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The map label for this gene is menB [H]

Identifier: 147674367

GI number: 147674367

Start: 1677440

End: 1678330

Strand: Reverse

Name: menB [H]

Synonym: VC0395_A1559

Alternate gene names: 147674367

Gene position: 1678330-1677440 (Counterclockwise)

Preceding gene: 147674495

Following gene: 147673492

Centisome position: 55.5

GC content: 53.2

Gene sequence:

>891_bases
GTGATAACGACAATGGGAACCACCATGGCTAAAACTACAGGCATTTCTGAGCAAGAACTCTACGCACCAGTGATTTGGCA
AGACTGCACCGGTGACTATCAAGATATCCACTACCACAAATCCGACGATGGGATTGCCAAAATCACCATCGCCAGACCAC
AAGTACGCAATGCGTTTCGTCCATTGACCGTCAAAGAGATGATCCATGCACTGGCGGATGCGCGTTATGACGACAAAGTG
GGTGTGATTATCCTGACCGGTTTAGGTGAAGATGCCTTCTGCTCCGGTGGCGATCAGAAAATTCGTGGTGACTACGGCGG
TTACCGCGATGATTCCGGTACTCACCACCTGAACGTGCTCGATTTCCAACGCCAGATCCGTACTTGTCCAAAGCCAGTGA
TTGCGGCTGTGGCTGGTTGGGCGGTGGGCGGCGGTCATGTACTGCACATGATGTGTGACCTGACCATCGCAGCAGAAAAT
GCACAATTTGGTCAAACGGGCCCGAAAGTCGGCTCATTCGATGGCGGCTGGGGAGCTTCTTACATGGCGCGTATTGTCGG
CCAGAAGAAAGCGCGCGAAATTTGGTTCCTATGCCGCTTCTACAATGCCCAAGAAGCCTTGGACATGGGGCTGGTGAACA
CGGTTGTGCCAGTGGAAGAGCTGGAAAGAGAAACCGTGCGCTGGTGTCGTGAAGTGCTGCAACACAGCCCAATGGCGATT
CGCTGCTTGAAAGCGGCACTGAATGCGGACTGTGATGGTCAAGCAGGACTGCAAGAGCTGGCTGGCAACGCGACCATGCT
GTTCTACATGACTGAAGAAGGTCAGGAAGGCCGTAACGCGTTTAATGAAAAACGCCGCCCGGACTTCAACAAGTTCCCGC
GTAACCCATAA

Upstream 100 bases:

>100_bases
TTACAGTCAGGTTGCGCAGGCGGGACACAATGTCCACCACGAACAGCCGCAAGCGTTTGCCAAGATTGTACAAGCGATGA
TCCACTCAATAATCGATTGA

Downstream 100 bases:

>100_bases
TTCTTCTCAGAGCGGCGTCCTGCCGCTCTTTCTCTTTGAGCATAAACCCCGTTTATGTGGATGTATTGGATATAGGAAGA
GATCAGCATGCGTCATGCAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MITTMGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARPQVRNAFRPLTVKEMIHALADARYDDKV
GVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAEN
AQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEELERETVRWCREVLQHSPMAI
RCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRRPDFNKFPRNP

Sequences:

>Translated_296_residues
MITTMGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARPQVRNAFRPLTVKEMIHALADARYDDKV
GVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAEN
AQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEELERETVRWCREVLQHSPMAI
RCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRRPDFNKFPRNP
>Mature_296_residues
MITTMGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARPQVRNAFRPLTVKEMIHALADARYDDKV
GVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVLDFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAEN
AQFGQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEELERETVRWCREVLQHSPMAI
RCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRRPDFNKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=33.7301587301587, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI31542718, Length=253, Percent_Identity=33.201581027668, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=29.8850574712644, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=29.6650717703349, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=29.6650717703349, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=29.6650717703349, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI25453481, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI51538573, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4757966, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI51538581, Length=251, Percent_Identity=24.7011952191235, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4757968, Length=222, Percent_Identity=27.4774774774775, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI49355787, Length=222, Percent_Identity=27.4774774774775, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI70995211, Length=257, Percent_Identity=27.2373540856031, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI68989263, Length=213, Percent_Identity=30.0469483568075, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=23.6607142857143, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=23.6607142857143, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=84.2857142857143, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=30.7377049180328, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=30.379746835443, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=30.5882352941176, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=27.7992277992278, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=33.4677419354839, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=232, Percent_Identity=28.8793103448276, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=34.4, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=27.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=216, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=206, Percent_Identity=29.126213592233, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=263, Percent_Identity=34.2205323193916, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24653477, Length=263, Percent_Identity=34.2205323193916, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24653139, Length=304, Percent_Identity=27.9605263157895, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21357171, Length=184, Percent_Identity=32.0652173913043, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24654903, Length=205, Percent_Identity=29.7560975609756, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650670, Length=179, Percent_Identity=30.1675977653631, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32839; Mature: 32839

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00018 EF_HAND_1 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTMGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARPQVRNAFR
CCCCCCCHHHHHCCCCHHHHHCCEEEECCCCCHHHCEEECCCCCEEEEEEECHHHHHHCC
PLTVKEMIHALADARYDDKVGVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVL
CCCHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHH
DFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGAS
HHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHH
YMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEELERETVRWCREVLQHSPMAI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHH
RCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRRPDFNKFPRNP
HHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MITTMGTTMAKTTGISEQELYAPVIWQDCTGDYQDIHYHKSDDGIAKITIARPQVRNAFR
CCCCCCCHHHHHCCCCHHHHHCCEEEECCCCCHHHCEEECCCCCEEEEEEECHHHHHHCC
PLTVKEMIHALADARYDDKVGVIILTGLGEDAFCSGGDQKIRGDYGGYRDDSGTHHLNVL
CCCHHHHHHHHHCCCCCCCCCEEEEEECCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHH
DFQRQIRTCPKPVIAAVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGAS
HHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHH
YMARIVGQKKAREIWFLCRFYNAQEALDMGLVNTVVPVEELERETVRWCREVLQHSPMAI
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHH
RCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRRPDFNKFPRNP
HHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]