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The map label for this gene is ethA [H]

Identifier: 146343658

GI number: 146343658

Start: 7170981

End: 7172483

Strand: Reverse

Name: ethA [H]

Synonym: BRADO6900

Alternate gene names: 146343658

Gene position: 7172483-7170981 (Counterclockwise)

Preceding gene: 146343659

Following gene: 146343655

Centisome position: 96.19

GC content: 61.68

Gene sequence:

>1503_bases
ATGAACGTCATCGCCCCCATCCGGGAGGCCGCGTCCTCTCAGACCATCGAACATTTTGACGTGCTGATCGTCGGCGCCGG
CATCTCCGGCATCGGCAGTGCCTATCAGCTGACGAAGCAGATGCCTGATACGAGGTTCGTGATCCTCGAGAGCCAGGATA
GTTTTGGCGGCACCTGGCGGACGCATCGCTACCCCGGCATCCGCTCCGACAGCGATCTGCACACCTTCGGCTACAGCTTC
AAGCCATGGGTCGGGCCGCCGATCGCGACGGCGGAAGAGATCCTGAAATACATGGGGGACGTGATCGAGGAGAACGATCT
CGGCCGCCATATCCGCTACGGCCATCGCATCCTCTCGGCGAGTTGGTCGAGCGCGACCAATCTCTGGACCGTTCACGCGG
TAAAGGGTCCTGGCGAAGAACCCGTCACGATCTCAGCGAATTTCCTGTGGATGTGCCAGGGCTATTATCGCCATTCGAAA
GGCTACACGCCGGAGTGGCCCGACATGGCCAAGTTCAAGGGCCGGATGGTGCACCCGCAGCTATGGCCCGAGGATCTCGA
TCTCACAGGCAAGCAGATCCTCGTCATCGGCTCCGGCGCGACCGCAGCGACGATCCTGCCGTCGATCGCAGGCAAATGCG
CGCATGTCACCATGCTGCAGCGCTCGCCGACCTACTTCCGCATCGGCCGCAATGCGATCGAGATCGCCGAGGAGCTGCGC
CGCCTGCAAGTCAAGGAGGAATGGATCCACGAGATCGTCCGGCGCAAGATCCTGTTCGAGCAGGACTGGTTCACCAAGCG
ATGCCTGACCGAGCCGGAGCAGGTGAAGAAGGAGCTGATCGGCCAGATCAGCGCCATCGTCGGACCCGACTACGCAGCCA
AGCATTTCACGCCGAGCTATCGTCCCTGGCGTCAACGCATCGCCTTCGTGCCGGATGCCGATCTGTTCGAGGGCATCAAG
AGCGGCAAGGCCTCCGTCGTCACCGACAAGATCGAGCGCTTCACCGAAGGCGGGATCAAGCTGAAGTCCGGCGACGAGCT
CAAGGCCGACATCATCGTCACCGCGACCGGATTCGATCTCTGCGTGCTCGGCGACATTGCCTTCACCATCGACGGCAAGC
CGCTGGATTTCGCCGATACCGTGACCTATCGCGGCATGATGTTCAGCGGCGTGCCGAACCTCGCCTGGGTGTTCGGCTAT
TTCCGTGCCAGCTGGACCTTGCGCACGGATCTGGTCGCGGAGTTCGTGTGCCGGCTGCTCGCCCATATGAGGGCGAAGGG
CGTCGAGAAGGTCACGCCTCAGCTGCGTCCCGAGGATCATAACATGCCGCTGCTGCCGTGGATCGATCCGGAGAACTTCA
ATCCGGGCTACATGATGCGCAACATGCATCTCTTGCCCAAGCGCGGCGACAAGCCGGAATGGCAGCACAGCCAGGACTAT
TGGCGCGAGAAGGACGAGATCCCGGCAATCGACCTGGATGATCCGGCGTTCGTGTATGGATAG

Upstream 100 bases:

>100_bases
CGCGCGCGTCCGCGGCTTGCTCTCGCGGGTTGACCGTCGTCGTGATCGGGTTCAGCCTGTCACGCGAGGAAACAACACCT
AGAGCAAGAGCCCAGGGCCC

Downstream 100 bases:

>100_bases
GTTTTGATCGTCATAGGCGGGCCTGTCGCTCCAACTCCGGTGTCATCCCGCGAAAGCGGGGATCCATAACCACAGGCGGA
CGTGGCGGGCACAACGCTCA

Product: putative flavin-containing monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNVIAPIREAASSQTIEHFDVLIVGAGISGIGSAYQLTKQMPDTRFVILESQDSFGGTWRTHRYPGIRSDSDLHTFGYSF
KPWVGPPIATAEEILKYMGDVIEENDLGRHIRYGHRILSASWSSATNLWTVHAVKGPGEEPVTISANFLWMCQGYYRHSK
GYTPEWPDMAKFKGRMVHPQLWPEDLDLTGKQILVIGSGATAATILPSIAGKCAHVTMLQRSPTYFRIGRNAIEIAEELR
RLQVKEEWIHEIVRRKILFEQDWFTKRCLTEPEQVKKELIGQISAIVGPDYAAKHFTPSYRPWRQRIAFVPDADLFEGIK
SGKASVVTDKIERFTEGGIKLKSGDELKADIIVTATGFDLCVLGDIAFTIDGKPLDFADTVTYRGMMFSGVPNLAWVFGY
FRASWTLRTDLVAEFVCRLLAHMRAKGVEKVTPQLRPEDHNMPLLPWIDPENFNPGYMMRNMHLLPKRGDKPEWQHSQDY
WREKDEIPAIDLDDPAFVYG

Sequences:

>Translated_500_residues
MNVIAPIREAASSQTIEHFDVLIVGAGISGIGSAYQLTKQMPDTRFVILESQDSFGGTWRTHRYPGIRSDSDLHTFGYSF
KPWVGPPIATAEEILKYMGDVIEENDLGRHIRYGHRILSASWSSATNLWTVHAVKGPGEEPVTISANFLWMCQGYYRHSK
GYTPEWPDMAKFKGRMVHPQLWPEDLDLTGKQILVIGSGATAATILPSIAGKCAHVTMLQRSPTYFRIGRNAIEIAEELR
RLQVKEEWIHEIVRRKILFEQDWFTKRCLTEPEQVKKELIGQISAIVGPDYAAKHFTPSYRPWRQRIAFVPDADLFEGIK
SGKASVVTDKIERFTEGGIKLKSGDELKADIIVTATGFDLCVLGDIAFTIDGKPLDFADTVTYRGMMFSGVPNLAWVFGY
FRASWTLRTDLVAEFVCRLLAHMRAKGVEKVTPQLRPEDHNMPLLPWIDPENFNPGYMMRNMHLLPKRGDKPEWQHSQDY
WREKDEIPAIDLDDPAFVYG
>Mature_500_residues
MNVIAPIREAASSQTIEHFDVLIVGAGISGIGSAYQLTKQMPDTRFVILESQDSFGGTWRTHRYPGIRSDSDLHTFGYSF
KPWVGPPIATAEEILKYMGDVIEENDLGRHIRYGHRILSASWSSATNLWTVHAVKGPGEEPVTISANFLWMCQGYYRHSK
GYTPEWPDMAKFKGRMVHPQLWPEDLDLTGKQILVIGSGATAATILPSIAGKCAHVTMLQRSPTYFRIGRNAIEIAEELR
RLQVKEEWIHEIVRRKILFEQDWFTKRCLTEPEQVKKELIGQISAIVGPDYAAKHFTPSYRPWRQRIAFVPDADLFEGIK
SGKASVVTDKIERFTEGGIKLKSGDELKADIIVTATGFDLCVLGDIAFTIDGKPLDFADTVTYRGMMFSGVPNLAWVFGY
FRASWTLRTDLVAEFVCRLLAHMRAKGVEKVTPQLRPEDHNMPLLPWIDPENFNPGYMMRNMHLLPKRGDKPEWQHSQDY
WREKDEIPAIDLDDPAFVYG

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56763; Mature: 56763

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIAPIREAASSQTIEHFDVLIVGAGISGIGSAYQLTKQMPDTRFVILESQDSFGGTWR
CCCCHHHHHHHCCCCHHEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEE
THRYPGIRSDSDLHTFGYSFKPWVGPPIATAEEILKYMGDVIEENDLGRHIRYGHRILSA
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
SWSSATNLWTVHAVKGPGEEPVTISANFLWMCQGYYRHSKGYTPEWPDMAKFKGRMVHPQ
CCCCCCCEEEEEEECCCCCCCEEEECCEEEEECHHHHHCCCCCCCCCCHHHHCCCCCCCC
LWPEDLDLTGKQILVIGSGATAATILPSIAGKCAHVTMLQRSPTYFRIGRNAIEIAEELR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHH
RLQVKEEWIHEIVRRKILFEQDWFTKRCLTEPEQVKKELIGQISAIVGPDYAAKHFTPSY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
RPWRQRIAFVPDADLFEGIKSGKASVVTDKIERFTEGGIKLKSGDELKADIIVTATGFDL
CCHHHHEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCE
CVLGDIAFTIDGKPLDFADTVTYRGMMFSGVPNLAWVFGYFRASWTLRTDLVAEFVCRLL
EEECCEEEEECCCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHCEEHHHHHHHHHHHHHH
AHMRAKGVEKVTPQLRPEDHNMPLLPWIDPENFNPGYMMRNMHLLPKRGDKPEWQHSQDY
HHHHHCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCCEEECEEECCCCCCCCCCCCCHHH
WREKDEIPAIDLDDPAFVYG
HHHHCCCCEECCCCCCEECC
>Mature Secondary Structure
MNVIAPIREAASSQTIEHFDVLIVGAGISGIGSAYQLTKQMPDTRFVILESQDSFGGTWR
CCCCHHHHHHHCCCCHHEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEE
THRYPGIRSDSDLHTFGYSFKPWVGPPIATAEEILKYMGDVIEENDLGRHIRYGHRILSA
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
SWSSATNLWTVHAVKGPGEEPVTISANFLWMCQGYYRHSKGYTPEWPDMAKFKGRMVHPQ
CCCCCCCEEEEEEECCCCCCCEEEECCEEEEECHHHHHCCCCCCCCCCHHHHCCCCCCCC
LWPEDLDLTGKQILVIGSGATAATILPSIAGKCAHVTMLQRSPTYFRIGRNAIEIAEELR
CCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHH
RLQVKEEWIHEIVRRKILFEQDWFTKRCLTEPEQVKKELIGQISAIVGPDYAAKHFTPSY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
RPWRQRIAFVPDADLFEGIKSGKASVVTDKIERFTEGGIKLKSGDELKADIIVTATGFDL
CCHHHHEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCE
CVLGDIAFTIDGKPLDFADTVTYRGMMFSGVPNLAWVFGYFRASWTLRTDLVAEFVCRLL
EEECCEEEEECCCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHCEEHHHHHHHHHHHHHH
AHMRAKGVEKVTPQLRPEDHNMPLLPWIDPENFNPGYMMRNMHLLPKRGDKPEWQHSQDY
HHHHHCCHHHCCCCCCCCCCCCCEEECCCCCCCCCCCEEECEEECCCCCCCCCCCCCHHH
WREKDEIPAIDLDDPAFVYG
HHHHCCCCEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA