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The map label for this gene is qacE [H]

Identifier: 148242162

GI number: 148242162

Start: 958724

End: 959059

Strand: Direct

Name: qacE [H]

Synonym: SynRCC307_1063

Alternate gene names: 148242162

Gene position: 958724-959059 (Clockwise)

Preceding gene: 148242161

Following gene: 148242163

Centisome position: 43.09

GC content: 56.85

Gene sequence:

>336_bases
TTGATGCTTCCTGCTTGGTCTTTGCTGCTCCTGGCGATTGCCGCTGAGGTGATCGGCACCTCGTGCCTGAAGCTCTCCGA
TGGTTTCAGCCGATTGTGGCCATCTGTTGTGGTGTTGCTGGCCTACAGCACGTCGATGCTGTTGCTATCGCGGGTGGTGC
AGACCATTCCCTTAGGCATCACCTATGCCCTGTGGAGCGGCATCGGAATTGTGGCCATCGTGCTAGTCGGCGTGTTCGTC
TACAGGCAAGTTCCAACCCCAACCCAGTTGTCAGGCATGGCATTGATCACAGCAGGGGTGGTGATGGTGAATATCACAGG
CCAGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
TCTGTTGGCTTGCTTGGCTTGGTACGAAGGGGAGGACTGGCTGGATCAGGTCTGAAGCCCAGGCTCGCAGAGCTGCTAGG
CCTAGGGCTGGTGTGGTGTT

Downstream 100 bases:

>100_bases
GGTTTTGTACAATTGCTCGTGAAACATGTAGCTTTTGAAACTTTCCCTTGGCGGGATATTTTTTAATGTTGATCTATTCA
AAGAACTCGTAAGCGTGTTT

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 111; Mature: 111

Protein sequence:

>111_residues
MMLPAWSLLLLAIAAEVIGTSCLKLSDGFSRLWPSVVVLLAYSTSMLLLSRVVQTIPLGITYALWSGIGIVAIVLVGVFV
YRQVPTPTQLSGMALITAGVVMVNITGQLKG

Sequences:

>Translated_111_residues
MMLPAWSLLLLAIAAEVIGTSCLKLSDGFSRLWPSVVVLLAYSTSMLLLSRVVQTIPLGITYALWSGIGIVAIVLVGVFV
YRQVPTPTQLSGMALITAGVVMVNITGQLKG
>Mature_111_residues
MMLPAWSLLLLAIAAEVIGTSCLKLSDGFSRLWPSVVVLLAYSTSMLLLSRVVQTIPLGITYALWSGIGIVAIVLVGVFV
YRQVPTPTQLSGMALITAGVVMVNITGQLKG

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=94, Percent_Identity=47.8723404255319, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI87082378, Length=97, Percent_Identity=37.1134020618557, Blast_Score=67, Evalue=4e-13,
Organism=Escherichia coli, GI1787884, Length=106, Percent_Identity=35.8490566037736, Blast_Score=59, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11746; Mature: 11746

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLPAWSLLLLAIAAEVIGTSCLKLSDGFSRLWPSVVVLLAYSTSMLLLSRVVQTIPLGI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TYALWSGIGIVAIVLVGVFVYRQVPTPTQLSGMALITAGVVMVNITGQLKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MMLPAWSLLLLAIAAEVIGTSCLKLSDGFSRLWPSVVVLLAYSTSMLLLSRVVQTIPLGI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TYALWSGIGIVAIVLVGVFVYRQVPTPTQLSGMALITAGVVMVNITGQLKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]