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The map label for this gene is hisN [H]

Identifier: 146343027

GI number: 146343027

Start: 6451007

End: 6451789

Strand: Direct

Name: hisN [H]

Synonym: BRADO6215

Alternate gene names: 146343027

Gene position: 6451007-6451789 (Clockwise)

Preceding gene: 146343026

Following gene: 146343028

Centisome position: 86.51

GC content: 66.41

Gene sequence:

>783_bases
GTGACGGTCATCGACTTTTCCGCCTTCATCGGTCGCCTGGCGACCGCCTCGGGCGAAACCATCCTGCCGTTCTTCCGGAC
CTCGCTCCTGGTCGACAACAAGAGCAACCGGCACGATTTCGATCCGGTCACCGAAGCCGACCGCGCCGCCGAGGCGGTGA
TGCGCCGGCTGATCAAGGCGAACTTCCCGCAGCACGGCATCGTCGGCGAGGAGTTCGGCAACGAGCGCGAGGACGCCGAC
TACGTCTGGGTGCTCGATCCGATCGACGGCACCAAGTCGTTCATCGCGGGCTTTCCGACCTGGGGCACGCTGATCGCGCT
CTTGCACAAGGGCACGCCGGTGTTCGGCATGATGCACCAGCCGTTCATCGCCGAGCGCTTCGCCGGCGACAACGGCTCGG
CCAACTACAAGAACGCGGCCGGCGAGCGCCGGCTGTCGGTACGGCGTTGCGAGCGGCTCGAGGACGCGGTCTGTTATACG
ACCAGCCCGCTGCTGATGAACGAGAGCGATCGCGCGATCTTCGCGAAGGTCGAAGCCGAGACGCGGCTGTCGCGCTATGG
TGGTGACTGCTACTCCTATTGCATGCTGGCCGCGGGCCATCTCGATCTCGTCATCGAGACCGAGCTCAAGCCCTACGACA
TCGCGGCGCTGATCCCGATCATCAACGGCGCCGGCGGCATCGTCACCGACTGGAACGGCGGGCCGGCGCAGAACGGCGGG
CGCATCATTGCCGCGGGCGACAGGCGCGTTCATGAGGCGGCGGTCAAACGGCTCGGGGGCTAG

Upstream 100 bases:

>100_bases
TGCCAAGTCGGCGTTCCATCTCCGGATGCGCGCCCGAGCGCTTTGAGCTACGCATGGGATGGCCTGGGCGCCATCCGATT
CCCTCAGCGAAGGACGTGTT

Downstream 100 bases:

>100_bases
GCTGGCCGTAGAACTACGTAATAAGCACTTTACCGTGCGATCTTAACCCCTCATTGAGAGCCACTGCCTAGCTTTTCAGC
ACATGCGACTAAAATACACA

Product: putative inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTVIDFSAFIGRLATASGETILPFFRTSLLVDNKSNRHDFDPVTEADRAAEAVMRRLIKANFPQHGIVGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPTWGTLIALLHKGTPVFGMMHQPFIAERFAGDNGSANYKNAAGERRLSVRRCERLEDAVCYT
TSPLLMNESDRAIFAKVEAETRLSRYGGDCYSYCMLAAGHLDLVIETELKPYDIAALIPIINGAGGIVTDWNGGPAQNGG
RIIAAGDRRVHEAAVKRLGG

Sequences:

>Translated_260_residues
MTVIDFSAFIGRLATASGETILPFFRTSLLVDNKSNRHDFDPVTEADRAAEAVMRRLIKANFPQHGIVGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPTWGTLIALLHKGTPVFGMMHQPFIAERFAGDNGSANYKNAAGERRLSVRRCERLEDAVCYT
TSPLLMNESDRAIFAKVEAETRLSRYGGDCYSYCMLAAGHLDLVIETELKPYDIAALIPIINGAGGIVTDWNGGPAQNGG
RIIAAGDRRVHEAAVKRLGG
>Mature_259_residues
TVIDFSAFIGRLATASGETILPFFRTSLLVDNKSNRHDFDPVTEADRAAEAVMRRLIKANFPQHGIVGEEFGNEREDADY
VWVLDPIDGTKSFIAGFPTWGTLIALLHKGTPVFGMMHQPFIAERFAGDNGSANYKNAAGERRLSVRRCERLEDAVCYTT
SPLLMNESDRAIFAKVEAETRLSRYGGDCYSYCMLAAGHLDLVIETELKPYDIAALIPIINGAGGIVTDWNGGPAQNGGR
IIAAGDRRVHEAAVKRLGG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI5031789, Length=260, Percent_Identity=24.6153846153846, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221625487, Length=260, Percent_Identity=24.6153846153846, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788882, Length=252, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193202570, Length=218, Percent_Identity=29.8165137614679, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=217, Percent_Identity=27.6497695852535, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664918, Length=238, Percent_Identity=29.8319327731092, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357957, Length=239, Percent_Identity=30.5439330543933, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357329, Length=223, Percent_Identity=26.457399103139, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664926, Length=205, Percent_Identity=25.8536585365854, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664922, Length=205, Percent_Identity=27.8048780487805, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357303, Length=221, Percent_Identity=25.3393665158371, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28440; Mature: 28308

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDFSAFIGRLATASGETILPFFRTSLLVDNKSNRHDFDPVTEADRAAEAVMRRLIKA
CEEEEHHHHHHHHHHCCCCEEHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NFPQHGIVGEEFGNEREDADYVWVLDPIDGTKSFIAGFPTWGTLIALLHKGTPVFGMMHQ
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCC
PFIAERFAGDNGSANYKNAAGERRLSVRRCERLEDAVCYTTSPLLMNESDRAIFAKVEAE
CHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEEEEEHHH
TRLSRYGGDCYSYCMLAAGHLDLVIETELKPYDIAALIPIINGAGGIVTDWNGGPAQNGG
HHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCC
RIIAAGDRRVHEAAVKRLGG
EEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
TVIDFSAFIGRLATASGETILPFFRTSLLVDNKSNRHDFDPVTEADRAAEAVMRRLIKA
EEEEHHHHHHHHHHCCCCEEHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NFPQHGIVGEEFGNEREDADYVWVLDPIDGTKSFIAGFPTWGTLIALLHKGTPVFGMMHQ
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCC
PFIAERFAGDNGSANYKNAAGERRLSVRRCERLEDAVCYTTSPLLMNESDRAIFAKVEAE
CHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEEEEEHHH
TRLSRYGGDCYSYCMLAAGHLDLVIETELKPYDIAALIPIINGAGGIVTDWNGGPAQNGG
HHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCC
RIIAAGDRRVHEAAVKRLGG
EEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]