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The map label for this gene is ccmE

Identifier: 147673770

GI number: 147673770

Start: 1763560

End: 1764042

Strand: Reverse

Name: ccmE

Synonym: VC0395_A1641

Alternate gene names: 147673770

Gene position: 1764042-1763560 (Counterclockwise)

Preceding gene: 147673210

Following gene: 147674378

Centisome position: 58.33

GC content: 47.83

Gene sequence:

>483_bases
ATGAACCCAAGACGTAAAAAGCGGCTCGGTGTTGTTTTGGCCATTCTATTTGGCCTTAGCGCGACCATTGGGCTCATCAT
CTATGCCTTGAATCAGAATATGGATCTCTTCTATACCCCGACTGAGCTCGTGTATGGCAAAGAGGGGAAAAAGCCGGAAA
TCGGCCAGCGTTTACGTATTGGCGGTATGGTGGTGGAAGGTTCGGTAAAACGTGATCCGAACTCATTGAAAGTCAGCTTT
GATCTACACGATGTGGGACCAAGTATTACCGTGACCTATGACGGTATTTTGCCCGATCTGTTCCGAGAAGGTCAGGGTAT
CGTAGCACAAGGGGTGTTAGTGGAGCCGACCAAAATTGAAGCGTTTGAAGTGCTGGCAAAGCATGATGAAAACTATATGC
CACCAGAAATTGCAGAGGCGATGAAAAAGACCCACGCTCCACTGCAATACTCGCAAGAACAGAAACAAGGAAGCGACCAA
TGA

Upstream 100 bases:

>100_bases
TCGTCAGCGTTCGACGCAAAACCAAGTTACTCAACCAAGTGCGCGATAAATTGGCGCGTCAGGCGCGTATTGATGCTGCG
AAACATATGGAGAACACACT

Downstream 100 bases:

>100_bases
TTGCTGAAATTGGCCACTTTGCACTGATTGTATCGCTCAGCTTAGCGATATTACTCAGTGTGCTGCCATTAGTTGGGGCG
TCACGCAACAACACACTATT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MNPRRKKRLGVVLAILFGLSATIGLIIYALNQNMDLFYTPTELVYGKEGKKPEIGQRLRIGGMVVEGSVKRDPNSLKVSF
DLHDVGPSITVTYDGILPDLFREGQGIVAQGVLVEPTKIEAFEVLAKHDENYMPPEIAEAMKKTHAPLQYSQEQKQGSDQ

Sequences:

>Translated_160_residues
MNPRRKKRLGVVLAILFGLSATIGLIIYALNQNMDLFYTPTELVYGKEGKKPEIGQRLRIGGMVVEGSVKRDPNSLKVSF
DLHDVGPSITVTYDGILPDLFREGQGIVAQGVLVEPTKIEAFEVLAKHDENYMPPEIAEAMKKTHAPLQYSQEQKQGSDQ
>Mature_160_residues
MNPRRKKRLGVVLAILFGLSATIGLIIYALNQNMDLFYTPTELVYGKEGKKPEIGQRLRIGGMVVEGSVKRDPNSLKVSF
DLHDVGPSITVTYDGILPDLFREGQGIVAQGVLVEPTKIEAFEVLAKHDENYMPPEIAEAMKKTHAPLQYSQEQKQGSDQ

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=147, Percent_Identity=61.2244897959184, Blast_Score=188, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_VIBC3 (A5F6K5)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F6K5
- SMR:   A5F6K5
- STRING:   A5F6K5
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1641
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13165
- BioCyc:   VCHO345073:VC0395_A1641-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17754; Mature: 17754

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: BINDING 128-128

Signals:

None

Transmembrane regions:

HASH(0x1aa0cd10)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKKRLGVVLAILFGLSATIGLIIYALNQNMDLFYTPTELVYGKEGKKPEIGQRLRI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHEEECCCCCCCCCCCEEEE
GGMVVEGSVKRDPNSLKVSFDLHDVGPSITVTYDGILPDLFREGQGIVAQGVLVEPTKIE
CCEEEECCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHCCCCEEECCEEECCCHHH
AFEVLAKHDENYMPPEIAEAMKKTHAPLQYSQEQKQGSDQ
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCH
>Mature Secondary Structure
MNPRRKKRLGVVLAILFGLSATIGLIIYALNQNMDLFYTPTELVYGKEGKKPEIGQRLRI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHEEECCCCCCCCCCCEEEE
GGMVVEGSVKRDPNSLKVSFDLHDVGPSITVTYDGILPDLFREGQGIVAQGVLVEPTKIE
CCEEEECCCCCCCCCEEEEEEEECCCCEEEEEECCCCHHHHHCCCCEEECCEEECCCHHH
AFEVLAKHDENYMPPEIAEAMKKTHAPLQYSQEQKQGSDQ
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA