLSRGDSGRLSVSQQPVALLPLLEQVQELAQSTQQRSIVLLLPDSAELIANADPDRLQQVLLNLI
ENACKYSGPQAPVELALLSSPDELTIEVRDQGIGVPPEDQERIFERFQRATNAPAGEGSGLGLSVVRLLVEGMGGQVSLR
SQLGRGSVFSLHLRPVERADHT

Sequences:

>Translated_502_residues
MAAGRLALILIRFCRLRLKARADNSAWAVDHGEMTSQRHWRDRLLGTLQGQLQLATYVTVFLGFTGASCAGLWVSERNLF
RQHSMAVVQSAAGIAQALERLPDPPSRLRVQQQLESISDKRTIFWFQQNDGSLIFPRSPLQPPSAYLLERAQAQPSQQVI
TDAQRRYLTKEVLRLPSGASVWAACDVSVSSLAFSSYISWMILIWSVCLVLTLLVVTVLVRRIVRPLRQLSELTETVTAD
TLQNSHVQFSAAPEEISRLAENYEELLQRLSLSWSHQRQFVSAVSHELRTPLTIVGGYIKRTLRTGDTLEASQRKGLQTA
EQETLRMRHLLDDLLDLSRGDSGRLSVSQQPVALLPLLEQVQELAQSTQQRSIVLLLPDSAELIANADPDRLQQVLLNLI
ENACKYSGPQAPVELALLSSPDELTIEVRDQGIGVPPEDQERIFERFQRATNAPAGEGSGLGLSVVRLLVEGMGGQVSLR
SQLGRGSVFSLHLRPVERADHT
>Mature_501_residues
AAGRLALILIRFCRLRLKARADNSAWAVDHGEMTSQRHWRDRLLGTLQGQLQLATYVTVFLGFTGASCAGLWVSERNLFR
QHSMAVVQSAAGIAQALERLPDPPSRLRVQQQLESISDKRTIFWFQQNDGSLIFPRSPLQPPSAYLLERAQAQPSQQVIT
DAQRRYLTKEVLRLPSGASVWAACDVSVSSLAFSSYISWMILIWSVCLVLTLLVVTVLVRRIVRPLRQLSELTETVTADT
LQNSHVQFSAAPEEISRLAENYEELLQRLSLSWSHQRQFVSAVSHELRTPLTIVGGYIKRTLRTGDTLEASQRKGLQTAE
QETLRMRHLLDDLLDLSRGDSGRLSVSQQPVALLPLLEQVQELAQSTQQRSIVLLLPDSAELIANADPDRLQQVLLNLIE
NACKYSGPQAPVELALLSSPDELTIEVRDQGIGVPPEDQERIFERFQRATNAPAGEGSGLGLSVVRLLVEGMGGQVSLRS
QLGRGSVFSLHLRPVERADHT

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=345, Percent_Identity=28.9855072463768, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=31.25, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1788393, Length=372, Percent_Identity=26.8817204301075, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=29.9180327868852, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=30.7339449541284, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790346, Length=295, Percent_Identity=28.8135593220339, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=29.3388429752066, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786783, Length=325, Percent_Identity=24.3076923076923, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=26.8707482993197, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=311, Percent_Identity=28.6173633440514, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=31.6363636363636, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.9475982532751, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=31.1643835616438, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081816, Length=219, Percent_Identity=31.9634703196347, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=33.7837837837838, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=28.7162162162162, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787894, Length=260, Percent_Identity=28.8461538461538, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=27.1186440677966, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=28.8990825688073, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=25.4385964912281, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55865; Mature: 55734

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGRLALILIRFCRLRLKARADNSAWAVDHGEMTSQRHWRDRLLGTLQGQLQLATYVTV
CCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGFTGASCAGLWVSERNLFRQHSMAVVQSAAGIAQALERLPDPPSRLRVQQQLESISDK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RTIFWFQQNDGSLIFPRSPLQPPSAYLLERAQAQPSQQVITDAQRRYLTKEVLRLPSGAS
CEEEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VWAACDVSVSSLAFSSYISWMILIWSVCLVLTLLVVTVLVRRIVRPLRQLSELTETVTAD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLQNSHVQFSAAPEEISRLAENYEELLQRLSLSWSHQRQFVSAVSHELRTPLTIVGGYIK
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RTLRTGDTLEASQRKGLQTAEQETLRMRHLLDDLLDLSRGDSGRLSVSQQPVALLPLLEQ
HHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
VQELAQSTQQRSIVLLLPDSAELIANADPDRLQQVLLNLIENACKYSGPQAPVELALLSS
HHHHHHHHHHCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
PDELTIEVRDQGIGVPPEDQERIFERFQRATNAPAGEGSGLGLSVVRLLVEGMGGQVSLR
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEHH
SQLGRGSVFSLHLRPVERADHT
HHCCCCCEEEEEECCHHCCCCC
>Mature Secondary Structure 
AAGRLALILIRFCRLRLKARADNSAWAVDHGEMTSQRHWRDRLLGTLQGQLQLATYVTV
CCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGFTGASCAGLWVSERNLFRQHSMAVVQSAAGIAQALERLPDPPSRLRVQQQLESISDK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RTIFWFQQNDGSLIFPRSPLQPPSAYLLERAQAQPSQQVITDAQRRYLTKEVLRLPSGAS
CEEEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VWAACDVSVSSLAFSSYISWMILIWSVCLVLTLLVVTVLVRRIVRPLRQLSELTETVTAD
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLQNSHVQFSAAPEEISRLAENYEELLQRLSLSWSHQRQFVSAVSHELRTPLTIVGGYIK
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RTLRTGDTLEASQRKGLQTAEQETLRMRHLLDDLLDLSRGDSGRLSVSQQPVALLPLLEQ
HHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
VQELAQSTQQRSIVLLLPDSAELIANADPDRLQQVLLNLIENACKYSGPQAPVELALLSS
HHHHHHHHHHCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
PDELTIEVRDQGIGVPPEDQERIFERFQRATNAPAGEGSGLGLSVVRLLVEGMGGQVSLR
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEHH
SQLGRGSVFSLHLRPVERADHT
HHCCCCCEEEEEECCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA