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The map label for this gene is purM [H]

Identifier: 146340321

GI number: 146340321

Start: 3541047

End: 3542126

Strand: Direct

Name: purM [H]

Synonym: BRADO3344

Alternate gene names: 146340321

Gene position: 3541047-3542126 (Clockwise)

Preceding gene: 146340316

Following gene: 146340322

Centisome position: 47.49

GC content: 68.33

Gene sequence:

>1080_bases
TTGACCATGACCGAGCGCAAAAACGGGCTCACTTATGCAGATTCGGGCGTCGATATCGACGCCGGCAATCGTCTGGTCGA
TCTGATCAAGCCGATGGTGCGCGCGACCGCGCGCCCGGGCGCGGACGCCGAGATCGGCGGCTTCGGCGGCCTGTTCGACC
TCAAGGCGGCCGGCTTCAAGGACCCCGTCCTGGTGGCGGCCACTGACGGCGTCGGCACCAAGGTCAAGATCGCGATCGAG
ACCGGGCTGCATGGCGGCATCGGCATCGACCTCGTGGCGATGTCGGTGAACGACCTCGTGGTGCAGGGCGCCGAGCCGCT
GTTCTTCCTCGACTACTTCGCCTGCGGCAAGCTCGACCCGGAGGCGACCGCCTCGATCGTCGCCGGCATCGCCGAAGGCT
GCCGGGAGTCCGGCTGCGCGCTGATCGGCGGCGAGACGGCGGAAATGCCGGGCCTCTACCAGGATGGCGACTACGACCTC
GGCGGTTTCGCTGTCGGCGCCGCTGAGCGCGGCACGCTGCTGCCGTCGCCCGACATCGCGGCCGGCGATATCGTGCTCGG
CCTGGCCTCGTCCGGCGTGCATTCAAACGGCTATTCGCTGGTGCGCAAGATCGTCGCCCAGTCGGGCCTCGGCTTCGATG
CGCCGGCGCCGTTCGCGCCAGTGCTGACGCTCGGCGCGGCGCTGCTGACGCCGACGCGGCTCTACGTGAAATCGTGCCTG
CGCGCCATCCGTGAGACCGGTGCTGTGAAGGGCCTGGCGCATATCACCGGCGGCGGCTTCACCGACAACATTCCGCGCGT
GCTGCCGAAGCATCTCGCCGTCTCCATCGACCTGACGCATCTGCCGGTGCTGCCGGTGTTCAAATGGCTGGCCGAGCAAG
GCGGCCTTGCCGAGCGCGAGCTGTTGCGCACCTTCAATTGCGGGATCGGCATGATCGTGATCGTCAGGGCCGACGCGGTC
GACGCCGTCGCCGAGGTGTTCACCGCCAATGGCGAGCATGTCGCGCGGCTCGGCGAGGTCGTCGCAGCCACGGGCGAGGA
GCGCGTGATCTACACCGGCGCGCTCGATTTGTCGCTGTGA

Upstream 100 bases:

>100_bases
CGGCGAACCCGTCCGGTTCCTAGATAGGGTGGGGACGAGCCCCTTGCGAGCCATTGCGCGCGGCCGGAATCCGACGTAAC
CAGCGGCCAGATTAGGGGTT

Downstream 100 bases:

>100_bases
GACGAGCCCGCCGATGAAGCGCCGCGTCGCGATCCTGATTTCCGGCCGCGGGTCCAACATGGCCGCACTCATCCGCGCGG
CGGCCGCGCCGGATTTCCCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTMTERKNGLTYADSGVDIDAGNRLVDLIKPMVRATARPGADAEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKVKIAIE
TGLHGGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEATASIVAGIAEGCRESGCALIGGETAEMPGLYQDGDYDL
GGFAVGAAERGTLLPSPDIAAGDIVLGLASSGVHSNGYSLVRKIVAQSGLGFDAPAPFAPVLTLGAALLTPTRLYVKSCL
RAIRETGAVKGLAHITGGGFTDNIPRVLPKHLAVSIDLTHLPVLPVFKWLAEQGGLAERELLRTFNCGIGMIVIVRADAV
DAVAEVFTANGEHVARLGEVVAATGEERVIYTGALDLSL

Sequences:

>Translated_359_residues
MTMTERKNGLTYADSGVDIDAGNRLVDLIKPMVRATARPGADAEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKVKIAIE
TGLHGGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEATASIVAGIAEGCRESGCALIGGETAEMPGLYQDGDYDL
GGFAVGAAERGTLLPSPDIAAGDIVLGLASSGVHSNGYSLVRKIVAQSGLGFDAPAPFAPVLTLGAALLTPTRLYVKSCL
RAIRETGAVKGLAHITGGGFTDNIPRVLPKHLAVSIDLTHLPVLPVFKWLAEQGGLAERELLRTFNCGIGMIVIVRADAV
DAVAEVFTANGEHVARLGEVVAATGEERVIYTGALDLSL
>Mature_358_residues
TMTERKNGLTYADSGVDIDAGNRLVDLIKPMVRATARPGADAEIGGFGGLFDLKAAGFKDPVLVAATDGVGTKVKIAIET
GLHGGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDPEATASIVAGIAEGCRESGCALIGGETAEMPGLYQDGDYDLG
GFAVGAAERGTLLPSPDIAAGDIVLGLASSGVHSNGYSLVRKIVAQSGLGFDAPAPFAPVLTLGAALLTPTRLYVKSCLR
AIRETGAVKGLAHITGGGFTDNIPRVLPKHLAVSIDLTHLPVLPVFKWLAEQGGLAERELLRTFNCGIGMIVIVRADAVD
AVAEVFTANGEHVARLGEVVAATGEERVIYTGALDLSL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=348, Percent_Identity=55.1724137931034, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=348, Percent_Identity=55.1724137931034, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=348, Percent_Identity=55.1724137931034, Blast_Score=372, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=348, Percent_Identity=50.2873563218391, Blast_Score=334, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17567511, Length=349, Percent_Identity=45.8452722063037, Blast_Score=297, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=57.1005917159763, Blast_Score=384, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=46.5034965034965, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37010; Mature: 36879

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTERKNGLTYADSGVDIDAGNRLVDLIKPMVRATARPGADAEIGGFGGLFDLKAAGFK
CCCCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHCCCCCC
DPVLVAATDGVGTKVKIAIETGLHGGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDP
CCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEHHHHHCCCCCCEEEEEHHHCCCCCH
EATASIVAGIAEGCRESGCALIGGETAEMPGLYQDGDYDLGGFAVGAAERGTLLPSPDIA
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AGDIVLGLASSGVHSNGYSLVRKIVAQSGLGFDAPAPFAPVLTLGAALLTPTRLYVKSCL
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
RAIRETGAVKGLAHITGGGFTDNIPRVLPKHLAVSIDLTHLPVLPVFKWLAEQGGLAERE
HHHHHHCHHCCHHEECCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCHHHH
LLRTFNCGIGMIVIVRADAVDAVAEVFTANGEHVARLGEVVAATGEERVIYTGALDLSL
HHHHHCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
TMTERKNGLTYADSGVDIDAGNRLVDLIKPMVRATARPGADAEIGGFGGLFDLKAAGFK
CCCCCCCCCEEECCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHCCCCCC
DPVLVAATDGVGTKVKIAIETGLHGGIGIDLVAMSVNDLVVQGAEPLFFLDYFACGKLDP
CCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEEHHHHHCCCCCCEEEEEHHHCCCCCH
EATASIVAGIAEGCRESGCALIGGETAEMPGLYQDGDYDLGGFAVGAAERGTLLPSPDIA
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AGDIVLGLASSGVHSNGYSLVRKIVAQSGLGFDAPAPFAPVLTLGAALLTPTRLYVKSCL
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHH
RAIRETGAVKGLAHITGGGFTDNIPRVLPKHLAVSIDLTHLPVLPVFKWLAEQGGLAERE
HHHHHHCHHCCHHEECCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCHHHH
LLRTFNCGIGMIVIVRADAVDAVAEVFTANGEHVARLGEVVAATGEERVIYTGALDLSL
HHHHHCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA