Click here to switch to the map view.

The map label for this gene is mug [H]

Identifier: 146342556

GI number: 146342556

Start: 5919526

End: 5920065

Strand: Direct

Name: mug [H]

Synonym: BRADO5719

Alternate gene names: 146342556

Gene position: 5919526-5920065 (Clockwise)

Preceding gene: 146342554

Following gene: 146342558

Centisome position: 79.39

GC content: 67.78

Gene sequence:

>540_bases
ATGGATCGCCTGCCCGATCAGTTGCAGCCCGGCCTGCGCCTCGTCTTCGTCGGCACGGCCGCGAGCGAACGGTCGGCTGC
GACCGGACACTACTACGCGCACCCCGGCAACCGCTTCTGGCGCACGCTGCATGCGACGGGCCTGACGCCGCGGCTGCATC
AGCCGGAGGAGTTTCCTCTGCTGCTGTCGCTCGGCATCGGCTTCACCGACCTGTGCAAGCAGGGCGCCGGGATGGATCAC
GTCGCCCTGAAGGCCGGCGTCGATGTCGCGGGCTTCGCGGCCAAGATCGAACGCTATCGGCCGGCGACGATCGCTTTCAC
CAGCAAAAAGGCCGCAAGCCTGTTTTACGGCCGGCCGACCGGCGCGATCGCACTGGGCCTGCAGCCGACGCAGAAGGATT
TTCCGGCCACCTTCGTGCTGGCGTCGCCGTCAGGCGCGGCATCGGGGGCGTGGACCTTGCAGCCATGGCTGGATCTGGCG
GCGCATGTCGAACGCGATCGTCCGCACGCGAAACAGCCGGCGTTCAACGATGCACCGTAA

Upstream 100 bases:

>100_bases
CCCGTTGCTGGAGCGACGTGTAGCGCCGGGCTGACAGATCAACAACGCCGGCCGCCATCAATGGCTTGTTGCGACCGGCG
CAATAATGCGACAACGGCTC

Downstream 100 bases:

>100_bases
GCTGGGCAAAGCAGCCGCTGGCAACGGAGATCGCGTGCCCAGCATGCATCCGCGTGCCCGCCGCGAGATGGAGCGCGGCA
GACACGAGCACGCGGGCGCG

Product: putative G/U mismatch-specific DNA glycosylase (mug-like)

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MDRLPDQLQPGLRLVFVGTAASERSAATGHYYAHPGNRFWRTLHATGLTPRLHQPEEFPLLLSLGIGFTDLCKQGAGMDH
VALKAGVDVAGFAAKIERYRPATIAFTSKKAASLFYGRPTGAIALGLQPTQKDFPATFVLASPSGAASGAWTLQPWLDLA
AHVERDRPHAKQPAFNDAP

Sequences:

>Translated_179_residues
MDRLPDQLQPGLRLVFVGTAASERSAATGHYYAHPGNRFWRTLHATGLTPRLHQPEEFPLLLSLGIGFTDLCKQGAGMDH
VALKAGVDVAGFAAKIERYRPATIAFTSKKAASLFYGRPTGAIALGLQPTQKDFPATFVLASPSGAASGAWTLQPWLDLA
AHVERDRPHAKQPAFNDAP
>Mature_179_residues
MDRLPDQLQPGLRLVFVGTAASERSAATGHYYAHPGNRFWRTLHATGLTPRLHQPEEFPLLLSLGIGFTDLCKQGAGMDH
VALKAGVDVAGFAAKIERYRPATIAFTSKKAASLFYGRPTGAIALGLQPTQKDFPATFVLASPSGAASGAWTLQPWLDLA
AHVERDRPHAKQPAFNDAP

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Escherichia coli, GI1789449, Length=147, Percent_Identity=34.0136054421769, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356805, Length=151, Percent_Identity=33.112582781457, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 19256; Mature: 19256

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLPDQLQPGLRLVFVGTAASERSAATGHYYAHPGNRFWRTLHATGLTPRLHQPEEFPL
CCCCCCHHCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCE
LLSLGIGFTDLCKQGAGMDHVALKAGVDVAGFAAKIERYRPATIAFTSKKAASLFYGRPT
EEEECCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCEEEECCCC
GAIALGLQPTQKDFPATFVLASPSGAASGAWTLQPWLDLAAHVERDRPHAKQPAFNDAP
CEEEECCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDRLPDQLQPGLRLVFVGTAASERSAATGHYYAHPGNRFWRTLHATGLTPRLHQPEEFPL
CCCCCCHHCCCEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCE
LLSLGIGFTDLCKQGAGMDHVALKAGVDVAGFAAKIERYRPATIAFTSKKAASLFYGRPT
EEEECCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCEEEECCCC
GAIALGLQPTQKDFPATFVLASPSGAASGAWTLQPWLDLAAHVERDRPHAKQPAFNDAP
CEEEECCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA