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The map label for this gene is nat [H]

Identifier: 146343051

GI number: 146343051

Start: 6488173

End: 6488988

Strand: Reverse

Name: nat [H]

Synonym: BRADO6242

Alternate gene names: 146343051

Gene position: 6488988-6488173 (Counterclockwise)

Preceding gene: 146343052

Following gene: 146343050

Centisome position: 87.02

GC content: 65.69

Gene sequence:

>816_bases
ATGCCTGACCATTTCGATCTCGACAAATATCTTGCCCGCATCGGCTATCGCGGAGCGCTGACGGTAAGCTTCGAGACGCT
CGCCGGATTGCAGGCGGCGCATGTCGATGCGATCGCGTTCGAGGGCATCGATCCCCTGCTCGGCCGTCCCGTGAATATCG
ATCTCGCTGCGGTGCAGGCCAAGATCGTCGACGGCCGCCGCGGCGGCTATTGCTTCGAGCAGAATGCGCTGCTGAAGGCC
GCGCTGGAGGCGATCGGCTTCGCGGTGACGCCGCTGTCGGCGCGGGTGCGCTGGCGGCTCGACGCGTCCGCGCCGCTGAC
GCCGCGCACGCACATGATGCTCAAGGTCGACCTGCCGCAGGGACCGCACATCGCCGATGTCGGCTTCGGCTCCTGCCTGC
TCGATACGCCTTTGCGGATGGTGCCGGACGTCGAGCAGGCGACCGCGATGGGCACGTTCCGACTGACCGTCTCCGATGGG
CTGCATTGGCTTGCGGCCAGGCAGCCGGCGGGCTGGCGAATGATGTATGTGTTCGATCTGACGCCGCAGATCCACGCCGA
CTACATGCTGTCCAACTGGTTCACCTCGACCAGCCCGCTCACGCCGTTCACCTCGATGCTGATCCTGGAGCGGCTGACGT
CGGAGGTTCGCTACAAGCTGGTCAACCGCCGGCTGGTGATCGAGGCGCGTGACGGCGAGATCAGGAGCGAACAGATCATC
GAGACGCCCGAGGCGTTGCAGCGCGTCGTCGAGGAGGTGTTCGGGCTCACGCTCCCGGTCGCCGTCGAAACGATCTGGGC
ACGGATCGAGACGTGA

Upstream 100 bases:

>100_bases
AGATGGAATGAGCGGCGGGGCAGGGCGACCATGCCCGCGTCCGGCTGTCTGCCCGCAGCGCCTCGTGCTATGGCTCCGGC
TGTCACAAAAAGGCGGGGCA

Downstream 100 bases:

>100_bases
CGGGGTAGGGCGCCGCGATGGCCGATGAGTTTCGACTGGACTCCTATCTCGCCCGCATCGCCTGCCGCGGGCCGTTCGCA
CCCGATCTGCCGACGCTCAG

Product: putative arylamine N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPDHFDLDKYLARIGYRGALTVSFETLAGLQAAHVDAIAFEGIDPLLGRPVNIDLAAVQAKIVDGRRGGYCFEQNALLKA
ALEAIGFAVTPLSARVRWRLDASAPLTPRTHMMLKVDLPQGPHIADVGFGSCLLDTPLRMVPDVEQATAMGTFRLTVSDG
LHWLAARQPAGWRMMYVFDLTPQIHADYMLSNWFTSTSPLTPFTSMLILERLTSEVRYKLVNRRLVIEARDGEIRSEQII
ETPEALQRVVEEVFGLTLPVAVETIWARIET

Sequences:

>Translated_271_residues
MPDHFDLDKYLARIGYRGALTVSFETLAGLQAAHVDAIAFEGIDPLLGRPVNIDLAAVQAKIVDGRRGGYCFEQNALLKA
ALEAIGFAVTPLSARVRWRLDASAPLTPRTHMMLKVDLPQGPHIADVGFGSCLLDTPLRMVPDVEQATAMGTFRLTVSDG
LHWLAARQPAGWRMMYVFDLTPQIHADYMLSNWFTSTSPLTPFTSMLILERLTSEVRYKLVNRRLVIEARDGEIRSEQII
ETPEALQRVVEEVFGLTLPVAVETIWARIET
>Mature_270_residues
PDHFDLDKYLARIGYRGALTVSFETLAGLQAAHVDAIAFEGIDPLLGRPVNIDLAAVQAKIVDGRRGGYCFEQNALLKAA
LEAIGFAVTPLSARVRWRLDASAPLTPRTHMMLKVDLPQGPHIADVGFGSCLLDTPLRMVPDVEQATAMGTFRLTVSDGL
HWLAARQPAGWRMMYVFDLTPQIHADYMLSNWFTSTSPLTPFTSMLILERLTSEVRYKLVNRRLVIEARDGEIRSEQIIE
TPEALQRVVEEVFGLTLPVAVETIWARIET

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649130, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649128, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649126, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649124, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649122, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649119, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI42741671, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI237649009, Length=277, Percent_Identity=27.4368231046931, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI116295260, Length=235, Percent_Identity=26.8085106382979, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787736, Length=252, Percent_Identity=36.5079365079365, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 30172; Mature: 30041

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHFDLDKYLARIGYRGALTVSFETLAGLQAAHVDAIAFEGIDPLLGRPVNIDLAAVQA
CCCCCCHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHEECCCCHHHCCCCCEEHEEEEE
KIVDGRRGGYCFEQNALLKAALEAIGFAVTPLSARVRWRLDASAPLTPRTHMMLKVDLPQ
EEECCCCCCEEECCHHHHHHHHHHHCEEECCCCEEEEEEECCCCCCCCCEEEEEEEECCC
GPHIADVGFGSCLLDTPLRMVPDVEQATAMGTFRLTVSDGLHWLAARQPAGWRMMYVFDL
CCCEECCCCCCHHHCCCHHHCCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEEEEEEEC
TPQIHADYMLSNWFTSTSPLTPFTSMLILERLTSEVRYKLVNRRLVIEARDGEIRSEQII
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHH
ETPEALQRVVEEVFGLTLPVAVETIWARIET
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PDHFDLDKYLARIGYRGALTVSFETLAGLQAAHVDAIAFEGIDPLLGRPVNIDLAAVQA
CCCCCHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHEECCCCHHHCCCCCEEHEEEEE
KIVDGRRGGYCFEQNALLKAALEAIGFAVTPLSARVRWRLDASAPLTPRTHMMLKVDLPQ
EEECCCCCCEEECCHHHHHHHHHHHCEEECCCCEEEEEEECCCCCCCCCEEEEEEEECCC
GPHIADVGFGSCLLDTPLRMVPDVEQATAMGTFRLTVSDGLHWLAARQPAGWRMMYVFDL
CCCEECCCCCCHHHCCCHHHCCCHHHHHHEEEEEEEECCCCEEEEECCCCCEEEEEEEEC
TPQIHADYMLSNWFTSTSPLTPFTSMLILERLTSEVRYKLVNRRLVIEARDGEIRSEQII
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHH
ETPEALQRVVEEVFGLTLPVAVETIWARIET
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]