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The map label for this gene is ndk

Identifier: 146340311

GI number: 146340311

Start: 3531391

End: 3531813

Strand: Direct

Name: ndk

Synonym: BRADO3334

Alternate gene names: 146340311

Gene position: 3531391-3531813 (Clockwise)

Preceding gene: 146340307

Following gene: 146340312

Centisome position: 47.36

GC content: 65.72

Gene sequence:

>423_bases
ATGGCGATTGAGCGCACCTTTTCGATCATCAAGCCCGACGCGACCGAGCGTAATCTCACCGGCGCGATCAACGCGCTGAT
CGAGAAGGCCGGACTGCGCATCGTGGCCCAGAAGCGCATCCGCATGACCCGCGACCAGGCCGAGACCTTCTACGCCGTCC
ACAAGGCCCGCCCGTTCTTCGGCGAGCTCGTCGACTTCATGATCTCCGGCCCGGTGGTGGTCCAGGTGCTCGAGGGCGAA
GGCGCCATCCTGAAGTACCGCGACGTCATGGGCGCCACCGATCCGTCGAAGGCTGCCGAGGGCACCATCCGCAAGGCGCA
TGCGAAGTCGATCGGCGAGAACTCGGTGCACGGCTCGGACGCGCCGGAGACCGCCGCGATCGAGATCGCACAGTTCTTCG
CCGGCAACGAGATCGTCGGCTGA

Upstream 100 bases:

>100_bases
GCGTCGCGCCTCTGGAAGGGCCTCGGTCGCTTGCCGTCGACCGATCGCGTCGATATAAGCCCGCAACCCACCCAAATCCC
GCACATCCGAGGACGATATC

Downstream 100 bases:

>100_bases
GCGACGATTGCTGCGGCGGAGCCTCGCTCCGCCGCAATCCCGCTGAATGCATCTGAAAGGTCTGGCCGTGAACTGGCTGT
CGCAGCTCGCTGATCCCGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTRDQAETFYAVHKARPFFGELVDFMISGPVVVQVLEGE
GAILKYRDVMGATDPSKAAEGTIRKAHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG

Sequences:

>Translated_140_residues
MAIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTRDQAETFYAVHKARPFFGELVDFMISGPVVVQVLEGE
GAILKYRDVMGATDPSKAAEGTIRKAHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG
>Mature_139_residues
AIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTRDQAETFYAVHKARPFFGELVDFMISGPVVVQVLEGEG
AILKYRDVMGATDPSKAAEGTIRKAHAKSIGENSVHGSDAPETAAIEIAQFFAGNEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=40.5797101449275, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.8759124087591, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.8759124087591, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.8759124087591, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.8759124087591, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.8759124087591, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=40.8759124087591, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=40.8759124087591, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=35.2941176470588, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.8235294117647, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI4505413, Length=121, Percent_Identity=28.9256198347107, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.9568345323741, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=39.7058823529412, Blast_Score=107, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=43.3823529411765, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_BRASO (A4YTA2)

Other databases:

- EMBL:   CU234118
- RefSeq:   YP_001205359.1
- ProteinModelPortal:   A4YTA2
- SMR:   A4YTA2
- STRING:   A4YTA2
- GeneID:   5118522
- GenomeReviews:   CU234118_GR
- KEGG:   bra:BRADO3334
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   BSP376:BRADO3334-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15129; Mature: 14997

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTRDQAETFYAVHKARPFF
CCCCCCHHEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GELVDFMISGPVVVQVLEGEGAILKYRDVMGATDPSKAAEGTIRKAHAKSIGENSVHGSD
HHHHHHHHCCCEEEEEECCCCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
APETAAIEIAQFFAGNEIVG
CCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDATERNLTGAINALIEKAGLRIVAQKRIRMTRDQAETFYAVHKARPFF
CCCCCHHEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GELVDFMISGPVVVQVLEGEGAILKYRDVMGATDPSKAAEGTIRKAHAKSIGENSVHGSD
HHHHHHHHCCCEEEEEECCCCCEEEEHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
APETAAIEIAQFFAGNEIVG
CCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA