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The map label for this gene is tlpA [H]

Identifier: 146343268

GI number: 146343268

Start: 6738755

End: 6739444

Strand: Direct

Name: tlpA [H]

Synonym: BRADO6488

Alternate gene names: 146343268

Gene position: 6738755-6739444 (Clockwise)

Preceding gene: 146343262

Following gene: 146343275

Centisome position: 90.37

GC content: 70.87

Gene sequence:

>690_bases
ATGACAAACGATAAGCCAGAGACGTCCCCCGCCCGCCCCGCCGCCCGCGGCCGAACCGTGCTCTTGGCCGGCGCCGTGGC
GGTCGCTGCCGTGGTCGGCATCGCGGCGGTTTCGTTCGGGGGACTCTTGAAGGGCAAGCCGGCCGGCGACCAGGCCTGCC
AGGGCGCGGTCGACACCGCGGCGCGGCTGGCGCCGCTCATCAAGGGCGAGGTGGCGGCGCTGACCGCCGCCAAGACGCCG
CTGCGGCTGCCGGACCTCGCCTTCGAGGACGCCGCGGGCAAGCCCGCGAAGCTCTCGGATTTCCGCGGCAGGACGGTGCT
ATTGAACCTCTGGGCGACCTGGTGCGTGCCCTGCCGCAAGGAGATGCCGGCGCTGGACGGCCTGCAGGCCAAGCTCGGCA
GCGACGCCTTCCAGGTGGTCGCGGTCAACATCGACACCCGCGATCCGGAGAAGCCGAAGACGTTCCTCGCCGACGCCAGG
CTGACGCAGCTCGCTTATTTCAGCGACGCCAAGGCCAAGGTGTTCCAGGATCTGAAGGCGGTCGGCCGCGCGCTGGGCAT
GCCGACCTCGGTGCTGGTCGACGGCAATGGCTGCGAGATCGCCACCATCGCCGGTCCCGCCGAATGGGACAGCGCCGATG
CGCTCAAGCTGATCCAGGCGGCGACGTCGAAGGCCGCGGCGGGGCTCTAA

Upstream 100 bases:

>100_bases
GCTCATGCCTGCCGCTCTTAGACCTTGCTGATCGCCACTGGATGGGACACACGTCCCGTGCCCCGAATTTCGCGCCTCTG
ATAGCCGCAACCGACCCGAG

Downstream 100 bases:

>100_bases
ACCAATCCAACGGACGTCACTCCGGGGCAGCCCGCAGGGCTGAACCCGGAATCTCGAGATGAGTCCGACAAGCTCTAGAT
TCCGGGTTCGATGCTGCGCA

Product: Thiol:disulfide interchange protein tlpA (cytochrome c biogenesis protein tlpA)

Products: NA

Alternate protein names: Cytochrome c biogenesis protein tlpA [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTNDKPETSPARPAARGRTVLLAGAVAVAAVVGIAAVSFGGLLKGKPAGDQACQGAVDTAARLAPLIKGEVAALTAAKTP
LRLPDLAFEDAAGKPAKLSDFRGRTVLLNLWATWCVPCRKEMPALDGLQAKLGSDAFQVVAVNIDTRDPEKPKTFLADAR
LTQLAYFSDAKAKVFQDLKAVGRALGMPTSVLVDGNGCEIATIAGPAEWDSADALKLIQAATSKAAAGL

Sequences:

>Translated_229_residues
MTNDKPETSPARPAARGRTVLLAGAVAVAAVVGIAAVSFGGLLKGKPAGDQACQGAVDTAARLAPLIKGEVAALTAAKTP
LRLPDLAFEDAAGKPAKLSDFRGRTVLLNLWATWCVPCRKEMPALDGLQAKLGSDAFQVVAVNIDTRDPEKPKTFLADAR
LTQLAYFSDAKAKVFQDLKAVGRALGMPTSVLVDGNGCEIATIAGPAEWDSADALKLIQAATSKAAAGL
>Mature_228_residues
TNDKPETSPARPAARGRTVLLAGAVAVAAVVGIAAVSFGGLLKGKPAGDQACQGAVDTAARLAPLIKGEVAALTAAKTPL
RLPDLAFEDAAGKPAKLSDFRGRTVLLNLWATWCVPCRKEMPALDGLQAKLGSDAFQVVAVNIDTRDPEKPKTFLADARL
TQLAYFSDAKAKVFQDLKAVGRALGMPTSVLVDGNGCEIATIAGPAEWDSADALKLIQAATSKAAAGL

Specific function: Involved in cytochrome aa3 assembly [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013740
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: NA

Molecular weight: Translated: 23575; Mature: 23444

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDKPETSPARPAARGRTVLLAGAVAVAAVVGIAAVSFGGLLKGKPAGDQACQGAVDTA
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ARLAPLIKGEVAALTAAKTPLRLPDLAFEDAAGKPAKLSDFRGRTVLLNLWATWCVPCRK
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
EMPALDGLQAKLGSDAFQVVAVNIDTRDPEKPKTFLADARLTQLAYFSDAKAKVFQDLKA
CCCCCCCHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VGRALGMPTSVLVDGNGCEIATIAGPAEWDSADALKLIQAATSKAAAGL
HHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNDKPETSPARPAARGRTVLLAGAVAVAAVVGIAAVSFGGLLKGKPAGDQACQGAVDTA
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ARLAPLIKGEVAALTAAKTPLRLPDLAFEDAAGKPAKLSDFRGRTVLLNLWATWCVPCRK
HHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
EMPALDGLQAKLGSDAFQVVAVNIDTRDPEKPKTFLADARLTQLAYFSDAKAKVFQDLKA
CCCCCCCHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VGRALGMPTSVLVDGNGCEIATIAGPAEWDSADALKLIQAATSKAAAGL
HHHHHCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8253065; 12597275 [H]