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The map label for this gene is htpX

Identifier: 147675037

GI number: 147675037

Start: 676895

End: 677758

Strand: Direct

Name: htpX

Synonym: VC0395_A0635

Alternate gene names: 147675037

Gene position: 676895-677758 (Clockwise)

Preceding gene: 147675610

Following gene: 147673637

Centisome position: 22.38

GC content: 49.42

Gene sequence:

>864_bases
ATGAAACGTATATTGTTATTCTTAGCAACCAACCTTGCTGTCGTATTGGTGCTTAGTGTTGTTTTGAATATTGTTTATGC
CGTCACGGGCATGCAGCCAGGGAGTTTGTCTGGTCTGTTGGTGATGGCGGCTGTGTTTGGCTTTGGCGGTGCATTTATTT
CACTGCTGATGTCAAAAAGTATGGCCCTACGCTCAGTGGGTGGTGTCGTCATTGATACTCCACGCAATGAGATGGAACAT
TGGCTATTGGAAACGGTACGTCGCCAAGCAAACCAAGCGGGTATCGGTATGCCAACGGTGGCGATTTATGATGCGCCAGA
CATGAATGCGTTTGCCACGGGTGCAAAGCGTGATGATTCTCTGGTCGCGGTCTCAACGGGATTGCTGCACAACATGACGC
GTGATGAGGCCGAAGCTGTGTTGGCGCATGAAGTTAGCCACATTGCTAACGGTGACATGGTCACCATGACGCTGATGCAA
GGGGTGGTGAACACCTTCGTGATCTTCTTGTCGCGCTTTATTGCCAATATCGTGGCTTCACGTGATTCGGAAGAAGGTGA
AGGTAGCAACATGATGGTCTATTTCGGTGTATCTATGGTGCTTGAATTGGTGTTTGGTTTCTTAGCCAGCTTCATCACCA
TGTGGTATAGCCGCCACCGTGAGTTCCATGCCGATGCGGGTGCCGCTCAGTTAGTCGGTAAGCACAAGATGATTGCGGCG
TTAGAACGCCTGAAAATGGGTCAGGAGTCGCATCTTGAAGGTTCGATGATGGCGTTTGGCATCACAGGTAAACGCTCTCT
ATCCGAATTAATGATGACTCACCCACCCCTTGAAAAACGTATCGCAGCACTGCGCAATATGTAA

Upstream 100 bases:

>100_bases
GTTTTTCAAATGGAAGAACATATGTTGTAAATAAGAACAAACGATGTGTGGTAAAGTCGCGCATCGCAACCGCTGAGAAG
TTTCCTTCGGAGATTAAGTC

Downstream 100 bases:

>100_bases
TCTCTTCCAACCAGCCTTCGGGCTGGTTTTGTTTATCTTGATTGATAGTCTTCTTGAGCTCGTTTTCTTAACGCTCTTTA
GTGATCCCTTACATTCTGAG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKSMALRSVGGVVIDTPRNEMEH
WLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQ
GVVNTFVIFLSRFIANIVASRDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM

Sequences:

>Translated_287_residues
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKSMALRSVGGVVIDTPRNEMEH
WLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQ
GVVNTFVIFLSRFIANIVASRDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM
>Mature_287_residues
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKSMALRSVGGVVIDTPRNEMEH
WLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQ
GVVNTFVIFLSRFIANIVASRDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=292, Percent_Identity=66.7808219178082, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_VIBC3 (A5F2H8)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F2H8
- SMR:   A5F2H8
- STRING:   A5F2H8
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0635
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   GKQKMIA
- ProtClustDB:   PRK05457
- BioCyc:   VCHO345073:VC0395_A0635-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31230; Mature: 31230

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0x18331498)-; HASH(0x18b9b874)-; HASH(0x18ae1c60)-; HASH(0x18caf33c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
8.0 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
8.0 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MALRSVGGVVIDTPRNEMEHWLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDS
HHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCCCC
LVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANIVAS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM
HHHHHCCCHHCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCH
>Mature Secondary Structure
MKRILLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGAFISLLMSKS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MALRSVGGVVIDTPRNEMEHWLLETVRRQANQAGIGMPTVAIYDAPDMNAFATGAKRDDS
HHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCCCC
LVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANIVAS
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RDSEEGEGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADAGAAQLVGKHKMIAA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LERLKMGQESHLEGSMMAFGITGKRSLSELMMTHPPLEKRIAALRNM
HHHHHCCCHHCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA