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The map label for this gene is cya [H]

Identifier: 148241991

GI number: 148241991

Start: 808276

End: 810645

Strand: Direct

Name: cya [H]

Synonym: SynRCC307_0892

Alternate gene names: 148241991

Gene position: 808276-810645 (Clockwise)

Preceding gene: 148241988

Following gene: 148241992

Centisome position: 36.33

GC content: 48.57

Gene sequence:

>2370_bases
ATGGCTTATTTTGTTGACTCTCAATACGAACACTACGGAACAGCACGAGCAACAGGAATCAACAGAGAACTAACTGAATC
AGAACGAAGCGAAAATCAACTTCGGATCAATGCTGGAGCTACTTCAGACAATGGGGGCGGGACAGGAACCACAAATATTG
CCATTGCTTCAGCAGTGCTCAATACGACACTTGATACCAGAGCGACAGACATTGACATCAGTGCAAGCGCTTGGGGCTAT
GAGGCTTATTCATATGGACTATCGGGATCAACACTGAACGCAACAAACAATGCTGGCGTTGATTTGGATATTCAAACCCA
CTCAACTGTTAGAGGGTACGATCCAGCTAATGGCCTAGACAATAGCCATATCTCAACTGGTGAAGGCAATGACAGAATTG
AAATTCTAGCTTCAGCATCTGGGAGCTCACAGGGAGCGAATCTCCAAAGCAATCAGCAGCTTTTTGCTCGCGGCATGACC
GCAGGCTCAAGCATCAATAGCGGTGGCGGTGATGACAATATAATTATCAATGCAAGTGCTGCTCAGCAATCATATTCAGC
AAATGCAGTGTTGTCAGCAACTGGCGTTGAGCGATCAATGATTGACACTGGCGATGGCAATGACACTCTTCACATTCTTG
CTTCTGCCTCGACTTATTACGGATCAGAATTAGGCGTTGGACTTTCCAGCTCTTCAGTTACACTTGGTTCGGGAGACGAC
AATTTCTATCTGCATGGCAATTATGAGAACTCAAGCGTTGATGGTGGCACTGGCTTCGATACACTAACCCTCAGCAGAGG
CACAGCTTCCTCGGTTGTTTCCAGGCAAGATGGGTCTTTGAGTGTAAGCAATGGGAATCAATCCCTGATTCTTCAAGGTA
TTGAAAGGATTAACTTCGCCGACGGGACTAGCTATGAGGCGCCTCCAGCAAAGCCTGGTGTAACTGTTGAATATGGATCG
ACCTTGATCTCGGAAAATGGCGATTCAACTACCATTTCATACAAACTCGACTCTCCGCCGTCGGAGACTGTTGCTATTTG
GCTTCGCAACTCAGATACAGCGGAGGCAAGTCTAAGCCATGAATATCTTGAGTTTGATGCAACAAACTGGAATCAAGAGC
AAGTTGTAACTGTTACGGGCCTAAGCGACAGGGAAGTCGACGGAGCGAAAGCTGCAACTATTACCCATGAAATTGTAAGC
AATGACTTTGATTATGCCCCTCGTGCCGATGGCACTGGTGGTGTCGTCATCGAAAATATTGTATTCACAAACGCAGATGC
AGATGAGCATCAAACTATTTATGGAGACCGAGAGGTAGGTAGGTATAATGATCGACTAATTGGCGAGGACGGAAATGATC
GGATTTACGGCGGATGGGGTCGTGATCAAGTTAATAGTGGCTGGGGTGGCGATCGAATTTATGGTGGCTATGACGACGAC
GTCCTTTACGGCGAAGAGGGTAATGATCAGCTTTATGGAGAGGCGGATGACGATCGCCTCTTTGGAGGCAGCGGCAATGA
CGTCCTAAATGGTGGTACTGGCGCCGACTACATGAGTGGCGGAGCTGGCAATGACACTTATTACGTTGACAATGAAAACG
ATATTATTGATGATCGTGGCTTGTCTTCCGATGTAGATACGGTCGTTCTACAAGGAGCTGTTCGATTCACCCTTGGTAAT
GGTATTGAGAGTGCTGTGGGGAATAATGCTAATAACACTCTCAATGGAAACTCATCAAATAACAACCTTGATGGGGGGGC
GGGAAACGACAGCCTTCAAGGCGCCAGTGGGAATGATCAACTCATTGGTGGTGCCGGGAATGACACGCTTAATGGTGGCT
CTGGTCGGGACACAGCTGTGTTTCATGGCCAGTCCAATCGCATCAACCTCAACATATCTGGTTGGCAAAACACGAGAGAA
GGTCGTGATCGCTTGGTCTCTATTGAGAGCGTTAATGCAGGAGGCGGCAATGATGTTGTGACTGGCAACCGTGGCAACAA
CACTCTTAGTGGCCAAAGTGGTAATGATTCACTGAGAGGAGCGGCTGGCAGCGATTACTTATTGGGGGGCAACGGCAGCG
ACAGGCTTATCGGTGGCTCCGGTAATGACAGGCTTGTTGGTGGGTCTGGTAATGACAGGCTTGTTGGTGGCTCTGGTCGT
GACACCTTTGTTCTCTCTGAGGGCGCTGGCTATGATCGCATCTCGGACTTCCGTAATGGCCAAGACCGCATTCAAGTAGG
CGCTGGTGTTGACAACCTGCGAGTTCAAAATCGCAATGGCCATGCCTACGTCTATGAAGGACGGGATCTGATGGCTGTGG
TCCAAGGCGGTGCAGGTGACTTGCAGGAAAGGGGAAACTTCCTGATCTGA

