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The map label for this gene is tmk

Identifier: 148241353

GI number: 148241353

Start: 253136

End: 253774

Strand: Direct

Name: tmk

Synonym: SynRCC307_0254

Alternate gene names: 148241353

Gene position: 253136-253774 (Clockwise)

Preceding gene: 148241352

Following gene: 148241354

Centisome position: 11.38

GC content: 64.01

Gene sequence:

>639_bases
ATGAGAGGCCGGTTTCTGGTGCTGGAGGGCATTGATGGCTGCGGCAAAACCACGCAGCTCAAGGCCTTGGCTGATTGGTT
GCCAGCCAGTGGCCTAATGCCCTCTGGCGCGCAGCTGATCACCACCCGCGAGCCCGGCGGCACCGCTTTGGGCCAGGCCC
TGCGGCAATTGCTGCTGCATCCTCCCGAGGAGCAGGCCCCGGCCACCCGCGCTGAGCTGCTGCTCTACGCGGCTGATCGC
GCCCAACATGTTCAGACCCGATTGGAGCCTGCCTTGGCTGCTGGTGATTGGGTGCTCAGTGATCGTTATTGCGGCTCCAC
CGCCGCGTATCAGGGCTATGGCCGCGGTTTGGACCTTGATTTGATTACCCAGCTGGAGCAGTTGGCCACAGCGGGGTTGC
AGCCAGATCTTTGCCTCTGGCTTGAGCTATCGCCTGAGCTGGCCGCCCAGCGCCGCTCCGGCCAGCAGCAAGACCGCATC
GAAGCCGAAGGTTTGGCTTTTTTGGCGCGGGTGCATCAAGGCTTTGCCGAGCTGAGCCAGCGGCCGCTTTGGCGGCGGGT
GGATGCCTCGCTTCCCCCTGAGCAGGTGCATCAGCAGGTGCAGCACTTGGTGCGTGAGGGTTTGGAGTTGGCCCTGTGA

Upstream 100 bases:

>100_bases
CAGGCTTTGGCCTCTTGCTCACTCCTCCTTTGGCCGCTCTGTTGATGGCACTGAGTTCGATCACGGTGGTGGCCAATGCT
CTGTTGCTGCGCGCTCCGGC

Downstream 100 bases:

>100_bases
GTGAGGCGCTGTTCGCCGGAATCGAAGGGCAGCAGCAGGCCCTTGAGCTGCTCACTGCTGCTTTGAATCAGCAGCGCCTG
GCCCCGGCTTATCTGTTTGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRGRFLVLEGIDGCGKTTQLKALADWLPASGLMPSGAQLITTREPGGTALGQALRQLLLHPPEEQAPATRAELLLYAADR
AQHVQTRLEPALAAGDWVLSDRYCGSTAAYQGYGRGLDLDLITQLEQLATAGLQPDLCLWLELSPELAAQRRSGQQQDRI
EAEGLAFLARVHQGFAELSQRPLWRRVDASLPPEQVHQQVQHLVREGLELAL

Sequences:

>Translated_212_residues
MRGRFLVLEGIDGCGKTTQLKALADWLPASGLMPSGAQLITTREPGGTALGQALRQLLLHPPEEQAPATRAELLLYAADR
AQHVQTRLEPALAAGDWVLSDRYCGSTAAYQGYGRGLDLDLITQLEQLATAGLQPDLCLWLELSPELAAQRRSGQQQDRI
EAEGLAFLARVHQGFAELSQRPLWRRVDASLPPEQVHQQVQHLVREGLELAL
>Mature_212_residues
MRGRFLVLEGIDGCGKTTQLKALADWLPASGLMPSGAQLITTREPGGTALGQALRQLLLHPPEEQAPATRAELLLYAADR
AQHVQTRLEPALAAGDWVLSDRYCGSTAAYQGYGRGLDLDLITQLEQLATAGLQPDLCLWLELSPELAAQRRSGQQQDRI
EAEGLAFLARVHQGFAELSQRPLWRRVDASLPPEQVHQQVQHLVREGLELAL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=213, Percent_Identity=30.5164319248826, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=37.3831775700935, Blast_Score=135, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SYNR3 (A5GQJ8)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001226510.1
- ProteinModelPortal:   A5GQJ8
- SMR:   A5GQJ8
- STRING:   A5GQJ8
- GeneID:   5157623
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_0254
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23227; Mature: 23227

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRFLVLEGIDGCGKTTQLKALADWLPASGLMPSGAQLITTREPGGTALGQALRQLLLH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
PPEEQAPATRAELLLYAADRAQHVQTRLEPALAAGDWVLSDRYCGSTAAYQGYGRGLDLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCHH
LITQLEQLATAGLQPDLCLWLELSPELAAQRRSGQQQDRIEAEGLAFLARVHQGFAELSQ
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RPLWRRVDASLPPEQVHQQVQHLVREGLELAL
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGRFLVLEGIDGCGKTTQLKALADWLPASGLMPSGAQLITTREPGGTALGQALRQLLLH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
PPEEQAPATRAELLLYAADRAQHVQTRLEPALAAGDWVLSDRYCGSTAAYQGYGRGLDLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCHH
LITQLEQLATAGLQPDLCLWLELSPELAAQRRSGQQQDRIEAEGLAFLARVHQGFAELSQ
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RPLWRRVDASLPPEQVHQQVQHLVREGLELAL
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA