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The map label for this gene is lysA [H]

Identifier: 148241889

GI number: 148241889

Start: 721085

End: 722476

Strand: Direct

Name: lysA [H]

Synonym: SynRCC307_0790

Alternate gene names: 148241889

Gene position: 721085-722476 (Clockwise)

Preceding gene: 148241883

Following gene: 148241890

Centisome position: 32.41

GC content: 62.64

Gene sequence:

>1392_bases
ATGGTCAGCACCTCCCCGGTTGCGACGAGTCCGCTGCCTTGGGCAGCTGGGGGAGTTGATCTCAGCAGCCCCAACCGCAA
TCTTGCTCCGCTCAGCACCGACATCGATCCAGACGGTCGCCTGCGCGTTGGCGAGTGCGTGTTGAGCGAGCTGGCCCAGC
GCTTTGGCACACCGCTTTATGTGATTGATGAGCGCAGCTTGCGCCAGGCCTGCACCGCCTACCGCGAGGCATTGGAACGC
CATTACCCAGGGCCGTCGTTGGCTGTCTACGCCTCCAAGGCGAACAGCAGCTTGGCGATCACCGCCGTGGTGGCATCGGA
AGGGTTGGGCCTGGATGCCGTCTCAGCCGGTGAGTTGTTGACGGCACTCGAGGGCGGCATGCCGCCTGAGCGAATCGTGC
TGCATGGCAACAACAAATCCAGCGAGGAATTGGCCCTAGCTGTTCAAAACGGTGTGACGGTGGTGGTCGATAACTGGCAC
GACATCACCTTGCTGCAGGAGTTGGCCCAGGGCCGCACGGAACCGGTGGCGCTGATGCTGCGCTTCACCCCTGGCATTGA
GTGCCACACGCACGAATACATCCGCACCGGGCATCTCGACAGCAAGTTCGGCTTTGATCCCGATCAGCTGGAGCAGGTGC
TGACCCATCTGGCTGGTTGCCGTTGGGCCCGGGTTCAGGGTTTGCATGCCCATATCGGCTCTCAAATTTTTGAAGTGGAG
CCCCACCGCGATTTGGCGGCTGTCTTGGCTGATGCCTTGGTGCTGGCTCGCCGCTTGGGCCATGAACCCAGCGATCTGAA
TGTGGGCGGTGGTTTGGGCATCCGCTATGTGGCCTCCGACGATCCACCGAGCATCGATGGCTGGGTTCAGGTGGTCGCCG
AAGCGATGGTGGCGGCCTGCCGGGAGCGCAATCTCGAGCTCCCCCGTCTGTTATGCGAGCCGGGCCGATCCCTGGTGGCT
CCTGCTGGGGTGACCCTCTACACCGTTGGCAGCCGAAAGCAGATCCCCGATCTCAATACGTATGTGGCTGTCGATGGCGG
CATGAGCGATAACCCCCGCCCGATTACCTACCAATCGGAGTACACCGCCTGCCTGGCCGATCGACCGGGGGCGGAAGCCA
CCGAAACCGTGACCTTGGTGGGCAAACACTGCGAATCCGGCGATGTGTTGCTCAAGCAGTTGCCTCTGCCGGCCACCGAG
CCTGGTGATGTGTTGGTGGTGCTCGCCACAGGCGCTTACAACGCCTCAATGGCCTCGAACTACAACCGAATCCCCAAGCC
GGCTGCCGTGTTGGTGGCGGATGGCTGCGCCGAGCTGGTGCAAAGGAGGGAGAGGCCAGACGAACTGTTGCGCTACGACG
TCCTGCCGGAGCGGCTGCGATCGGTAGTGTGA

Upstream 100 bases:

>100_bases
GTCAAGGGCCAGGCACGCCGCCAGGTCACAGGCAGCCAGTGGTTGTGGATCCTGCGGACTGAAAGGATGGGAGGACGTTG
AAGCTTGCGTTGTTCCCGAC

Downstream 100 bases:

>100_bases
TCGCAACGAAGGAGGGATTCAGCGGTGCTGTGGCTGCGCATGCTGCTGGATCTGTTTTGTGCCGGGGCGCTTGGCTATCT
CCTGCTTGGCCGGGTCAGTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MVSTSPVATSPLPWAAGGVDLSSPNRNLAPLSTDIDPDGRLRVGECVLSELAQRFGTPLYVIDERSLRQACTAYREALER
HYPGPSLAVYASKANSSLAITAVVASEGLGLDAVSAGELLTALEGGMPPERIVLHGNNKSSEELALAVQNGVTVVVDNWH
DITLLQELAQGRTEPVALMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLEQVLTHLAGCRWARVQGLHAHIGSQIFEVE
PHRDLAAVLADALVLARRLGHEPSDLNVGGGLGIRYVASDDPPSIDGWVQVVAEAMVAACRERNLELPRLLCEPGRSLVA
PAGVTLYTVGSRKQIPDLNTYVAVDGGMSDNPRPITYQSEYTACLADRPGAEATETVTLVGKHCESGDVLLKQLPLPATE
PGDVLVVLATGAYNASMASNYNRIPKPAAVLVADGCAELVQRRERPDELLRYDVLPERLRSVV

Sequences:

>Translated_463_residues
MVSTSPVATSPLPWAAGGVDLSSPNRNLAPLSTDIDPDGRLRVGECVLSELAQRFGTPLYVIDERSLRQACTAYREALER
HYPGPSLAVYASKANSSLAITAVVASEGLGLDAVSAGELLTALEGGMPPERIVLHGNNKSSEELALAVQNGVTVVVDNWH
DITLLQELAQGRTEPVALMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLEQVLTHLAGCRWARVQGLHAHIGSQIFEVE
PHRDLAAVLADALVLARRLGHEPSDLNVGGGLGIRYVASDDPPSIDGWVQVVAEAMVAACRERNLELPRLLCEPGRSLVA
PAGVTLYTVGSRKQIPDLNTYVAVDGGMSDNPRPITYQSEYTACLADRPGAEATETVTLVGKHCESGDVLLKQLPLPATE
PGDVLVVLATGAYNASMASNYNRIPKPAAVLVADGCAELVQRRERPDELLRYDVLPERLRSVV
>Mature_463_residues
MVSTSPVATSPLPWAAGGVDLSSPNRNLAPLSTDIDPDGRLRVGECVLSELAQRFGTPLYVIDERSLRQACTAYREALER
HYPGPSLAVYASKANSSLAITAVVASEGLGLDAVSAGELLTALEGGMPPERIVLHGNNKSSEELALAVQNGVTVVVDNWH
DITLLQELAQGRTEPVALMLRFTPGIECHTHEYIRTGHLDSKFGFDPDQLEQVLTHLAGCRWARVQGLHAHIGSQIFEVE
PHRDLAAVLADALVLARRLGHEPSDLNVGGGLGIRYVASDDPPSIDGWVQVVAEAMVAACRERNLELPRLLCEPGRSLVA
PAGVTLYTVGSRKQIPDLNTYVAVDGGMSDNPRPITYQSEYTACLADRPGAEATETVTLVGKHCESGDVLLKQLPLPATE
PGDVLVVLATGAYNASMASNYNRIPKPAAVLVADGCAELVQRRERPDELLRYDVLPERLRSVV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=444, Percent_Identity=29.0540540540541, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789307, Length=316, Percent_Identity=25.9493670886076, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586474, Length=402, Percent_Identity=24.3781094527363, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49725; Mature: 49725

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTSPVATSPLPWAAGGVDLSSPNRNLAPLSTDIDPDGRLRVGECVLSELAQRFGTPLY
CCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEE
VIDERSLRQACTAYREALERHYPGPSLAVYASKANSSLAITAVVASEGLGLDAVSAGELL
EECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHH
TALEGGMPPERIVLHGNNKSSEELALAVQNGVTVVVDNWHDITLLQELAQGRTEPVALML
HHHHCCCCCCEEEEECCCCCCHHEEEEEECCCEEEEECCCHHHHHHHHHCCCCCCEEEEE
RFTPGIECHTHEYIRTGHLDSKFGFDPDQLEQVLTHLAGCRWARVQGLHAHIGSQIFEVE
EECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEC
PHRDLAAVLADALVLARRLGHEPSDLNVGGGLGIRYVASDDPPSIDGWVQVVAEAMVAAC
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
RERNLELPRLLCEPGRSLVAPAGVTLYTVGSRKQIPDLNTYVAVDGGMSDNPRPITYQSE
HHCCCCCHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEECCC
YTACLADRPGAEATETVTLVGKHCESGDVLLKQLPLPATEPGDVLVVLATGAYNASMASN
CCEEECCCCCCCCHHEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCHHHCC
YNRIPKPAAVLVADGCAELVQRRERPDELLRYDVLPERLRSVV
CCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSTSPVATSPLPWAAGGVDLSSPNRNLAPLSTDIDPDGRLRVGECVLSELAQRFGTPLY
CCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEE
VIDERSLRQACTAYREALERHYPGPSLAVYASKANSSLAITAVVASEGLGLDAVSAGELL
EECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHH
TALEGGMPPERIVLHGNNKSSEELALAVQNGVTVVVDNWHDITLLQELAQGRTEPVALML
HHHHCCCCCCEEEEECCCCCCHHEEEEEECCCEEEEECCCHHHHHHHHHCCCCCCEEEEE
RFTPGIECHTHEYIRTGHLDSKFGFDPDQLEQVLTHLAGCRWARVQGLHAHIGSQIFEVE
EECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEC
PHRDLAAVLADALVLARRLGHEPSDLNVGGGLGIRYVASDDPPSIDGWVQVVAEAMVAAC
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
RERNLELPRLLCEPGRSLVAPAGVTLYTVGSRKQIPDLNTYVAVDGGMSDNPRPITYQSE
HHCCCCCHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEECCC
YTACLADRPGAEATETVTLVGKHCESGDVLLKQLPLPATEPGDVLVVLATGAYNASMASN
CCEEECCCCCCCCHHEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCHHHCC
YNRIPKPAAVLVADGCAELVQRRERPDELLRYDVLPERLRSVV
CCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]