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The map label for this gene is aadR [H]

Identifier: 146340402

GI number: 146340402

Start: 3620725

End: 3621462

Strand: Reverse

Name: aadR [H]

Synonym: BRADO3435

Alternate gene names: 146340402

Gene position: 3621462-3620725 (Counterclockwise)

Preceding gene: 146340404

Following gene: 146340401

Centisome position: 48.57

GC content: 63.96

Gene sequence:

>738_bases
TTGAGTCACTTGGTCCGCAAGCTCGAGAACTTCGTCCGCCTCTCGGCGGCCGACCGTCTGATGCTCAATCGCGCGTCGGC
GCAGCGGGTCAGAACCTTTGCACCGCGGACCGACATCGCGCGCGAGGGCGAGAAGCCGAAGGACGTCCACCTGATCCTCA
ACGGATGGGCCTGCCGCTACAAGCAGCTCGAGGATGGCCGCCGCCAGATCGTGTCATTCTTCCTGCCCGGCGACATCTGC
GACCTCAACATCTTCATCCTGCGCGAGATGGACCATTCGATCGGCACCATCACCTCGGTGTCGGTCGCCGACCTGTCGCG
CGAGTTCTTCGATGAGATCAGCGCGGGCTATCCGCGCGTCGCGACGGCGTTCTGGTGGGAGACGCTGGTCAATGCCGCGA
TCCAGCGCGAGTGGACCATGAACCTCGGGCAGCGCACCGCCTCCGAGCGCATGGCGCATCTATTGTGCGAGCTGTTCTTC
CGCCTGCGGCTCGCGGGCCTCGCCGACGACCACAGCTGCAGTTTTCCACTGACGCAGGCCGACCTCGCCGAAGCCACGGG
ACTGTCGAAGGTCCACGTCAACCGCACGCTCCAGGAGCTGCGCGCCAGCAACCTGATCGTGCTGAAGGGTAAGATGCTGG
TCCTTCCCGACCTGGATCGCCTCATGAGCGCTGGCCTGTTCAATGCCAATTATCTGCATCTCGACCGTGAAGGTCGCCAG
CTCGACGCGAACGAGTGA

Upstream 100 bases:

>100_bases
TGCGTCGGCGCGAGATCGCAAATGATGAGCTTCCGTGCTAACATAAGTTATTGTGGTGGCCCCGTGAGGAACTCCTATAA
GCAATTGGGGGAACCGATCC

Downstream 100 bases:

>100_bases
GAGATTCCTGCGCCGAGGGCATGCGACTTGCGCCAGGCCTGCCGGCTCGGGCATGGTACCGGAGAAACGGCAATGGTCGA
ACAGCGTATGGGCGAAGGAA

Product: CRP/FNR family transcriptional regulator

Products: NA

Alternate protein names: Anaerobic aromatic degradation regulator [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSHLVRKLENFVRLSAADRLMLNRASAQRVRTFAPRTDIAREGEKPKDVHLILNGWACRYKQLEDGRRQIVSFFLPGDIC
DLNIFILREMDHSIGTITSVSVADLSREFFDEISAGYPRVATAFWWETLVNAAIQREWTMNLGQRTASERMAHLLCELFF
RLRLAGLADDHSCSFPLTQADLAEATGLSKVHVNRTLQELRASNLIVLKGKMLVLPDLDRLMSAGLFNANYLHLDREGRQ
LDANE

Sequences:

>Translated_245_residues
MSHLVRKLENFVRLSAADRLMLNRASAQRVRTFAPRTDIAREGEKPKDVHLILNGWACRYKQLEDGRRQIVSFFLPGDIC
DLNIFILREMDHSIGTITSVSVADLSREFFDEISAGYPRVATAFWWETLVNAAIQREWTMNLGQRTASERMAHLLCELFF
RLRLAGLADDHSCSFPLTQADLAEATGLSKVHVNRTLQELRASNLIVLKGKMLVLPDLDRLMSAGLFNANYLHLDREGRQ
LDANE
>Mature_244_residues
SHLVRKLENFVRLSAADRLMLNRASAQRVRTFAPRTDIAREGEKPKDVHLILNGWACRYKQLEDGRRQIVSFFLPGDICD
LNIFILREMDHSIGTITSVSVADLSREFFDEISAGYPRVATAFWWETLVNAAIQREWTMNLGQRTASERMAHLLCELFFR
LRLAGLADDHSCSFPLTQADLAEATGLSKVHVNRTLQELRASNLIVLKGKMLVLPDLDRLMSAGLFNANYLHLDREGRQL
DANE

Specific function: Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27899; Mature: 27768

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLVRKLENFVRLSAADRLMLNRASAQRVRTFAPRTDIAREGEKPKDVHLILNGWACRY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCHHHH
KQLEDGRRQIVSFFLPGDICDLNIFILREMDHSIGTITSVSVADLSREFFDEISAGYPRV
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
ATAFWWETLVNAAIQREWTMNLGQRTASERMAHLLCELFFRLRLAGLADDHSCSFPLTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
DLAEATGLSKVHVNRTLQELRASNLIVLKGKMLVLPDLDRLMSAGLFNANYLHLDREGRQ
HHHHHCCCHHHHHHHHHHHHHHCCEEEEECCEEECCCHHHHHHCCCCCCEEEEECCCCCC
LDANE
CCCCC
>Mature Secondary Structure 
SHLVRKLENFVRLSAADRLMLNRASAQRVRTFAPRTDIAREGEKPKDVHLILNGWACRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEECCHHHH
KQLEDGRRQIVSFFLPGDICDLNIFILREMDHSIGTITSVSVADLSREFFDEISAGYPRV
HHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
ATAFWWETLVNAAIQREWTMNLGQRTASERMAHLLCELFFRLRLAGLADDHSCSFPLTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
DLAEATGLSKVHVNRTLQELRASNLIVLKGKMLVLPDLDRLMSAGLFNANYLHLDREGRQ
HHHHHCCCHHHHHHHHHHHHHHCCEEEEECCEEECCCHHHHHHCCCCCCEEEEECCCCCC
LDANE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1522059; 10094687 [H]