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The map label for this gene is gyrA [H]

Identifier: 148241841

GI number: 148241841

Start: 667687

End: 670266

Strand: Direct

Name: gyrA [H]

Synonym: SynRCC307_0742

Alternate gene names: 148241841

Gene position: 667687-670266 (Clockwise)

Preceding gene: 148241833

Following gene: 148241842

Centisome position: 30.01

GC content: 60.85

Gene sequence:

>2580_bases
ATGGCGGATCCCACCGGAGCGGGCAACCCCAGCGAGCGGATCATCCAAACCGACCTGCGCAACGAGATGTCGCGCTCCTA
CCTGGAGTACGCGATGAGTGTGATCGTGGGCCGGGCGCTGCCTGATGCTCGCGATGGCCTGAAGCCCGTGCATCGCCGCA
TTCTCTATGCGATGTACGAGTTGGGCCTCACCGCTGAGAGGCCCTACCGCAAATGCGCCCGTGTGGTGGGCGAGGTGTTG
GGCAAATATCACCCCCACGGGGACACCGCCGTCTACGACGCGCTGGTGCGCATGGCCCAGAACTTCTCGATGCGGGCACC
CCTGATCGATGGTCATGGCAACTTCGGCTCGGTGGATAACGACCCGCCGGCGGCGATGCGATACACCGAGTCGCGCTTGC
AGTCGCTAACGACCGACAGCCTGCTGGAGGACATCGAAAGCGAGACCGTCGATTTCATCGACAACTTCGATGGGTCCCAG
CAGGAGCCGACCGTGCTGCCGGCGCGTGTGCCGCAGCTGCTGCTCAATGGCTCAGCCGGTATTGCCGTTGGCATGGCGAC
CAACATTCCTCCCCACAACCTTGGGGAGTTGATTGATGGCGTTCTGGCGCTGATCGCTGATCCACAGATCGAAGAGCGGC
AGCTGATGTCGATCATTCCGGGGCCTGATTTTCCGACCGGTGGTCAAATTCTTGGCCGCAAGGGCATTCGCGAGACCTAC
ACCGGTGGACGTGGTTCGATCACCATGCGCGGTGTTGCCGCGATCGAAACGATTGAGGCGAAAGGACGTCCCGATCGCGA
TGCGGTGATCATCACCGAGCTGCCTTATCAGACCAACAAGGCCTCGTTGATTGAGCGCATTGCCGAGCTCGTCAATGACA
AGAAGCTCGAAGGCATCGCCGACATTCGCGATGAAAGCGACCGCGACGGCATGCGCATCGTCATCGAACTGCGCCGTGAT
GCCTACCCGCAGGTCGTTCTCAACAACCTCTACAAACTCACCCCGCTTCAGAACAACTTCAGTGCCTACACGTTGGCGCT
GGTCAAAGGTGAGCCCGTGGTGCTCAACCTCAAGCGGATGCTTGAGGTGTTTCTCGACTTCCGCATTGAGACGATTGAAC
GGCGCACCAAATACCTGCTGCGCAAAGCCGAGGAGCGCGATCACATTCTTCAGGGCTTGTTGGTGGCCCTCAATGATCTC
GACGCGATCATCCAGCTGATTCGCAATGCCGCCGATGCCGCCACCGCCCGTCAGGGGCTGGTCAATGACCATGGCCTCAG
CGAGATCCAGGCCGACGCCATCTTGCAGATGCAGTTGCGCCGTTTAACGGCGCTAGAAGCCGACAAGATCCGCCTCGAGC
ACGAGGACTTGATCGCCAAAATCGCTGACTACAAGGACATCCTCCAGCGTCGTGAGCGTGTGCTGTCGATCATTGAAGAG
GAGCTGCGGCAGCTCAAGGAACGCCACAACACGCCTCGCCGCACTGAGATCCTTGATCTCGAAGGTGGCCTGGAAGATAT
CGATCTGATCGCCAATGAGCGCTCGGTGGTGCTGCTGACCGAGAACGGCTACCTCAAGCGCATGCCGGTCAGCGAATTTG
AGTCCACCAGTCGCGGCACCCGCGGCAAGGCTGGGACCAAGAGCCAAGGCGAAGAGGCGGTGCGGCTGTTCATCAGCTGC
AACGACCACGATTCACTGCTGCTGTTCTCTGATCGAGGGGTCGTCTACTCATTACCGGCGTATCGGGTGCCCATTGCCAG
TCGTGCGGCCAAAGGAACCCCTGTGGTTCAGCTGTTGCCGATCCCCCGCGAAGAGCAAATCACCTCACTGCTCGCGGTAA
GTGCCTTCGAAGAGGACGTGCAATTGGTGATGTTGACCACTGGTGGTTTCATCAAGCGCACACCGCTGTCGGCCTTCTCC
AACATCCGCGCCAACGGCTTGATTGCCATCAATCTCGAAGACGCCGATTCCTTGCGCTGGGTTCGCTTGGCCCGTGCTGG
CGACAGCGTGCTGATCGGCTCCATCAATGGCATGACGATCCACTTCCGCATCAATGATCAGGATCTCCGGCCCCTGGGCC
GCACCGCCCGCGGTGTGCGTGCCATGGCCCTGCGCGATGGCGACAGCCTGGTGAGCATGGACGTGTTGCCCGCTGAGCTA
GCCGATCGCATTGCGGCCGCTGGTGAGGCCAGTGACGGAGAGAGTGAAGAGGCGGCCAGCAGTGATGGCCCTTGGGTGCT
GGTGGCCACAGCCAGCGGTCTGGGTAAGCGGGTTCCGGTCGATCAGTTCCGCTTGCAGCGCAGAGCCGGCCTTGGTTTGC
GCGGCATCAAGTTCCGCCGTGATGGTGATGCCTTGGTTGGCTTGTGCGTGATGGGCGCTGAAGAAGAGTTGCTACTGGTG
AGCGAGCGCGGCGTGATTGTGCGGTTGCAATCCGATGTCATTCCGCAACAGTCACGCGCCGCCACGGGTGTGCGTTTGCA
GCGGCTCGATAAGGGCGATCGCTTGGCTGAGGTGGTGCTGGTGCCGCCCGAAGCCGAAACAGACGATGAGTCTGCTGAGG
CGGCTGAAGCTGAGGCGTGA

Upstream 100 bases:

>100_bases
CGCTCAAGCAGCTGATCGGGGGTGCGGGGCGCAAAGCCCATGCGCTAGCGGCATACAACAGTAATGTTGGGGCTTCACAA
GGCTTAGCGCAGCAGGCGGA

Downstream 100 bases:

>100_bases
GCCCCACCCGATGGCGTGATGTCGCCGTTGTTGGTGGCGGTCCAGCAGCGCTGTGCATAGCGGCGGCCCTGGCCAAGCAG
CAGCTCCAGGTCACCTTGGT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 859; Mature: 858

Protein sequence:

>859_residues
MADPTGAGNPSERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTAERPYRKCARVVGEVL
GKYHPHGDTAVYDALVRMAQNFSMRAPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFIDNFDGSQ
QEPTVLPARVPQLLLNGSAGIAVGMATNIPPHNLGELIDGVLALIADPQIEERQLMSIIPGPDFPTGGQILGRKGIRETY
TGGRGSITMRGVAAIETIEAKGRPDRDAVIITELPYQTNKASLIERIAELVNDKKLEGIADIRDESDRDGMRIVIELRRD
AYPQVVLNNLYKLTPLQNNFSAYTLALVKGEPVVLNLKRMLEVFLDFRIETIERRTKYLLRKAEERDHILQGLLVALNDL
DAIIQLIRNAADAATARQGLVNDHGLSEIQADAILQMQLRRLTALEADKIRLEHEDLIAKIADYKDILQRRERVLSIIEE
ELRQLKERHNTPRRTEILDLEGGLEDIDLIANERSVVLLTENGYLKRMPVSEFESTSRGTRGKAGTKSQGEEAVRLFISC
NDHDSLLLFSDRGVVYSLPAYRVPIASRAAKGTPVVQLLPIPREEQITSLLAVSAFEEDVQLVMLTTGGFIKRTPLSAFS
NIRANGLIAINLEDADSLRWVRLARAGDSVLIGSINGMTIHFRINDQDLRPLGRTARGVRAMALRDGDSLVSMDVLPAEL
ADRIAAAGEASDGESEEAASSDGPWVLVATASGLGKRVPVDQFRLQRRAGLGLRGIKFRRDGDALVGLCVMGAEEELLLV
SERGVIVRLQSDVIPQQSRAATGVRLQRLDKGDRLAEVVLVPPEAETDDESAEAAEAEA

Sequences:

>Translated_859_residues
MADPTGAGNPSERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTAERPYRKCARVVGEVL
GKYHPHGDTAVYDALVRMAQNFSMRAPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFIDNFDGSQ
QEPTVLPARVPQLLLNGSAGIAVGMATNIPPHNLGELIDGVLALIADPQIEERQLMSIIPGPDFPTGGQILGRKGIRETY
TGGRGSITMRGVAAIETIEAKGRPDRDAVIITELPYQTNKASLIERIAELVNDKKLEGIADIRDESDRDGMRIVIELRRD
AYPQVVLNNLYKLTPLQNNFSAYTLALVKGEPVVLNLKRMLEVFLDFRIETIERRTKYLLRKAEERDHILQGLLVALNDL
DAIIQLIRNAADAATARQGLVNDHGLSEIQADAILQMQLRRLTALEADKIRLEHEDLIAKIADYKDILQRRERVLSIIEE
ELRQLKERHNTPRRTEILDLEGGLEDIDLIANERSVVLLTENGYLKRMPVSEFESTSRGTRGKAGTKSQGEEAVRLFISC
NDHDSLLLFSDRGVVYSLPAYRVPIASRAAKGTPVVQLLPIPREEQITSLLAVSAFEEDVQLVMLTTGGFIKRTPLSAFS
NIRANGLIAINLEDADSLRWVRLARAGDSVLIGSINGMTIHFRINDQDLRPLGRTARGVRAMALRDGDSLVSMDVLPAEL
ADRIAAAGEASDGESEEAASSDGPWVLVATASGLGKRVPVDQFRLQRRAGLGLRGIKFRRDGDALVGLCVMGAEEELLLV
SERGVIVRLQSDVIPQQSRAATGVRLQRLDKGDRLAEVVLVPPEAETDDESAEAAEAEA
>Mature_858_residues
ADPTGAGNPSERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTAERPYRKCARVVGEVLG
KYHPHGDTAVYDALVRMAQNFSMRAPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTTDSLLEDIESETVDFIDNFDGSQQ
EPTVLPARVPQLLLNGSAGIAVGMATNIPPHNLGELIDGVLALIADPQIEERQLMSIIPGPDFPTGGQILGRKGIRETYT
GGRGSITMRGVAAIETIEAKGRPDRDAVIITELPYQTNKASLIERIAELVNDKKLEGIADIRDESDRDGMRIVIELRRDA
YPQVVLNNLYKLTPLQNNFSAYTLALVKGEPVVLNLKRMLEVFLDFRIETIERRTKYLLRKAEERDHILQGLLVALNDLD
AIIQLIRNAADAATARQGLVNDHGLSEIQADAILQMQLRRLTALEADKIRLEHEDLIAKIADYKDILQRRERVLSIIEEE
LRQLKERHNTPRRTEILDLEGGLEDIDLIANERSVVLLTENGYLKRMPVSEFESTSRGTRGKAGTKSQGEEAVRLFISCN
DHDSLLLFSDRGVVYSLPAYRVPIASRAAKGTPVVQLLPIPREEQITSLLAVSAFEEDVQLVMLTTGGFIKRTPLSAFSN
IRANGLIAINLEDADSLRWVRLARAGDSVLIGSINGMTIHFRINDQDLRPLGRTARGVRAMALRDGDSLVSMDVLPAELA
DRIAAAGEASDGESEEAASSDGPWVLVATASGLGKRVPVDQFRLQRRAGLGLRGIKFRRDGDALVGLCVMGAEEELLLVS
ERGVIVRLQSDVIPQQSRAATGVRLQRLDKGDRLAEVVLVPPEAETDDESAEAAEAEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=356, Percent_Identity=24.7191011235955, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI19913406, Length=359, Percent_Identity=25.6267409470752, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788562, Length=849, Percent_Identity=43.8162544169611, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=709, Percent_Identity=36.6713681241185, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=358, Percent_Identity=24.8603351955307, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=291, Percent_Identity=27.4914089347079, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94636; Mature: 94505

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPTGAGNPSERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHH
LGLTAERPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQNFSMRAPLIDGHGNFGSVDN
HCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
DPPAAMRYTESRLQSLTTDSLLEDIESETVDFIDNFDGSQQEPTVLPARVPQLLLNGSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
IAVGMATNIPPHNLGELIDGVLALIADPQIEERQLMSIIPGPDFPTGGQILGRKGIRETY
EEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHC
TGGRGSITMRGVAAIETIEAKGRPDRDAVIITELPYQTNKASLIERIAELVNDKKLEGIA
CCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHCCCHH
DIRDESDRDGMRIVIELRRDAYPQVVLNNLYKLTPLQNNFSAYTLALVKGEPVVLNLKRM
HHCCCCCCCCCEEEEEEHHCCCHHHHHHHHHEECCCCCCCCEEEEEEEECCCEEEEHHHH
LEVFLDFRIETIERRTKYLLRKAEERDHILQGLLVALNDLDAIIQLIRNAADAATARQGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNDHGLSEIQADAILQMQLRRLTALEADKIRLEHEDLIAKIADYKDILQRRERVLSIIEE
CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRQLKERHNTPRRTEILDLEGGLEDIDLIANERSVVLLTENGYLKRMPVSEFESTSRGT
HHHHHHHHCCCCCCEEEEECCCCCCHHHHEECCCEEEEEECCCCEECCCHHHHHHCCCCC
RGKAGTKSQGEEAVRLFISCNDHDSLLLFSDRGVVYSLPAYRVPIASRAAKGTPVVQLLP
CCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCEEEECCCCCCCHHHHCCCCCCEEEEEC
IPREEQITSLLAVSAFEEDVQLVMLTTGGFIKRTPLSAFSNIRANGLIAINLEDADSLRW
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCHHHHHCCCCCCEEEEEECCCCCCHH
VRLARAGDSVLIGSINGMTIHFRINDQDLRPLGRTARGVRAMALRDGDSLVSMDVLPAEL
HHEECCCCCEEEEECCCEEEEEEECCCCCCHHHHHHHCEEEEEEECCCCEEEECCCHHHH
ADRIAAAGEASDGESEEAASSDGPWVLVATASGLGKRVPVDQFRLQRRAGLGLRGIKFRR
HHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEC
DGDALVGLCVMGAEEELLLVSERGVIVRLQSDVIPQQSRAATGVRLQRLDKGDRLAEVVL
CCCCEEEEEEECCCCCEEEEECCCEEEEECCCCCCCHHHHHCCCHHHHCCCCCCEEEEEE
VPPEAETDDESAEAAEAEA
ECCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
ADPTGAGNPSERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHH
LGLTAERPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQNFSMRAPLIDGHGNFGSVDN
HCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCC
DPPAAMRYTESRLQSLTTDSLLEDIESETVDFIDNFDGSQQEPTVLPARVPQLLLNGSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
IAVGMATNIPPHNLGELIDGVLALIADPQIEERQLMSIIPGPDFPTGGQILGRKGIRETY
EEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHC
TGGRGSITMRGVAAIETIEAKGRPDRDAVIITELPYQTNKASLIERIAELVNDKKLEGIA
CCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHHCCCHH
DIRDESDRDGMRIVIELRRDAYPQVVLNNLYKLTPLQNNFSAYTLALVKGEPVVLNLKRM
HHCCCCCCCCCEEEEEEHHCCCHHHHHHHHHEECCCCCCCCEEEEEEEECCCEEEEHHHH
LEVFLDFRIETIERRTKYLLRKAEERDHILQGLLVALNDLDAIIQLIRNAADAATARQGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNDHGLSEIQADAILQMQLRRLTALEADKIRLEHEDLIAKIADYKDILQRRERVLSIIEE
CCCCCHHHHHHHHHHHHHHHHHHHHCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRQLKERHNTPRRTEILDLEGGLEDIDLIANERSVVLLTENGYLKRMPVSEFESTSRGT
HHHHHHHHCCCCCCEEEEECCCCCCHHHHEECCCEEEEEECCCCEECCCHHHHHHCCCCC
RGKAGTKSQGEEAVRLFISCNDHDSLLLFSDRGVVYSLPAYRVPIASRAAKGTPVVQLLP
CCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCEEEECCCCCCCHHHHCCCCCCEEEEEC
IPREEQITSLLAVSAFEEDVQLVMLTTGGFIKRTPLSAFSNIRANGLIAINLEDADSLRW
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCHHHHHCCCCCCEEEEEECCCCCCHH
VRLARAGDSVLIGSINGMTIHFRINDQDLRPLGRTARGVRAMALRDGDSLVSMDVLPAEL
HHEECCCCCEEEEECCCEEEEEEECCCCCCHHHHHHHCEEEEEEECCCCEEEECCCHHHH
ADRIAAAGEASDGESEEAASSDGPWVLVATASGLGKRVPVDQFRLQRRAGLGLRGIKFRR
HHHHHHCCCCCCCCCHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEC
DGDALVGLCVMGAEEELLLVSERGVIVRLQSDVIPQQSRAATGVRLQRLDKGDRLAEVVL
CCCCEEEEEEECCCCCEEEEECCCEEEEECCCCCCCHHHHHCCCHHHHCCCCCCEEEEEE
VPPEAETDDESAEAAEAEA
ECCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]