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The map label for this gene is parE [H]

Identifier: 146340513

GI number: 146340513

Start: 3747154

End: 3749229

Strand: Reverse

Name: parE [H]

Synonym: BRADO3555

Alternate gene names: 146340513

Gene position: 3749229-3747154 (Counterclockwise)

Preceding gene: 146340525

Following gene: 146340512

Centisome position: 50.28

GC content: 67.05

Gene sequence:

>2076_bases
ATGGGTAAGCCGTTGAAATCAGCTGCAAAAGCCAAGGCCAAGGGGGTCGCCGACCCGCTGGCGGCGTTCGCCGCCAAGGG
CAAGGCCCAGACCAAGCATCAAGCCAAGCCAGCCGCACGCGCGGCCGGATCCGAGGGCGAATATACCGCCCGCGACATCG
AGGTGCTCGAGGGCCTGGAGCCGGTGCGCCGCCGCCCCGGCATGTATATCGGCGGCACCGACGAGAAGGCGCTGCACCAC
CTCTTCGCAGAGGTCATCGACAACTCGATGGACGAGGCGCTGGCCGGCCACGCCACCTTCATCGAGGTCGAACTCGACGC
CCAGGGCTTCCTGACCGTGACCGACAACGGCCGCGGCATTCCGATTGATCCGCATCCGAAGTTTCCGAAGAAGTCGGCGC
TCGAGATCATCATGTGCACGCTGCATGCAGGCGGCAAGTTCGACTCCAAGGTCTACGAGACCTCGGGCGGCTTGCACGGC
GTCGGCATCTCCGTGGTGAACGCGCTGTCGACCCGGCTCGAGGTCGAGGTCGCGCGCAACCAGAAGCTCTACCGCATGAT
CTTCGAGCGCGGCCATCCCAAGGGCAAGCTCGAGGAGGTCGGCAAGGCCCCCAACCGCCGCGGCACCAAGGTGCGCTTCC
AGCCCGACCCGACCATCTTCGGCGCCAAGGCGACATTCAAGCCGCAGCGCCTGTTCAAGATGGCCCGCTCCAAGGCCTAT
CTGTTCGGCGGCGTCGAGATCCGCTGGAAGTGCGATCCGTCGCTGCTCAAGGGCATCGAGGACGTCCAGCCCGAGGCGAC
GTTCCACTTCCCGGGCGGCCTGAAGGACTATCTGGCCGCAGCGATCCATGCCGACACGCTGGTCCATCCGGACATCTTCG
CCGGCAAGTCCGGCCGCACCGGCGGCCATGGCGGCTGCGAATGGGCGGTCGCCTGGACGGCCGATGCCGACGGCTTCTTG
TCGTCCTACTGCAACACCATCCCGACGCCCGACGGCGGCACGCACGAATCGGGCATCCGCAGCGCACTCCTTCGCGGCCT
GAAGGACCATGCCGAGCGCGTCGGCCAGGGCAAGCGCTCGGCCAACATCACCTCCGAGGACATCATGGCGGGCGCCGCCA
TCATGCTCTCGGTGTTCGTGCGCGAGCCGGAATTCCAGGGCCAGACCAAGGACCGACTCGCGACCGCCGAGGCGCAGCGC
ATCGTCGAGCAGGCCGTCAAGGACCCGTTCGACCACTGGCTGTCGGGCAATCCGGTGCAGGCGAACAGGCTGCTCGACTT
CGTCGTCGAGCGCGCCGAGGAGCGCATCCGCCGCCGCCAGGAGAAGGAGACGGCGCGCAAGACCGCGACCAAGAAGCTGC
GCCTGCCCGGCAAACTCGCCGACTGCACCGACGCCGGGACGGAAGGCTCCGAGCTGTTCATCGTCGAGGGCGATTCGGCC
GGCGGCAGCGCCAAGCAGGCGCGCGACCGCAAGAAGCAGGCGGTGCTGCCGCTGCGCGGCAAGATCCTCAACGTCGCCTC
CGCCGGCAAGGACAAGCTGACCGCCAACGCCCAGCTCGCCGACCTCGTGATGGCGATCGGCGCCGGGACCGGAACGTCGT
ACCGCGAAGAGGATCTGCGCTACCAGCGCATCATCATCATGACCGACGCCGACGTCGACGGCGCCCACATCGCCTCGCTG
CTGATCACCTTCTTCTACCGGCAGATGCCGCGGCTGATCGACGAGGGGCACCTCTATCTGGCGGTGCCGCCGCTGTACCG
GCTCACCCATGGCAGCAAGACGTTCTACGCCCGCGACGACGCCCACAGGGATGAGCTTTTGAGGCGCGAGTTCAACGCCA
ATGCCAAGGTCGAGATCGGCCGCTTCAAAGGCCTGGGCGAGATGATGCCGGCGCAGCTCAAGGAGACCACCATGGATCCG
GCCAAGCGGACCCTGCTCCGGGTGATGCTGCTGGCCGACGATCGCGATGGCACCGCCGACTCGGTCGAGCGGCTGATGGG
CACCAAGGCCGAGGCGCGTTTCGCCTTCATCTCGGAAAAGGCGGAATTCGCCAGCGACGAGTTGCTCGACGTCTAG

