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The map label for this gene is caiC [H]

Identifier: 146343098

GI number: 146343098

Start: 6534497

End: 6536299

Strand: Reverse

Name: caiC [H]

Synonym: BRADO6293

Alternate gene names: 146343098

Gene position: 6536299-6534497 (Counterclockwise)

Preceding gene: 146343100

Following gene: 146343097

Centisome position: 87.66

GC content: 65.39

Gene sequence:

>1803_bases
ATGAACATCGAGCGCGCGGATCGGTCTGCGGAACTCATGAGGCCCGCTCCGCGGCCATCCGCAGCAAAGATCTGGCTGAG
GGCCATCGAGCTGACCGCGCGCATCGAGGCCGAGCCGACGCGGCTGTTCGCCGATGAGATCGAGGAGTGGGCGGCGAAGC
AGCCGGAGCGACCGGCGCTGATCGCCGATCGCGGGACGCTCAGCTATTCCGCGCTGTCCGCGCGCATCAATCAATATGCC
CGCTGGGCGCTCGCCCAAGGCATCGGCTCAGGCGAAACCGTTGCGCTGATCATGCCGAGCCGGCCGGACTATCTGGCCGC
GTGGCTCGGGATCAGCCGCGTGGGCGGCGTTGTCGCGCTGATCAACACCAACCTCGTCGGCGCCTCGCTCGCGCATTGCA
TCGACGTGGCCAAGCCGGCGCATGTCATCTTGTCGGATGAGTTGCGGGAGACCTATGCGACTGCCCAAGCGCTGATTTCA
GGCACGCCCCCAGTCTGGATACATGGCGGCGATCTCGACGCCGCGCTGGCTCCGATGCACACGCATGCGCTTGATCAGAG
CGAGCGATCCGGCGTGACGATCAACGACCGCGCACTTCTAATCTATACGTCCGGCACCACCGGCCTGCCCAAGGCAGCGA
GCATCAGCCACCGCCGCATCCTGAACTGGGGCGGCTGGTTTGCGGGGCTTACCGGGGCCAGTCCCGACGATCGCCTTTAC
GATTGCCTGCCGGTCTATCATTCCGTCGGCGGTATCGTCGCGCCCTGCAGCATGCTGCGCGCCGGCGGAACCGCGGTTCT
GGCTGAGAAGTTCTCGGTGCGTCAGTTCTGGCGCGATATCGTCCGCCATGATTGCACGCTGGTGCAATATATCGGCGAGC
TTTGCCGCTATCTGCTGGCGGCACCTGCGTCGGATCTCGATCGAGCACATCACTTGCGGCTGGCTTGCGGCAATGGCCTG
CGCGGCGACGTCTGGAAGGCGTTCCAGACGCGCTTTGCGATCCCGCAGGTGCTGGAATTCTATGCGGCCACCGAGGGCAA
CTTCTCGCTTTACAATGTCGAAGGGAAAGTGGGCTCGGTCGGTCGCGTGCCGTCGCTGCTCGCGCATCGCTTTCCGGCGT
CGCTCATCCGGCTCGACGAGGACCGTCGCGCGCCTCTGCGCGGGCCCGATGGACTATGCCTGCCATGTTCGCGCGGCGAG
ATCGGCGAGGCCATCGGGCGCATCGGCAAGGCCGACGACGGCGGCGGTCGCTTCGAGGGCTACACGGATAGCGCGGAGAC
CGAGAAGAAGATCTTGCGCAATGTCTTCGCCCCGGGCGACGCGTGGTTCCGCACCGGCGATCTGATGCGCCAGGACGAGC
AGGGCTTCTTCTACTTCGTCGACCGCGTCGGCGACACCTTCCGCTGGAAAGGCGAAAACGTCGCGACCAGCGAGGTCAAC
GAAGCCATTTTGCAATGCCCGGGGGTCGCGGAAGCCTCGACCTACGGTGTCGCAGTGCCGGGCACCGATGGTCGGGCCGG
CATGGCGGCGCTCGTCGTCACGGAGGATTTCGATCTTGCAAGGTTGTCGTCCGAGCTTGCGCGCCGATTGCCGGCCTATG
CGCAGCCGGTCGCGCTGCGCATCACGCCCTCGCTGCAGTCCACCGAAACGTTCAAGCAGAAGAAACAGCAGCTGATGCAC
GACGGCTTCGATCCCTCGGTCGTTTCAGCGCCAATGTACATGCGCGATGCCGCTACTGGAGCCTACCGCCCGCTCGACGC
CGCCCTCTATGCGCAGATCGCGACCGGAGAGATCCGCTTGTAG

Upstream 100 bases:

>100_bases
GCATGAATCCCGCCAGGCTCTCAGGCGGTTAACCGTTCCGGTTAACCGTCAGTCAGGCGCCGCCGCCTATAACCACGCCG
AACTCGAGGCGGTAGCAGTG

Downstream 100 bases:

>100_bases
ATGATTTTAATCATAGGCGACGCGGTGCATTTACCAGTGGTCTCGAAACGTATCGCGAAGGTCCGGGTTCCTTCACCATC
TCGCTCTAGGGTCGAGTTTA

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MNIERADRSAELMRPAPRPSAAKIWLRAIELTARIEAEPTRLFADEIEEWAAKQPERPALIADRGTLSYSALSARINQYA
RWALAQGIGSGETVALIMPSRPDYLAAWLGISRVGGVVALINTNLVGASLAHCIDVAKPAHVILSDELRETYATAQALIS
GTPPVWIHGGDLDAALAPMHTHALDQSERSGVTINDRALLIYTSGTTGLPKAASISHRRILNWGGWFAGLTGASPDDRLY
DCLPVYHSVGGIVAPCSMLRAGGTAVLAEKFSVRQFWRDIVRHDCTLVQYIGELCRYLLAAPASDLDRAHHLRLACGNGL
RGDVWKAFQTRFAIPQVLEFYAATEGNFSLYNVEGKVGSVGRVPSLLAHRFPASLIRLDEDRRAPLRGPDGLCLPCSRGE
IGEAIGRIGKADDGGGRFEGYTDSAETEKKILRNVFAPGDAWFRTGDLMRQDEQGFFYFVDRVGDTFRWKGENVATSEVN
EAILQCPGVAEASTYGVAVPGTDGRAGMAALVVTEDFDLARLSSELARRLPAYAQPVALRITPSLQSTETFKQKKQQLMH
DGFDPSVVSAPMYMRDAATGAYRPLDAALYAQIATGEIRL

Sequences:

>Translated_600_residues
MNIERADRSAELMRPAPRPSAAKIWLRAIELTARIEAEPTRLFADEIEEWAAKQPERPALIADRGTLSYSALSARINQYA
RWALAQGIGSGETVALIMPSRPDYLAAWLGISRVGGVVALINTNLVGASLAHCIDVAKPAHVILSDELRETYATAQALIS
GTPPVWIHGGDLDAALAPMHTHALDQSERSGVTINDRALLIYTSGTTGLPKAASISHRRILNWGGWFAGLTGASPDDRLY
DCLPVYHSVGGIVAPCSMLRAGGTAVLAEKFSVRQFWRDIVRHDCTLVQYIGELCRYLLAAPASDLDRAHHLRLACGNGL
RGDVWKAFQTRFAIPQVLEFYAATEGNFSLYNVEGKVGSVGRVPSLLAHRFPASLIRLDEDRRAPLRGPDGLCLPCSRGE
IGEAIGRIGKADDGGGRFEGYTDSAETEKKILRNVFAPGDAWFRTGDLMRQDEQGFFYFVDRVGDTFRWKGENVATSEVN
EAILQCPGVAEASTYGVAVPGTDGRAGMAALVVTEDFDLARLSSELARRLPAYAQPVALRITPSLQSTETFKQKKQQLMH
DGFDPSVVSAPMYMRDAATGAYRPLDAALYAQIATGEIRL
>Mature_600_residues
MNIERADRSAELMRPAPRPSAAKIWLRAIELTARIEAEPTRLFADEIEEWAAKQPERPALIADRGTLSYSALSARINQYA
RWALAQGIGSGETVALIMPSRPDYLAAWLGISRVGGVVALINTNLVGASLAHCIDVAKPAHVILSDELRETYATAQALIS
GTPPVWIHGGDLDAALAPMHTHALDQSERSGVTINDRALLIYTSGTTGLPKAASISHRRILNWGGWFAGLTGASPDDRLY
DCLPVYHSVGGIVAPCSMLRAGGTAVLAEKFSVRQFWRDIVRHDCTLVQYIGELCRYLLAAPASDLDRAHHLRLACGNGL
RGDVWKAFQTRFAIPQVLEFYAATEGNFSLYNVEGKVGSVGRVPSLLAHRFPASLIRLDEDRRAPLRGPDGLCLPCSRGE
IGEAIGRIGKADDGGGRFEGYTDSAETEKKILRNVFAPGDAWFRTGDLMRQDEQGFFYFVDRVGDTFRWKGENVATSEVN
EAILQCPGVAEASTYGVAVPGTDGRAGMAALVVTEDFDLARLSSELARRLPAYAQPVALRITPSLQSTETFKQKKQQLMH
DGFDPSVVSAPMYMRDAATGAYRPLDAALYAQIATGEIRL

