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The map label for this gene is sufS [H]

Identifier: 146342289

GI number: 146342289

Start: 5630220

End: 5631464

Strand: Reverse

Name: sufS [H]

Synonym: BRADO5444

Alternate gene names: 146342289

Gene position: 5631464-5630220 (Counterclockwise)

Preceding gene: 146342290

Following gene: 146342286

Centisome position: 75.52

GC content: 65.62

Gene sequence:

>1245_bases
ATGATGCATGCAGCGGTGAACGGGAGCGGCTACGACGTCAGCCGCATCCGGGCGGATTTTCCCATTCTCGGCATGCAGGT
CCACGGCAAGCCGCTGGTCTATCTCGACAACGCCGCCTCGGCGCAGAAGCCGCAGGCCGTGCTGGACCGGATGAACCAGG
TCTACACGTCCGAATACGCCAACGTGCATCGCGGGCTGCATTATCTCGCCAACGCCGCCACCGAGGCCTATGAGGGCGCC
CGCGCCAAGGTGGCGACCTTCCTCAACGCCGAGAGCCCCGAGCAGATCATCTTCACCCGCGGTGCCACCGAGGCGGTGAA
CCTGGTGGCCCAAACCTTCGGCCGCGAGCGCATCGGGCCGGGCGACGAGATCGTGCTCTCGATCATGGAGCACCACGCCA
ACATCATTCCCTGGCATTTCCTCCGGGAGCGCCAGGGCGCCGTGATCAAGTGGGCTCCCGTCGACGATGACGGCAACTTC
CTGCTGGATGAATTCGAGAAGCTGCTGAGCCCGCGCACCAAGATGGTGGCGATGACGCAGATGTCGAACGTGCTCGGCAC
GGTCGTGCCTGTGAAGGAGGTCATCCGCATCGCGCATGACCGCGGCATTCCGGTGCTCGTCGACGGCTCGCAGGCTGCGG
TGCACATGGAGGTCGACGTCCGGGATATCGATGCGGATTTCTACTGCATCACCGGGCACAAGATCTACGGCCCGACCGGG
ATCGGTGCGCTGTATGGAAAGCGCGAGCTCCTGGCCTCGATGCCGCCGTTCAACGGCGGCGGCGAGATGATCCGCGAGGT
GTCACGCGACTGGGTCACCTATGGCGATCCGCCGCACCGCTTCGAGGCCGGCACGCCGCCGATCGTCGAGGCCGCAGGCC
TCGGCGCCGCGATCGACTACGTCGCCTCGATCGGCAAGCAGCGTATCGCGGCGCATGAGCATGATCTCGTGACCTACGCG
ACCGAGCAGCTCCGCGAGATCAATTCGCTGCGCATCATCGGCAACGCCGCCGACAAGGGCGCCATCGTCTCGTTCGAGAT
GCAGGGCGCCCATGCCCACGATTTTGCAACGGTCATTGACCGTTCCGGCGTCGCGGTGCGCGCCGGGACCCACTGCGCCA
TGCCGCTCTTGGAGCGCTTCGGCGTGTCCGCGACCTGCCGGGCGTCGTTCGCGATGTACAACACGCGGGAAGAGGTCGAC
GTGCTGGTGCGCGCGCTGAAGAAGGCGCAGGAGTTCTTCTCGTAG

Upstream 100 bases:

>100_bases
CCAGGCCTTCATCGGCGAGATCATCGAGGGCGCGGCCAACGAAGCCGTGCGTGACGCGCTGACCGGGGCGCTGCTGGGCT
GGCTCGGACGACGGGAGTAG

Downstream 100 bases:

>100_bases
AGACAGAATTCCGCGCGCAATTGACGCGAAGAAGCGGTGCCAATTGCTGCGCCCTCTCCCCTTGTGGGAGAGGGCTACAC
CGCTATCAGCTCCAGACTCG

Product: cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MMHAAVNGSGYDVSRIRADFPILGMQVHGKPLVYLDNAASAQKPQAVLDRMNQVYTSEYANVHRGLHYLANAATEAYEGA
RAKVATFLNAESPEQIIFTRGATEAVNLVAQTFGRERIGPGDEIVLSIMEHHANIIPWHFLRERQGAVIKWAPVDDDGNF
LLDEFEKLLSPRTKMVAMTQMSNVLGTVVPVKEVIRIAHDRGIPVLVDGSQAAVHMEVDVRDIDADFYCITGHKIYGPTG
IGALYGKRELLASMPPFNGGGEMIREVSRDWVTYGDPPHRFEAGTPPIVEAAGLGAAIDYVASIGKQRIAAHEHDLVTYA
TEQLREINSLRIIGNAADKGAIVSFEMQGAHAHDFATVIDRSGVAVRAGTHCAMPLLERFGVSATCRASFAMYNTREEVD
VLVRALKKAQEFFS

Sequences:

>Translated_414_residues
MMHAAVNGSGYDVSRIRADFPILGMQVHGKPLVYLDNAASAQKPQAVLDRMNQVYTSEYANVHRGLHYLANAATEAYEGA
RAKVATFLNAESPEQIIFTRGATEAVNLVAQTFGRERIGPGDEIVLSIMEHHANIIPWHFLRERQGAVIKWAPVDDDGNF
LLDEFEKLLSPRTKMVAMTQMSNVLGTVVPVKEVIRIAHDRGIPVLVDGSQAAVHMEVDVRDIDADFYCITGHKIYGPTG
IGALYGKRELLASMPPFNGGGEMIREVSRDWVTYGDPPHRFEAGTPPIVEAAGLGAAIDYVASIGKQRIAAHEHDLVTYA
TEQLREINSLRIIGNAADKGAIVSFEMQGAHAHDFATVIDRSGVAVRAGTHCAMPLLERFGVSATCRASFAMYNTREEVD
VLVRALKKAQEFFS
>Mature_414_residues
MMHAAVNGSGYDVSRIRADFPILGMQVHGKPLVYLDNAASAQKPQAVLDRMNQVYTSEYANVHRGLHYLANAATEAYEGA
RAKVATFLNAESPEQIIFTRGATEAVNLVAQTFGRERIGPGDEIVLSIMEHHANIIPWHFLRERQGAVIKWAPVDDDGNF
LLDEFEKLLSPRTKMVAMTQMSNVLGTVVPVKEVIRIAHDRGIPVLVDGSQAAVHMEVDVRDIDADFYCITGHKIYGPTG
IGALYGKRELLASMPPFNGGGEMIREVSRDWVTYGDPPHRFEAGTPPIVEAAGLGAAIDYVASIGKQRIAAHEHDLVTYA
TEQLREINSLRIIGNAADKGAIVSFEMQGAHAHDFATVIDRSGVAVRAGTHCAMPLLERFGVSATCRASFAMYNTREEVD
VLVRALKKAQEFFS

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=393, Percent_Identity=27.9898218829517, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI156713448, Length=459, Percent_Identity=27.8867102396514, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=47.029702970297, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=42.4317617866005, Blast_Score=331, Evalue=4e-92,
Organism=Escherichia coli, GI48994898, Length=394, Percent_Identity=25.1269035532995, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=216, Percent_Identity=30.0925925925926, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=28.643216080402, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI20129463, Length=280, Percent_Identity=31.7857142857143, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45324; Mature: 45324

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHAAVNGSGYDVSRIRADFPILGMQVHGKPLVYLDNAASAQKPQAVLDRMNQVYTSEYA
CCEEEECCCCCCHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NVHRGLHYLANAATEAYEGARAKVATFLNAESPEQIIFTRGATEAVNLVAQTFGRERIGP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC
GDEIVLSIMEHHANIIPWHFLRERQGAVIKWAPVDDDGNFLLDEFEKLLSPRTKMVAMTQ
HHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHH
MSNVLGTVVPVKEVIRIAHDRGIPVLVDGSQAAVHMEVDVRDIDADFYCITGHKIYGPTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEEECCCCEEEEECCEEECCCC
IGALYGKRELLASMPPFNGGGEMIREVSRDWVTYGDPPHRFEAGTPPIVEAAGLGAAIDY
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHH
VASIGKQRIAAHEHDLVTYATEQLREINSLRIIGNAADKGAIVSFEMQGAHAHDFATVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHC
RSGVAVRAGTHCAMPLLERFGVSATCRASFAMYNTREEVDVLVRALKKAQEFFS
CCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMHAAVNGSGYDVSRIRADFPILGMQVHGKPLVYLDNAASAQKPQAVLDRMNQVYTSEYA
CCEEEECCCCCCHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NVHRGLHYLANAATEAYEGARAKVATFLNAESPEQIIFTRGATEAVNLVAQTFGRERIGP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC
GDEIVLSIMEHHANIIPWHFLRERQGAVIKWAPVDDDGNFLLDEFEKLLSPRTKMVAMTQ
HHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHH
MSNVLGTVVPVKEVIRIAHDRGIPVLVDGSQAAVHMEVDVRDIDADFYCITGHKIYGPTG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEEEECCCCEEEEECCEEECCCC
IGALYGKRELLASMPPFNGGGEMIREVSRDWVTYGDPPHRFEAGTPPIVEAAGLGAAIDY
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHH
VASIGKQRIAAHEHDLVTYATEQLREINSLRIIGNAADKGAIVSFEMQGAHAHDFATVID
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHC
RSGVAVRAGTHCAMPLLERFGVSATCRASFAMYNTREEVDVLVRALKKAQEFFS
CCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]