| Definition | Vibrio cholerae O395 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_009457 |
| Length | 3,024,069 |
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The map label for this gene is clpA [H]
Identifier: 147674845
GI number: 147674845
Start: 737632
End: 739902
Strand: Direct
Name: clpA [H]
Synonym: VC0395_A0714
Alternate gene names: 147674845
Gene position: 737632-739902 (Clockwise)
Preceding gene: 147674267
Following gene: 147673279
Centisome position: 24.39
GC content: 48.66
Gene sequence:
>2271_bases ATGCTTAACAAAGAATTAGAGTCGAGTCTAAACGGCGCGTTCGCTCGGGCACGAGACAAAAGACATGAATTTATGACCGT CGAGCACCTCCTACTTGCATTGTTGGAAAACGATGCAGCGCGGGAAGCCCTGTTAGCCTGTCAAGCCGACATTGATGTAT TACGCCGTGAGCTGGATACTTTTATCGACCAGACCACGCCTCTTATCCCCAAAAATGACGAAACTCGCGAGACACAACCG ACGTTGAGTTTCCAACGCGTACTGCAACGCGCGGTGTTCCACGTGCAATCTTCCGGTCGAAGCGAAGTGACGGGAGCCAA CGTGCTGGTGGCGATTTTCAGTGAGCAAGAGTCGCACGCGGCCTATCTGCTGAAGAAAAATGACATCAGCCGCTTGGACA TTGTTAACTTTATTTCGCACGGCATTACCAAAGCGTCTAACCATAGTGAAGACTCTTCTTCCGATTCGTTTGGCAGCAGT GATACTTCTGAAGAGGTGAGTGCTGACGAGCGTTTGGAAAGTTTTGCGACCAACCTTAATCAGTTAGCAAAACAAGGCCA GATCGATCCACTGATTGGCCGTGACAAAGAGTTGGAACGTACGATTCAAGTTCTGTGTCGCCGTCGTAAAAACAACCCAC TGCTGGTGGGAGAAGCGGGTGTCGGCAAAACTGCGATTGCGGAGGGCTTGGCATGGCGAATTGTTGAAGGCAATGTGCCG GAAGTGATTCAGCGCAGTGTGATTTATTCACTGGATATTGGTTCGCTGTTAGCGGGCACCAAATATCGTGGTGATTTCGA AAAACGTTTCAAATCGATTTTGAAACAGCTTGAGAAAGAGAAAGACGCCATCCTGTTTATCGATGAAATTCACACCATCA TCGGTGCGGGTGCCGCTTCTGGCGGTCAAGTCGATGCGGCGAACCTAATTAAGCCTCTGCTCAGTAGCGGTAAACTGCGT TGTATCGGCTCAACCACCTATCAAGAGTACAGCAACATTTTTGAGAAAGAGCGTGCGCTATCTCGCCGCTTCCAAAAGAT TGATATTGTTGAGCCTTCATTGGACGATACCACCAAGATTTTGATGGGATTGAAAACCAAATACGAAGCTCACCATGATG TGCGCTATACCAATAAAGCGCTGCGTGCTGCGGTTGAACTTTCAGCCAAATACATTAATGAGCGTCATCTGCCTGATAAA GCGATTGATGTGATTGATGAAGCGGGTGCGCGGGCACGTTTGATGCCAGCAAGCCGTCGTAAGAAAACGGTCGGTGTGGC GGAAATTGAATCCATGGTCGCCAAAATGGCGCGGATCCCAGAAAAATCCGTCTCCTCTTCTGATAAAGACATCCTGAAGA ATCTGGATCAGAAGATGAAAATGTTGGTGTTTGGACAAGATGCGGCGATTGATGTGCTGACAGAGGCGATCAAGCTGACC CGTGCTGGATTAGGCGCAGAACATAAGCCAGTCGGTTCTTTCCTGTTTGCAGGTCCAACTGGGGTTGGTAAAACAGAAGT GACTCTGCAGCTTTCTAAGCTGCTCGGTATCGAACTGCTACGTTTTGATATGTCTGAATACGGTGAGCGCCATTCGGTAA GCCGTTTGATTGGTGCACCTCCAGGTTATGTGGGTTATGACCAAGGTGGGTTATTGACGGACGCTGTGATTAAGCACCCG CACTCGGTTGTTTTGTTGGACGAAATTGAAAAAGCGCACCCCGATATTTTTAACTTGCTCCTACAAGTGATGGATAACGG TACGCTGACGGATAACAACGGCCGTAAAGCCGATTTCCGTAACGTGATTCTTGTGATGACCACCAACGCGGGTGTGGCCG AAACGGTGAAAAAATCGATTGGTTTGATCCAGCAAGATAATAGTCATGATGCGATGTCGGAAATTAAAAAGGTGTTCACT CCCGAATTCCGTAACCGTCTTGATCACATTATCTGGTTCAATAGCTTAGATGAGCGTGTGATTCATCAAGTGGTCGATAA ATTTATCGTGGAACTGCAAGCTCAGTTGGATGCGCGTGGCGTTTCTCTGGAAGTCTCGGAAGATGCCCGCCACTGGTTAG CAGTGAAAGGTTATGACCGTGAGATGGGCGCTCGTCCGATGGGACGTGTGATCCAAGAACAACTGAAGAAACCACTCGCC AATGAGCTGTTGTTTGGCTCGTTAGTCGATGGTGGCACAGTGAAAGTGACGCTGAGTGATGACAGACTGGCTTTCGAGTA TTTCGGTACTCGCGAAGAGGTGGTCCACTAG
Upstream 100 bases:
>100_bases AAGTAACGATGTACTCAAGGGAAAATGAGCACCCACTTTTGTGCACGATGGAGCAAGCTTAAACTTGCCGGGCAATGTGG TTGTTCCTTAAGGAGGCCTT
Downstream 100 bases:
>100_bases ACATCTCACAATACGCAAAAGGCACCGCAAGGTGCCTTTTTTGATCCACAGTATTGGATAACTCCAATTTAACTGAGCAA GATAAAGATGGTACCCGTTA
Product: ATP-dependent Clp protease ATP-binding subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 756; Mature: 756
Protein sequence:
>756_residues MLNKELESSLNGAFARARDKRHEFMTVEHLLLALLENDAAREALLACQADIDVLRRELDTFIDQTTPLIPKNDETRETQP TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKASNHSEDSSSDSFGSS DTSEEVSADERLESFATNLNQLAKQGQIDPLIGRDKELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGNVP EVIQRSVIYSLDIGSLLAGTKYRGDFEKRFKSILKQLEKEKDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLR CIGSTTYQEYSNIFEKERALSRRFQKIDIVEPSLDDTTKILMGLKTKYEAHHDVRYTNKALRAAVELSAKYINERHLPDK AIDVIDEAGARARLMPASRRKKTVGVAEIESMVAKMARIPEKSVSSSDKDILKNLDQKMKMLVFGQDAAIDVLTEAIKLT RAGLGAEHKPVGSFLFAGPTGVGKTEVTLQLSKLLGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKHP HSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETVKKSIGLIQQDNSHDAMSEIKKVFT PEFRNRLDHIIWFNSLDERVIHQVVDKFIVELQAQLDARGVSLEVSEDARHWLAVKGYDREMGARPMGRVIQEQLKKPLA NELLFGSLVDGGTVKVTLSDDRLAFEYFGTREEVVH
Sequences:
>Translated_756_residues MLNKELESSLNGAFARARDKRHEFMTVEHLLLALLENDAAREALLACQADIDVLRRELDTFIDQTTPLIPKNDETRETQP TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKASNHSEDSSSDSFGSS DTSEEVSADERLESFATNLNQLAKQGQIDPLIGRDKELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGNVP EVIQRSVIYSLDIGSLLAGTKYRGDFEKRFKSILKQLEKEKDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLR CIGSTTYQEYSNIFEKERALSRRFQKIDIVEPSLDDTTKILMGLKTKYEAHHDVRYTNKALRAAVELSAKYINERHLPDK AIDVIDEAGARARLMPASRRKKTVGVAEIESMVAKMARIPEKSVSSSDKDILKNLDQKMKMLVFGQDAAIDVLTEAIKLT RAGLGAEHKPVGSFLFAGPTGVGKTEVTLQLSKLLGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKHP HSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETVKKSIGLIQQDNSHDAMSEIKKVFT PEFRNRLDHIIWFNSLDERVIHQVVDKFIVELQAQLDARGVSLEVSEDARHWLAVKGYDREMGARPMGRVIQEQLKKPLA NELLFGSLVDGGTVKVTLSDDRLAFEYFGTREEVVH >Mature_756_residues MLNKELESSLNGAFARARDKRHEFMTVEHLLLALLENDAAREALLACQADIDVLRRELDTFIDQTTPLIPKNDETRETQP TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNFISHGITKASNHSEDSSSDSFGSS DTSEEVSADERLESFATNLNQLAKQGQIDPLIGRDKELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGNVP EVIQRSVIYSLDIGSLLAGTKYRGDFEKRFKSILKQLEKEKDAILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLR CIGSTTYQEYSNIFEKERALSRRFQKIDIVEPSLDDTTKILMGLKTKYEAHHDVRYTNKALRAAVELSAKYINERHLPDK AIDVIDEAGARARLMPASRRKKTVGVAEIESMVAKMARIPEKSVSSSDKDILKNLDQKMKMLVFGQDAAIDVLTEAIKLT RAGLGAEHKPVGSFLFAGPTGVGKTEVTLQLSKLLGIELLRFDMSEYGERHSVSRLIGAPPGYVGYDQGGLLTDAVIKHP HSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVILVMTTNAGVAETVKKSIGLIQQDNSHDAMSEIKKVFT PEFRNRLDHIIWFNSLDERVIHQVVDKFIVELQAQLDARGVSLEVSEDARHWLAVKGYDREMGARPMGRVIQEQLKKPLA NELLFGSLVDGGTVKVTLSDDRLAFEYFGTREEVVH
Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]
COG id: COG0542
COG function: function code O; ATPases with chaperone activity, ATP-binding subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the clpA/clpB family [H]
Homologues:
Organism=Homo sapiens, GI13540606, Length=319, Percent_Identity=30.7210031347962, Blast_Score=153, Evalue=5e-37, Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=78.3132530120482, Blast_Score=1213, Evalue=0.0, Organism=Escherichia coli, GI1788943, Length=422, Percent_Identity=40.521327014218, Blast_Score=289, Evalue=5e-79, Organism=Saccharomyces cerevisiae, GI6320464, Length=328, Percent_Identity=44.5121951219512, Blast_Score=286, Evalue=1e-77, Organism=Saccharomyces cerevisiae, GI6323002, Length=399, Percent_Identity=38.5964912280702, Blast_Score=258, Evalue=3e-69,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR013093 - InterPro: IPR003959 - InterPro: IPR018368 - InterPro: IPR001270 - InterPro: IPR019489 - InterPro: IPR004176 - InterPro: IPR013461 - InterPro: IPR023150 [H]
Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]
EC number: NA
Molecular weight: Translated: 84025; Mature: 84025
Theoretical pI: Translated: 6.45; Mature: 6.45
Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNKELESSLNGAFARARDKRHEFMTVEHLLLALLENDAAREALLACQADIDVLRRELDT CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH FIDQTTPLIPKNDETRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC AYLLKKNDISRLDIVNFISHGITKASNHSEDSSSDSFGSSDTSEEVSADERLESFATNLN EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH QLAKQGQIDPLIGRDKELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGNVP HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEECCCHH EVIQRSVIYSLDIGSLLAGTKYRGDFEKRFKSILKQLEKEKDAILFIDEIHTIIGAGAAS HHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCC GGQVDAANLIKPLLSSGKLRCIGSTTYQEYSNIFEKERALSRRFQKIDIVEPSLDDTTKI CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH LMGLKTKYEAHHDVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARARLMPASRR HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCHHH KKTVGVAEIESMVAKMARIPEKSVSSSDKDILKNLDQKMKMLVFGQDAAIDVLTEAIKLT HHHCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH RAGLGAEHKPVGSFLFAGPTGVGKTEVTLQLSKLLGIELLRFDMSEYGERHSVSRLIGAP HHCCCCCCCCCCCEEEECCCCCCCCHHHEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC PGYVGYDQGGLLTDAVIKHPHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFR CCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCCC NVILVMTTNAGVAETVKKSIGLIQQDNSHDAMSEIKKVFTPEFRNRLDHIIWFNSLDERV CEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEECCCHHHHH IHQVVDKFIVELQAQLDARGVSLEVSEDARHWLAVKGYDREMGARPMGRVIQEQLKKPLA HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHCCCCHHHHHHHHHHHHHHH NELLFGSLVDGGTVKVTLSDDRLAFEYFGTREEVVH HHHHHHHCCCCCEEEEEECCCCEEEHHCCCHHHHCC >Mature Secondary Structure MLNKELESSLNGAFARARDKRHEFMTVEHLLLALLENDAAREALLACQADIDVLRRELDT CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH FIDQTTPLIPKNDETRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC AYLLKKNDISRLDIVNFISHGITKASNHSEDSSSDSFGSSDTSEEVSADERLESFATNLN EEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH QLAKQGQIDPLIGRDKELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEGNVP HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEEECCCHH EVIQRSVIYSLDIGSLLAGTKYRGDFEKRFKSILKQLEKEKDAILFIDEIHTIIGAGAAS HHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCC GGQVDAANLIKPLLSSGKLRCIGSTTYQEYSNIFEKERALSRRFQKIDIVEPSLDDTTKI CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH LMGLKTKYEAHHDVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARARLMPASRR HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCHHH KKTVGVAEIESMVAKMARIPEKSVSSSDKDILKNLDQKMKMLVFGQDAAIDVLTEAIKLT HHHCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH RAGLGAEHKPVGSFLFAGPTGVGKTEVTLQLSKLLGIELLRFDMSEYGERHSVSRLIGAP HHCCCCCCCCCCCEEEECCCCCCCCHHHEEHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC PGYVGYDQGGLLTDAVIKHPHSVVLLDEIEKAHPDIFNLLLQVMDNGTLTDNNGRKADFR CCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCCC NVILVMTTNAGVAETVKKSIGLIQQDNSHDAMSEIKKVFTPEFRNRLDHIIWFNSLDERV CEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHEEECCCHHHHH IHQVVDKFIVELQAQLDARGVSLEVSEDARHWLAVKGYDREMGARPMGRVIQEQLKKPLA HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHCCCCHHHHHHHHHHHHHHH NELLFGSLVDGGTVKVTLSDDRLAFEYFGTREEVVH HHHHHHHCCCCCEEEEEECCCCEEEHHCCCHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]