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The map label for this gene is uvrD [H]

Identifier: 146342459

GI number: 146342459

Start: 5806225

End: 5808822

Strand: Direct

Name: uvrD [H]

Synonym: BRADO5618

Alternate gene names: 146342459

Gene position: 5806225-5808822 (Clockwise)

Preceding gene: 146342457

Following gene: 146342460

Centisome position: 77.87

GC content: 66.71

Gene sequence:

>2598_bases
ATGACCGAGCCCAATCGCGTGAGCCGTATTCCTGCGCCTGACCACCAGCCCGTCGCCGGCGGTATCGCTGCGCGCGCCCG
TGCAGCCGCGAGTGGCGGTGCGCGTTACCTCGCGGGCCTCAATCCGGAGCAGCGCGACGCGGTCGAGACGCTCGACGGCC
CTGTGCTGGTGCTGGCCGGCGCAGGCACAGGCAAGACCCGCGTGCTGACGACGCGCATCGCGCACATATTGAGCATGGGC
CGCGCGCGTCCCGGCGAGATCCTGTCGGTGACCTTCACCAACAAGGCCGCGCGCGAGATGAAGACGCGCCTCGCCGAGAT
GCTCGGCCAGGCGGTGGAGGGCATGCCATGGCTCGGCACCTTCCACTCCATCGCCGGCCGCATCCTGCGCAGCCATGCCG
AACTGGTGCAGCTGAAATCCAACTTCACCGTGCTCGATGTCGACGACCAGATCCGCCTGCTCAAGCAACTGCTGCAGGCC
GAGAATATCGACGACAAGCGCTGGCCGGCGCGCATGCTCGCCAATCTGATCGACGGCTGGAAGAATCGCGGCCTGGCGCC
GGCGCAGGTGCCGTCGGGCGAAGCCGCCGTTTTTGCCAACGGCAAGGGCGGCAAGCTCTATGCGAGCTACCAGGAGCGGC
TGAAGATTCTCAACGCCGCCGATTTCGGCGACCTGCTGCTCGAGAACATCCGGCTGTTTCGCGAGAACCCGGACGTGCTC
CGGCAATATCAGGGCCGCTTCAAGTTCATCCTGGTCGACGAGTATCAGGACACCAACGTCGCGCAATATCTGTGGCTGCG
GCTGCTGTCGCAGGCGCCGAGCTCGTCGCGCGCCGTCACGCCATCCTCCGTCATTCCGGGGCGGCTCGAAGAGGCGAGCC
CGGAATCTCGAGCTGAGGACCCACAACTGCGGGATTCCGGGTTCGCACCTGACGGTGCGCTCCGGAATGACGACGCGGCA
CAGAGCGCGCCTGCGCCCAAGAACATCTGCTGCGTCGGCGATGACGATCAGTCGATCTATGGCTGGCGCGGCGCCGAGGT
CGACAACATCCTGCGCTTCGAGCACGACTTTCCGGGCGCCAAGGTGATCCGTCTCGAGCGCAACTATCGCTCGACCGGCC
ACATCCTCGCGGCCGCCTCGCACCTCATCACCCATAACGAAGGCCGGCTCGGCAAGACGCTGCACACCGAGGACGTCGAG
GGCGAGAAGGTCACCGTCACCGGCGCCTGGGACTCGGAAGAGGAGGCGCGCGGCATTGGCGAGGAGATCGAGGAGCTGCA
GCGCAAGGGCGAGCATCTCAACGACATCGCGATCCTGGTGCGCGCCTCCTACCAGATGCGCGAGTTCGAGGACCGCTTCG
TCACGCTCGGCCTGCCCTACCGCGTCATCGGCGGTCCGCGCTTCTACGAGCGCGCCGAGATCCGCGATGCGCTCGCATAT
CTGCGCGTCATCAACTCGCCGGCCGACGACCTCGCCTTCGAGCGCATCGTCAACGTGCCGAAGCGCGGGCTCGGCGATGC
CACCGTGCAGCTGCTGCACGACCATGCCCGCAAGCGTCGCATCCCGTTGTTCGAGGCGGCGCGCGCGGTCGCCGAAACTG
ATGAGCTCAAGCCGAAGGCGCGCGGCTCGCTGCGCGGGCTGATCCTGCAGTTCGAGCGCTGGCGCGCGCAGCGCGAGGTG
ACGCCGCACACCGAGCTCGCCGAGATCGTGCTCGACGAGAGCGGCTACACCGAGATGTGGCAGAAGGACCGCTCGGCCGA
TGCCGCCGGACGTCTCGACAACCTGAAAGAGCTCATCCGCTCGATGGAGGAGTTCGAGAATCTGCACGGCTTCCTCGAGC
ACATCTCGCTGGTGATGGACCGCGAGGGCGGCGCCGACGAGGAGGCGGTGTCGCTGATGACCCTGCACTCGGCGAAGGGC
TTAGAGTTCGACAACGTCTTCCTGCCCGGCTGGGAGGAAGGCCTGTTTCCGAGCCAACGCACCCTCGACGAGCAGGGCCG
CGCCGGCCTGGAAGAAGAGCGTCGCCTTGCCCATGTCGGCCTGACGCGCGCGCGGCGGCGCGCCAAGATCTATTTTGCCA
CCAATCGCCGCATCCACGGCACCTGGACCACGACCATCCCCTCGCGCTTCCTCGACGAACTGCCGGCCGCGAGCGTCGAG
ATCACCGAATCCAAGGGCGGCTCGGGCTGGGGCGGCGCCGGCGGCTATGGCCCATCGCGTTTCGACAATGTCGAATCGTT
CGGGTCGAGCTATTCGACGCCCGGCTGGCAGCGCGCGCAGGCGCGGCGTCCTGGTGGGGCTCGGGGCAGCTCAGAGGGTG
GCTTCCAGGAGGAGCAATCACCGTTCTCGGGGCGCGATCCGTTCGGCGGCGGCTTCAACGGTAATTTCGGCCGCAACAAG
CGCGGGCCGCTGACCATCGAAGGCGAGCTGGTGGCGAAATCCACCGGCACCACGTCGGAATTTTCGGTCGACGACCGCGT
CTTTCACCAGAAGTTCGGCTATGGCAACGTCATCAAGGTCGACGGCAACAAGCTGACCATCAGCTTCGACAAGGCCGGCG
AAAAGCACGTCGTCGACAGCTTCGTGCAGCGCGCGTGA

Upstream 100 bases:

>100_bases
CGGCCCCATATCACCGTCAATCCCTGCTATGAGGGCTCCTTCCTGTAGACCCCTTGATGTCGTCATATGATGCCGTCAGA
GGGATGAGACTGATTCGCTG

Downstream 100 bases:

>100_bases
CCTGACGGCCACGGCGGGATCTGCCGCCGTGCGACAGCAGTCGCATCATCGTCACCGAACTTCACACTTCGCCTTTGTTA
GGCCTTGACCATGGCAGCTC

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 865; Mature: 864

Protein sequence:

>865_residues
MTEPNRVSRIPAPDHQPVAGGIAARARAAASGGARYLAGLNPEQRDAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSMG
RARPGEILSVTFTNKAAREMKTRLAEMLGQAVEGMPWLGTFHSIAGRILRSHAELVQLKSNFTVLDVDDQIRLLKQLLQA
ENIDDKRWPARMLANLIDGWKNRGLAPAQVPSGEAAVFANGKGGKLYASYQERLKILNAADFGDLLLENIRLFRENPDVL
RQYQGRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSRAVTPSSVIPGRLEEASPESRAEDPQLRDSGFAPDGALRNDDAA
QSAPAPKNICCVGDDDQSIYGWRGAEVDNILRFEHDFPGAKVIRLERNYRSTGHILAAASHLITHNEGRLGKTLHTEDVE
GEKVTVTGAWDSEEEARGIGEEIEELQRKGEHLNDIAILVRASYQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAY
LRVINSPADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEAARAVAETDELKPKARGSLRGLILQFERWRAQREV
TPHTELAEIVLDESGYTEMWQKDRSADAAGRLDNLKELIRSMEEFENLHGFLEHISLVMDREGGADEEAVSLMTLHSAKG
LEFDNVFLPGWEEGLFPSQRTLDEQGRAGLEEERRLAHVGLTRARRRAKIYFATNRRIHGTWTTTIPSRFLDELPAASVE
ITESKGGSGWGGAGGYGPSRFDNVESFGSSYSTPGWQRAQARRPGGARGSSEGGFQEEQSPFSGRDPFGGGFNGNFGRNK
RGPLTIEGELVAKSTGTTSEFSVDDRVFHQKFGYGNVIKVDGNKLTISFDKAGEKHVVDSFVQRA

Sequences:

>Translated_865_residues
MTEPNRVSRIPAPDHQPVAGGIAARARAAASGGARYLAGLNPEQRDAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSMG
RARPGEILSVTFTNKAAREMKTRLAEMLGQAVEGMPWLGTFHSIAGRILRSHAELVQLKSNFTVLDVDDQIRLLKQLLQA
ENIDDKRWPARMLANLIDGWKNRGLAPAQVPSGEAAVFANGKGGKLYASYQERLKILNAADFGDLLLENIRLFRENPDVL
RQYQGRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSRAVTPSSVIPGRLEEASPESRAEDPQLRDSGFAPDGALRNDDAA
QSAPAPKNICCVGDDDQSIYGWRGAEVDNILRFEHDFPGAKVIRLERNYRSTGHILAAASHLITHNEGRLGKTLHTEDVE
GEKVTVTGAWDSEEEARGIGEEIEELQRKGEHLNDIAILVRASYQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAY
LRVINSPADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEAARAVAETDELKPKARGSLRGLILQFERWRAQREV
TPHTELAEIVLDESGYTEMWQKDRSADAAGRLDNLKELIRSMEEFENLHGFLEHISLVMDREGGADEEAVSLMTLHSAKG
LEFDNVFLPGWEEGLFPSQRTLDEQGRAGLEEERRLAHVGLTRARRRAKIYFATNRRIHGTWTTTIPSRFLDELPAASVE
ITESKGGSGWGGAGGYGPSRFDNVESFGSSYSTPGWQRAQARRPGGARGSSEGGFQEEQSPFSGRDPFGGGFNGNFGRNK
RGPLTIEGELVAKSTGTTSEFSVDDRVFHQKFGYGNVIKVDGNKLTISFDKAGEKHVVDSFVQRA
>Mature_864_residues
TEPNRVSRIPAPDHQPVAGGIAARARAAASGGARYLAGLNPEQRDAVETLDGPVLVLAGAGTGKTRVLTTRIAHILSMGR
ARPGEILSVTFTNKAAREMKTRLAEMLGQAVEGMPWLGTFHSIAGRILRSHAELVQLKSNFTVLDVDDQIRLLKQLLQAE
NIDDKRWPARMLANLIDGWKNRGLAPAQVPSGEAAVFANGKGGKLYASYQERLKILNAADFGDLLLENIRLFRENPDVLR
QYQGRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSRAVTPSSVIPGRLEEASPESRAEDPQLRDSGFAPDGALRNDDAAQ
SAPAPKNICCVGDDDQSIYGWRGAEVDNILRFEHDFPGAKVIRLERNYRSTGHILAAASHLITHNEGRLGKTLHTEDVEG
EKVTVTGAWDSEEEARGIGEEIEELQRKGEHLNDIAILVRASYQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYL
RVINSPADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEAARAVAETDELKPKARGSLRGLILQFERWRAQREVT
PHTELAEIVLDESGYTEMWQKDRSADAAGRLDNLKELIRSMEEFENLHGFLEHISLVMDREGGADEEAVSLMTLHSAKGL
EFDNVFLPGWEEGLFPSQRTLDEQGRAGLEEERRLAHVGLTRARRRAKIYFATNRRIHGTWTTTIPSRFLDELPAASVEI
TESKGGSGWGGAGGYGPSRFDNVESFGSSYSTPGWQRAQARRPGGARGSSEGGFQEEQSPFSGRDPFGGGFNGNFGRNKR
GPLTIEGELVAKSTGTTSEFSVDDRVFHQKFGYGNVIKVDGNKLTISFDKAGEKHVVDSFVQRA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=695, Percent_Identity=41.294964028777, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI48994965, Length=698, Percent_Identity=35.1002865329513, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1787196, Length=403, Percent_Identity=26.7990074441687, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322369, Length=809, Percent_Identity=25.7107540173053, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 95748; Mature: 95616

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNRVSRIPAPDHQPVAGGIAARARAAASGGARYLAGLNPEQRDAVETLDGPVLVLAG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEEEE
AGTGKTRVLTTRIAHILSMGRARPGEILSVTFTNKAAREMKTRLAEMLGQAVEGMPWLGT
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHH
FHSIAGRILRSHAELVQLKSNFTVLDVDDQIRLLKQLLQAENIDDKRWPARMLANLIDGW
HHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KNRGLAPAQVPSGEAAVFANGKGGKLYASYQERLKILNAADFGDLLLENIRLFRENPDVL
HCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
RQYQGRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSRAVTPSSVIPGRLEEASPESRAED
HHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQLRDSGFAPDGALRNDDAAQSAPAPKNICCVGDDDQSIYGWRGAEVDNILRFEHDFPGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCC
KVIRLERNYRSTGHILAAASHLITHNEGRLGKTLHTEDVEGEKVTVTGAWDSEEEARGIG
EEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCH
EEIEELQRKGEHLNDIAILVRASYQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAY
HHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHHH
LRVINSPADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEAARAVAETDELKPKA
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
RGSLRGLILQFERWRAQREVTPHTELAEIVLDESGYTEMWQKDRSADAAGRLDNLKELIR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
SMEEFENLHGFLEHISLVMDREGGADEEAVSLMTLHSAKGLEFDNVFLPGWEEGLFPSQR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHH
TLDEQGRAGLEEERRLAHVGLTRARRRAKIYFATNRRIHGTWTTTIPSRFLDELPAASVE
HHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEECCEEEEEEECCHHHHHHHHCCCCCEE
ITESKGGSGWGGAGGYGPSRFDNVESFGSSYSTPGWQRAQARRPGGARGSSEGGFQEEQS
EECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
PFSGRDPFGGGFNGNFGRNKRGPLTIEGELVAKSTGTTSEFSVDDRVFHQKFGYGNVIKV
CCCCCCCCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEE
DGNKLTISFDKAGEKHVVDSFVQRA
CCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TEPNRVSRIPAPDHQPVAGGIAARARAAASGGARYLAGLNPEQRDAVETLDGPVLVLAG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCCCEEEEEE
AGTGKTRVLTTRIAHILSMGRARPGEILSVTFTNKAAREMKTRLAEMLGQAVEGMPWLGT
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHH
FHSIAGRILRSHAELVQLKSNFTVLDVDDQIRLLKQLLQAENIDDKRWPARMLANLIDGW
HHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KNRGLAPAQVPSGEAAVFANGKGGKLYASYQERLKILNAADFGDLLLENIRLFRENPDVL
HCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
RQYQGRFKFILVDEYQDTNVAQYLWLRLLSQAPSSSRAVTPSSVIPGRLEEASPESRAED
HHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PQLRDSGFAPDGALRNDDAAQSAPAPKNICCVGDDDQSIYGWRGAEVDNILRFEHDFPGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCC
KVIRLERNYRSTGHILAAASHLITHNEGRLGKTLHTEDVEGEKVTVTGAWDSEEEARGIG
EEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCH
EEIEELQRKGEHLNDIAILVRASYQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAY
HHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHHH
LRVINSPADDLAFERIVNVPKRGLGDATVQLLHDHARKRRIPLFEAARAVAETDELKPKA
HHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
RGSLRGLILQFERWRAQREVTPHTELAEIVLDESGYTEMWQKDRSADAAGRLDNLKELIR
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
SMEEFENLHGFLEHISLVMDREGGADEEAVSLMTLHSAKGLEFDNVFLPGWEEGLFPSQR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHH
TLDEQGRAGLEEERRLAHVGLTRARRRAKIYFATNRRIHGTWTTTIPSRFLDELPAASVE
HHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEECCEEEEEEECCHHHHHHHHCCCCCEE
ITESKGGSGWGGAGGYGPSRFDNVESFGSSYSTPGWQRAQARRPGGARGSSEGGFQEEQS
EECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
PFSGRDPFGGGFNGNFGRNKRGPLTIEGELVAKSTGTTSEFSVDDRVFHQKFGYGNVIKV
CCCCCCCCCCCCCCCCCCCCCCCEEEECEEEEECCCCCCCCCCHHHHHHHHCCCCCEEEE
DGNKLTISFDKAGEKHVVDSFVQRA
CCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA