Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 146341611

GI number: 146341611

Start: 4900619

End: 4902004

Strand: Reverse

Name: gor [H]

Synonym: BRADO4712

Alternate gene names: 146341611

Gene position: 4902004-4900619 (Counterclockwise)

Preceding gene: 146341612

Following gene: 146341610

Centisome position: 65.74

GC content: 66.52

Gene sequence:

>1386_bases
ATGGCTGAATTCGATGTCGACCTGTTCGTGATCGGCGGCGGCTCGGGTGGCGTGCGCGCCGCCCGGATCGCGGCCGGCTA
TGGCGCCCGCGTCATGGTCGCCGAGGAATACCGCATGGGCGGCACCTGCGTGATTCGCGGCTGCGTGCCCAAGAAGCTGT
TCGTGATCGGCTCGCATGTCCGCCAGGAGATCGCTGACGCCGCCGGCTTCGGCTGGACGATCCCGACCGCGACGTTCGAC
TGGTCGACGCTGATCGCCAACAAGGACAAGGAGATCGCGCGGCTCGAGGCAGCCTACGCCGCCAATGTCGAGAAGTCGGG
CGCCAGGATCGTCAAGACCCGCGCCGTGCTGGAGGACGCCCACACCGTGCGGCTCGCCAACGGCGAGACGGTGCGTGCGA
AATACATCCTGATCGCGACCGGCGGCGCGCCCAACCATGGCACGCCGATTCCCGGCATCGAGCACGTCATCTCCTCCAAC
GAGGCGTTTCACCTTGACGAGCTGCCGCGCCGCATCGTGATCCAGGGCGGCGGCTACATCGCGCTGGAATTCGCCTGCAT
CTTCGCCAATTTCGGCTCCGACGTCACCGTGGTCTATCGCGGCGACAACATCCTGCGCGGCTTCGACGAGGACGTCCGCA
AGCATGTCCGCAGCGAGATGGAGAAGGAAGGCATCACCATCCTGACCGGCTGCACGGTGGCGAGCGTCGACAAGCACGGC
AAGGACTACACGACGCATCTGTCGAACGGCTCCAGCATCGCCTCCGACAAGGTGATGTTCGCGATCGGCCGCCATCCGGC
GGTCGCCAATCTCGGCCTGGAGAAGGCGGGCGTCGCGATCAATCCGCGCAATGGCGGCATCGCGGTCGACGCGTTCTCGC
AGAGCTCGGTGCCGAGCATCTACGCGATCGGCGACGTCACCCATCGCTTCAACCTGACGCCGGTGGCGATCCGCGAGGGC
CATGCCTTCGCCGACACCGTGTTCGGCGGCAAGACCGTGCGGGTCGACCACGCCGACATTCCAACCGCGGTGTTCTGCCA
GCCTGAAGTCGGCACCGTTGGGCTGACGGAAACCCAGGCGCGCGAGCTGCACGACCGGGTCGACATCTACAAGTCCACGT
TCCGTCCGATCAAGGCGACGATGTCCGGCCGCGACACCCGCGTGCTGATGAAGCTCGTCGTCGACGGCGCGAGCGATCGC
GTGCTCGGCTGCCATATCGTCGGCGACACCGCGGCCGAGATCACCCAGGCGGTGGCCATCGCTATCAAGATGAAGGCGAC
CAAGGCCGATTTCGACGCGACGATCGCGCTGCATCCGTCCGCCGCCGAGGAACTGGTGACGATGCGCACCGTGACCGAGC
GGCATGTGAGGCAGGCCGCGGAGTAG

Upstream 100 bases:

>100_bases
GAGTTCTCGGAGACCGTGACCGCGCAGTTCCGCGCCGAGATGCGCAAGCGCAACAAGCCGATCTGAGGCTTGCGGCGGCA
AAGGTCGATTCGGAGGACAC

Downstream 100 bases:

>100_bases
GGGCCGGCAGGGGACGGTCGCGACCCGTCTTGAAAAGGTGGGGGTTGGATGTTGGTCTGGCGTCGCTCTGTCTGGTTTGC
AGGCCTGCTGGGGAGTTTGG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAEFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLFVIGSHVRQEIADAAGFGWTIPTATFD
WSTLIANKDKEIARLEAAYAANVEKSGARIVKTRAVLEDAHTVRLANGETVRAKYILIATGGAPNHGTPIPGIEHVISSN
EAFHLDELPRRIVIQGGGYIALEFACIFANFGSDVTVVYRGDNILRGFDEDVRKHVRSEMEKEGITILTGCTVASVDKHG
KDYTTHLSNGSSIASDKVMFAIGRHPAVANLGLEKAGVAINPRNGGIAVDAFSQSSVPSIYAIGDVTHRFNLTPVAIREG
HAFADTVFGGKTVRVDHADIPTAVFCQPEVGTVGLTETQARELHDRVDIYKSTFRPIKATMSGRDTRVLMKLVVDGASDR
VLGCHIVGDTAAEITQAVAIAIKMKATKADFDATIALHPSAAEELVTMRTVTERHVRQAAE

Sequences:

>Translated_461_residues
MAEFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLFVIGSHVRQEIADAAGFGWTIPTATFD
WSTLIANKDKEIARLEAAYAANVEKSGARIVKTRAVLEDAHTVRLANGETVRAKYILIATGGAPNHGTPIPGIEHVISSN
EAFHLDELPRRIVIQGGGYIALEFACIFANFGSDVTVVYRGDNILRGFDEDVRKHVRSEMEKEGITILTGCTVASVDKHG
KDYTTHLSNGSSIASDKVMFAIGRHPAVANLGLEKAGVAINPRNGGIAVDAFSQSSVPSIYAIGDVTHRFNLTPVAIREG
HAFADTVFGGKTVRVDHADIPTAVFCQPEVGTVGLTETQARELHDRVDIYKSTFRPIKATMSGRDTRVLMKLVVDGASDR
VLGCHIVGDTAAEITQAVAIAIKMKATKADFDATIALHPSAAEELVTMRTVTERHVRQAAE
>Mature_460_residues
AEFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLFVIGSHVRQEIADAAGFGWTIPTATFDW
STLIANKDKEIARLEAAYAANVEKSGARIVKTRAVLEDAHTVRLANGETVRAKYILIATGGAPNHGTPIPGIEHVISSNE
AFHLDELPRRIVIQGGGYIALEFACIFANFGSDVTVVYRGDNILRGFDEDVRKHVRSEMEKEGITILTGCTVASVDKHGK
DYTTHLSNGSSIASDKVMFAIGRHPAVANLGLEKAGVAINPRNGGIAVDAFSQSSVPSIYAIGDVTHRFNLTPVAIREGH
AFADTVFGGKTVRVDHADIPTAVFCQPEVGTVGLTETQARELHDRVDIYKSTFRPIKATMSGRDTRVLMKLVVDGASDRV
LGCHIVGDTAAEITQAVAIAIKMKATKADFDATIALHPSAAEELVTMRTVTERHVRQAAE

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=38.8646288209607, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI148277065, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI33519430, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI33519428, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI33519426, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI148277071, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=34.061135371179, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=33.1923890063425, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI291045268, Length=471, Percent_Identity=30.7855626326964, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=30.5676855895196, Blast_Score=175, Evalue=8e-44,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=39.4431554524362, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=30.5010893246187, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=30.7349665924276, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87082354, Length=450, Percent_Identity=25.5555555555556, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789065, Length=194, Percent_Identity=27.8350515463918, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=38.5321100917431, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=38.5321100917431, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=31.7124735729387, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71982272, Length=440, Percent_Identity=30.6818181818182, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=29.6703296703297, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17559934, Length=226, Percent_Identity=29.2035398230088, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=36.6594360086768, Blast_Score=282, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=28.8793103448276, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=29.2631578947368, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=32.4380165289256, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=32.4947589098532, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=32.4947589098532, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=32.4947589098532, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=31.0043668122271, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49334; Mature: 49203

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLFVIGSHV
CCCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCEEEEEHHHH
RQEIADAAGFGWTIPTATFDWSTLIANKDKEIARLEAAYAANVEKSGARIVKTRAVLEDA
HHHHHHHCCCCEECCCCCCCHHHEECCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCC
HTVRLANGETVRAKYILIATGGAPNHGTPIPGIEHVISSNEAFHLDELPRRIVIQGGGYI
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCCEE
ALEFACIFANFGSDVTVVYRGDNILRGFDEDVRKHVRSEMEKEGITILTGCTVASVDKHG
EEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCEEEEHHHCC
KDYTTHLSNGSSIASDKVMFAIGRHPAVANLGLEKAGVAINPRNGGIAVDAFSQSSVPSI
CCEEEEECCCCCCCCCCEEEEECCCCCEECCCCCCCCCEEECCCCCEEEEECCCCCCCEE
YAIGDVTHRFNLTPVAIREGHAFADTVFGGKTVRVDHADIPTAVFCQPEVGTVGLTETQA
EEEECEEEEECCCEEEEECCCEEEHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHH
RELHDRVDIYKSTFRPIKATMSGRDTRVLMKLVVDGASDRVLGCHIVGDTAAEITQAVAI
HHHHHHHHHHHHHCCHHEECCCCCHHHEEHHHHHCCCCCCEEEEEEECCCHHHHHHHEEE
AIKMKATKADFDATIALHPSAAEELVTMRTVTERHVRQAAE
EEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEFDVDLFVIGGGSGGVRAARIAAGYGARVMVAEEYRMGGTCVIRGCVPKKLFVIGSHV
CCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCEEEEEHHHH
RQEIADAAGFGWTIPTATFDWSTLIANKDKEIARLEAAYAANVEKSGARIVKTRAVLEDA
HHHHHHHCCCCEECCCCCCCHHHEECCCCHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCC
HTVRLANGETVRAKYILIATGGAPNHGTPIPGIEHVISSNEAFHLDELPRRIVIQGGGYI
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCCEE
ALEFACIFANFGSDVTVVYRGDNILRGFDEDVRKHVRSEMEKEGITILTGCTVASVDKHG
EEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCEEEEHHHCC
KDYTTHLSNGSSIASDKVMFAIGRHPAVANLGLEKAGVAINPRNGGIAVDAFSQSSVPSI
CCEEEEECCCCCCCCCCEEEEECCCCCEECCCCCCCCCEEECCCCCEEEEECCCCCCCEE
YAIGDVTHRFNLTPVAIREGHAFADTVFGGKTVRVDHADIPTAVFCQPEVGTVGLTETQA
EEEECEEEEECCCEEEEECCCEEEHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHH
RELHDRVDIYKSTFRPIKATMSGRDTRVLMKLVVDGASDRVLGCHIVGDTAAEITQAVAI
HHHHHHHHHHHHHCCHHEECCCCCHHHEEHHHHHCCCCCCEEEEEEECCCHHHHHHHEEE
AIKMKATKADFDATIALHPSAAEELVTMRTVTERHVRQAAE
EEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]