Upstream 100 bases:

>100_bases
AGGTCAAGAGGCAAAAAAACAATTTGAGTGACATCAAGTTGATGCCAATTGACTGATTGAAACAATCATTTTCCTCAACA
GCATTCTGGAGGGTTTTAAA

Downstream 100 bases:

>100_bases
TCCAACTCGGCAGAACTATCCACGGCCCCTGCTTCGGTAGGGGCTTTTATTTGGGAGATTGGATGGAGATCGGCTGATAT
CGCTCTCTGGCACACGGTTT

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MAYFVDSQYEHYGTARATGINRELTESERSENQLRINAGATSDNGGGTGTTNIAIASAVLNTTLDTRATDIDISASAWGY
EAYSYGLSGSTLNATNNAGVDLDIQTHSTVRGYDPANGLDNSHISTGEGNDRIEILASASGSSQGANLQSNQQLFARGMT
AGSSINSGGGDDNIIINASAAQQSYSANAVLSATGVERSMIDTGDGNDTLHILASASTYYGSELGVGLSSSSVTLGSGDD
NFYLHGNYENSSVDGGTGFDTLTLSRGTASSVVSRQDGSLSVSNGNQSLILQGIERINFADGTSYEAPPAKPGVTVEYGS
TLISENGDSTTISYKLDSPPSETVAIWLRNSDTAEASLSHEYLEFDATNWNQEQVVTVTGLSDREVDGAKAATITHEIVS
NDFDYAPRADGTGGVVIENIVFTNADADEHQTIYGDREVGRYNDRLIGEDGNDRIYGGWGRDQVNSGWGGDRIYGGYDDD
VLYGEEGNDQLYGEADDDRLFGGSGNDVLNGGTGADYMSGGAGNDTYYVDNENDIIDDRGLSSDVDTVVLQGAVRFTLGN
GIESAVGNNANNTLNGNSSNNNLDGGAGNDSLQGASGNDQLIGGAGNDTLNGGSGRDTAVFHGQSNRINLNISGWQNTRE
GRDRLVSIESVNAGGGNDVVTGNRGNNTLSGQSGNDSLRGAAGSDYLLGGNGSDRLIGGSGNDRLVGGSGNDRLVGGSGR
DTFVLSEGAGYDRISDFRNGQDRIQVGAGVDNLRVQNRNGHAYVYEGRDLMAVVQGGAGDLQERGNFLI

Sequences:

>Translated_789_residues
MAYFVDSQYEHYGTARATGINRELTESERSENQLRINAGATSDNGGGTGTTNIAIASAVLNTTLDTRATDIDISASAWGY
EAYSYGLSGSTLNATNNAGVDLDIQTHSTVRGYDPANGLDNSHISTGEGNDRIEILASASGSSQGANLQSNQQLFARGMT
AGSSINSGGGDDNIIINASAAQQSYSANAVLSATGVERSMIDTGDGNDTLHILASASTYYGSELGVGLSSSSVTLGSGDD
NFYLHGNYENSSVDGGTGFDTLTLSRGTASSVVSRQDGSLSVSNGNQSLILQGIERINFADGTSYEAPPAKPGVTVEYGS
TLISENGDSTTISYKLDSPPSETVAIWLRNSDTAEASLSHEYLEFDATNWNQEQVVTVTGLSDREVDGAKAATITHEIVS
NDFDYAPRADGTGGVVIENIVFTNADADEHQTIYGDREVGRYNDRLIGEDGNDRIYGGWGRDQVNSGWGGDRIYGGYDDD
VLYGEEGNDQLYGEADDDRLFGGSGNDVLNGGTGADYMSGGAGNDTYYVDNENDIIDDRGLSSDVDTVVLQGAVRFTLGN
GIESAVGNNANNTLNGNSSNNNLDGGAGNDSLQGASGNDQLIGGAGNDTLNGGSGRDTAVFHGQSNRINLNISGWQNTRE
GRDRLVSIESVNAGGGNDVVTGNRGNNTLSGQSGNDSLRGAAGSDYLLGGNGSDRLIGGSGNDRLVGGSGNDRLVGGSGR
DTFVLSEGAGYDRISDFRNGQDRIQVGAGVDNLRVQNRNGHAYVYEGRDLMAVVQGGAGDLQERGNFLI
>Mature_788_residues
AYFVDSQYEHYGTARATGINRELTESERSENQLRINAGATSDNGGGTGTTNIAIASAVLNTTLDTRATDIDISASAWGYE
AYSYGLSGSTLNATNNAGVDLDIQTHSTVRGYDPANGLDNSHISTGEGNDRIEILASASGSSQGANLQSNQQLFARGMTA
GSSINSGGGDDNIIINASAAQQSYSANAVLSATGVERSMIDTGDGNDTLHILASASTYYGSELGVGLSSSSVTLGSGDDN
FYLHGNYENSSVDGGTGFDTLTLSRGTASSVVSRQDGSLSVSNGNQSLILQGIERINFADGTSYEAPPAKPGVTVEYGST
LISENGDSTTISYKLDSPPSETVAIWLRNSDTAEASLSHEYLEFDATNWNQEQVVTVTGLSDREVDGAKAATITHEIVSN
DFDYAPRADGTGGVVIENIVFTNADADEHQTIYGDREVGRYNDRLIGEDGNDRIYGGWGRDQVNSGWGGDRIYGGYDDDV
LYGEEGNDQLYGEADDDRLFGGSGNDVLNGGTGADYMSGGAGNDTYYVDNENDIIDDRGLSSDVDTVVLQGAVRFTLGNG
IESAVGNNANNTLNGNSSNNNLDGGAGNDSLQGASGNDQLIGGAGNDTLNGGSGRDTAVFHGQSNRINLNISGWQNTREG
RDRLVSIESVNAGGGNDVVTGNRGNNTLSGQSGNDSLRGAAGSDYLLGGNGSDRLIGGSGNDRLVGGSGNDRLVGGSGRD
TFVLSEGAGYDRISDFRNGQDRIQVGAGVDNLRVQNRNGHAYVYEGRDLMAVVQGGAGDLQERGNFLI

