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The map label for this gene is adh [H]

Identifier: 146343382

GI number: 146343382

Start: 6861037

End: 6862074

Strand: Direct

Name: adh [H]

Synonym: BRADO6611

Alternate gene names: 146343382

Gene position: 6861037-6862074 (Clockwise)

Preceding gene: 146343380

Following gene: 146343393

Centisome position: 92.01

GC content: 65.22

Gene sequence:

>1038_bases
ATGAAAGCCCTGGTCTATCACGGTCCCGGTCAGAAATCCCTCGACGAGCGCCCGAAGCCGGCGATCCTCGAACCCGGCGA
TGCCGTGGTCAAAATCCTGAAGACCACGATCTGCGGCACCGACCTGCACATCCTGAAAGGCGACGTGCCGACCTGCACGC
CGGGCCGCATCCTCGGTCACGAGGGGGTCGGCGTGGTCGACGCGGTCGGCAGCGCTGTGCGCGCGTTCAAGCCGGGCGAC
CACGTCATCATCTCCTGCATCTCGGCGTGCGGAACCTGCGACTATTGCCGGCGCGGCATGTACTCGCATTGCCGCCACGG
CGGCTGGATCCTCGGCCACAAGATCGACGGCACCCAGGCGGAATATGTGCGCACCCCGCATGCCGACACCAGCCTGTATC
ACGTGCCCGCCGGCACCGAGGAGGAGGCGCTGGTGATGCTGAGCGACATCCTGCCGACCGGCTTCGAATGCGGCGTGCTC
AACGGCAAGGTCGAGCCGGGCTCCAGCGTGGCCATCGTCGGCGCCGGCCCGATCGGGTTGGCGTCGCTACTGACCGCGCA
GTTCTACTCGCCGGCCGAAATCATCATGATCGACCTCGACGACAACCGTCTCGAGGTCGCCGCCCGCTTCGGCGCCACCA
GCGTGATCAACAATAGCGACGGCAAGGCGGTCGAAAAGGTGATGGCGCTGACCAATGGCCGCGGCGTGGATACCGCGATC
GAGGCGGTCGGTGTGCCCGCCACCTTCGTGACCTGCGAGGACATCATCGCTCCCGGCGGCATCATCGCCAATGTCGGCGT
GCACGGCGTCAAGGCCGACCTGCATCTGGAGAAGCTGTGGGACCGCAACATCGCGATCACCACGCGGCTGGTCGACACCG
TGACGACGCCGATGCTGCTCAAGACGGTGCAATCCAAGAAACTGGAGCCGAAGCGGCTGATCACTCACCGCTTCAAGCTG
GATCAGATTCTCGACGCCTATGAAACCTTCGGCGCGGCCGCGAAAACGCATGCCCTGAAGGTCCTCATCGAGGCCTAG

Upstream 100 bases:

>100_bases
CGCGATCGTGAGACGGAACGCCTCCGCCCTTGATACGCCTCAACGGCGCACAACCTCGTCTGCGCCACTCTCCCTCCAGC
AAACTTTGCGGAGGAGCGTC

Downstream 100 bases:

>100_bases
GGCCATGACCTCCGCGCAGCGCTCACCCCGCCGGGCGGCGCTGCGCGACGATCTGGCGGTACAGCTCGGCATAACGCCCC
GCGCGGTGCCGCCATGACAC

Product: putative zinc-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKALVYHGPGQKSLDERPKPAILEPGDAVVKILKTTICGTDLHILKGDVPTCTPGRILGHEGVGVVDAVGSAVRAFKPGD
HVIISCISACGTCDYCRRGMYSHCRHGGWILGHKIDGTQAEYVRTPHADTSLYHVPAGTEEEALVMLSDILPTGFECGVL
NGKVEPGSSVAIVGAGPIGLASLLTAQFYSPAEIIMIDLDDNRLEVAARFGATSVINNSDGKAVEKVMALTNGRGVDTAI
EAVGVPATFVTCEDIIAPGGIIANVGVHGVKADLHLEKLWDRNIAITTRLVDTVTTPMLLKTVQSKKLEPKRLITHRFKL
DQILDAYETFGAAAKTHALKVLIEA

Sequences:

