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The map label for this gene is ldc [H]

Identifier: 146343068

GI number: 146343068

Start: 6506523

End: 6507665

Strand: Direct

Name: ldc [H]

Synonym: BRADO6260

Alternate gene names: 146343068

Gene position: 6506523-6507665 (Clockwise)

Preceding gene: 146343067

Following gene: 146343069

Centisome position: 87.26

GC content: 66.32

Gene sequence:

>1143_bases
ATGACCGAACGTATCCGGGAATTCCTGCGCAACCGCCGCGAGGAAGGTCTGGACCACGAGCCCTGTCTCGTCGTCGACCT
CGACATCGTGCGCGACAACTACATGAACTTCGCTCGCGCCTTGCCGGACAGCCGCGTGTTCTACGCGGTCAAGGCCAACC
CGGCGCCGGAAGTGCTGTCGCTGCTCGCCTCGCTCGGCTCCTCCTTCGACACGGCGACCGTCGCCGAGATCGAGATGGCG
CTGGCCGCCGGTGCGACGCCGGACCGCATCTCCTATGGCAACACCATCAAGAAGGAGCGGGATATCGCGCGCGCCTATGC
GCTCGGCATCCGTCTCTTTGCCGTGGACTGCGCCGCCGAGGTCGAGAAGATCTCGCGCGCCGCACCGGGCGCGAAGGTGT
TCTGCCGCATCCTGTACGATTGCGCCGGCGCCGAGTGGCCGCTGTCGCGCAAGTTCGGCTGCGATCCGGAGATGGCCGTC
GAAGTGCTGGACCTGGCGAAGCGCCTCGGCCTGGAGCCGTGCGGCATCTCGTTCCATGTCGGCTCGCAGCAGCGCAAGGT
GAAGGCGTGGGACCGCGCGCTGGCGATGGCCTCGACGGTGTTCCGCGACTGCGCCGAGCGCGGCATCAACCTCTCCATGG
TCAACATGGGCGGCGGCTTCCCGACTAAGTACCTGAAGGACGTGCCGCCGGTCGTGCAGTACGGCCGCTCGATCTTCCGC
GCGCTGCGCAAGCATTTCGGCAACCAGATCCCGGAGACGATCATCGAGCCGGGCCGCGGCATGGTCGGCAATGCCGGGAT
CATCGAGTCGGAAGTGGTGCTGATCTCGAAGAAGAGCGACGAGGACGAGCTGCGCTGGGTCTATCTCGACATCGGCAAGT
TCGGCGGCCTCGCCGAGACGATGGACGAGTCGATCCGCTACGCCATCCGCACCCCGCATGAGGGCGCGGAGACGACCCCG
TGCGTGCTCGCCGGCCCGACCTGCGATTCGGCCGACGTGATGTACGAGAAGCTGCCGTATCCGCTGCCGGTGACGCTCTC
GATCGGCGACAAGGTGCTGATCGAGGGGACCGGGGCGTATACCTCGACCTACTCGTCGGTGGCCTTCAACGGCATCCCGC
CGCTGAAGACGTATCACATCTGA

Upstream 100 bases:

>100_bases
CGAGGTTTCTGCGCCTTTCCATCGGGCGTCGAGGCCAAGGCACCCGTGTCGGGATCATTTTGAACGGGCCACGTCGCAAA
CGGGCCGTTTGGAGGGTGCT

Downstream 100 bases:

>100_bases
TCTGGCTGCCCTCGCCCGTGCGCGGGTGAGATAGGCAAGAGCCCTGGGTGGGGCGTTCCCCCACCCCGACCCTCCCCCGC
AAGCGGGGGAGGGAGCGAGA

Product: putative ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTERIREFLRNRREEGLDHEPCLVVDLDIVRDNYMNFARALPDSRVFYAVKANPAPEVLSLLASLGSSFDTATVAEIEMA
LAAGATPDRISYGNTIKKERDIARAYALGIRLFAVDCAAEVEKISRAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAV
EVLDLAKRLGLEPCGISFHVGSQQRKVKAWDRALAMASTVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDELRWVYLDIGKFGGLAETMDESIRYAIRTPHEGAETTP
CVLAGPTCDSADVMYEKLPYPLPVTLSIGDKVLIEGTGAYTSTYSSVAFNGIPPLKTYHI

Sequences:

>Translated_380_residues
MTERIREFLRNRREEGLDHEPCLVVDLDIVRDNYMNFARALPDSRVFYAVKANPAPEVLSLLASLGSSFDTATVAEIEMA
LAAGATPDRISYGNTIKKERDIARAYALGIRLFAVDCAAEVEKISRAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAV
EVLDLAKRLGLEPCGISFHVGSQQRKVKAWDRALAMASTVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVQYGRSIFR
ALRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDELRWVYLDIGKFGGLAETMDESIRYAIRTPHEGAETTP
CVLAGPTCDSADVMYEKLPYPLPVTLSIGDKVLIEGTGAYTSTYSSVAFNGIPPLKTYHI
>Mature_379_residues
TERIREFLRNRREEGLDHEPCLVVDLDIVRDNYMNFARALPDSRVFYAVKANPAPEVLSLLASLGSSFDTATVAEIEMAL
AAGATPDRISYGNTIKKERDIARAYALGIRLFAVDCAAEVEKISRAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAVE
VLDLAKRLGLEPCGISFHVGSQQRKVKAWDRALAMASTVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVQYGRSIFRA
LRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDELRWVYLDIGKFGGLAETMDESIRYAIRTPHEGAETTPC
VLAGPTCDSADVMYEKLPYPLPVTLSIGDKVLIEGTGAYTSTYSSVAFNGIPPLKTYHI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=379, Percent_Identity=31.1345646437995, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI22538418, Length=376, Percent_Identity=28.9893617021277, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI21361583, Length=376, Percent_Identity=28.9893617021277, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI16506287, Length=354, Percent_Identity=30.225988700565, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789203, Length=381, Percent_Identity=24.1469816272966, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562780, Length=371, Percent_Identity=30.7277628032345, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=31.2997347480106, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586472, Length=370, Percent_Identity=30.5405405405405, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24586474, Length=381, Percent_Identity=29.9212598425197, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41754; Mature: 41623

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERIREFLRNRREEGLDHEPCLVVDLDIVRDNYMNFARALPDSRVFYAVKANPAPEVLS
CCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
LLASLGSSFDTATVAEIEMALAAGATPDRISYGNTIKKERDIARAYALGIRLFAVDCAAE
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHHHH
VEKISRAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAVEVLDLAKRLGLEPCGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GSQQRKVKAWDRALAMASTVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDELRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCCEECEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIRTPHEGAETTPCVLAGPTCDSADVMYEKLPYPLPVTLSIGDKVLIEGTGAY
HHHHHHEEECCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSSVAFNGIPPLKTYHI
HHHHHHHEECCCCCCCCCCC
>Mature Secondary Structure 
TERIREFLRNRREEGLDHEPCLVVDLDIVRDNYMNFARALPDSRVFYAVKANPAPEVLS
CHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
LLASLGSSFDTATVAEIEMALAAGATPDRISYGNTIKKERDIARAYALGIRLFAVDCAAE
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHHHHH
VEKISRAAPGAKVFCRILYDCAGAEWPLSRKFGCDPEMAVEVLDLAKRLGLEPCGISFHV
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GSQQRKVKAWDRALAMASTVFRDCAERGINLSMVNMGGGFPTKYLKDVPPVVQYGRSIFR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHH
ALRKHFGNQIPETIIEPGRGMVGNAGIIESEVVLISKKSDEDELRWVYLDIGKFGGLAET
HHHHHHCCCCCHHHHCCCCCCCCCCCCEECEEEEEECCCCCCCEEEEEEECCCCCCHHHH
MDESIRYAIRTPHEGAETTPCVLAGPTCDSADVMYEKLPYPLPVTLSIGDKVLIEGTGAY
HHHHHHEEECCCCCCCCCCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCEEEEEECCCC
TSTYSSVAFNGIPPLKTYHI
HHHHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]