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The map label for this gene is ccmA

Identifier: 147673545

GI number: 147673545

Start: 1765753

End: 1766376

Strand: Reverse

Name: ccmA

Synonym: VC0395_A1645

Alternate gene names: 147673545

Gene position: 1766376-1765753 (Counterclockwise)

Preceding gene: 147675281

Following gene: 147673754

Centisome position: 58.41

GC content: 47.28

Gene sequence:

>624_bases
ATGTTAGAAGTTAAAAATCTCACCGCCATACGTGATGAACGGATTTTATTCGAATCACTCTCTTTTGAGATCCATGCTGG
CGAACTCGTTCAAATCGAAGGTCGTAATGGCACAGGCAAAACGACCTTGTTACGTATTATTGCGGGTCTTGGAGAGTGTG
AGTGTGGGGAAATCCTCTGGCAACGGAGCAAAATTCAAAGTGACCGCGAAAGTTATCATCAAGACTTGCTGTTTTTAGGT
CATCAAACCGGCATCAAGCGAGAACTCACCGCACTGGAAAATTTACGTTTTTATCTGGCGGTTCATCAACAAACGGTGGA
TGACCCCGCGATTTTTGAAGCGCTAGCCAAAGTTGGTTTAGCTGGGCGTGAAGATGTGCCGGTTGCACAGTTGTCGGCAG
GGCAACAGCGTCGAGTTGCCTTGGCAAGATTATGGTTAAGTAAAAAGCCACTGTGGATTTTGGATGAACCGCTCACCGCC
ATCGATAAGCAAGGAGTGAGTGTGCTTGAGGCGCTCTTTTTAAGCCATGCGCAGCAAGGGGGGATAGTGATACTGACGAC
TCACCAAGACATGTTTGCCGATAACCCTAAACTGCGCAAAATTCGCTTGGGTGATCCGAAATGA

Upstream 100 bases:

>100_bases
TAGATTCTTACTTAGTTTCGTGATTAGTAATAGAGTTCGCGTCTTTAGTCTCCCCCTCGCTGTGTTAATATAGCCGTCCC
AACGCTCTTAGTAGATAAGC

Downstream 100 bases:

>100_bases
TGCCTGCTTTTATTCAGTTTATTCATCGTGAACTTTTAATTGCTTTTCGCCGTCAGGCGGATGTGTTTAACCCTCTGTGG
TTTTTTATCATCGTGATTAC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLEVKNLTAIRDERILFESLSFEIHAGELVQIEGRNGTGKTTLLRIIAGLGECECGEILWQRSKIQSDRESYHQDLLFLG
HQTGIKRELTALENLRFYLAVHQQTVDDPAIFEALAKVGLAGREDVPVAQLSAGQQRRVALARLWLSKKPLWILDEPLTA
IDKQGVSVLEALFLSHAQQGGIVILTTHQDMFADNPKLRKIRLGDPK

Sequences:

>Translated_207_residues
MLEVKNLTAIRDERILFESLSFEIHAGELVQIEGRNGTGKTTLLRIIAGLGECECGEILWQRSKIQSDRESYHQDLLFLG
HQTGIKRELTALENLRFYLAVHQQTVDDPAIFEALAKVGLAGREDVPVAQLSAGQQRRVALARLWLSKKPLWILDEPLTA
IDKQGVSVLEALFLSHAQQGGIVILTTHQDMFADNPKLRKIRLGDPK
>Mature_207_residues
MLEVKNLTAIRDERILFESLSFEIHAGELVQIEGRNGTGKTTLLRIIAGLGECECGEILWQRSKIQSDRESYHQDLLFLG
HQTGIKRELTALENLRFYLAVHQQTVDDPAIFEALAKVGLAGREDVPVAQLSAGQQRRVALARLWLSKKPLWILDEPLTA
IDKQGVSVLEALFLSHAQQGGIVILTTHQDMFADNPKLRKIRLGDPK

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI153792144, Length=166, Percent_Identity=29.5180722891566, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21536376, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI45446740, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI47078218, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI215820660, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI20143975, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI105990541, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=203, Percent_Identity=58.128078817734, Blast_Score=210, Evalue=4e-56,
Organism=Escherichia coli, GI1787029, Length=200, Percent_Identity=32.5, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788225, Length=217, Percent_Identity=31.3364055299539, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789991, Length=199, Percent_Identity=28.643216080402, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87081709, Length=165, Percent_Identity=31.5151515151515, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1788761, Length=169, Percent_Identity=33.1360946745562, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1787370, Length=189, Percent_Identity=31.7460317460317, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787105, Length=200, Percent_Identity=28.5, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787164, Length=182, Percent_Identity=34.0659340659341, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081791, Length=166, Percent_Identity=30.7228915662651, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081834, Length=184, Percent_Identity=29.8913043478261, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790467, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1786563, Length=197, Percent_Identity=30.4568527918782, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787041, Length=194, Percent_Identity=27.319587628866, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786703, Length=170, Percent_Identity=30.5882352941176, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787712, Length=163, Percent_Identity=30.0613496932515, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=202, Percent_Identity=27.2277227722772, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789672, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790544, Length=213, Percent_Identity=24.8826291079812, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788506, Length=168, Percent_Identity=30.3571428571429, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=25.9067357512953, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789586, Length=206, Percent_Identity=28.1553398058252, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786872, Length=170, Percent_Identity=29.4117647058824, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1787112, Length=183, Percent_Identity=32.2404371584699, Blast_Score=60, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322640, Length=191, Percent_Identity=26.7015706806283, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19920532, Length=184, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24580930, Length=184, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666092, Length=190, Percent_Identity=24.2105263157895, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648314, Length=191, Percent_Identity=24.6073298429319, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_VIBCH (Q9KQE3)

Other databases:

- EMBL:   AE003852
- PIR:   C82125
- RefSeq:   NP_231689.1
- ProteinModelPortal:   Q9KQE3
- SMR:   Q9KQE3
- GeneID:   2613437
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2057
- TIGR:   VC_2057
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- ProtClustDB:   PRK13538
- BRENDA:   3.6.3.41
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23198; Mature: 23198

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEVKNLTAIRDERILFESLSFEIHAGELVQIEGRNGTGKTTLLRIIAGLGECECGEILW
CCCCCCCHHHHHHHHHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHH
QRSKIQSDRESYHQDLLFLGHQTGIKRELTALENLRFYLAVHQQTVDDPAIFEALAKVGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCC
AGREDVPVAQLSAGQQRRVALARLWLSKKPLWILDEPLTAIDKQGVSVLEALFLSHAQQG
CCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCC
GIVILTTHQDMFADNPKLRKIRLGDPK
CEEEEEECHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MLEVKNLTAIRDERILFESLSFEIHAGELVQIEGRNGTGKTTLLRIIAGLGECECGEILW
CCCCCCCHHHHHHHHHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHH
QRSKIQSDRESYHQDLLFLGHQTGIKRELTALENLRFYLAVHQQTVDDPAIFEALAKVGL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCC
AGREDVPVAQLSAGQQRRVALARLWLSKKPLWILDEPLTAIDKQGVSVLEALFLSHAQQG
CCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCC
GIVILTTHQDMFADNPKLRKIRLGDPK
CEEEEEECHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301