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The map label for this gene is ilvX [H]

Identifier: 146341370

GI number: 146341370

Start: 4657161

End: 4658822

Strand: Reverse

Name: ilvX [H]

Synonym: BRADO4456

Alternate gene names: 146341370

Gene position: 4658822-4657161 (Counterclockwise)

Preceding gene: 146341372

Following gene: 146341369

Centisome position: 62.48

GC content: 68.35

Gene sequence:

>1662_bases
ATGCCCAATGGCGCGCAAGCTCTGGTCAGGACCCTCGCCAATGCCGGCGTGCGGGTCTGCTTCACCAATCCCGGCACCTC
TGAAATGCACTTCGTCGCCGCGTTGGACACGGCGTCGGAGATGCGCGCGGTGCTGTGCCTGTTCGAAGGCGTCGCCACCG
GTGCTGCGGACGGCTATGCCCGCATGACCGGCACGCCGGCGGCGACTCTGCTGCATCTCGGCTGCGGGCTCGGTAACGGC
CTCGCCAACCTGCACAATGCGCGCAAGGGCAAGGTGCCCGTCGTCAACATCGTCGGTGACCACGCGACCTATCACGTCAA
ATACGACGCTCAGCTGCAGTCGGACATCGAGACCGTCGCGCGCAACGTCTCACCGAGCTTCGTCTGGACCTCGCAGGTGA
CATCCGAACTCTGCCGCGATGCGGTCGCGGCGGTGAAAGCTGCGTGCTCATGGCCGGGGCAGGTGGCGACCCTGATCCTG
CCGGCCGACGTGTCCTGGGGCGAGGGCGGCGTGCCCGAGCCGGCACCGGTGATCGAGCCGCCGCCTTTGGCCGACGACGC
GGCCGTGCAGGCAGTCGCCGCCGCGATCAAGGCGGGCGGCCGCAGCGCCATCCTGCTGGGCGGCACGGCGTTGCAGGAGC
AGGCGCTGCTCGCCGCCGCACGCATCGCCGCGAGCTGCGGCGTCAAGGTTTTCGCCGAGACGTTTCCGACGCGGATGGAA
CGCGGCGCCGGCCTGCCGGGCGTCGAACGCATCGCCTATCTCGCCGAGATGGCACAGATCCAGCTCAAGGAGATCGACAC
GCTCGTCCTGGTCGATGCCAAGGCGCCGGTCTCGTTCTTTGCCTATCCTGGCAAGAGGAGCTATCTGCCGCACGACGGCT
GCAAGGTGCTGACGCTCTCGACGCCTGCGGAAGATGCCGCGGGAAGCCTGGCCAAGCTGGTCAAGGCGCTCGGCGCCGAG
CAGGCGACACCAGAATTGGCGGCCCCTTCGCGGCCCGGGCGTCCGCGCGGCAACAGGCTGACGGCTGAGAAGGTCTGCAA
GGCCGTCGGCCATCTTCTGCCGGAGAACGCCATCATCATCGACGAGGCGATCAGCTCCGGCCTGATGCTGTCGAAGTTCA
CCGCCGGCGCGCCGCGCCACGATCTGATCACCTTGACCGGCGGCGCCATCGGGCAGGGGCTGCCGAATGCGATCGGCGCC
GCGATTGCCTGCCCGGACCGGCCGGTGATCGCGCTGATCGGCGATGGCAGCTCGATGTACACGATCCAGTCGTTGTGGAC
GATCGCGCGCGAGCGGCTCAACGTCACCGCGGTGATCTTCAACAACGCATCCTACTCGGTGCTCAATGTCGAACTGGAGC
GGGTCGGGGCCGAGAAGATCGGACCGAAGGCGCGTGCGCAGCTCGACCTGCACGGGCCGGTGCTGAAATTCGCGCAGATC
GCCGACGGCATGGGCGTGCGGGCGACACGCGTCACCACGCCGGACGAGTTCACCGATGCGCTGGCCTGTTCGCTGAAGCG
CCCGGGTCCCCATCTGATCGAGGCCGTGGTGCCGCCGGCGCTGAGCGGGCTGAAGCTGAAGCTGCTGCCGCATCTGCTGG
GATCGCTCGACCGCGTGCCGCTGCCGGTGGCGCGCATGCTCAAGCGCAAGATTGCGCCGTGA

Upstream 100 bases:

>100_bases
AGACGGTCAATCTCAGAATGGCGCAAACATATCAGGGGAAATACCGGGGCGGGCCGCCGTGTCGCGCCAGTCTCCGGCTT
CCCCGTCAAGAGGCTTTCCA

Downstream 100 bases:

>100_bases
CATGAGCGCGCCGCTGCAAGCCGACCTCGTCATCGCCGGCGGCGGCCTCGCCGGCATCGTCACCGCGCTCGAGGCTTTGC
GCGCCGGCAACTCCGTCGTA

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MPNGAQALVRTLANAGVRVCFTNPGTSEMHFVAALDTASEMRAVLCLFEGVATGAADGYARMTGTPAATLLHLGCGLGNG
LANLHNARKGKVPVVNIVGDHATYHVKYDAQLQSDIETVARNVSPSFVWTSQVTSELCRDAVAAVKAACSWPGQVATLIL
PADVSWGEGGVPEPAPVIEPPPLADDAAVQAVAAAIKAGGRSAILLGGTALQEQALLAAARIAASCGVKVFAETFPTRME
RGAGLPGVERIAYLAEMAQIQLKEIDTLVLVDAKAPVSFFAYPGKRSYLPHDGCKVLTLSTPAEDAAGSLAKLVKALGAE
QATPELAAPSRPGRPRGNRLTAEKVCKAVGHLLPENAIIIDEAISSGLMLSKFTAGAPRHDLITLTGGAIGQGLPNAIGA
AIACPDRPVIALIGDGSSMYTIQSLWTIARERLNVTAVIFNNASYSVLNVELERVGAEKIGPKARAQLDLHGPVLKFAQI
ADGMGVRATRVTTPDEFTDALACSLKRPGPHLIEAVVPPALSGLKLKLLPHLLGSLDRVPLPVARMLKRKIAP

Sequences:

>Translated_553_residues
MPNGAQALVRTLANAGVRVCFTNPGTSEMHFVAALDTASEMRAVLCLFEGVATGAADGYARMTGTPAATLLHLGCGLGNG
LANLHNARKGKVPVVNIVGDHATYHVKYDAQLQSDIETVARNVSPSFVWTSQVTSELCRDAVAAVKAACSWPGQVATLIL
PADVSWGEGGVPEPAPVIEPPPLADDAAVQAVAAAIKAGGRSAILLGGTALQEQALLAAARIAASCGVKVFAETFPTRME
RGAGLPGVERIAYLAEMAQIQLKEIDTLVLVDAKAPVSFFAYPGKRSYLPHDGCKVLTLSTPAEDAAGSLAKLVKALGAE
QATPELAAPSRPGRPRGNRLTAEKVCKAVGHLLPENAIIIDEAISSGLMLSKFTAGAPRHDLITLTGGAIGQGLPNAIGA
AIACPDRPVIALIGDGSSMYTIQSLWTIARERLNVTAVIFNNASYSVLNVELERVGAEKIGPKARAQLDLHGPVLKFAQI
ADGMGVRATRVTTPDEFTDALACSLKRPGPHLIEAVVPPALSGLKLKLLPHLLGSLDRVPLPVARMLKRKIAP
>Mature_552_residues
PNGAQALVRTLANAGVRVCFTNPGTSEMHFVAALDTASEMRAVLCLFEGVATGAADGYARMTGTPAATLLHLGCGLGNGL
ANLHNARKGKVPVVNIVGDHATYHVKYDAQLQSDIETVARNVSPSFVWTSQVTSELCRDAVAAVKAACSWPGQVATLILP
ADVSWGEGGVPEPAPVIEPPPLADDAAVQAVAAAIKAGGRSAILLGGTALQEQALLAAARIAASCGVKVFAETFPTRMER
GAGLPGVERIAYLAEMAQIQLKEIDTLVLVDAKAPVSFFAYPGKRSYLPHDGCKVLTLSTPAEDAAGSLAKLVKALGAEQ
ATPELAAPSRPGRPRGNRLTAEKVCKAVGHLLPENAIIIDEAISSGLMLSKFTAGAPRHDLITLTGGAIGQGLPNAIGAA
IACPDRPVIALIGDGSSMYTIQSLWTIARERLNVTAVIFNNASYSVLNVELERVGAEKIGPKARAQLDLHGPVLKFAQIA
DGMGVRATRVTTPDEFTDALACSLKRPGPHLIEAVVPPALSGLKLKLLPHLLGSLDRVPLPVARMLKRKIAP

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=548, Percent_Identity=24.4525547445255, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081685, Length=543, Percent_Identity=22.6519337016575, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787096, Length=185, Percent_Identity=23.7837837837838, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 57570; Mature: 57439

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNGAQALVRTLANAGVRVCFTNPGTSEMHFVAALDTASEMRAVLCLFEGVATGAADGYA
CCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
RMTGTPAATLLHLGCGLGNGLANLHNARKGKVPVVNIVGDHATYHVKYDAQLQSDIETVA
EECCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
RNVSPSFVWTSQVTSELCRDAVAAVKAACSWPGQVATLILPADVSWGEGGVPEPAPVIEP
HCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
PPLADDAAVQAVAAAIKAGGRSAILLGGTALQEQALLAAARIAASCGVKVFAETFPTRME
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RGAGLPGVERIAYLAEMAQIQLKEIDTLVLVDAKAPVSFFAYPGKRSYLPHDGCKVLTLS
HCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEC
TPAEDAAGSLAKLVKALGAEQATPELAAPSRPGRPRGNRLTAEKVCKAVGHLLPENAIII
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
DEAISSGLMLSKFTAGAPRHDLITLTGGAIGQGLPNAIGAAIACPDRPVIALIGDGSSMY
EHHHHCCCEEEHHCCCCCCCCEEEEECCHHCCCCCHHHCCEEECCCCCEEEEEECCCCCH
TIQSLWTIARERLNVTAVIFNNASYSVLNVELERVGAEKIGPKARAQLDLHGPVLKFAQI
HHHHHHHHHHHHCCEEEEEECCCCEEEEEEEHHHCCHHHCCCCHHEEEECCCHHHHHHHH
ADGMGVRATRVTTPDEFTDALACSLKRPGPHLIEAVVPPALSGLKLKLLPHLLGSLDRVP
HCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
LPVARMLKRKIAP
CHHHHHHHHHCCC
>Mature Secondary Structure 
PNGAQALVRTLANAGVRVCFTNPGTSEMHFVAALDTASEMRAVLCLFEGVATGAADGYA
CCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCE
RMTGTPAATLLHLGCGLGNGLANLHNARKGKVPVVNIVGDHATYHVKYDAQLQSDIETVA
EECCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
RNVSPSFVWTSQVTSELCRDAVAAVKAACSWPGQVATLILPADVSWGEGGVPEPAPVIEP
HCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
PPLADDAAVQAVAAAIKAGGRSAILLGGTALQEQALLAAARIAASCGVKVFAETFPTRME
CCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RGAGLPGVERIAYLAEMAQIQLKEIDTLVLVDAKAPVSFFAYPGKRSYLPHDGCKVLTLS
HCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEC
TPAEDAAGSLAKLVKALGAEQATPELAAPSRPGRPRGNRLTAEKVCKAVGHLLPENAIII
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
DEAISSGLMLSKFTAGAPRHDLITLTGGAIGQGLPNAIGAAIACPDRPVIALIGDGSSMY
EHHHHCCCEEEHHCCCCCCCCEEEEECCHHCCCCCHHHCCEEECCCCCEEEEEECCCCCH
TIQSLWTIARERLNVTAVIFNNASYSVLNVELERVGAEKIGPKARAQLDLHGPVLKFAQI
HHHHHHHHHHHHCCEEEEEECCCCEEEEEEEHHHCCHHHCCCCHHEEEECCCHHHHHHHH
ADGMGVRATRVTTPDEFTDALACSLKRPGPHLIEAVVPPALSGLKLKLLPHLLGSLDRVP
HCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
LPVARMLKRKIAP
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]