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The map label for this gene is toxR [H]

Identifier: 147674563

GI number: 147674563

Start: 537865

End: 538749

Strand: Reverse

Name: toxR [H]

Synonym: VC0395_A0505

Alternate gene names: 147674563

Gene position: 538749-537865 (Counterclockwise)

Preceding gene: 147675039

Following gene: 147673605

Centisome position: 17.82

GC content: 45.08

Gene sequence:

>885_bases
ATGTTCGGATTAGGACACAACTCAAAAGAGATATCGATGAGTCATATTGGTACTAAATTCATTCTTGCTGAAAAATTTAC
CTTCGATCCCCTAAGCAATACTCTGATTGACAAAGAAGATAGTGAAGAGATCATTCGATTAGGCAGCAACGAAAGCCGAA
TTCTTTGGCTGCTGGCCCAACGTCCAAACGAGGTGATTTCTCGCAATGATTTGCATGACTTTGTTTGGCGAGAGCAAGGT
TTTGAAGTCGATGATTCCAGCTTAACCCAAGCCATTTCGACTCTGCGCAAAATGCTCAAAGATTCGACAAAGTCCCCACA
ATACGTCAAAACGGTTCCGAAGCGCGGTTACCAATTGATCGCCCGAGTGGAAACGGTTGAAGAAGAGATGGCTCGCGAAA
ACGAAGCTGCTCATGACATCTCTCAGCCAGAATCTGTCAATGAATACGCAGAATCAAGCAGTGTGCCTTCATCAGCCACT
GTAGTGAACACACCGCAGCCAGCCAATGTCGTGGCGAATAAATCGGCTCCAAACTTGGGGAATCGACTGTTTATTCTGAT
AGCGGTCTTACTTCCCCTCGCAGTATTACTGCTCACTAACCCAAGCCAATCCAGCTTTAAACCCCTAACGGTTGTCGATG
GCGTAGCCGTCAATATGCCGAATAACCACCCTGATCTTTCAAATTGGCTACCGTCAATCGAACTGTGCGTTAAAAAATAC
AATGAAAAACATACTGGTGGACTCAAGCCGATAGAAGTGATTGCCACTGGTGGACAAAATAACCAGTTAACGCTGAATTA
CATTCACAGCCCTGAAGTTTCAGGGGAAAACATAACCTTACGCATCGTTGCTAACCCTAACGATGCCATCAAAGTGTGTG
AGTAG

Upstream 100 bases:

>100_bases
TTGATCGAGATTGGATTATTCTAAGTCTGCATTTTTATCAAAGAAGATAAAAAAACCAGTAAAGTCTGAGTGTTGGGACA
GGGAGATACTGGGACATTAG

Downstream 100 bases:

>100_bases
GATCTTGCTATGCAAAATAGACACATCGCCATGGGTATTCTTCTGCTCTCTCTGCTGCTCAGTAGCTGGTTATATTGGGG
GAGTGACTTCAAGCTTGAGC

Product: cholera toxin transcriptional activator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQRPNEVISRNDLHDFVWREQG
FEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLIARVETVEEEMARENEAAHDISQPESVNEYAESSSVPSSAT
VVNTPQPANVVANKSAPNLGNRLFILIAVLLPLAVLLLTNPSQSSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKY
NEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE

Sequences:

>Translated_294_residues
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQRPNEVISRNDLHDFVWREQG
FEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLIARVETVEEEMARENEAAHDISQPESVNEYAESSSVPSSAT
VVNTPQPANVVANKSAPNLGNRLFILIAVLLPLAVLLLTNPSQSSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKY
NEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE
>Mature_294_residues
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQRPNEVISRNDLHDFVWREQG
FEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLIARVETVEEEMARENEAAHDISQPESVNEYAESSSVPSSAT
VVNTPQPANVVANKSAPNLGNRLFILIAVLLPLAVLLLTNPSQSSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKY
NEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE

Specific function: This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the

COG id: COG3710

COG function: function code K; DNA-binding winged-HTH domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790576, Length=116, Percent_Identity=39.6551724137931, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 32523; Mature: 32523

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQ
CCCCCCCCCEEEHHHCCEEEEEEECCCCCCHHHHHCCCCCCHHHHHCCCCCCEEEEEEEC
RPNEVISRNDLHDFVWREQGFEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLI
CCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARVETVEEEMARENEAAHDISQPESVNEYAESSSVPSSATVVNTPQPANVVANKSAPNLG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCCCCC
NRLFILIAVLLPLAVLLLTNPSQSSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
NEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEECC
>Mature Secondary Structure
MFGLGHNSKEISMSHIGTKFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQ
CCCCCCCCCEEEHHHCCEEEEEEECCCCCCHHHHHCCCCCCHHHHHCCCCCCEEEEEEEC
RPNEVISRNDLHDFVWREQGFEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQLI
CCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARVETVEEEMARENEAAHDISQPESVNEYAESSSVPSSATVVNTPQPANVVANKSAPNLG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCCCCCC
NRLFILIAVLLPLAVLLLTNPSQSSFKPLTVVDGVAVNMPNNHPDLSNWLPSIELCVKKY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
NEKHTGGLKPIEVIATGGQNNQLTLNYIHSPEVSGENITLRIVANPNDAIKVCE
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3802195; 10952301; 2124707; 1898871; 1400230 [H]