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The map label for this gene is irgA

Identifier: 147674899

GI number: 147674899

Start: 22921

End: 24879

Strand: Direct

Name: irgA

Synonym: VC0395_A0028

Alternate gene names: 147674899

Gene position: 22921-24879 (Clockwise)

Preceding gene: 147675757

Following gene: 229259769

Centisome position: 0.76

GC content: 49.57

Gene sequence:

>1959_bases
ATGTCCAGATTCAATCCATCCCCCGTCAGTTTATCTGTGACACTAGGCTTAATGTTTTCGGCTAGCGCTTTTGCTCAAGA
CGCGACGAAAACGGATGAAACCATGGTGGTCACTGCGGCGGGATACGCGCAAGTGATTCAAAATGCACCAGCCAGTATCA
GTGTGATTTCAAGAGAAGATCTGGAATCTCGCTATTACCGTGATGTGACCGATGCGCTAAAAAGCGTACCGGGTGTGACA
GTCACCGGAGGGGGCGATACTACCGATATCAGCATTCGTGGTATGGGATCAAACTATACTCTTATCTTGGTGGATGGTAA
GCGCCAAACCTCACGCCAGACCCGTCCAAACAGCGATGGCCCGGGCATTGAGCAAGGTTGGTTACCGCCACTGCAAGCGA
TTGAACGTATCGAGGTGATCCGTGGCCCGATGTCTACGCTGTACGGCTCGGATGCGATTGGCGGCGTGATCAACATCATC
ACTCGTAAAGATCAGCAGCAGTGGTCAGGCAATGTGCAGCTATCGACCGTGGTACAAGAAAATCGCGCCTCAGGCGATGA
ACAAAGCGCTAATTTCTTCGTAACAGGACCTTTAAGTGATGCTCTATCGCTGCAAGTCTACGGACAAACCACGCAACGCG
ATGAAGACGAAATTGAGCATGGTTACGGCGATAAATCACTGCGCAGCTTAACCTCAAAGCTCAACTACCAGCTTAATCCA
GATCATCAACTGCAACTGGAAGCCGGTGTATCAGCCCAAGATCGCGAAAATAACGTGGGCAAGTCGGCGCAATCCAGCGG
ATGTCGCGGTACATGCAGCAATACCGATAACCAGTACCGTCGCAACCATGTTGCCGTCTCTCACCAAGGGGATTGGCAGG
GTGTTGGGCAGTCTGATACTTATCTGCAATATGAAGAGAACACCAATAAATCTCGTGAGATGAGCATTGATAATACGGTG
TTCAAATCCACGTTAGTGGCTCCTATTGGTGAGCATATGTTGAGCTTTGGTGTGGAAGGTAAACACGAAAGTTTAGAGGA
TAAAACCTCCAACAAAATTTCGTCTCGCACGCATATCTCGAACACTCAATGGGCGGGATTCATTGAAGATGAATGGGCGC
TCGCAGAGCAATTCCGCCTGACCTTTGGTGGCCGTCTGGATCATGATAAAAACTACGGCAGCCACTTCAGCCCACGTGTG
TATGGCGTATGGAATCTCGATCCTCTATGGACAGTAAAAGGTGGTGTTTCTACTGGCTTCCGTGCACCGCAATTACGTGA
AGTGACGCCGGATTGGGGGCAAGTTAGTGGCGGCGGTAATATTTACGGCAACCCGGATTTACAGCCTGAAACTTCGATTA
ACAAAGAACTGAGTTTGATGTACAGCACTGGCTCAGGTCTGGCGGCATCGTTAACCGCTTTCCATAATGATTTTAAAGAT
AAAATCACCCGCGTCGCTTGCCCTGCAAATATTTGTACTGCCGGCCCCAACCAATGGGGTGCAACTCCTACTTATCGTGT
GAATATTGATGAAGCGGAAACCTATGGTGCAGAAGCTACGTTAAGTCTGCCGATTACCGAAAGCGTTGAGTTATCGTCTA
GCTACACGTACACCCATTCGGAGCAAAAATCAGGGAATTTTGCTGGCCGTCCGCTACTGCAGTTACCTAAACATCTGTTC
AATGCCAACTTGAGCTGGCAAACCACAGATCGCCTCAATAGCTGGGCTAACCTCAACTATCGTGGTAAGGAGATGCAGCC
GGAGGGTGGGGCATCGAACGATGATTTCATCGCGCCAAGCTACACCTTTATCGATACTGGCGTGACTTACGCACTCACCG
ATACCGCAACGATTAAAGCTGCGGTGTACAACCTGTTTGATCAAGAGGTGAATTACGCGGAGTATGGCTATGTAGAAGAT
GGCCGCCGCTACTGGTTGGGTTTAGACATCGCCTTCTAA

Upstream 100 bases:

>100_bases
TTGGACCGAACTATTCCATGTGTCGATCTATCTCCAGTACAGAATATATGAATAATCCGCTTCTGAAATTAAGAATAATT
ATCATTTAAAGGAGTGGTAA

Downstream 100 bases:

>100_bases
TTGCTAGAGGTTCAGAGGATTGGCGGCAGCGCCAATCCTCTGTTTGTTTTGCGATCGGCGGTGGAATCATTTATTGCACA
GGATCGCCGTGCCAAAGCCT

Product: enterobactin receptor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVT
VTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINII
TRKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQGVGQSDTYLQYEENTNKSREMSIDNTV
FKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRV
YGVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLQPETSINKELSLMYSTGSGLAASLTAFHNDFKD
KITRVACPANICTAGPNQWGATPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLF
NANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVED
GRRYWLGLDIAF

Sequences:

>Translated_652_residues
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVT
VTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINII
TRKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQGVGQSDTYLQYEENTNKSREMSIDNTV
FKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRV
YGVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLQPETSINKELSLMYSTGSGLAASLTAFHNDFKD
KITRVACPANICTAGPNQWGATPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLF
NANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVED
GRRYWLGLDIAF
>Mature_651_residues
SRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISREDLESRYYRDVTDALKSVPGVTV
TGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDGPGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIIT
RKDQQQWSGNVQLSTVVQENRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNPD
HQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQGVGQSDTYLQYEENTNKSREMSIDNTVF
KSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHISNTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVY
GVWNLDPLWTVKGGVSTGFRAPQLREVTPDWGQVSGGGNIYGNPDLQPETSINKELSLMYSTGSGLAASLTAFHNDFKDK
ITRVACPANICTAGPNQWGATPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHSEQKSGNFAGRPLLQLPKHLFN
ANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPSYTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDG
RRYWLGLDIAF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family

Homologues:

Organism=Escherichia coli, GI1788478, Length=694, Percent_Identity=36.3112391930836, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1786798, Length=759, Percent_Identity=28.1949934123847, Blast_Score=235, Evalue=8e-63,
Organism=Escherichia coli, GI1790405, Length=675, Percent_Identity=24.2962962962963, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1787723, Length=160, Percent_Identity=33.75, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IRGA_VIBC3 (A5F9G0)

Other databases:

- EMBL:   U72152
- EMBL:   CP000627
- EMBL:   CP001235
- PIR:   S25265
- ProteinModelPortal:   A5F9G0
- STRING:   A5F9G0
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0028
- eggNOG:   COG4771
- HOGENOM:   HBG464298
- OMA:   KANMRGV
- ProtClustDB:   PRK13483
- BioCyc:   VCHO345073:VC0395_A0028-MONOMER
- GO:   GO:0009405
- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- Gene3D:   G3DSA:2.170.130.10
- Gene3D:   G3DSA:2.40.170.20

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec

EC number: NA

Molecular weight: Translated: 71642; Mature: 71510

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00430 TONB_DEPENDENT_REC_1; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISRED
CCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECHHHHHHHCCCCEEEEEEHHH
LESRYYRDVTDALKSVPGVTVTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDG
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCHHCCCCCCCCCC
PGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIITRKDQQQWSGNVQLSTVVQE
CCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHEEEEECCCHHHHCCCEEEEEEEHH
NRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
HCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCEEECC
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQGVGQSDT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCEEEEEECCCCCCCCCCCC
YLQYEENTNKSREMSIDNTVFKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHIS
EEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
NTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVYGVWNLDPLWTVKGGVSTGF
CCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCC
RAPQLREVTPDWGQVSGGGNIYGNPDLQPETSINKELSLMYSTGSGLAASLTAFHNDFKD
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
KITRVACPANICTAGPNQWGATPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHS
HHHEEECCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEEECCCCCEECCCCEEEECC
EQKSGNFAGRPLLQLPKHLFNANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPS
CCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCC
YTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDGRRYWLGLDIAF
EEEEECCEEEEEECCHHHHHHHHHHHHHCCCHHHCCEEECCCEEEEEEEEEC
>Mature Secondary Structure 
SRFNPSPVSLSVTLGLMFSASAFAQDATKTDETMVVTAAGYAQVIQNAPASISVISRED
CCCCCCCEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECHHHHHHHCCCCEEEEEEHHH
LESRYYRDVTDALKSVPGVTVTGGGDTTDISIRGMGSNYTLILVDGKRQTSRQTRPNSDG
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCHHCCCCCCCCCC
PGIEQGWLPPLQAIERIEVIRGPMSTLYGSDAIGGVINIITRKDQQQWSGNVQLSTVVQE
CCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHEEEEECCCHHHHCCCEEEEEEEHH
NRASGDEQSANFFVTGPLSDALSLQVYGQTTQRDEDEIEHGYGDKSLRSLTSKLNYQLNP
HCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCEEECC
DHQLQLEAGVSAQDRENNVGKSAQSSGCRGTCSNTDNQYRRNHVAVSHQGDWQGVGQSDT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHCEEEEEECCCCCCCCCCCC
YLQYEENTNKSREMSIDNTVFKSTLVAPIGEHMLSFGVEGKHESLEDKTSNKISSRTHIS
EEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
NTQWAGFIEDEWALAEQFRLTFGGRLDHDKNYGSHFSPRVYGVWNLDPLWTVKGGVSTGF
CCCCCEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCC
RAPQLREVTPDWGQVSGGGNIYGNPDLQPETSINKELSLMYSTGSGLAASLTAFHNDFKD
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
KITRVACPANICTAGPNQWGATPTYRVNIDEAETYGAEATLSLPITESVELSSSYTYTHS
HHHEEECCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCEEEEECCCCCEECCCCEEEECC
EQKSGNFAGRPLLQLPKHLFNANLSWQTTDRLNSWANLNYRGKEMQPEGGASNDDFIAPS
CCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCC
YTFIDTGVTYALTDTATIKAAVYNLFDQEVNYAEYGYVEDGRRYWLGLDIAF
EEEEECCEEEEEECCHHHHHHHHHHHHHCCCHHHCCEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861