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The map label for this gene is cysK [H]

Identifier: 148241366

GI number: 148241366

Start: 271080

End: 272021

Strand: Direct

Name: cysK [H]

Synonym: SynRCC307_0267

Alternate gene names: 148241366

Gene position: 271080-272021 (Clockwise)

Preceding gene: 148241365

Following gene: 148241367

Centisome position: 12.18

GC content: 61.78

Gene sequence:

>942_bases
ATGGCGATTGCCCCGGACATCACCACCTTGGTTGGCCGCACGCCCTTGGTGCGGCTCAACCGTCTCCCCGCAGAAGAGAA
CTGCAAGGCTGAAATCGTCGCCAAGTTGGAAAGCTTCAACCCCACGGCATCGGTGAAAGACCGGATCGGTGTGGCGATGA
TCCGCGACGCCGAAGCGGCTGGTCGCATCGCGCCAGATCGCACGGTGCTGGTGGAACCCACCAGCGGCAACACCGGCATT
GCGCTGGCGATGGTGGCGGCAGCCCGCGGCTACCGGCTGATCTTGATCATGCCCGACACGATGAGCACCGAACGTCGTTC
GATGTTGCGGGCCTATGGCGCAGAACTGGAGCTCACTCCCGGTTCAGAAGGCATGAAGGGTGCGATCTCTAGAGCCAGAG
AACTCGCCGATGAGCTGCCCAATGCCTACTTGCTGCAGCAGTTCTCCAATAGCGCCAACCCGGCAATCCATGCCGCCACC
ACCGCAGAAGAGCTGTGGAGCGATACCGAGGGCCGCATTGATGCCTTGGTGGCGGGTGTTGGCACTGGCGGCACCATCAC
CGGTTGCAGTGAGGTGCTCAAGCAGCGCAAGCCCAGCTTTCAAGCCTTTGCCGTTGAACCAACAGGCAGTCCTGTTTTGA
GCGGTGGTCCCCCAGGCCCGCACCGCATCCAGGGCATTGGCGCCGGCTTTGTGCCCGACAACTATCAACCCTCCCTCGTT
GATGAGGTACTGCAAGTCGACGATGCCGAGGCGATGGTGATGGGACGCCGGCTCGCTCGCGTTGAAGGCTTGTTAAGTGG
GGTGAGCAGTGGGGCGGCCATGGCGGCTGCCTTGAAGTTGGGCCAGCGCCCTGAAATGGAGGGCAAGTTGATCGTGGTGG
TGTTGGCCAGCTTTGGTGAGCGCTATCTCAGCACGCCGATGTTCACGGAAATCGGCTTCTGA

Upstream 100 bases:

>100_bases
TTGGAATGTTCCGATCAAAGCAATACAAAGCCGTCTGGGAGCTTGGCTAGCTGAGCCCGCTAGCCAGAATGAAGGGCAAC
AGCTGAGCTGACGCCCTGCG

Downstream 100 bases:

>100_bases
TGACACGCGACCCCTACCAGGTGTTGGGGGTGTCGCCATCGGCGTCAGCGGCCGAGATCAAATCGGCGTATCGCGCGCTG
GTCAAGCAGCATCATCCCGA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MAIAPDITTLVGRTPLVRLNRLPAEENCKAEIVAKLESFNPTASVKDRIGVAMIRDAEAAGRIAPDRTVLVEPTSGNTGI
ALAMVAAARGYRLILIMPDTMSTERRSMLRAYGAELELTPGSEGMKGAISRARELADELPNAYLLQQFSNSANPAIHAAT
TAEELWSDTEGRIDALVAGVGTGGTITGCSEVLKQRKPSFQAFAVEPTGSPVLSGGPPGPHRIQGIGAGFVPDNYQPSLV
DEVLQVDDAEAMVMGRRLARVEGLLSGVSSGAAMAAALKLGQRPEMEGKLIVVVLASFGERYLSTPMFTEIGF

Sequences:

>Translated_313_residues
MAIAPDITTLVGRTPLVRLNRLPAEENCKAEIVAKLESFNPTASVKDRIGVAMIRDAEAAGRIAPDRTVLVEPTSGNTGI
ALAMVAAARGYRLILIMPDTMSTERRSMLRAYGAELELTPGSEGMKGAISRARELADELPNAYLLQQFSNSANPAIHAAT
TAEELWSDTEGRIDALVAGVGTGGTITGCSEVLKQRKPSFQAFAVEPTGSPVLSGGPPGPHRIQGIGAGFVPDNYQPSLV
DEVLQVDDAEAMVMGRRLARVEGLLSGVSSGAAMAAALKLGQRPEMEGKLIVVVLASFGERYLSTPMFTEIGF
>Mature_312_residues
AIAPDITTLVGRTPLVRLNRLPAEENCKAEIVAKLESFNPTASVKDRIGVAMIRDAEAAGRIAPDRTVLVEPTSGNTGIA
LAMVAAARGYRLILIMPDTMSTERRSMLRAYGAELELTPGSEGMKGAISRARELADELPNAYLLQQFSNSANPAIHAATT
AEELWSDTEGRIDALVAGVGTGGTITGCSEVLKQRKPSFQAFAVEPTGSPVLSGGPPGPHRIQGIGAGFVPDNYQPSLVD
EVLQVDDAEAMVMGRRLARVEGLLSGVSSGAAMAAALKLGQRPEMEGKLIVVVLASFGERYLSTPMFTEIGF

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=323, Percent_Identity=40.5572755417957, Blast_Score=234, Evalue=6e-62,
Organism=Homo sapiens, GI295821200, Length=323, Percent_Identity=40.5572755417957, Blast_Score=234, Evalue=6e-62,
Organism=Homo sapiens, GI4557415, Length=323, Percent_Identity=40.5572755417957, Blast_Score=234, Evalue=6e-62,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=54.4025157232704, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=43.8311688311688, Blast_Score=218, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=50.9933774834437, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=51.4950166112957, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=52.901023890785, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=51.2903225806452, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=50.4983388704319, Blast_Score=277, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=51.6279069767442, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17534315, Length=306, Percent_Identity=39.2156862745098, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=36.0128617363344, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=49.5798319327731, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=39.171974522293, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=32.9268292682927, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=39.6774193548387, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=39.6774193548387, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33018; Mature: 32887

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAPDITTLVGRTPLVRLNRLPAEENCKAEIVAKLESFNPTASVKDRIGVAMIRDAEAA
CCCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEECCHHC
GRIAPDRTVLVEPTSGNTGIALAMVAAARGYRLILIMPDTMSTERRSMLRAYGAELELTP
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEECC
GSEGMKGAISRARELADELPNAYLLQQFSNSANPAIHAATTAEELWSDTEGRIDALVAGV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCEEEEEEEC
GTGGTITGCSEVLKQRKPSFQAFAVEPTGSPVLSGGPPGPHRIQGIGAGFVPDNYQPSLV
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHH
DEVLQVDDAEAMVMGRRLARVEGLLSGVSSGAAMAAALKLGQRPEMEGKLIVVVLASFGE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHH
RYLSTPMFTEIGF
HHHCCCCHHHCCC
>Mature Secondary Structure 
AIAPDITTLVGRTPLVRLNRLPAEENCKAEIVAKLESFNPTASVKDRIGVAMIRDAEAA
CCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEECCHHC
GRIAPDRTVLVEPTSGNTGIALAMVAAARGYRLILIMPDTMSTERRSMLRAYGAELELTP
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEEEECC
GSEGMKGAISRARELADELPNAYLLQQFSNSANPAIHAATTAEELWSDTEGRIDALVAGV
CCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCCEEEEEEEC
GTGGTITGCSEVLKQRKPSFQAFAVEPTGSPVLSGGPPGPHRIQGIGAGFVPDNYQPSLV
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHH
DEVLQVDDAEAMVMGRRLARVEGLLSGVSSGAAMAAALKLGQRPEMEGKLIVVVLASFGE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHH
RYLSTPMFTEIGF
HHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]