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The map label for this gene is serA [H]

Identifier: 146342578

GI number: 146342578

Start: 5937152

End: 5938114

Strand: Direct

Name: serA [H]

Synonym: BRADO5741

Alternate gene names: 146342578

Gene position: 5937152-5938114 (Clockwise)

Preceding gene: 146342577

Following gene: 146342580

Centisome position: 79.62

GC content: 68.02

Gene sequence:

>963_bases
ATGACGCGGCTGCGCTGTGCAATCCTCGACGACTATTACGACACGGCCCTGTCGCTGGCGGACTGGCCTGGGCTTTCCGA
CCGCGTCGATGTGACGGCCTTCACTCATCCGTTCGCCGATGAGGACGCGGCCGCCGCCGCGCTGGCCGACGTCGACATCG
TCTGCGCGATGCGCGAGCGGACGCCGTTCCCGCGCGGCCTGATCGAGCGGCTGCCGAAGCTGAAATTGCTGATCACCTCC
GGCATGCGCAATGCCGCCATCGACAGCGAAGCCGCGAAGTCGCGCGGGATCGTGCTCTGCGGCACGCAATATGGCCGTGA
TCCGACGGCGCCGCTCACCATGGGCCTGATCCTGGAACTGACCCGCAAGATCGGCCAGGAAAACGCCCGCATGCACGCCG
GAGAGCCCTGGCAGGCGCTGGGCGGGATCGAAATCGAGGGCCGGACGCTCGGCATCCTCGGCCTCGGCAAGCTCGGCACC
AAGGTCGCCGGGCTTGCCAAGGCGTTTGGCATGAACGTGATCGCCTGGAGCCCGAACCTGACGCCGGAGCGTTGCAAGGA
CGCCGGCGTCGGCTACGCCGGCAAGGACGAGCTATTTGCCGCCGCCGACATCATCACGATCCATGTCGTGCTCAGCGACC
GCTCCCGCGGGCTGGTCGGCGCGGCCGACATCGCCCGAATGAAACCCTCGGCCTATCTGGTCAACACGTCGCGGGCGCCG
ATCGTGGACGAGGTCGCGCTGCTACAGGCCCTCAAGGACAAGCGAATCGCCGGCGCCGGCCTCGACGTGTTCTCCGTCGA
GCCGCTTCCGGTCACGCACCCGCTGCGCAGGCTCGACAACGTCGTGCTGACCCCACATCTCGGCTACGTCACCGAAGAGA
GCTTTCGCGCCCATTATGGCCAGATGGTCGCGTGCATCGCCGCCTGGCTTGACGGCGCCGAGCCGCCGCGGCGGCTGGCC
TGA

Upstream 100 bases:

>100_bases
GCGGCACCCCGCTTGCGCCATCGGCGCTTTGCGCGCAAGCATGACATCCATTCGCCCAGGCGACCGCGCGTCGCCCTTTC
CTGCCGAATGGATTTGACCG

Downstream 100 bases:

>100_bases
TCGGCTCCCAAAAGCAAAACACCCTCCGCGAGGAGGGTGTTGCGAGATCGATCAGCGCCTGTTCAGCGAATGGTGACCGG
CGGCGGCAGTGGCTGCATGG

Product: putative phosphoglycerate dehydrogenase (PGDH), serA-like

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTRLRCAILDDYYDTALSLADWPGLSDRVDVTAFTHPFADEDAAAAALADVDIVCAMRERTPFPRGLIERLPKLKLLITS
GMRNAAIDSEAAKSRGIVLCGTQYGRDPTAPLTMGLILELTRKIGQENARMHAGEPWQALGGIEIEGRTLGILGLGKLGT
KVAGLAKAFGMNVIAWSPNLTPERCKDAGVGYAGKDELFAAADIITIHVVLSDRSRGLVGAADIARMKPSAYLVNTSRAP
IVDEVALLQALKDKRIAGAGLDVFSVEPLPVTHPLRRLDNVVLTPHLGYVTEESFRAHYGQMVACIAAWLDGAEPPRRLA

Sequences:

>Translated_320_residues
MTRLRCAILDDYYDTALSLADWPGLSDRVDVTAFTHPFADEDAAAAALADVDIVCAMRERTPFPRGLIERLPKLKLLITS
GMRNAAIDSEAAKSRGIVLCGTQYGRDPTAPLTMGLILELTRKIGQENARMHAGEPWQALGGIEIEGRTLGILGLGKLGT
KVAGLAKAFGMNVIAWSPNLTPERCKDAGVGYAGKDELFAAADIITIHVVLSDRSRGLVGAADIARMKPSAYLVNTSRAP
IVDEVALLQALKDKRIAGAGLDVFSVEPLPVTHPLRRLDNVVLTPHLGYVTEESFRAHYGQMVACIAAWLDGAEPPRRLA
>Mature_319_residues
TRLRCAILDDYYDTALSLADWPGLSDRVDVTAFTHPFADEDAAAAALADVDIVCAMRERTPFPRGLIERLPKLKLLITSG
MRNAAIDSEAAKSRGIVLCGTQYGRDPTAPLTMGLILELTRKIGQENARMHAGEPWQALGGIEIEGRTLGILGLGKLGTK
VAGLAKAFGMNVIAWSPNLTPERCKDAGVGYAGKDELFAAADIITIHVVLSDRSRGLVGAADIARMKPSAYLVNTSRAPI
VDEVALLQALKDKRIAGAGLDVFSVEPLPVTHPLRRLDNVVLTPHLGYVTEESFRAHYGQMVACIAAWLDGAEPPRRLA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=251, Percent_Identity=37.0517928286853, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI145580578, Length=239, Percent_Identity=33.8912133891213, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557499, Length=239, Percent_Identity=33.8912133891213, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI145580575, Length=239, Percent_Identity=33.8912133891213, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI6912396, Length=223, Percent_Identity=32.7354260089686, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI87082289, Length=246, Percent_Identity=34.5528455284553, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789279, Length=267, Percent_Identity=32.9588014981273, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787645, Length=274, Percent_Identity=27.7372262773723, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87081824, Length=189, Percent_Identity=30.1587301587302, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=226, Percent_Identity=36.7256637168142, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=250, Percent_Identity=32.8, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=27.4509803921569, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=269, Percent_Identity=29.368029739777, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=217, Percent_Identity=32.7188940092166, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=258, Percent_Identity=29.8449612403101, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=35.1464435146443, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=35.1464435146443, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=35.1464435146443, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=35.1464435146443, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=35.5648535564854, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19921140, Length=226, Percent_Identity=35.8407079646018, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28571528, Length=230, Percent_Identity=33.4782608695652, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=236, Percent_Identity=33.8983050847458, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45552429, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551003, Length=236, Percent_Identity=30.0847457627119, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585516, Length=214, Percent_Identity=25.2336448598131, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34403; Mature: 34272

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLRCAILDDYYDTALSLADWPGLSDRVDVTAFTHPFADEDAAAAALADVDIVCAMRER
CCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEHHHC
TPFPRGLIERLPKLKLLITSGMRNAAIDSEAAKSRGIVLCGTQYGRDPTAPLTMGLILEL
CCCCHHHHHHCCCEEEEEECCCCCHHCCCHHHHHCCEEEECCCCCCCCCCHHHHHHHHHH
TRKIGQENARMHAGEPWQALGGIEIEGRTLGILGLGKLGTKVAGLAKAFGMNVIAWSPNL
HHHHCCCCCCCCCCCCHHHHCCEEECCEEEEEEECCHHHHHHHHHHHHHCCEEEEECCCC
TPERCKDAGVGYAGKDELFAAADIITIHVVLSDRSRGLVGAADIARMKPSAYLVNTSRAP
CHHHHHHCCCCCCCCCHHHEEEEEEEEEEEEECCCCCCEEHHHHHHCCCCEEEEECCCCC
IVDEVALLQALKDKRIAGAGLDVFSVEPLPVTHPLRRLDNVVLTPHLGYVTEESFRAHYG
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHCCEEECCCCCCCCHHHHHHHHH
QMVACIAAWLDGAEPPRRLA
HHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TRLRCAILDDYYDTALSLADWPGLSDRVDVTAFTHPFADEDAAAAALADVDIVCAMRER
CCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEEHHHC
TPFPRGLIERLPKLKLLITSGMRNAAIDSEAAKSRGIVLCGTQYGRDPTAPLTMGLILEL
CCCCHHHHHHCCCEEEEEECCCCCHHCCCHHHHHCCEEEECCCCCCCCCCHHHHHHHHHH
TRKIGQENARMHAGEPWQALGGIEIEGRTLGILGLGKLGTKVAGLAKAFGMNVIAWSPNL
HHHHCCCCCCCCCCCCHHHHCCEEECCEEEEEEECCHHHHHHHHHHHHHCCEEEEECCCC
TPERCKDAGVGYAGKDELFAAADIITIHVVLSDRSRGLVGAADIARMKPSAYLVNTSRAP
CHHHHHHCCCCCCCCCHHHEEEEEEEEEEEEECCCCCCEEHHHHHHCCCCEEEEECCCCC
IVDEVALLQALKDKRIAGAGLDVFSVEPLPVTHPLRRLDNVVLTPHLGYVTEESFRAHYG
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHCCEEECCCCCCCCHHHHHHHHH
QMVACIAAWLDGAEPPRRLA
HHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]