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The map label for this gene is livH [H]

Identifier: 146343654

GI number: 146343654

Start: 7163927

End: 7164853

Strand: Reverse

Name: livH [H]

Synonym: BRADO6896

Alternate gene names: 146343654

Gene position: 7164853-7163927 (Counterclockwise)

Preceding gene: 146343655

Following gene: 146343653

Centisome position: 96.09

GC content: 63.21

Gene sequence:

>927_bases
ATGTTCGGCGACTATTCCATCGGCGACCTCGGGGCCATCTTCGCGATGCAGGGCTTCGCGGGCCTCATCCTGTTTTCGGT
CTACGTGCTGATGGCGCTCGGGCTTGCCATCATCTTCGGCCAGATGGGCGTCATCAACATGGCGCATGGCGAATTCATGA
TCCTCGGTGCCTACGTCACCTGGATGACGTCGAACGCCTTCCAGAATTTCCTGCCATCGCTGTTTCCCGGCTACTTCTTC
GTCGCTATGGCGCTCGCCTTCGTCGCGTCCGGGTCGCTCGGCATGCTGGTCGAGTGGGCGATGATCCGGCGGCTTTACAA
GCGTCCGCTGGATACGCTGCTTGCCACCTGGGGCCTCAGCTTGATCCTGCAGCAGGCCTATCGCTCGGTATTCGGCGCAC
GCGAGGTCGGCGTTGAATTGCCGGAGTGGATGATGGGCTCGTGGCAGGCCACCGACTCGATCCAAATTCCGATCAACGGC
ATGTTCGTGATGTGCCTGACGATCCTGATCACCATTGTGGTCGCCTATGTCCTGTTCCTGTCTCGCTGGGGGCGCCAGGT
CCGCGCCGTGGTGCAGAACCGCGTGATGGCCGGCGCCGTCGGCATCAACACCGAGAAGGTCGACCGCTACACCTTCGGCC
TCGGTTGCGGCATCGCCGGTGTCGCGGGCTCCGCCTTCACCATGATCGGTTCGACCGGTCCGACCGCCGGCCAGCTCTAC
ATTGTCGACACCTTCCTGGTCGTCGTGTTCGGCGGGGCCGCCAGCCTGCTCGGCACCATCGCCTCGGCCTTCACCATCTC
CCAGGCGCAGTCGACGATGGAGTTCTTCATGTCCGGCTCGATGGCCAAGGTGCTGACGCTGCTGGCGATCGTCGCCATCC
TGATGCTGCGGCCGCAGGGGCTGTTCGCCCTCAAGGTCCGCAAATGA

Upstream 100 bases:

>100_bases
TCCTTAGCTCCTCCCGACGGGAGGGGACGATCTTGGCCGCGAGCTCACCAGCTCGCGAGCCGATCCAATTTTCCAGCAGG
GCATCACGAGAGGACGGATC

Downstream 100 bases:

>100_bases
GCCTGCTCCGTCAGTCCAACAAGAAGGCACGGCCATGATCAACTCTCGCTTCTTCAACCGCTCGGAGCTCATCGGCTTCG
TCTCGCTGCTGCTCCTGCTC

Product: branched chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MFGDYSIGDLGAIFAMQGFAGLILFSVYVLMALGLAIIFGQMGVINMAHGEFMILGAYVTWMTSNAFQNFLPSLFPGYFF
VAMALAFVASGSLGMLVEWAMIRRLYKRPLDTLLATWGLSLILQQAYRSVFGAREVGVELPEWMMGSWQATDSIQIPING
MFVMCLTILITIVVAYVLFLSRWGRQVRAVVQNRVMAGAVGINTEKVDRYTFGLGCGIAGVAGSAFTMIGSTGPTAGQLY
IVDTFLVVVFGGAASLLGTIASAFTISQAQSTMEFFMSGSMAKVLTLLAIVAILMLRPQGLFALKVRK

Sequences:

>Translated_308_residues
MFGDYSIGDLGAIFAMQGFAGLILFSVYVLMALGLAIIFGQMGVINMAHGEFMILGAYVTWMTSNAFQNFLPSLFPGYFF
VAMALAFVASGSLGMLVEWAMIRRLYKRPLDTLLATWGLSLILQQAYRSVFGAREVGVELPEWMMGSWQATDSIQIPING
MFVMCLTILITIVVAYVLFLSRWGRQVRAVVQNRVMAGAVGINTEKVDRYTFGLGCGIAGVAGSAFTMIGSTGPTAGQLY
IVDTFLVVVFGGAASLLGTIASAFTISQAQSTMEFFMSGSMAKVLTLLAIVAILMLRPQGLFALKVRK
>Mature_308_residues
MFGDYSIGDLGAIFAMQGFAGLILFSVYVLMALGLAIIFGQMGVINMAHGEFMILGAYVTWMTSNAFQNFLPSLFPGYFF
VAMALAFVASGSLGMLVEWAMIRRLYKRPLDTLLATWGLSLILQQAYRSVFGAREVGVELPEWMMGSWQATDSIQIPING
MFVMCLTILITIVVAYVLFLSRWGRQVRAVVQNRVMAGAVGINTEKVDRYTFGLGCGIAGVAGSAFTMIGSTGPTAGQLY
IVDTFLVVVFGGAASLLGTIASAFTISQAQSTMEFFMSGSMAKVLTLLAIVAILMLRPQGLFALKVRK

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=299, Percent_Identity=27.7591973244147, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 33278; Mature: 33278

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDYSIGDLGAIFAMQGFAGLILFSVYVLMALGLAIIFGQMGVINMAHGEFMILGAYVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHH
WMTSNAFQNFLPSLFPGYFFVAMALAFVASGSLGMLVEWAMIRRLYKRPLDTLLATWGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILQQAYRSVFGAREVGVELPEWMMGSWQATDSIQIPINGMFVMCLTILITIVVAYVLFL
HHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
SRWGRQVRAVVQNRVMAGAVGINTEKVDRYTFGLGCGIAGVAGSAFTMIGSTGPTAGQLY
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCHHEEECCCCCCCCEEH
IVDTFLVVVFGGAASLLGTIASAFTISQAQSTMEFFMSGSMAKVLTLLAIVAILMLRPQG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LFALKVRK
CEEEEECC
>Mature Secondary Structure
MFGDYSIGDLGAIFAMQGFAGLILFSVYVLMALGLAIIFGQMGVINMAHGEFMILGAYVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEHHHHHH
WMTSNAFQNFLPSLFPGYFFVAMALAFVASGSLGMLVEWAMIRRLYKRPLDTLLATWGLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILQQAYRSVFGAREVGVELPEWMMGSWQATDSIQIPINGMFVMCLTILITIVVAYVLFL
HHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
SRWGRQVRAVVQNRVMAGAVGINTEKVDRYTFGLGCGIAGVAGSAFTMIGSTGPTAGQLY
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCHHEEECCCCCCCCEEH
IVDTFLVVVFGGAASLLGTIASAFTISQAQSTMEFFMSGSMAKVLTLLAIVAILMLRPQG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LFALKVRK
CEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]