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The map label for this gene is lktD [H]

Identifier: 146343682

GI number: 146343682

Start: 7215421

End: 7216917

Strand: Reverse

Name: lktD [H]

Synonym: BRADO6925

Alternate gene names: 146343682

Gene position: 7216917-7215421 (Counterclockwise)

Preceding gene: 146343683

Following gene: 146343681

Centisome position: 96.79

GC content: 68.34

Gene sequence:

>1497_bases
GTGAGGCGGGCCATGGTTGAACCGACGCCGTTGCGCAACACCGACACTGCGACATCCGCCGAGCCGCAGGCCGCAGCCAA
GCCTGCGGCCAAGGTGATGGCGTTCCCCGGCAAGCCGGTCCGGCTGAATGCCGAGGAGCGCGAGTTCCTTCCCGCGGCGC
TCGAAGTGATCGAGACACCGCTGTCGCCGACCTTGCGCCTCACCGCGGCCACGCTGTGCGCGATCATCGTCGGTGCGATC
GCCTGGGCCTCGCTGTCGCATCTCGACATGGTCGCGGTGGCCGATGGCAAGGTGGTGCCGCTCGGGCAGGTCAAGGTGGT
GCAGCCGCTGGAGACGGCCATGATCCGCGCCATCCATGTCGACGAGGGCGATCACGTCCGGGCCGGTCAGCTGCTGGTCG
ATCTCGACCCCACTGAGGCCCGCGCGGATCTCGATTCGCTGCGCTCGGTCCGCGCGCAGGCCGCGCTCGACGCCGAGGTC
GCCCGGGTGCTGCTGACGCGCAATGCGGAGGAGGAGTTTCGGCCGCCGGCCGATGCCGATCCGGTGCTGGTCACGCAAAG
CCGCGATCAGGCCAGGCGCGAGATCGAGAAGCATCTGGCGACCACGGCGGCCTATCTCGCCGACATCGCGCAAAAGAGTG
CCGCGCTGGAGGCCAACGACGCGCAGATCGAGCGCGTGCAACTGACGATCCCGCTGCTGCAGGAAAAGAACGACGTCGCA
AAGGGGTTGTTCGAGAAGGGCTACGGCGCGCGTCCCCCGGTGCTGGAAAGCGAGCAGCAGCTGGTCGAGAAGCGTGCCGA
ACTGCGCGCTGCGCAAGTCAATGTCGATCAGATCCAGGCCGAGATCCGCGCGCTCAAGGCGCGGCTCGCGGAGGCCGCCG
CGGGGTATCTCGCCGATGCGACCGACCGGCGCACCAAGGCGCTGACCAAGGTCGCGCAGCTCGACCAGGACCTGACCAAG
GCGCGGCAGAAGGAGAGCTATCGCCGTCTCGTGGCGCCCGTCGACGGCAGCGTGCAGGGCCTGAAGATTCATACGCCGGG
CGCGGTAGTCACCACCGCCGATACGCTGATGACTATCGTGCCCGACGGCACCGGCATCGAGGTCGACTGCCTGATCGCGA
ACAAGGACATCGGCTTCGTCAGCGAAGGCCAGGACGTCGAGGTGAAGCTGGAGGCGTTTCCGTTCACCCGCTTCGGCCTC
GTCCATGGCCGCGTCCGCAAGCTGGGCCGTGACGCCGCGACTTCGCCGAACGCTCCGCCCGGAAGCACGGCTGCGCTGAT
GACGCAGTCGGCCAATTTGCCCGGCGCGCCGCCGGAGCTGTCTTATCCCGCCAAGGTCACGCTGGCGCAGGACTGGATCG
AGGTCAACGGCCGTCACGAGCCGATCCGTCCCGGCATGCGCGTCTCCGCCGAGATCAAGACCGGCGAGCGCCGGGTGATC
GAATATCTGCTGTCGCCGGTGGTGCAGGCGGTGAAGGAAGCGGGGAGGGAGCGGTGA

Upstream 100 bases:

>100_bases
TCATCGTCATGGAGCGCGGTCGGCTCGCCGAGGCCGGCACACATGATGCGCTGATGACGCATAACGGCCTGTACGCCAAT
CTCGTGCGCCAAGCGGTGGG

Downstream 100 bases:

>100_bases
TGGGACATCTCCGGCGTAGCGACGATGTTCTTGCGAGACCTTTTAAAAAGCAAGAACCCACGTTTGCACGGCGCATCAGC
GCACCAACAGCAAGAATAGA

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MRRAMVEPTPLRNTDTATSAEPQAAAKPAAKVMAFPGKPVRLNAEEREFLPAALEVIETPLSPTLRLTAATLCAIIVGAI
AWASLSHLDMVAVADGKVVPLGQVKVVQPLETAMIRAIHVDEGDHVRAGQLLVDLDPTEARADLDSLRSVRAQAALDAEV
ARVLLTRNAEEEFRPPADADPVLVTQSRDQARREIEKHLATTAAYLADIAQKSAALEANDAQIERVQLTIPLLQEKNDVA
KGLFEKGYGARPPVLESEQQLVEKRAELRAAQVNVDQIQAEIRALKARLAEAAAGYLADATDRRTKALTKVAQLDQDLTK
ARQKESYRRLVAPVDGSVQGLKIHTPGAVVTTADTLMTIVPDGTGIEVDCLIANKDIGFVSEGQDVEVKLEAFPFTRFGL
VHGRVRKLGRDAATSPNAPPGSTAALMTQSANLPGAPPELSYPAKVTLAQDWIEVNGRHEPIRPGMRVSAEIKTGERRVI
EYLLSPVVQAVKEAGRER

Sequences:

>Translated_498_residues
MRRAMVEPTPLRNTDTATSAEPQAAAKPAAKVMAFPGKPVRLNAEEREFLPAALEVIETPLSPTLRLTAATLCAIIVGAI
AWASLSHLDMVAVADGKVVPLGQVKVVQPLETAMIRAIHVDEGDHVRAGQLLVDLDPTEARADLDSLRSVRAQAALDAEV
ARVLLTRNAEEEFRPPADADPVLVTQSRDQARREIEKHLATTAAYLADIAQKSAALEANDAQIERVQLTIPLLQEKNDVA
KGLFEKGYGARPPVLESEQQLVEKRAELRAAQVNVDQIQAEIRALKARLAEAAAGYLADATDRRTKALTKVAQLDQDLTK
ARQKESYRRLVAPVDGSVQGLKIHTPGAVVTTADTLMTIVPDGTGIEVDCLIANKDIGFVSEGQDVEVKLEAFPFTRFGL
VHGRVRKLGRDAATSPNAPPGSTAALMTQSANLPGAPPELSYPAKVTLAQDWIEVNGRHEPIRPGMRVSAEIKTGERRVI
EYLLSPVVQAVKEAGRER
>Mature_498_residues
MRRAMVEPTPLRNTDTATSAEPQAAAKPAAKVMAFPGKPVRLNAEEREFLPAALEVIETPLSPTLRLTAATLCAIIVGAI
AWASLSHLDMVAVADGKVVPLGQVKVVQPLETAMIRAIHVDEGDHVRAGQLLVDLDPTEARADLDSLRSVRAQAALDAEV
ARVLLTRNAEEEFRPPADADPVLVTQSRDQARREIEKHLATTAAYLADIAQKSAALEANDAQIERVQLTIPLLQEKNDVA
KGLFEKGYGARPPVLESEQQLVEKRAELRAAQVNVDQIQAEIRALKARLAEAAAGYLADATDRRTKALTKVAQLDQDLTK
ARQKESYRRLVAPVDGSVQGLKIHTPGAVVTTADTLMTIVPDGTGIEVDCLIANKDIGFVSEGQDVEVKLEAFPFTRFGL
VHGRVRKLGRDAATSPNAPPGSTAALMTQSANLPGAPPELSYPAKVTLAQDWIEVNGRHEPIRPGMRVSAEIKTGERRVI
EYLLSPVVQAVKEAGRER

Specific function: Involved in the transport of the Leukotoxin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 53752; Mature: 53752

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00543 HLYD_FAMILY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRAMVEPTPLRNTDTATSAEPQAAAKPAAKVMAFPGKPVRLNAEEREFLPAALEVIETP
CCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEEECCCCCEEECCHHHHHHHHHHHHHHCC
LSPTLRLTAATLCAIIVGAIAWASLSHLDMVAVADGKVVPLGQVKVVQPLETAMIRAIHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEECCCCEEECCHHHHHHEEEEEC
DEGDHVRAGQLLVDLDPTEARADLDSLRSVRAQAALDAEVARVLLTRNAEEEFRPPADAD
CCCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
PVLVTQSRDQARREIEKHLATTAAYLADIAQKSAALEANDAQIERVQLTIPLLQEKNDVA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEHHHCCCHHH
KGLFEKGYGARPPVLESEQQLVEKRAELRAAQVNVDQIQAEIRALKARLAEAAAGYLADA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TDRRTKALTKVAQLDQDLTKARQKESYRRLVAPVDGSVQGLKIHTPGAVVTTADTLMTIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCEEEEEE
PDGTGIEVDCLIANKDIGFVSEGQDVEVKLEAFPFTRFGLVHGRVRKLGRDAATSPNAPP
CCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
GSTAALMTQSANLPGAPPELSYPAKVTLAQDWIEVNGRHEPIRPGMRVSAEIKTGERRVI
CCCCEEEEECCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCEEEEEECCCHHHHH
EYLLSPVVQAVKEAGRER
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRAMVEPTPLRNTDTATSAEPQAAAKPAAKVMAFPGKPVRLNAEEREFLPAALEVIETP
CCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHEEECCCCCEEECCHHHHHHHHHHHHHHCC
LSPTLRLTAATLCAIIVGAIAWASLSHLDMVAVADGKVVPLGQVKVVQPLETAMIRAIHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCEECCCCEEECCHHHHHHEEEEEC
DEGDHVRAGQLLVDLDPTEARADLDSLRSVRAQAALDAEVARVLLTRNAEEEFRPPADAD
CCCCCEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
PVLVTQSRDQARREIEKHLATTAAYLADIAQKSAALEANDAQIERVQLTIPLLQEKNDVA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEHHHCCCHHH
KGLFEKGYGARPPVLESEQQLVEKRAELRAAQVNVDQIQAEIRALKARLAEAAAGYLADA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TDRRTKALTKVAQLDQDLTKARQKESYRRLVAPVDGSVQGLKIHTPGAVVTTADTLMTIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCEEEEEE
PDGTGIEVDCLIANKDIGFVSEGQDVEVKLEAFPFTRFGLVHGRVRKLGRDAATSPNAPP
CCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
GSTAALMTQSANLPGAPPELSYPAKVTLAQDWIEVNGRHEPIRPGMRVSAEIKTGERRVI
CCCCEEEEECCCCCCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCEEEEEECCCHHHHH
EYLLSPVVQAVKEAGRER
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3040588; 2914876; 2707120 [H]