Upstream 100 bases:

>100_bases
GCGATGGTCCGCGTTCCCAGGTCATTGTTTTATGCCGGGGCATGGCATAGTCAGGCGCAACGATTCGTTCCATCTTGCGC
CAGCGCAACATCAAGATTCT

Downstream 100 bases:

>100_bases
CTTTTGACCCGATGTCTCGTATCGATTGCAGGTTCCACGCGTTCGCGTGGGCCTGCTTTTTTCTTTTATAAACAATTTGT
TACCACGGAGCCTCGCATCC

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 690

Protein sequence:

>691_residues
MGKPLKSAAKAKAKGVADPLAAFAAKGKAQTKHQAKPAARAAGSEGEYTARDIEVLEGLEPVRRRPGMYIGGTDEKALHH
LFAEVIDNSMDEALAGHATFIEVELDAQGFLTVTDNGRGIPIDPHPKFPKKSALEIIMCTLHAGGKFDSKVYETSGGLHG
VGISVVNALSTRLEVEVARNQKLYRMIFERGHPKGKLEEVGKAPNRRGTKVRFQPDPTIFGAKATFKPQRLFKMARSKAY
LFGGVEIRWKCDPSLLKGIEDVQPEATFHFPGGLKDYLAAAIHADTLVHPDIFAGKSGRTGGHGGCEWAVAWTADADGFL
SSYCNTIPTPDGGTHESGIRSALLRGLKDHAERVGQGKRSANITSEDIMAGAAIMLSVFVREPEFQGQTKDRLATAEAQR
IVEQAVKDPFDHWLSGNPVQANRLLDFVVERAEERIRRRQEKETARKTATKKLRLPGKLADCTDAGTEGSELFIVEGDSA
GGSAKQARDRKKQAVLPLRGKILNVASAGKDKLTANAQLADLVMAIGAGTGTSYREEDLRYQRIIIMTDADVDGAHIASL
LITFFYRQMPRLIDEGHLYLAVPPLYRLTHGSKTFYARDDAHRDELLRREFNANAKVEIGRFKGLGEMMPAQLKETTMDP
AKRTLLRVMLLADDRDGTADSVERLMGTKAEARFAFISEKAEFASDELLDV

Sequences:

>Translated_691_residues
MGKPLKSAAKAKAKGVADPLAAFAAKGKAQTKHQAKPAARAAGSEGEYTARDIEVLEGLEPVRRRPGMYIGGTDEKALHH
LFAEVIDNSMDEALAGHATFIEVELDAQGFLTVTDNGRGIPIDPHPKFPKKSALEIIMCTLHAGGKFDSKVYETSGGLHG
VGISVVNALSTRLEVEVARNQKLYRMIFERGHPKGKLEEVGKAPNRRGTKVRFQPDPTIFGAKATFKPQRLFKMARSKAY
LFGGVEIRWKCDPSLLKGIEDVQPEATFHFPGGLKDYLAAAIHADTLVHPDIFAGKSGRTGGHGGCEWAVAWTADADGFL
SSYCNTIPTPDGGTHESGIRSALLRGLKDHAERVGQGKRSANITSEDIMAGAAIMLSVFVREPEFQGQTKDRLATAEAQR
IVEQAVKDPFDHWLSGNPVQANRLLDFVVERAEERIRRRQEKETARKTATKKLRLPGKLADCTDAGTEGSELFIVEGDSA
GGSAKQARDRKKQAVLPLRGKILNVASAGKDKLTANAQLADLVMAIGAGTGTSYREEDLRYQRIIIMTDADVDGAHIASL
LITFFYRQMPRLIDEGHLYLAVPPLYRLTHGSKTFYARDDAHRDELLRREFNANAKVEIGRFKGLGEMMPAQLKETTMDP
AKRTLLRVMLLADDRDGTADSVERLMGTKAEARFAFISEKAEFASDELLDV
>Mature_690_residues
GKPLKSAAKAKAKGVADPLAAFAAKGKAQTKHQAKPAARAAGSEGEYTARDIEVLEGLEPVRRRPGMYIGGTDEKALHHL
FAEVIDNSMDEALAGHATFIEVELDAQGFLTVTDNGRGIPIDPHPKFPKKSALEIIMCTLHAGGKFDSKVYETSGGLHGV
GISVVNALSTRLEVEVARNQKLYRMIFERGHPKGKLEEVGKAPNRRGTKVRFQPDPTIFGAKATFKPQRLFKMARSKAYL
FGGVEIRWKCDPSLLKGIEDVQPEATFHFPGGLKDYLAAAIHADTLVHPDIFAGKSGRTGGHGGCEWAVAWTADADGFLS
SYCNTIPTPDGGTHESGIRSALLRGLKDHAERVGQGKRSANITSEDIMAGAAIMLSVFVREPEFQGQTKDRLATAEAQRI
VEQAVKDPFDHWLSGNPVQANRLLDFVVERAEERIRRRQEKETARKTATKKLRLPGKLADCTDAGTEGSELFIVEGDSAG
GSAKQARDRKKQAVLPLRGKILNVASAGKDKLTANAQLADLVMAIGAGTGTSYREEDLRYQRIIIMTDADVDGAHIASLL
ITFFYRQMPRLIDEGHLYLAVPPLYRLTHGSKTFYARDDAHRDELLRREFNANAKVEIGRFKGLGEMMPAQLKETTMDPA
KRTLLRVMLLADDRDGTADSVERLMGTKAEARFAFISEKAEFASDELLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=626, Percent_Identity=24.4408945686901, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI19913408, Length=678, Percent_Identity=24.3362831858407, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1789408, Length=644, Percent_Identity=42.7018633540373, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI48994957, Length=565, Percent_Identity=44.6017699115044, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17535065, Length=650, Percent_Identity=25.2307692307692, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=563, Percent_Identity=23.4458259325044, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=205, Percent_Identity=29.2682926829268, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=663, Percent_Identity=25.7918552036199, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136538, Length=594, Percent_Identity=25.9259259259259, Blast_Score=132, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 75580; Mature: 75449

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKPLKSAAKAKAKGVADPLAAFAAKGKAQTKHQAKPAARAAGSEGEYTARDIEVLEGLE
CCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCHHHHHHHHHCCH
PVRRRPGMYIGGTDEKALHHLFAEVIDNSMDEALAGHATFIEVELDAQGFLTVTDNGRGI
HHHHCCCEEECCCCHHHHHHHHHHHHHCHHHHHHCCCEEEEEEEECCCEEEEECCCCCCC
PIDPHPKFPKKSALEIIMCTLHAGGKFDSKVYETSGGLHGVGISVVNALSTRLEVEVARN
CCCCCCCCCCHHHHEEEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEEEHHC
QKLYRMIFERGHPKGKLEEVGKAPNRRGTKVRFQPDPTIFGAKATFKPQRLFKMARSKAY
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHHHHCCEE
LFGGVEIRWKCDPSLLKGIEDVQPEATFHFPGGLKDYLAAAIHADTLVHPDIFAGKSGRT
EEECEEEEEECCHHHHCCHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGHGGCEWAVAWTADADGFLSSYCNTIPTPDGGTHESGIRSALLRGLKDHAERVGQGKRS
CCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
ANITSEDIMAGAAIMLSVFVREPEFQGQTKDRLATAEAQRIVEQAVKDPFDHWLSGNPVQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCC
ANRLLDFVVERAEERIRRRQEKETARKTATKKLRLPGKLADCTDAGTEGSELFIVEGDSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCC
GGSAKQARDRKKQAVLPLRGKILNVASAGKDKLTANAQLADLVMAIGAGTGTSYREEDLR
CCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC
YQRIIIMTDADVDGAHIASLLITFFYRQMPRLIDEGHLYLAVPPLYRLTHGSKTFYARDD
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCEEEECCC
AHRDELLRREFNANAKVEIGRFKGLGEMMPAQLKETTMDPAKRTLLRVMLLADDRDGTAD
HHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHH
SVERLMGTKAEARFAFISEKAEFASDELLDV
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
GKPLKSAAKAKAKGVADPLAAFAAKGKAQTKHQAKPAARAAGSEGEYTARDIEVLEGLE
CCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCHHHHHHHHHCCH
PVRRRPGMYIGGTDEKALHHLFAEVIDNSMDEALAGHATFIEVELDAQGFLTVTDNGRGI
HHHHCCCEEECCCCHHHHHHHHHHHHHCHHHHHHCCCEEEEEEEECCCEEEEECCCCCCC
PIDPHPKFPKKSALEIIMCTLHAGGKFDSKVYETSGGLHGVGISVVNALSTRLEVEVARN
CCCCCCCCCCHHHHEEEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEEEHHC
QKLYRMIFERGHPKGKLEEVGKAPNRRGTKVRFQPDPTIFGAKATFKPQRLFKMARSKAY
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHHHHCCEE
LFGGVEIRWKCDPSLLKGIEDVQPEATFHFPGGLKDYLAAAIHADTLVHPDIFAGKSGRT
EEECEEEEEECCHHHHCCHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGHGGCEWAVAWTADADGFLSSYCNTIPTPDGGTHESGIRSALLRGLKDHAERVGQGKRS
CCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
ANITSEDIMAGAAIMLSVFVREPEFQGQTKDRLATAEAQRIVEQAVKDPFDHWLSGNPVQ
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCC
ANRLLDFVVERAEERIRRRQEKETARKTATKKLRLPGKLADCTDAGTEGSELFIVEGDSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCC
GGSAKQARDRKKQAVLPLRGKILNVASAGKDKLTANAQLADLVMAIGAGTGTSYREEDLR
CCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC
YQRIIIMTDADVDGAHIASLLITFFYRQMPRLIDEGHLYLAVPPLYRLTHGSKTFYARDD
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCEEEECCC
AHRDELLRREFNANAKVEIGRFKGLGEMMPAQLKETTMDPAKRTLLRVMLLADDRDGTAD
HHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHH
SVERLMGTKAEARFAFISEKAEFASDELLDV
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9797224 [H]