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The map label for this gene is envZ [H]

Identifier: 146342542

GI number: 146342542

Start: 5906778

End: 5908181

Strand: Direct

Name: envZ [H]

Synonym: BRADO5704

Alternate gene names: 146342542

Gene position: 5906778-5908181 (Clockwise)

Preceding gene: 146342541

Following gene: 146342546

Centisome position: 79.22

GC content: 68.09

Gene sequence:

>1404_bases
ATGATGTCGTTCGGCTTTCTCAACCTGAAGGGAATCCGCGGCCAGATCACGGCGCTGGTGGCCATCTCGATCGTGGCGCT
GCACGCCATCATCACTGCGACCTTCCTGATCTATCGCGCCGAGCAGCCTCCGGGTGAGAACGAGGCCGGCCCGTTCCAGC
TCGCCACCGTGATCCGCGTGCTCGGACACGCTCCCGCCGATGAGCGCGCCCGGCTGCTGGCCGACATCGCCCGCGCCTAT
CCCGAGTTCGACATCAAGGCGCAATCGGGACCACTGCCGTCCGATCTGGCACAACCGGCCGCCGGGCCGGAGAGAGACGG
CACGGCTCATGGCGGGGAGCCCGAGTCGGGGCCACGCGGCCCATCGGAGACCGCTCACGGACCGGGCGGCTTCCGCGGCC
TCGGCCCTGGCTATCGAGTCTTCATGCCGCCACCGGGATCGAGCGCGCACCGCGTGGTATTCGCGCTGCCGGACGGCGAC
CTCATTTCGGCCAAGGCGCCGGAGCGGCCCCGCCGGCCGCCGTTCTGGGGCGCGCCGTGGCTGACCACGATCCTGTTCGC
ATTGATCAGCACCACACTGCTCGGCCTGTGGGCGGCGCGCGCGCTGACGTCGCCGCTGTCGAGCTTCGCCAAGGCGGCCG
AGAATTTCAGCCTCGATGGCGAGGGCCCTGCTCTGCCCGAGCGCGGACCGGAGGAAATCCGCTCGCTGGCGCGCGCGCTG
AACCGGATGCGTTCACGCATCACGGCATTGATCAATGACCGGACCAAAATGCTCGCGGCAATCAGCCACGACCTGCGCAC
GCCCTTGACGCGCATGCGGCTGCGCTGCGAGTTCGTTGAAGACGAGTTGCAGCGCAGCCGCATGCTGGCCGATCTCGACC
AGATGCACGCGATGCTGGGCTCGGTGCTGTCGTTCCTGCGCAACGGCCGCAAGCTCGAGCCGATGACCCTGGTCGACATC
GCAAGCATCCTGCAGCTTGTCGCCGACCAGTTCGCCGACGTGGGCCACGTTGTCAGCTATGTGGGACCGGCGCGCGCGAT
GGCGACGGTGCGCCCGGACGATCTGATGCGCTCGGTGACCAACCTGGTCGAGAACGCCACGAAGTACGGCAAGGAGATCG
TCGTCCGGCTGACCATCTCCGGCAAGCGCCTGACCATCGATGTCGAGGATGACGGCCCGGGTATCGCAGATGCCCGCAAG
TCCGACATGCTCGAGCCGTTCGTGCGCGGCGACGACGCCCGCAACATGGACGAGGCGACCGGCTTCGGACTCGGCCTGTC
GATCGCCAAGGCGATCGTCCAGGCGCATGGTGGCGAGCTGTCGCTGCACGATCGCAAGCCGCATGGGCTAATCGCGCGCA
TCGAGCTTCCGCTCAGCCGGAGCAAGCTGCGCCCCGCGGCCTGA

Upstream 100 bases:

>100_bases
TGATCAAGACCGTGCGGTCCGGCGGCTACATGTTCACGCCCGTCGTCGAGGTGGTGACCGCGCCGCAGAGCCATTGACCG
GTCGATCGGGTGGCGCTGGC

Downstream 100 bases:

>100_bases
TACGCAAACGCGCCCGGATGGTCCGGGCGCGCCGCGTCGAGACAATCAACCGATCGTCGGTGACGTCGTTACTCGGAGTA
CTTGAACTCCGGCATCGACT

Product: putative two component sensor histidine kinase osmolarity sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MMSFGFLNLKGIRGQITALVAISIVALHAIITATFLIYRAEQPPGENEAGPFQLATVIRVLGHAPADERARLLADIARAY
PEFDIKAQSGPLPSDLAQPAAGPERDGTAHGGEPESGPRGPSETAHGPGGFRGLGPGYRVFMPPPGSSAHRVVFALPDGD
LISAKAPERPRRPPFWGAPWLTTILFALISTTLLGLWAARALTSPLSSFAKAAENFSLDGEGPALPERGPEEIRSLARAL
NRMRSRITALINDRTKMLAAISHDLRTPLTRMRLRCEFVEDELQRSRMLADLDQMHAMLGSVLSFLRNGRKLEPMTLVDI
ASILQLVADQFADVGHVVSYVGPARAMATVRPDDLMRSVTNLVENATKYGKEIVVRLTISGKRLTIDVEDDGPGIADARK
SDMLEPFVRGDDARNMDEATGFGLGLSIAKAIVQAHGGELSLHDRKPHGLIARIELPLSRSKLRPAA

Sequences:

>Translated_467_residues
MMSFGFLNLKGIRGQITALVAISIVALHAIITATFLIYRAEQPPGENEAGPFQLATVIRVLGHAPADERARLLADIARAY
PEFDIKAQSGPLPSDLAQPAAGPERDGTAHGGEPESGPRGPSETAHGPGGFRGLGPGYRVFMPPPGSSAHRVVFALPDGD
LISAKAPERPRRPPFWGAPWLTTILFALISTTLLGLWAARALTSPLSSFAKAAENFSLDGEGPALPERGPEEIRSLARAL
NRMRSRITALINDRTKMLAAISHDLRTPLTRMRLRCEFVEDELQRSRMLADLDQMHAMLGSVLSFLRNGRKLEPMTLVDI
ASILQLVADQFADVGHVVSYVGPARAMATVRPDDLMRSVTNLVENATKYGKEIVVRLTISGKRLTIDVEDDGPGIADARK
SDMLEPFVRGDDARNMDEATGFGLGLSIAKAIVQAHGGELSLHDRKPHGLIARIELPLSRSKLRPAA
>Mature_467_residues
MMSFGFLNLKGIRGQITALVAISIVALHAIITATFLIYRAEQPPGENEAGPFQLATVIRVLGHAPADERARLLADIARAY
PEFDIKAQSGPLPSDLAQPAAGPERDGTAHGGEPESGPRGPSETAHGPGGFRGLGPGYRVFMPPPGSSAHRVVFALPDGD
LISAKAPERPRRPPFWGAPWLTTILFALISTTLLGLWAARALTSPLSSFAKAAENFSLDGEGPALPERGPEEIRSLARAL
NRMRSRITALINDRTKMLAAISHDLRTPLTRMRLRCEFVEDELQRSRMLADLDQMHAMLGSVLSFLRNGRKLEPMTLVDI
ASILQLVADQFADVGHVVSYVGPARAMATVRPDDLMRSVTNLVENATKYGKEIVVRLTISGKRLTIDVEDDGPGIADARK
SDMLEPFVRGDDARNMDEATGFGLGLSIAKAIVQAHGGELSLHDRKPHGLIARIELPLSRSKLRPAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=36.25, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=33.9366515837104, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.5303643724696, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI87082128, Length=321, Percent_Identity=27.4143302180685, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790551, Length=273, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790861, Length=422, Percent_Identity=24.4075829383886, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=30.9417040358744, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=26.4822134387352, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=26.8382352941176, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081816, Length=343, Percent_Identity=27.9883381924198, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=296, Percent_Identity=28.0405405405405, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50425; Mature: 50425

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSFGFLNLKGIRGQITALVAISIVALHAIITATFLIYRAEQPPGENEAGPFQLATVIRV
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LGHAPADERARLLADIARAYPEFDIKAQSGPLPSDLAQPAAGPERDGTAHGGEPESGPRG
HCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
PSETAHGPGGFRGLGPGYRVFMPPPGSSAHRVVFALPDGDLISAKAPERPRRPPFWGAPW
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCHH
LTTILFALISTTLLGLWAARALTSPLSSFAKAAENFSLDGEGPALPERGPEEIRSLARAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
NRMRSRITALINDRTKMLAAISHDLRTPLTRMRLRCEFVEDELQRSRMLADLDQMHAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLSFLRNGRKLEPMTLVDIASILQLVADQFADVGHVVSYVGPARAMATVRPDDLMRSVT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHH
NLVENATKYGKEIVVRLTISGKRLTIDVEDDGPGIADARKSDMLEPFVRGDDARNMDEAT
HHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
GFGLGLSIAKAIVQAHGGELSLHDRKPHGLIARIELPLSRSKLRPAA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MMSFGFLNLKGIRGQITALVAISIVALHAIITATFLIYRAEQPPGENEAGPFQLATVIRV
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LGHAPADERARLLADIARAYPEFDIKAQSGPLPSDLAQPAAGPERDGTAHGGEPESGPRG
HCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
PSETAHGPGGFRGLGPGYRVFMPPPGSSAHRVVFALPDGDLISAKAPERPRRPPFWGAPW
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCHH
LTTILFALISTTLLGLWAARALTSPLSSFAKAAENFSLDGEGPALPERGPEEIRSLARAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
NRMRSRITALINDRTKMLAAISHDLRTPLTRMRLRCEFVEDELQRSRMLADLDQMHAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVLSFLRNGRKLEPMTLVDIASILQLVADQFADVGHVVSYVGPARAMATVRPDDLMRSVT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHH
NLVENATKYGKEIVVRLTISGKRLTIDVEDDGPGIADARKSDMLEPFVRGDDARNMDEAT
HHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
GFGLGLSIAKAIVQAHGGELSLHDRKPHGLIARIELPLSRSKLRPAA
CCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]