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The map label for this gene is moaE [H]

Identifier: 147675319

GI number: 147675319

Start: 586176

End: 586628

Strand: Direct

Name: moaE [H]

Synonym: VC0395_A0548

Alternate gene names: 147675319

Gene position: 586176-586628 (Clockwise)

Preceding gene: 147674797

Following gene: 147674350

Centisome position: 19.38

GC content: 52.1

Gene sequence:

>453_bases
ATGGACCATCGCGTATCGGTGCAGAAGGAAGATTTCTCTGTTGCTCAAGAATATGAAGCGTTAGCGCAAGGCTCACAAGC
GGGGGCTGTGGTGACTTTTGTCGGCAAAGTTCGGGATATGAACTTGGGCGATAATGTCGTGGGCTTACACCTTGAACACT
ATCCGGGCATGACGGAAAAATCCTTTCTGGAGATTTGCGATATGGCTCAGGAGCGTTGGCCTCTACAACGCGTTCGCGTT
ATTCATCGCATCGGCGATATGCTCAGCGGCGATCAAATCGTGTTGGTTGGTGTCAGCAGTGCGCACCGCAATGCTGCGTT
TGCAGCGTGCGAGTTCATCATGGATTACTTGAAAACCCGCGCGCCATTTTGGAAAAAAGAGCTGACGACCGAAGCGAGTC
GCTGGATTGATTCACGCGACAGTGATCATCAAGCCGCGCAGCGCTGGGAATAA

Upstream 100 bases:

>100_bases
AAGCTATTGGCGGCCGTTAATCAATCGATTGTGCCATTCGATACAGAGCTACAAGATGGCGATGAAGTGGCCTTTTTCCC
ACCAGTGACTGGAGGCTAGT

Downstream 100 bases:

>100_bases
GAAGAGTAATAAGGCTATTCATGCCAAGTGGTACTACTAAACATATGAATGGTGCCACGTTGCTCATGTTTGGCATGAAA
CAGCGCTTTATCGGCGACTA

Product: molybdenum cofactor biosynthesis protein E

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MDHRVSVQKEDFSVAQEYEALAQGSQAGAVVTFVGKVRDMNLGDNVVGLHLEHYPGMTEKSFLEICDMAQERWPLQRVRV
IHRIGDMLSGDQIVLVGVSSAHRNAAFAACEFIMDYLKTRAPFWKKELTTEASRWIDSRDSDHQAAQRWE

Sequences:

>Translated_150_residues
MDHRVSVQKEDFSVAQEYEALAQGSQAGAVVTFVGKVRDMNLGDNVVGLHLEHYPGMTEKSFLEICDMAQERWPLQRVRV
IHRIGDMLSGDQIVLVGVSSAHRNAAFAACEFIMDYLKTRAPFWKKELTTEASRWIDSRDSDHQAAQRWE
>Mature_150_residues
MDHRVSVQKEDFSVAQEYEALAQGSQAGAVVTFVGKVRDMNLGDNVVGLHLEHYPGMTEKSFLEICDMAQERWPLQRVRV
IHRIGDMLSGDQIVLVGVSSAHRNAAFAACEFIMDYLKTRAPFWKKELTTEASRWIDSRDSDHQAAQRWE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=131, Percent_Identity=34.3511450381679, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1787003, Length=146, Percent_Identity=62.3287671232877, Blast_Score=198, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21356259, Length=144, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17066; Mature: 17066

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHRVSVQKEDFSVAQEYEALAQGSQAGAVVTFVGKVRDMNLGDNVVGLHLEHYPGMTEK
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCEEEEEECCCCCCCHH
SFLEICDMAQERWPLQRVRVIHRIGDMLSGDQIVLVGVSSAHRNAAFAACEFIMDYLKTR
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHC
APFWKKELTTEASRWIDSRDSDHQAAQRWE
CCHHHHHHHHHHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure
MDHRVSVQKEDFSVAQEYEALAQGSQAGAVVTFVGKVRDMNLGDNVVGLHLEHYPGMTEK
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCEEEEEECCCCCCCHH
SFLEICDMAQERWPLQRVRVIHRIGDMLSGDQIVLVGVSSAHRNAAFAACEFIMDYLKTR
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHC
APFWKKELTTEASRWIDSRDSDHQAAQRWE
CCHHHHHHHHHHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]