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The map label for this gene is pleC [H]

Identifier: 146341638

GI number: 146341638

Start: 4934146

End: 4935744

Strand: Direct

Name: pleC [H]

Synonym: BRADO4741

Alternate gene names: 146341638

Gene position: 4934146-4935744 (Clockwise)

Preceding gene: 146341637

Following gene: 146341639

Centisome position: 66.17

GC content: 66.6

Gene sequence:

>1599_bases
ATGAGTAAACCCGCGGAAAAGCCCGAGATCGTCGAGCTTCCGGCCGATGCGCCGGCGCTCGCGCCGGTCAGCCAGCGCCG
GGCGGCGCAGCAGCGGGTGCGCGAGGCGCGCGACCGGTTAACGTCGACATCGGGAACGCGGCCGGCCTTCGACCGCGAGC
TGCTGCGCCAATATGCGCAGACCCGCATCTCCGCCTCCTACATCGTGATGCTGCTGGTCGTCGCGACCGGCATGATGCTG
AGCGTCTGGCTGCACGCGGTCGCCGCGGGCGCCTGGACGCTCGGCGTGCTCTGCATCCACGCCGCGATCGTGCGCAACTG
CTCGAACTTCCTGGCCGACCAGCCATCGCTGGCGGCGACGCGGCGCTGGCGGACCCGCTTCGTGCTGCTCGACCTGCTCT
ACGGCGTGTGCTGGATGGCGATCCTGATCCACCCCGCGCTGGCGGAGGTGTCGGGCACGCTGATGATGTTCCTGATGCTG
CTGGTCATCGCCGTGTCCAGCATGCTCGCAGCGAACCTGCCAGTGGCAGCCGTCGCGGTGACCGCGCCGGTGACGGTCGC
GATCACGCTGAGCCTCGCGCTGTCGGGCACGTTCGACAATTATCTGCTTGCCGGATTTGCCGTCGCGGCCGAAGGCTATT
TCGTGCTGCTCGCGCATCAGCTGCATTCGACCACGCTGGCCACGCTCGAGGCGCGCGCCGAGAAGGATGCGCTGATCGGC
GAGCTCGAGCAGGCCAAGGCGATCTCCGACGAGGCACGCTACCGCGCCGAAGCGGCCAATGTCGCCAAATCGCGCTTCCT
CGCCCAGATGAGCCACGAGCTGCGCACGCCGCTGAACGCCATTCTCGGCTTCTCCGAGGTGATGAAGAGCGAGATCTTCG
GCGCCCATGCGGTGCCGGTCTACAAGGAATACTCGGCCGACATCCACAATTCCGGCGTCCACCTGCTCAATTTGATCAAC
GAGATCCTCGACCTCTCGCGCATCGAGGCCGGCCGCTACGAGCTTAACGAGGAAGCGGTGGCGCTGGTGCATGTGATCGC
GGACTGCCATCATCTGCTCAAGCTGCGCGCCTCGAGCCGCGGCATCACCATCCACGAGGTGTTCGAGCAGAAAATGCCGC
GTCTGTGGGCCGACGAGCGCGCGATCCGCCAGGTCGTGCTGAACCTGCTGTCCAACGCCATCAAGTTCACGCCGCAGGGC
GGCGAGATCTGGCTGAAGGCGGGCTGGACGGCGTCCGGCGGGCAATATCTCAGCGTCAAGGACACCGGCTCCGGCATCCC
GGAGAACGAGATCCCGATCGTGCTCGCCTCGTTCGGCCAGGGCTCGAATTCGATCAAGTCAGCCGAACAAGGCGCGGGCC
TGGGGCTTCCGATCGCCAAGAACCTGATCGAGATGCATGGCGGCACGTTCACGCTGAAATCGAAGGTCCGCATCGGCACC
GAGGTGATCGTCACCTTCCCGCCCGAGCGCGTGATGTCGGCGCTGGCGCCGCTGTCCGACGAGGCGCCGCCGCTGCAACC
GGATCCTGCCACCGCGCCCGCTCAGGAGAAGCGGCGGCTGCTGCGCAAACCGATCATGAATGCCGGAACGGGACTGTGA

Upstream 100 bases:

>100_bases
CAAATTTTTCGTTGTCTATAATCCGTCTTAAGGATTTGGAGCCAGTTATAGACGATGCAGAAAGCAGCCCGTGCGGCCCC
GGGCAGGATTTGTGTTGTTG

Downstream 100 bases:

>100_bases
GATGATTGACCTTGCAAAGCCGGACCAGAACCTTTTCAACTCGCGGCATGAGCCAGGATTCCCCCTGCATTGCCGTCTGC
TTGATCGACCCCAAGACGAA

Product: putative sensor histidine kinase membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSKPAEKPEIVELPADAPALAPVSQRRAAQQRVREARDRLTSTSGTRPAFDRELLRQYAQTRISASYIVMLLVVATGMML
SVWLHAVAAGAWTLGVLCIHAAIVRNCSNFLADQPSLAATRRWRTRFVLLDLLYGVCWMAILIHPALAEVSGTLMMFLML
LVIAVSSMLAANLPVAAVAVTAPVTVAITLSLALSGTFDNYLLAGFAVAAEGYFVLLAHQLHSTTLATLEARAEKDALIG
ELEQAKAISDEARYRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLIN
EILDLSRIEAGRYELNEEAVALVHVIADCHHLLKLRASSRGITIHEVFEQKMPRLWADERAIRQVVLNLLSNAIKFTPQG
GEIWLKAGWTASGGQYLSVKDTGSGIPENEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKNLIEMHGGTFTLKSKVRIGT
EVIVTFPPERVMSALAPLSDEAPPLQPDPATAPAQEKRRLLRKPIMNAGTGL

Sequences:

>Translated_532_residues
MSKPAEKPEIVELPADAPALAPVSQRRAAQQRVREARDRLTSTSGTRPAFDRELLRQYAQTRISASYIVMLLVVATGMML
SVWLHAVAAGAWTLGVLCIHAAIVRNCSNFLADQPSLAATRRWRTRFVLLDLLYGVCWMAILIHPALAEVSGTLMMFLML
LVIAVSSMLAANLPVAAVAVTAPVTVAITLSLALSGTFDNYLLAGFAVAAEGYFVLLAHQLHSTTLATLEARAEKDALIG
ELEQAKAISDEARYRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLIN
EILDLSRIEAGRYELNEEAVALVHVIADCHHLLKLRASSRGITIHEVFEQKMPRLWADERAIRQVVLNLLSNAIKFTPQG
GEIWLKAGWTASGGQYLSVKDTGSGIPENEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKNLIEMHGGTFTLKSKVRIGT
EVIVTFPPERVMSALAPLSDEAPPLQPDPATAPAQEKRRLLRKPIMNAGTGL
>Mature_531_residues
SKPAEKPEIVELPADAPALAPVSQRRAAQQRVREARDRLTSTSGTRPAFDRELLRQYAQTRISASYIVMLLVVATGMMLS
VWLHAVAAGAWTLGVLCIHAAIVRNCSNFLADQPSLAATRRWRTRFVLLDLLYGVCWMAILIHPALAEVSGTLMMFLMLL
VIAVSSMLAANLPVAAVAVTAPVTVAITLSLALSGTFDNYLLAGFAVAAEGYFVLLAHQLHSTTLATLEARAEKDALIGE
LEQAKAISDEARYRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPVYKEYSADIHNSGVHLLNLINE
ILDLSRIEAGRYELNEEAVALVHVIADCHHLLKLRASSRGITIHEVFEQKMPRLWADERAIRQVVLNLLSNAIKFTPQGG
EIWLKAGWTASGGQYLSVKDTGSGIPENEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKNLIEMHGGTFTLKSKVRIGTE
VIVTFPPERVMSALAPLSDEAPPLQPDPATAPAQEKRRLLRKPIMNAGTGL

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=31.0483870967742, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=33.0508474576271, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=34.3629343629344, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=34.9442379182156, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=31.7343173431734, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=28.3950617283951, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87082128, Length=213, Percent_Identity=31.4553990610329, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=339, Percent_Identity=24.188790560472, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=26.9076305220884, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=24.7863247863248, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=26.4423076923077, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=27.1551724137931, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=22.0338983050847, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=238, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57616; Mature: 57484

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50109 HIS_KIN ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPAEKPEIVELPADAPALAPVSQRRAAQQRVREARDRLTSTSGTRPAFDRELLRQYAQ
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TRISASYIVMLLVVATGMMLSVWLHAVAAGAWTLGVLCIHAAIVRNCSNFLADQPSLAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RRWRTRFVLLDLLYGVCWMAILIHPALAEVSGTLMMFLMLLVIAVSSMLAANLPVAAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAPVTVAITLSLALSGTFDNYLLAGFAVAAEGYFVLLAHQLHSTTLATLEARAEKDALIG
HCCHHEEEEEHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
ELEQAKAISDEARYRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YKEYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAVALVHVIADCHHLLKLRASSR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GITIHEVFEQKMPRLWADERAIRQVVLNLLSNAIKFTPQGGEIWLKAGWTASGGQYLSVK
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEE
DTGSGIPENEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKNLIEMHGGTFTLKSKVRIGT
CCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCEEECC
EVIVTFPPERVMSALAPLSDEAPPLQPDPATAPAQEKRRLLRKPIMNAGTGL
EEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPAEKPEIVELPADAPALAPVSQRRAAQQRVREARDRLTSTSGTRPAFDRELLRQYAQ
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TRISASYIVMLLVVATGMMLSVWLHAVAAGAWTLGVLCIHAAIVRNCSNFLADQPSLAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RRWRTRFVLLDLLYGVCWMAILIHPALAEVSGTLMMFLMLLVIAVSSMLAANLPVAAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAPVTVAITLSLALSGTFDNYLLAGFAVAAEGYFVLLAHQLHSTTLATLEARAEKDALIG
HCCHHEEEEEHHHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
ELEQAKAISDEARYRAEAANVAKSRFLAQMSHELRTPLNAILGFSEVMKSEIFGAHAVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
YKEYSADIHNSGVHLLNLINEILDLSRIEAGRYELNEEAVALVHVIADCHHLLKLRASSR
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GITIHEVFEQKMPRLWADERAIRQVVLNLLSNAIKFTPQGGEIWLKAGWTASGGQYLSVK
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCEEEEE
DTGSGIPENEIPIVLASFGQGSNSIKSAEQGAGLGLPIAKNLIEMHGGTFTLKSKVRIGT
CCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCEEECC
EVIVTFPPERVMSALAPLSDEAPPLQPDPATAPAQEKRRLLRKPIMNAGTGL
EEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]