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The map label for this gene is ywnE [H]

Identifier: 148241537

GI number: 148241537

Start: 413190

End: 414197

Strand: Direct

Name: ywnE [H]

Synonym: SynRCC307_0438

Alternate gene names: 148241537

Gene position: 413190-414197 (Clockwise)

Preceding gene: 148241532

Following gene: 148241538

Centisome position: 18.57

GC content: 60.02

Gene sequence:

>1008_bases
ATGACGCGTGGGGTAACCACAGCAGGTCATCACCAACAGCTGTTGGTGATGCCTGACGACGGCGTTGAGCCGGTGACTGA
TTTCATCGCATCGGCCCAGCAGGAGCTGCGTTTAAAGCAATTCAAGCTGCAGTCGCCTGCCGTTCTCGAGGCGCTGCGTC
AGGCCCACGAGCGAGGCGTGCAGGTGCGCGTGATGCTGAATCCCCACACCTCCGGCGGGGATCGCTGGAACGATCAGGCC
TATGCCGCCCTGCAGTCGTGGGGGGTGGCTGTGGCCTGGACGAGTGAATCGTTCCCGGTGACCCACGAGAAATCGATCGT
GGTGGATGACAGCGCGGCGCTCATTGCCACGTTCAACCTCTCGGATAAGTACTTCACCGAGACCCGTGATTACGGCGTTA
TCACCTATGCGGCTCCAGCGGTGGAGCAGGTGATCGATGGCTTTGAGCACGACTGGAACCGCAGCTTCTTCAATCCCGAT
CTCAGCGTTGGTTTGGTGTGGAGCAGTTTTCACAGCCGTGGCCAGATGGCCAAAGTGATTGATGCGGCTAAGGAACGCCT
GTGGGTTCAGCACCCCAAATTTGTTGATGCGGTCATCCTTGAGCGCTTGATTGCCGCCTGCGAACGCGGGGTGAAAGTCA
GGGTCCTGTGCGGCGGCAAGCACGGCATCTCTGATTGGGACATCTACGACACCTTCGCCAGCCTGCGGGTGCTGAGCCGC
TCAGGGGTGAAGGTTCGCCGCCAGAAACACCTCAAGCTGCACGCCAAGTTGATCGTCGTCGATAAGAAGATGGCGTTGAT
TGGCTCGATGAACATCGATCGCAGTGCGTTCGATCTGCGCCGCGAGCTGGGCATCGAAACCGATGCGCCGGAGGTGCTGG
CCCGTTGCGTTGAGCTGTACAAGCACGACTGGAATGAAGCCACGCCCTACGCCGCACCGGATCCGTTGGATCCCGCGATG
CATGAGGAGGGGGAGCTGCCTCCGGATCCCCACTTCATTCACGAGTGA

Upstream 100 bases:

>100_bases
CCGAGCACTGTGGCTCAGACAATTAGGTGAATCCGAGGAAATTACAGCCCTTTAATCGATTTATTTGCATCGTTGGTGGC
AGCGCAACGAATGGTTCGCA

Downstream 100 bases:

>100_bases
TGGCAGCTCAGCTGGATCAAGAACCGTTGGCTGCAGCCCCAAGCCGTAAGGGGTTGTTCCTGGGCATGTTGCAGGTGGCG
CTGTCCTCCTTTGGTGGGGG

Product: phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase-like protein

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase 2 [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTRGVTTAGHHQQLLVMPDDGVEPVTDFIASAQQELRLKQFKLQSPAVLEALRQAHERGVQVRVMLNPHTSGGDRWNDQA
YAALQSWGVAVAWTSESFPVTHEKSIVVDDSAALIATFNLSDKYFTETRDYGVITYAAPAVEQVIDGFEHDWNRSFFNPD
LSVGLVWSSFHSRGQMAKVIDAAKERLWVQHPKFVDAVILERLIAACERGVKVRVLCGGKHGISDWDIYDTFASLRVLSR
SGVKVRRQKHLKLHAKLIVVDKKMALIGSMNIDRSAFDLRRELGIETDAPEVLARCVELYKHDWNEATPYAAPDPLDPAM
HEEGELPPDPHFIHE

Sequences:

>Translated_335_residues
MTRGVTTAGHHQQLLVMPDDGVEPVTDFIASAQQELRLKQFKLQSPAVLEALRQAHERGVQVRVMLNPHTSGGDRWNDQA
YAALQSWGVAVAWTSESFPVTHEKSIVVDDSAALIATFNLSDKYFTETRDYGVITYAAPAVEQVIDGFEHDWNRSFFNPD
LSVGLVWSSFHSRGQMAKVIDAAKERLWVQHPKFVDAVILERLIAACERGVKVRVLCGGKHGISDWDIYDTFASLRVLSR
SGVKVRRQKHLKLHAKLIVVDKKMALIGSMNIDRSAFDLRRELGIETDAPEVLARCVELYKHDWNEATPYAAPDPLDPAM
HEEGELPPDPHFIHE
>Mature_334_residues
TRGVTTAGHHQQLLVMPDDGVEPVTDFIASAQQELRLKQFKLQSPAVLEALRQAHERGVQVRVMLNPHTSGGDRWNDQAY
AALQSWGVAVAWTSESFPVTHEKSIVVDDSAALIATFNLSDKYFTETRDYGVITYAAPAVEQVIDGFEHDWNRSFFNPDL
SVGLVWSSFHSRGQMAKVIDAAKERLWVQHPKFVDAVILERLIAACERGVKVRVLCGGKHGISDWDIYDTFASLRVLSRS
GVKVRRQKHLKLHAKLIVVDKKMALIGSMNIDRSAFDLRRELGIETDAPEVLARCVELYKHDWNEATPYAAPDPLDPAMH
EEGELPPDPHFIHE

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 37652; Mature: 37521

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGVTTAGHHQQLLVMPDDGVEPVTDFIASAQQELRLKQFKLQSPAVLEALRQAHERGV
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QVRVMLNPHTSGGDRWNDQAYAALQSWGVAVAWTSESFPVTHEKSIVVDDSAALIATFNL
EEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECCCEEEEEEEC
SDKYFTETRDYGVITYAAPAVEQVIDGFEHDWNRSFFNPDLSVGLVWSSFHSRGQMAKVI
CCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHH
DAAKERLWVQHPKFVDAVILERLIAACERGVKVRVLCGGKHGISDWDIYDTFASLRVLSR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SGVKVRRQKHLKLHAKLIVVDKKMALIGSMNIDRSAFDLRRELGIETDAPEVLARCVELY
CCCHHHHHHHHEEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
KHDWNEATPYAAPDPLDPAMHEEGELPPDPHFIHE
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRGVTTAGHHQQLLVMPDDGVEPVTDFIASAQQELRLKQFKLQSPAVLEALRQAHERGV
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QVRVMLNPHTSGGDRWNDQAYAALQSWGVAVAWTSESFPVTHEKSIVVDDSAALIATFNL
EEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEECCCEEEEEEEC
SDKYFTETRDYGVITYAAPAVEQVIDGFEHDWNRSFFNPDLSVGLVWSSFHSRGQMAKVI
CCHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHH
DAAKERLWVQHPKFVDAVILERLIAACERGVKVRVLCGGKHGISDWDIYDTFASLRVLSR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
SGVKVRRQKHLKLHAKLIVVDKKMALIGSMNIDRSAFDLRRELGIETDAPEVLARCVELY
CCCHHHHHHHHEEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
KHDWNEATPYAAPDPLDPAMHEEGELPPDPHFIHE
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]