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807357, Length=573, Percent_Identity=40.4886561954625, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI38524616, Length=562, Percent_Identity=40.0355871886121, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI227499619, Length=578, Percent_Identity=40.1384083044983, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI13236579, Length=527, Percent_Identity=42.314990512334, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI62865631, Length=567, Percent_Identity=37.9188712522046, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI13325055, Length=567, Percent_Identity=37.9188712522046, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI13325057, Length=605, Percent_Identity=36.8595041322314, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI227499621, Length=571, Percent_Identity=36.4273204903678, Blast_Score=333, Evalue=3e-91,
Organism=Escherichia coli, GI221142682, Length=452, Percent_Identity=27.212389380531, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1788107, Length=585, Percent_Identity=24.7863247863248, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI145693145, Length=544, Percent_Identity=23.7132352941176, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551278, Length=610, Percent_Identity=39.1803278688525, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI115534440, Length=584, Percent_Identity=37.8424657534247, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319515, Length=488, Percent_Identity=32.5819672131148, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6319699, Length=365, Percent_Identity=25.2054794520548, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281364798, Length=592, Percent_Identity=36.8243243243243, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583465, Length=592, Percent_Identity=36.8243243243243, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583463, Length=592, Percent_Identity=36.8243243243243, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573631, Length=574, Percent_Identity=38.8501742160279, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI20130353, Length=574, Percent_Identity=38.8501742160279, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45552801, Length=612, Percent_Identity=36.437908496732, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI45550496, Length=612, Percent_Identity=36.437908496732, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI18859661, Length=470, Percent_Identity=22.9787234042553, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922652, Length=444, Percent_Identity=22.972972972973, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 65250; Mature: 65250

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIERADRSAELMRPAPRPSAAKIWLRAIELTARIEAEPTRLFADEIEEWAAKQPERPAL
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCEE
IADRGTLSYSALSARINQYARWALAQGIGSGETVALIMPSRPDYLAAWLGISRVGGVVAL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEE
INTNLVGASLAHCIDVAKPAHVILSDELRETYATAQALISGTPPVWIHGGDLDAALAPMH
EECCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCHH
THALDQSERSGVTINDRALLIYTSGTTGLPKAASISHRRILNWGGWFAGLTGASPDDRLY
HHHCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCHHHEECCCCHHCCCCCCCCCCHHH
DCLPVYHSVGGIVAPCSMLRAGGTAVLAEKFSVRQFWRDIVRHDCTLVQYIGELCRYLLA
HHHHHHHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
APASDLDRAHHLRLACGNGLRGDVWKAFQTRFAIPQVLEFYAATEGNFSLYNVEGKVGSV
CCCHHHHHHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCC
GRVPSLLAHRFPASLIRLDEDRRAPLRGPDGLCLPCSRGEIGEAIGRIGKADDGGGRFEG
CCHHHHHHHHCCHHHEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCC
YTDSAETEKKILRNVFAPGDAWFRTGDLMRQDEQGFFYFVDRVGDTFRWKGENVATSEVN
CCCCHHHHHHHHHHHCCCCCHHCCCCHHHCCCCCCEEEEEECCCCCEEECCCCCCHHHHH
EAILQCPGVAEASTYGVAVPGTDGRAGMAALVVTEDFDLARLSSELARRLPAYAQPVALR
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEE
ITPSLQSTETFKQKKQQLMHDGFDPSVVSAPMYMRDAATGAYRPLDAALYAQIATGEIRL
ECCCCCHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHEECCCCCCC
>Mature Secondary Structure
MNIERADRSAELMRPAPRPSAAKIWLRAIELTARIEAEPTRLFADEIEEWAAKQPERPAL
CCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCEE
IADRGTLSYSALSARINQYARWALAQGIGSGETVALIMPSRPDYLAAWLGISRVGGVVAL
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEE
INTNLVGASLAHCIDVAKPAHVILSDELRETYATAQALISGTPPVWIHGGDLDAALAPMH
EECCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCHH
THALDQSERSGVTINDRALLIYTSGTTGLPKAASISHRRILNWGGWFAGLTGASPDDRLY
HHHCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCHHHEECCCCHHCCCCCCCCCCHHH
DCLPVYHSVGGIVAPCSMLRAGGTAVLAEKFSVRQFWRDIVRHDCTLVQYIGELCRYLLA
HHHHHHHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
APASDLDRAHHLRLACGNGLRGDVWKAFQTRFAIPQVLEFYAATEGNFSLYNVEGKVGSV
CCCHHHHHHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCC
GRVPSLLAHRFPASLIRLDEDRRAPLRGPDGLCLPCSRGEIGEAIGRIGKADDGGGRFEG
CCHHHHHHHHCCHHHEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCC
YTDSAETEKKILRNVFAPGDAWFRTGDLMRQDEQGFFYFVDRVGDTFRWKGENVATSEVN
CCCCHHHHHHHHHHHCCCCCHHCCCCHHHCCCCCCEEEEEECCCCCEEECCCCCCHHHHH
EAILQCPGVAEASTYGVAVPGTDGRAGMAALVVTEDFDLARLSSELARRLPAYAQPVALR
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEE
ITPSLQSTETFKQKKQQLMHDGFDPSVVSAPMYMRDAATGAYRPLDAALYAQIATGEIRL
ECCCCCHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHCCCCCCCCHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA