Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 146342405

GI number: 146342405

Start: 5748099

End: 5749082

Strand: Reverse

Name: ilvA [H]

Synonym: BRADO5563

Alternate gene names: 146342405

Gene position: 5749082-5748099 (Counterclockwise)

Preceding gene: 146342406

Following gene: 146342404

Centisome position: 77.1

GC content: 68.09

Gene sequence:

>984_bases
GTGTTCACACTAGCAGAGTTGGAGCAGGCCCACGCGATCGTCGGCATGGCCGTGCCGGCGACGCCTACGCATGCGTGGCC
GCTGCTGGCGCAGCGGCTGGGGACGCATGTGGTCGTCAAGCACGAGAACCATACGCCGGCCGGCGCTTTCAAAGTGCGCG
GCGGGTTGGTCTATGTCGACAACCTCAAGCGAACTCATCCGGATGTCCGCGGCCTGATCACCGCAACGCGCGGCAATCAC
GGCCAGAGCATTGCGTTCGCCGGCCGCCGCAACGGCCTGCCGGTAACGATCTACGTGCCCGAGGGCAACTCGGTCGAGAA
GAACCGGGCGATGGCCGCGTTTGGGGCTGAACTGATCGAGCATGGCAGCGACTTCCAGGAATCGCGCGAGGAGGCGATCC
GCCGCGCCGCGCGCGAAGGCCTGCACATGGTGCCGTCGTTTCATTCGGACATCGTCCGCGGCGTCGCGACCTACGCGCTG
GAGCTGCTGCGTGCGGCGCCTGATCTCGACGTGCTCTATGTGTCGGTCGGGCAGGGCTCGGGCATCTGCGGCTGCATCCT
GGCGCGCGACCTGCTCGGGCTGAAGACAGAGATCGTCGGCGTGCAGTCGACGGGCGCGCCGTCCTATGCGCTGTCGTTCG
CGGCGCGGACCGTCGTGACCACCAACAGCGCCGACACACACGCTGACGGGCTCGCGACTCGCAGCCCGGATGCCGATGCG
CTCGCGATCATCCTGAAGGGCGCGTCGCGCATCGTGCAGGTCAGCGACGCCGAGATTGCCGACGCCATCCGCATCTTCTG
GACCGACACGCACAATGTCGCCGAGGGCGCCGGCGCGGCGTCGCTCGCCGCCGCGTTGCAGGAGAAGCCCAAGCTCGCCG
GCAAGCGCGTCGGCCTGGTGCTGACCGGCGGCAACATCGATCTCGACCTGTTCAGGCGCTGGGTGATGCCGGCGGCCGCC
GAAGACATCGCAGGAGCGTCTTGA

Upstream 100 bases:

>100_bases
GGGCGATCCAGTACGCCGCGGCCGTGGTGAGTCCCACGACCGCCGCAGCGTACCGGATGCCCGCCTTCGCGGGCATGACA
GTCGTGATGAGGAGGCGGCT

Downstream 100 bases:

>100_bases
TGGGCACTCCGCTCACCACACCCACCGCTGTCATCGCCCGGCTTGACCGGGCGATCCAGTACGCCGCGGCGTCCGTGAGT
CTCACGACTGCCGGCGTTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MFTLAELEQAHAIVGMAVPATPTHAWPLLAQRLGTHVVVKHENHTPAGAFKVRGGLVYVDNLKRTHPDVRGLITATRGNH
GQSIAFAGRRNGLPVTIYVPEGNSVEKNRAMAAFGAELIEHGSDFQESREEAIRRAAREGLHMVPSFHSDIVRGVATYAL
ELLRAAPDLDVLYVSVGQGSGICGCILARDLLGLKTEIVGVQSTGAPSYALSFAARTVVTTNSADTHADGLATRSPDADA
LAIILKGASRIVQVSDAEIADAIRIFWTDTHNVAEGAGAASLAAALQEKPKLAGKRVGLVLTGGNIDLDLFRRWVMPAAA
EDIAGAS

Sequences:

>Translated_327_residues
MFTLAELEQAHAIVGMAVPATPTHAWPLLAQRLGTHVVVKHENHTPAGAFKVRGGLVYVDNLKRTHPDVRGLITATRGNH
GQSIAFAGRRNGLPVTIYVPEGNSVEKNRAMAAFGAELIEHGSDFQESREEAIRRAAREGLHMVPSFHSDIVRGVATYAL
ELLRAAPDLDVLYVSVGQGSGICGCILARDLLGLKTEIVGVQSTGAPSYALSFAARTVVTTNSADTHADGLATRSPDADA
LAIILKGASRIVQVSDAEIADAIRIFWTDTHNVAEGAGAASLAAALQEKPKLAGKRVGLVLTGGNIDLDLFRRWVMPAAA
EDIAGAS
>Mature_327_residues
MFTLAELEQAHAIVGMAVPATPTHAWPLLAQRLGTHVVVKHENHTPAGAFKVRGGLVYVDNLKRTHPDVRGLITATRGNH
GQSIAFAGRRNGLPVTIYVPEGNSVEKNRAMAAFGAELIEHGSDFQESREEAIRRAAREGLHMVPSFHSDIVRGVATYAL
ELLRAAPDLDVLYVSVGQGSGICGCILARDLLGLKTEIVGVQSTGAPSYALSFAARTVVTTNSADTHADGLATRSPDADA
LAIILKGASRIVQVSDAEIADAIRIFWTDTHNVAEGAGAASLAAALQEKPKLAGKRVGLVLTGGNIDLDLFRRWVMPAAA
EDIAGAS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=328, Percent_Identity=27.7439024390244, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI19923959, Length=262, Percent_Identity=29.3893129770992, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790207, Length=300, Percent_Identity=28.3333333333333, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789505, Length=283, Percent_Identity=26.8551236749117, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71991565, Length=307, Percent_Identity=29.6416938110749, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17537387, Length=324, Percent_Identity=29.320987654321, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508781, Length=288, Percent_Identity=28.4722222222222, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322631, Length=299, Percent_Identity=33.7792642140468, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320930, Length=294, Percent_Identity=27.5510204081633, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355833, Length=286, Percent_Identity=33.9160839160839, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645328, Length=217, Percent_Identity=34.5622119815668, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34498; Mature: 34498

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTLAELEQAHAIVGMAVPATPTHAWPLLAQRLGTHVVVKHENHTPAGAFKVRGGLVYVD
CCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCEEEEC
NLKRTHPDVRGLITATRGNHGQSIAFAGRRNGLPVTIYVPEGNSVEKNRAMAAFGAELIE
CCCCCCCCHHEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
HGSDFQESREEAIRRAAREGLHMVPSFHSDIVRGVATYALELLRAAPDLDVLYVSVGQGS
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GICGCILARDLLGLKTEIVGVQSTGAPSYALSFAARTVVTTNSADTHADGLATRSPDADA
CHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
LAIILKGASRIVQVSDAEIADAIRIFWTDTHNVAEGAGAASLAAALQEKPKLAGKRVGLV
EEEEEECCCCEEEECCCHHHCEEEEEEECCCCHHCCCCHHHHHHHHHHCCCCCCCEEEEE
LTGGNIDLDLFRRWVMPAAAEDIAGAS
EECCCCCHHHHHHHHCCHHHHHCCCCC
>Mature Secondary Structure
MFTLAELEQAHAIVGMAVPATPTHAWPLLAQRLGTHVVVKHENHTPAGAFKVRGGLVYVD
CCCHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCEEEEC
NLKRTHPDVRGLITATRGNHGQSIAFAGRRNGLPVTIYVPEGNSVEKNRAMAAFGAELIE
CCCCCCCCHHEEEEEECCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
HGSDFQESREEAIRRAAREGLHMVPSFHSDIVRGVATYALELLRAAPDLDVLYVSVGQGS
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GICGCILARDLLGLKTEIVGVQSTGAPSYALSFAARTVVTTNSADTHADGLATRSPDADA
CHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCC
LAIILKGASRIVQVSDAEIADAIRIFWTDTHNVAEGAGAASLAAALQEKPKLAGKRVGLV
EEEEEECCCCEEEECCCHHHCEEEEEEECCCCHHCCCCHHHHHHHHHHCCCCCCCEEEEE
LTGGNIDLDLFRRWVMPAAAEDIAGAS
EECCCCCHHHHHHHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]