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The map label for this gene is accC [H]

Identifier: 148241440

GI number: 148241440

Start: 331042

End: 332391

Strand: Direct

Name: accC [H]

Synonym: SynRCC307_0341

Alternate gene names: 148241440

Gene position: 331042-332391 (Clockwise)

Preceding gene: 148241437

Following gene: 148241442

Centisome position: 14.88

GC content: 61.41

Gene sequence:

>1350_bases
TTGGGAATTGGCAAGCTTCTGATCGCCAACCGGGGTGAGATCGCTCTACGGATCATCCGCACTTGCCGGGAGATGGGCAT
CTCCACAGTGGCTGTGTACAGCACGGTGGACCGCAACGCCCTGCATGTGCAATTGGCTGATGAGGCCGTCTGCGTTGGGG
ACCCCCCCAGCGGCCGCAGTTATCTGAATATCCCCAACATCATTGCGGCGGCCACCTCCCGCGGTGCCGATGCGATTCAC
CCCGGTTACGGCTTTCTGGCTGAAAACGACCGCTTCGCTGAAATCTGCAGCGCCCATGGGCTGATCTTTGTGGGTCCATC
GCCGGAGTCCATCCGGTCCATGGGTGATAAATCCACCGCTAAAGCCACCATGCAGCGGGTTGGGGTGCCCACCATCCCCG
GCAGCGAAGGCCTGCTCGCCAGCGTCGATGAAGCAGCCCGTCTGGCGGGCTCGATGGGCTATCCCGTGATGATCAAAGCC
ACCGCAGGCGGTGGTGGTCGTGGCATGCGTCTGGTGCGCAGTGCCGATGAGCTGGAAAACCTCTTTAAAGCGGCCCAGGG
TGAAGCCGAAGCGGCCTTCGGCAACCCGGGGCTCTACATGGAGAAATTCATCACGCGGCCGCGCCACGTTGAAGTGCAGA
TCCTCGCCGACCGCTTCGGCAACGTCGTGCACCTCGGCGAGCGGGATTGCTCCATCCAGCGCCGCCACCAGAAATTGCTG
GAGGAAGCTCCGAGCCCTGGGCTTGATCCTGAAACCCGCCGCCGCATGGGCGAAGCAGCCGTGGCAGCAGCCAAAACCAT
TGGCTACGAGGGCGCCGGCACTGTGGAATTCCTGCTGGATGCCTCCGGCGAGTTCTATTTCATGGAAATGAACACGCGCA
TTCAAGTGGAGCATCCCGTCACCGAGGTGGTGACCGGCGTGGACTTGATCGCGCAACAGCTCAAGATTGCTGCCGGCGAA
ACCCTGGAGCTCAAACAGGACAGCATCAAGCTCCATGGCCATGCGATCGAGTGCCGCATCAATGCGGAGGATCCGCGACA
TGGCTTCCGCCCCTCACCAGGCACCATCTCCGGTTGGCTGCCCCCCGGAGGGCCTGGCATTCGCATCGATAGCCACGTGT
ACACCGGCTACGACATCCCGCCCTTTTACGACTCGTTGATCGGCAAATTGATTGTCTGGGCGGAAGACCGGCCGGCAGCG
TTGTTGCGTCTGCGCCGGGCGCTATCGGAATGCGCCGTGATTGGTGTGCCAACGACCATCGACTTCCATCTCGCGCTGCT
GGATCGTCCGGAGTTTCAAAACGCCCAGGTGCACACCAAATTTGTTGAGCAGGAGATGCTCAGCGACTAA

Upstream 100 bases:

>100_bases
TCTGCCAAGAGGCAGAAAGCGAGCGTACCAGTCGGTCTGGACGTTTGTGAAAGCGCCATGTGAATCGCTGATAAAATCGC
TCGCTGACGCGCTCCCCCCA

Downstream 100 bases:

>100_bases
GCGCTTTTGAGCACCAGCTGGGTGATCAGCCCCTGCTGACCAACAAGAAGCTCGCGCAGCAAGCTCACCAAGCCAACCCA
GATCACCGGGGTGACATCCA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MGIGKLLIANRGEIALRIIRTCREMGISTVAVYSTVDRNALHVQLADEAVCVGDPPSGRSYLNIPNIIAAATSRGADAIH
PGYGFLAENDRFAEICSAHGLIFVGPSPESIRSMGDKSTAKATMQRVGVPTIPGSEGLLASVDEAARLAGSMGYPVMIKA
TAGGGGRGMRLVRSADELENLFKAAQGEAEAAFGNPGLYMEKFITRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
EEAPSPGLDPETRRRMGEAAVAAAKTIGYEGAGTVEFLLDASGEFYFMEMNTRIQVEHPVTEVVTGVDLIAQQLKIAAGE
TLELKQDSIKLHGHAIECRINAEDPRHGFRPSPGTISGWLPPGGPGIRIDSHVYTGYDIPPFYDSLIGKLIVWAEDRPAA
LLRLRRALSECAVIGVPTTIDFHLALLDRPEFQNAQVHTKFVEQEMLSD

Sequences:

>Translated_449_residues
MGIGKLLIANRGEIALRIIRTCREMGISTVAVYSTVDRNALHVQLADEAVCVGDPPSGRSYLNIPNIIAAATSRGADAIH
PGYGFLAENDRFAEICSAHGLIFVGPSPESIRSMGDKSTAKATMQRVGVPTIPGSEGLLASVDEAARLAGSMGYPVMIKA
TAGGGGRGMRLVRSADELENLFKAAQGEAEAAFGNPGLYMEKFITRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
EEAPSPGLDPETRRRMGEAAVAAAKTIGYEGAGTVEFLLDASGEFYFMEMNTRIQVEHPVTEVVTGVDLIAQQLKIAAGE
TLELKQDSIKLHGHAIECRINAEDPRHGFRPSPGTISGWLPPGGPGIRIDSHVYTGYDIPPFYDSLIGKLIVWAEDRPAA
LLRLRRALSECAVIGVPTTIDFHLALLDRPEFQNAQVHTKFVEQEMLSD
>Mature_448_residues
GIGKLLIANRGEIALRIIRTCREMGISTVAVYSTVDRNALHVQLADEAVCVGDPPSGRSYLNIPNIIAAATSRGADAIHP
GYGFLAENDRFAEICSAHGLIFVGPSPESIRSMGDKSTAKATMQRVGVPTIPGSEGLLASVDEAARLAGSMGYPVMIKAT
AGGGGRGMRLVRSADELENLFKAAQGEAEAAFGNPGLYMEKFITRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLLE
EAPSPGLDPETRRRMGEAAVAAAKTIGYEGAGTVEFLLDASGEFYFMEMNTRIQVEHPVTEVVTGVDLIAQQLKIAAGET
LELKQDSIKLHGHAIECRINAEDPRHGFRPSPGTISGWLPPGGPGIRIDSHVYTGYDIPPFYDSLIGKLIVWAEDRPAAL
LRLRRALSECAVIGVPTTIDFHLALLDRPEFQNAQVHTKFVEQEMLSD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=52.027027027027, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=49.0909090909091, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=49.0909090909091, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=49.0909090909091, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=48.0984340044743, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=48.0984340044743, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=48.0984340044743, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=33.6614173228346, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=33.6614173228346, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=33.6614173228346, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=33.6614173228346, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=33.6614173228346, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=33.6614173228346, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=55.2808988764045, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=50.1133786848073, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=46.8181818181818, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.9821428571429, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=31.0975609756098, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=30.1181102362205, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=30.1181102362205, Blast_Score=224, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319685, Length=438, Percent_Identity=44.0639269406393, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.0892857142857, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.2053571428571, Blast_Score=352, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=34.3023255813954, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6323863, Length=466, Percent_Identity=33.9055793991416, Blast_Score=252, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=50, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=48.993288590604, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=48.993288590604, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=48.993288590604, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=48.993288590604, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=48.993288590604, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=48.993288590604, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=48.993288590604, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=48.993288590604, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=48.993288590604, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=48.993288590604, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=49.2647058823529, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=33.2669322709163, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=33.2669322709163, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=33.2669322709163, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=33.2669322709163, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48567; Mature: 48436

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIGKLLIANRGEIALRIIRTCREMGISTVAVYSTVDRNALHVQLADEAVCVGDPPSGRS
CCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEECCCCCCCC
YLNIPNIIAAATSRGADAIHPGYGFLAENDRFAEICSAHGLIFVGPSPESIRSMGDKSTA
EECCCHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHCCCHHHH
KATMQRVGVPTIPGSEGLLASVDEAARLAGSMGYPVMIKATAGGGGRGMRLVRSADELEN
HHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LFKAAQGEAEAAFGNPGLYMEKFITRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHCCCEEEECCCCCHHHHHHHHHH
EEAPSPGLDPETRRRMGEAAVAAAKTIGYEGAGTVEFLLDASGEFYFMEMNTRIQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEVVTGVDLIAQQLKIAAGETLELKQDSIKLHGHAIECRINAEDPRHGFRPSPGTISGWL
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCEECCC
PPGGPGIRIDSHVYTGYDIPPFYDSLIGKLIVWAEDRPAALLRLRRALSECAVIGVPTTI
CCCCCCCEECCEEEECCCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCEEEECCCEE
DFHLALLDRPEFQNAQVHTKFVEQEMLSD
EEEEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GIGKLLIANRGEIALRIIRTCREMGISTVAVYSTVDRNALHVQLADEAVCVGDPPSGRS
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCEEEECCCCCCCC
YLNIPNIIAAATSRGADAIHPGYGFLAENDRFAEICSAHGLIFVGPSPESIRSMGDKSTA
EECCCHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHCCCHHHH
KATMQRVGVPTIPGSEGLLASVDEAARLAGSMGYPVMIKATAGGGGRGMRLVRSADELEN
HHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
LFKAAQGEAEAAFGNPGLYMEKFITRPRHVEVQILADRFGNVVHLGERDCSIQRRHQKLL
HHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEHHCCCEEEECCCCCHHHHHHHHHH
EEAPSPGLDPETRRRMGEAAVAAAKTIGYEGAGTVEFLLDASGEFYFMEMNTRIQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCH
TEVVTGVDLIAQQLKIAAGETLELKQDSIKLHGHAIECRINAEDPRHGFRPSPGTISGWL
HHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECEEEEEEECCCCCCCCCCCCCCCEECCC
PPGGPGIRIDSHVYTGYDIPPFYDSLIGKLIVWAEDRPAALLRLRRALSECAVIGVPTTI
CCCCCCCEECCEEEECCCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCEEEECCCEE
DFHLALLDRPEFQNAQVHTKFVEQEMLSD
EEEEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]