>Translated_345_residues
MKALVYHGPGQKSLDERPKPAILEPGDAVVKILKTTICGTDLHILKGDVPTCTPGRILGHEGVGVVDAVGSAVRAFKPGD
HVIISCISACGTCDYCRRGMYSHCRHGGWILGHKIDGTQAEYVRTPHADTSLYHVPAGTEEEALVMLSDILPTGFECGVL
NGKVEPGSSVAIVGAGPIGLASLLTAQFYSPAEIIMIDLDDNRLEVAARFGATSVINNSDGKAVEKVMALTNGRGVDTAI
EAVGVPATFVTCEDIIAPGGIIANVGVHGVKADLHLEKLWDRNIAITTRLVDTVTTPMLLKTVQSKKLEPKRLITHRFKL
DQILDAYETFGAAAKTHALKVLIEA
>Mature_345_residues
MKALVYHGPGQKSLDERPKPAILEPGDAVVKILKTTICGTDLHILKGDVPTCTPGRILGHEGVGVVDAVGSAVRAFKPGD
HVIISCISACGTCDYCRRGMYSHCRHGGWILGHKIDGTQAEYVRTPHADTSLYHVPAGTEEEALVMLSDILPTGFECGVL
NGKVEPGSSVAIVGAGPIGLASLLTAQFYSPAEIIMIDLDDNRLEVAARFGATSVINNSDGKAVEKVMALTNGRGVDTAI
EAVGVPATFVTCEDIIAPGGIIANVGVHGVKADLHLEKLWDRNIAITTRLVDTVTTPMLLKTVQSKKLEPKRLITHRFKL
DQILDAYETFGAAAKTHALKVLIEA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=29.5454545454545, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI71565154, Length=329, Percent_Identity=28.2674772036474, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI4501929, Length=329, Percent_Identity=27.355623100304, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=26.4044943820225, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=26.4044943820225, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI34577061, Length=329, Percent_Identity=26.7477203647416, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI71743840, Length=333, Percent_Identity=27.9279279279279, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI262073058, Length=333, Percent_Identity=27.9279279279279, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501933, Length=331, Percent_Identity=26.2839879154079, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565152, Length=330, Percent_Identity=25.4545454545455, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=30.4, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=27.7456647398844, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788073, Length=309, Percent_Identity=30.0970873786408, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790045, Length=323, Percent_Identity=28.1733746130031, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=26.5193370165746, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=28.448275862069, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786552, Length=332, Percent_Identity=29.5180722891566, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87081918, Length=272, Percent_Identity=32.7205882352941, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=26.5671641791045, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=24.2424242424242, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=332, Percent_Identity=30.1204819277108, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=29.4117647058824, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71997431, Length=331, Percent_Identity=29.607250755287, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=26.865671641791, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=336, Percent_Identity=28.2738095238095, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=28.6135693215339, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=28.6135693215339, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=346, Percent_Identity=27.1676300578035, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=338, Percent_Identity=28.1065088757396, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=303, Percent_Identity=28.3828382838284, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=224, Percent_Identity=31.25, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=301, Percent_Identity=25.9136212624585, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=268, Percent_Identity=29.4776119402985, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=331, Percent_Identity=29.607250755287, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=30.7228915662651, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=32.3353293413174, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551930, Length=327, Percent_Identity=22.9357798165138, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550770, Length=327, Percent_Identity=22.9357798165138, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221457811, Length=327, Percent_Identity=22.9357798165138, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36640; Mature: 36640

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYHGPGQKSLDERPKPAILEPGDAVVKILKTTICGTDLHILKGDVPTCTPGRILGH
CCEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECC
EGVGVVDAVGSAVRAFKPGDHVIISCISACGTCDYCRRGMYSHCRHGGWILGHKIDGTQA
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCH
EYVRTPHADTSLYHVPAGTEEEALVMLSDILPTGFECGVLNGKVEPGSSVAIVGAGPIGL
HEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCHHH
ASLLTAQFYSPAEIIMIDLDDNRLEVAARFGATSVINNSDGKAVEKVMALTNGRGVDTAI
HHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCHHHH
EAVGVPATFVTCEDIIAPGGIIANVGVHGVKADLHLEKLWDRNIAITTRLVDTVTTPMLL
HHCCCCEEEEEHHHHHCCCCEEEECCCCEEEEEEEHHHHHCCCEEEEEHHHHHHHHHHHH
KTVQSKKLEPKRLITHRFKLDQILDAYETFGAAAKTHALKVLIEA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEEEC
>Mature Secondary Structure
MKALVYHGPGQKSLDERPKPAILEPGDAVVKILKTTICGTDLHILKGDVPTCTPGRILGH
CCEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECC
EGVGVVDAVGSAVRAFKPGDHVIISCISACGTCDYCRRGMYSHCRHGGWILGHKIDGTQA
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCH
EYVRTPHADTSLYHVPAGTEEEALVMLSDILPTGFECGVLNGKVEPGSSVAIVGAGPIGL
HEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCHHH
ASLLTAQFYSPAEIIMIDLDDNRLEVAARFGATSVINNSDGKAVEKVMALTNGRGVDTAI
HHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCHHHH
EAVGVPATFVTCEDIIAPGGIIANVGVHGVKADLHLEKLWDRNIAITTRLVDTVTTPMLL
HHCCCCEEEEEHHHHHCCCCEEEECCCCEEEEEEEHHHHHCCCEEEEEHHHHHHHHHHHH
KTVQSKKLEPKRLITHRFKLDQILDAYETFGAAAKTHALKVLIEA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]