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 82173; Mature: 82042

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYFVDSQYEHYGTARATGINRELTESERSENQLRINAGATSDNGGGTGTTNIAIASAVL
CEEEECCCHHHCCCEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHEEEHHHH
NTTLDTRATDIDISASAWGYEAYSYGLSGSTLNATNNAGVDLDIQTHSTVRGYDPANGLD
HCCCCCCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCEEEEEECCCEECCCCCCCCCC
NSHISTGEGNDRIEILASASGSSQGANLQSNQQLFARGMTAGSSINSGGGDDNIIINASA
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECC
AQQSYSANAVLSATGVERSMIDTGDGNDTLHILASASTYYGSELGVGLSSSSVTLGSGDD
CCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEECCEECCCHHCCCCCCCEEEECCCCC
NFYLHGNYENSSVDGGTGFDTLTLSRGTASSVVSRQDGSLSVSNGNQSLILQGIERINFA
CEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCEEECCCCCEEEEEHHHHCCCC
DGTSYEAPPAKPGVTVEYGSTLISENGDSTTISYKLDSPPSETVAIWLRNSDTAEASLSH
CCCCCCCCCCCCCEEEECCCEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHCCC
EYLEFDATNWNQEQVVTVTGLSDREVDGAKAATITHEIVSNDFDYAPRADGTGGVVIENI
EEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEE
VFTNADADEHQTIYGDREVGRYNDRLIGEDGNDRIYGGWGRDQVNSGWGGDRIYGGYDDD
EEECCCCCCCEEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCCCCCCCCCEECCCCCC
VLYGEEGNDQLYGEADDDRLFGGSGNDVLNGGTGADYMSGGAGNDTYYVDNENDIIDDRG
EEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHCCCCCCCCCEEECCCCCEECCCC
LSSDVDTVVLQGAVRFTLGNGIESAVGNNANNTLNGNSSNNNLDGGAGNDSLQGASGNDQ
CCCCHHHEEEECEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LIGGAGNDTLNGGSGRDTAVFHGQSNRINLNISGWQNTREGRDRLVSIESVNAGGGNDVV
EEECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHHEEEEEEEECCCCCCCEE
TGNRGNNTLSGQSGNDSLRGAAGSDYLLGGNGSDRLIGGSGNDRLVGGSGNDRLVGGSGR
ECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCEEECCCCC
DTFVLSEGAGYDRISDFRNGQDRIQVGAGVDNLRVQNRNGHAYVYEGRDLMAVVQGGAGD
CEEEEECCCCCHHHHHHCCCCCEEEECCCCCCEEEECCCCCEEEECCCEEEEEEECCCCC
LQERGNFLI
HHHCCCCCC
>Mature Secondary Structure 
AYFVDSQYEHYGTARATGINRELTESERSENQLRINAGATSDNGGGTGTTNIAIASAVL
EEEECCCHHHCCCEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHEEEHHHH
NTTLDTRATDIDISASAWGYEAYSYGLSGSTLNATNNAGVDLDIQTHSTVRGYDPANGLD
HCCCCCCCEEEEEECCCCCCEEEEECCCCCEECCCCCCCEEEEEECCCEECCCCCCCCCC
NSHISTGEGNDRIEILASASGSSQGANLQSNQQLFARGMTAGSSINSGGGDDNIIINASA
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEECC
AQQSYSANAVLSATGVERSMIDTGDGNDTLHILASASTYYGSELGVGLSSSSVTLGSGDD
CCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEECCEECCCHHCCCCCCCEEEECCCCC
NFYLHGNYENSSVDGGTGFDTLTLSRGTASSVVSRQDGSLSVSNGNQSLILQGIERINFA
CEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCEEECCCCCEEEEEHHHHCCCC
DGTSYEAPPAKPGVTVEYGSTLISENGDSTTISYKLDSPPSETVAIWLRNSDTAEASLSH
CCCCCCCCCCCCCEEEECCCEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCCHHCCC
EYLEFDATNWNQEQVVTVTGLSDREVDGAKAATITHEIVSNDFDYAPRADGTGGVVIENI
EEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEE
VFTNADADEHQTIYGDREVGRYNDRLIGEDGNDRIYGGWGRDQVNSGWGGDRIYGGYDDD
EEECCCCCCCEEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCCCCCCCCCEECCCCCC
VLYGEEGNDQLYGEADDDRLFGGSGNDVLNGGTGADYMSGGAGNDTYYVDNENDIIDDRG
EEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHCCCCCCCCCEEECCCCCEECCCC
LSSDVDTVVLQGAVRFTLGNGIESAVGNNANNTLNGNSSNNNLDGGAGNDSLQGASGNDQ
CCCCHHHEEEECEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LIGGAGNDTLNGGSGRDTAVFHGQSNRINLNISGWQNTREGRDRLVSIESVNAGGGNDVV
EEECCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCHHEEEEEEEECCCCCCCEE
TGNRGNNTLSGQSGNDSLRGAAGSDYLLGGNGSDRLIGGSGNDRLVGGSGNDRLVGGSGR
ECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCEEECCCCC
DTFVLSEGAGYDRISDFRNGQDRIQVGAGVDNLRVQNRNGHAYVYEGRDLMAVVQGGAGD
CEEEEECCCCCHHHHHHCCCCCEEEECCCCCCEEEECCCCCEEEECCCEEEEEEECCCCC
LQERGNFLI
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]