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The map label for this gene is cvrA [H]

Identifier: 147674945

GI number: 147674945

Start: 2428572

End: 2430317

Strand: Reverse

Name: cvrA [H]

Synonym: VC0395_A2276

Alternate gene names: 147674945

Gene position: 2430317-2428572 (Counterclockwise)

Preceding gene: 147674537

Following gene: 147673258

Centisome position: 80.37

GC content: 52.0

Gene sequence:

>1746_bases
GTGGACGCCGTTACGATTAACAGTTTTTTTATGATAGGTGCCTTATTGATAGGCATCAGCGTATTACTTAGCCCTGTCTC
CTCGAAATTGGGGATCCCGATTTTATTGGTGTTTCTCGCGGTTGGTATGTTGGCGGGAGAAGATGGCATTGGACAGATTG
CCTTTGATAATTATCCCGTAGCCTATTTAGTCAGTAACCTCGCTCTGGCGATTATCTTGCTCGATGGCGGGATGCGCACT
CGAGTGGCGAGTTTTCGCGTCGCATTCTGGCCTTCGGTCTCTCTCGCAACCTTAGGTGTTGCTGTGACCACCTTGCTTAC
TGGTTTGCTCGCGATGTGGCTATTCAATCTGAGCCTACTGCAAGGTGTCTTAGTTGGTGCGATTGTAGGTTCGACGGATG
CGGCGGCGGTATTTTCTCTGCTCAAAGGGCGCAGCCTCAATGAACGGGTTGGTGCAACCTTGGAAATTGAGTCGGGAACC
AACGACCCGATGGCGGTGTTTTTGACCGTTACCTTGATCGCAGTGCTTGGCAGCGCTGAAACCAATTTAAGCGCAGGCTT
TTTATTGCTCAGTTTTGCCCAGCAGTTTGGTGTCGGAGCGCTGCTTGGCTTGGCGGGTGGCTGGATTTTATGGTGGCTAA
TCAATCGCAACCAATTACCGGAAGGTTTGTACTCGATTCTTGCGGTGAGTGGCGGTTTGATGATTTTCGCCTTGTCTAAC
GCATTGGGTGGCAGCGGAATTTTGTCGATTTATTTGACGGGGTTATTGCTCGGCAATCGTCCTACGCGCAGTCGTCACGC
GATCCTTAACGTGCTCGATGGCATGACGTGGCTGGCGCAAATTGGCATGTTCTTGGTGCTGGGTTTGTTAGTCACACCAT
CGGAATTGATGGAGATTGCACTTCCCGGTTTAGCGTTGGCGGTGGGGATGATCCTCTTTGCGCGCCCCATTGCGGTATGG
ATTGGCCTTGCGCCGTTTAAAAGTTTTACCGCACGTGAGAAATGGTTTGTCTCTTGGGTTGGGCTACGTGGCGCCGTGCC
GATCATCCTTGCGGTCTTCCCAATGATGGCGGGTTTGCCCAACGCCCAGCTTTACTTCAACCTCGCGTTTTTCGTGGTTA
TGGTGTCGCTGGTGGTGCAGGGTGGAACGCTGACCAAAGCCATGTCGCTGGCTAAAGTGGAACTGCCCCCAAAACCGGAG
CCGATTTCGCGCACGGGCGTGGAAATTTATCCGACCAGCGAGTGGGAGTTGTTTATCTATAAACTCAAAGCCGACAAATG
GTGTATCGGTGAGCCGCTGCGCAATCTCTTTATGCCGGAAGGTACCCGGATTGCGGCGGTGTTTCGCGATAATCAACTGC
TGCACCCATCGGGGAGTACCGAATTATGCGAAGGCGACACCTTGTGTGTGATGGCGCAGGAGCGCGATCTGGAATCGCTC
AGTCGTCTATTCAGCGAAGCACCAGAAAAAGCTTCTCTTGCGCGCTTCTTTGGCGACTTTTTCCTCGATATTGAAGCGAA
ATTGCAAGATGTGGCTTTGTTGTATGGTCTGGACTTAGGTGAGCTTGAGGCTGACGCTAAGCTTAAAGATCTGGTGTTAG
AGCATTTGGGTGAAACGCCAGTGCTCGGCGATTACTTCGAATGGCATGGTTTGCAATGGGTGGTCGCCGATGTAGTGGAC
TGGAAAGTGACCAAAATCGGTCTGCGCTTACCGCCCGAAGAAGAGCTACAAGAAGGCGCCGAGTAA

Upstream 100 bases:

>100_bases
GTGATGTCATGAATTCGTGCACAATAGGCGGGCAAACTTATTGATAAACAGGGCAATCCGTTAACGACATCAAGTCGTTA
ATCGCAGACTGGGAGGTAGA

Downstream 100 bases:

>100_bases
CGATCGTTTGCGCCTTGACGTTGAGGTGGTGTTCAACGCCGACCAGCAATGGCAAGGCGTTTGGGTATAGCGCGAGTAAG
CAGAAATGAGCGAGTAGATC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRT
RVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGT
NDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVW
IGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPE
PISRTGVEIYPTSEWELFIYKLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETPVLGDYFEWHGLQWVVADVVD
WKVTKIGLRLPPEEELQEGAE

Sequences:

>Translated_581_residues
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRT
RVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGT
NDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVW
IGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPE
PISRTGVEIYPTSEWELFIYKLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETPVLGDYFEWHGLQWVVADVVD
WKVTKIGLRLPPEEELQEGAE
>Mature_581_residues
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRT
RVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGT
NDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVW
IGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPE
PISRTGVEIYPTSEWELFIYKLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETPVLGDYFEWHGLQWVVADVVD
WKVTKIGLRLPPEEELQEGAE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=576, Percent_Identity=61.4583333333333, Blast_Score=650, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 62657; Mature: 62657

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLL
HHHHHHHHEEEEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAE
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCC
TNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
CCCHHHHHHHHHHHHHCHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIA
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCC
NAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPEPISRTGVEIYPTSEWELFIY
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCEEEEE
KLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
EECCCCCCCCHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEECCCCHHHH
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCC
VLGDYFEWHGLQWVVADVVDWKVTKIGLRLPPEEELQEGAE
CCCCHHHHCCHHEEEHHHHCCEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure
MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLL
HHHHHHHHEEEEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAE
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCC
TNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSN
CCCHHHHHHHHHHHHHCHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
ALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIA
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
LPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCC
NAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPEPISRTGVEIYPTSEWELFIY
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCCCCEEEEECCCCEEEEE
KLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESL
EECCCCCCCCHHHHHHCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEECCCCHHHH
SRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCC
VLGDYFEWHGLQWVVADVVDWKVTKIGLRLPPEEELQEGAE
CCCCHHHHCCHHEEEHHHHCCEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]