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The map label for this gene is dxs [C]

Identifier: 146341659

GI number: 146341659

Start: 4957153

End: 4958166

Strand: Reverse

Name: dxs [C]

Synonym: BRADO4763

Alternate gene names: 146341659

Gene position: 4958166-4957153 (Counterclockwise)

Preceding gene: 146341660

Following gene: 146341658

Centisome position: 66.49

GC content: 67.85

Gene sequence:

>1014_bases
ATGACTTCCAAGAGACCCGCTCCGGATCTGAGCAAGCCGCGCCTGACGACCTCGGCGATGATCGCCTCGATCGCCTCCGA
GGGCCAGCGCACCAAGCCGGCGCCGTTCGGCCACGCGCTGGTCGAGCTGGCGCGCAGCCGGCCCGAGGTCGTCGGCATGA
CTGCCGATCTCGGCAAATACACCGACCTGCACATCTTCGCGAAGGAGTTCCCCGATCGCACCTACCAGATGGGCATGGCC
GAGCAGCTGTTGTTCGGCGCGGCGTCCGGCCTGGCGGCGGAAGGCTTCATGCCGTTCACCACGACCTATGCCGTGTTCGC
CTCGCGCCGCGCCTACGACTTCATCCATCAGACGATCGCCGAGGAAGATCGCAACGTGAAGATCGCCTGCGCGCTGCCAG
GCCTGACCTCCGGCTACGGCCCGAGCCACCAGGCGGCCGAGGATCTCGCGCTGATGCGCGCGATGCCGAACATGACGGTG
ATCGATCCGTGCGACGCGCATGAGATCGCGCAGGTGGTGCCGGCAATGGCTGCTCATCAGGGCCCGGTCTACATGCGGCT
GCTGCGCGGCCAGGTGCCGCTGGTGCTCGACGAGTACGACTACAAGTTCGAGCTCGGCAAGGCCAAGCTGCTGCGCGACG
GCCGCGACGTCCTGTTCATCTCCTCCGGCCTGATGACGATGCGCGCGCTGGAGGCAGCCACGGCCTTGTCCGACGATCAC
GTCGACGTCGCGGTGCTGCACGTGCCGACGATCAAGCCCCTCGACGCCGAGACCATCGCGCGCGAGGCCGGCCGCTCCGG
CCGTCTCGTCGTCGTCGCCGAGAACCATACGGTGATCGGCGGGCTGGGTGAGGCCGTCGCCGGGGTGCTGATGCGTGCAG
GCGTGCATGTGCCGTTCCGGCAGATCGGCCTGCCCGACGAATTCCTCGACGCCGGCGCGCTGCCGACGCTGCACGACCGC
TACGGCATCTCGCTGTCGGAGGTCGTGAAGCAGGTGAAGGGCTGGCTCAAATAG

Upstream 100 bases:

>100_bases
GCGTGCCGTTCCTCGAACAACGCGAGAAGAACCATTTCATTCGCGTCGAGCCGCATGAATGGCAGCTCGCGATTGCCGCA
CTCGACGCCGGGAGGCCGTG

Downstream 100 bases:

>100_bases
CGGACCAGCCGCGGACATCGACACGCCGGCGCGTGGACGCGCCGGCCATAACAACAATTCAGACTGGAGGGATGGGAATG
CGCAAGGGAACGACGCGTCG

Product: putative transketolase, beta-subunit

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTSKRPAPDLSKPRLTTSAMIASIASEGQRTKPAPFGHALVELARSRPEVVGMTADLGKYTDLHIFAKEFPDRTYQMGMA
EQLLFGAASGLAAEGFMPFTTTYAVFASRRAYDFIHQTIAEEDRNVKIACALPGLTSGYGPSHQAAEDLALMRAMPNMTV
IDPCDAHEIAQVVPAMAAHQGPVYMRLLRGQVPLVLDEYDYKFELGKAKLLRDGRDVLFISSGLMTMRALEAATALSDDH
VDVAVLHVPTIKPLDAETIAREAGRSGRLVVVAENHTVIGGLGEAVAGVLMRAGVHVPFRQIGLPDEFLDAGALPTLHDR
YGISLSEVVKQVKGWLK

Sequences:

>Translated_337_residues
MTSKRPAPDLSKPRLTTSAMIASIASEGQRTKPAPFGHALVELARSRPEVVGMTADLGKYTDLHIFAKEFPDRTYQMGMA
EQLLFGAASGLAAEGFMPFTTTYAVFASRRAYDFIHQTIAEEDRNVKIACALPGLTSGYGPSHQAAEDLALMRAMPNMTV
IDPCDAHEIAQVVPAMAAHQGPVYMRLLRGQVPLVLDEYDYKFELGKAKLLRDGRDVLFISSGLMTMRALEAATALSDDH
VDVAVLHVPTIKPLDAETIAREAGRSGRLVVVAENHTVIGGLGEAVAGVLMRAGVHVPFRQIGLPDEFLDAGALPTLHDR
YGISLSEVVKQVKGWLK
>Mature_336_residues
TSKRPAPDLSKPRLTTSAMIASIASEGQRTKPAPFGHALVELARSRPEVVGMTADLGKYTDLHIFAKEFPDRTYQMGMAE
QLLFGAASGLAAEGFMPFTTTYAVFASRRAYDFIHQTIAEEDRNVKIACALPGLTSGYGPSHQAAEDLALMRAMPNMTVI
DPCDAHEIAQVVPAMAAHQGPVYMRLLRGQVPLVLDEYDYKFELGKAKLLRDGRDVLFISSGLMTMRALEAATALSDDHV
DVAVLHVPTIKPLDAETIAREAGRSGRLVVVAENHTVIGGLGEAVAGVLMRAGVHVPFRQIGLPDEFLDAGALPTLHDRY
GISLSEVVKQVKGWLK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637461, Length=307, Percent_Identity=33.8762214983713, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI225637463, Length=307, Percent_Identity=33.5504885993485, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI225637459, Length=307, Percent_Identity=33.8762214983713, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI205277463, Length=260, Percent_Identity=31.5384615384615, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4507521, Length=260, Percent_Identity=31.5384615384615, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI133778974, Length=303, Percent_Identity=32.3432343234323, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786622, Length=325, Percent_Identity=29.2307692307692, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788808, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=306, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24645119, Length=335, Percent_Identity=31.044776119403, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551847, Length=335, Percent_Identity=31.044776119403, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45550715, Length=335, Percent_Identity=31.044776119403, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24666278, Length=259, Percent_Identity=32.046332046332, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 36462; Mature: 36330

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKRPAPDLSKPRLTTSAMIASIASEGQRTKPAPFGHALVELARSRPEVVGMTADLGKY
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
TDLHIFAKEFPDRTYQMGMAEQLLFGAASGLAAEGFMPFTTTYAVFASRRAYDFIHQTIA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDRNVKIACALPGLTSGYGPSHQAAEDLALMRAMPNMTVIDPCDAHEIAQVVPAMAAHQ
HCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCC
GPVYMRLLRGQVPLVLDEYDYKFELGKAKLLRDGRDVLFISSGLMTMRALEAATALSDDH
CHHHHHHHCCCCCEEEECCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCC
VDVAVLHVPTIKPLDAETIAREAGRSGRLVVVAENHTVIGGLGEAVAGVLMRAGVHVPFR
CEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHCCCCCCHH
QIGLPDEFLDAGALPTLHDRYGISLSEVVKQVKGWLK
HCCCCHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TSKRPAPDLSKPRLTTSAMIASIASEGQRTKPAPFGHALVELARSRPEVVGMTADLGKY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
TDLHIFAKEFPDRTYQMGMAEQLLFGAASGLAAEGFMPFTTTYAVFASRRAYDFIHQTIA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDRNVKIACALPGLTSGYGPSHQAAEDLALMRAMPNMTVIDPCDAHEIAQVVPAMAAHQ
HCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCC
GPVYMRLLRGQVPLVLDEYDYKFELGKAKLLRDGRDVLFISSGLMTMRALEAATALSDDH
CHHHHHHHCCCCCEEEECCCCEEECCHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCC
VDVAVLHVPTIKPLDAETIAREAGRSGRLVVVAENHTVIGGLGEAVAGVLMRAGVHVPFR
CEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHCCCCCCHH
QIGLPDEFLDAGALPTLHDRYGISLSEVVKQVKGWLK
HCCCCHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]