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The map label for this gene is phr [H]

Identifier: 146340206

GI number: 146340206

Start: 3422975

End: 3424222

Strand: Reverse

Name: phr [H]

Synonym: BRADO3224

Alternate gene names: 146340206

Gene position: 3424222-3422975 (Counterclockwise)

Preceding gene: 146340208

Following gene: 146340205

Centisome position: 45.92

GC content: 68.91

Gene sequence:

>1248_bases
TTGCAGTCGCTCGGCTCTGATCTGGTGATCCGCCGCGGGCCGGCGGCGCAGGTTCTCGGCCAGCTCGCACGCGAGACCAA
CGCCAGCGCAGTGTACTGGAACGATGTCGCTCAAGCGGGACCGCGCCGGGTGGCCGCCTCCGTCGAGGCCGACCTCGATC
ACATCGGCGTCGCGTCACGCGTGTTTCCAGACGACCTGCTGGTCGATCCGGCGACCATGAGCGGAAAGGATGGACGCGGC
CCGCGCGTGTTCACGCCGTTCTGGAAGCGCGTGCTGGCCCTCGGCGATCCGCCGAAGCCGCTGCCGACACCGGCGAGGCT
GCCCATGGTGCCGGACGTCACCGGCCTCACCGTGGATGACCTGAGGCTGGAGCCGACCAAACCGGACTGGGCGGGCGGCC
TGCGCGCCACGTGGCAGGCCGGCGAGCGCGCCGCGCAGCAGCGCCTCCGGAGCTTCCTCGAGAGCACCGTCAGCGGCTAC
GCCGCCGATCGCGACCGCCCCGACATCGACGCCACGTCGCGGTTGTCGCCGCATTTACGTTTTGGCGAAATCACTCCGCG
GCAGATCTGGCACGCCGCCCGCTTCGCGGCCGAGGAGCGCCCCGCGCAGGCGAAGGGGATCGACAAGTTCCTGAGCGAGA
TCGGCTGGCGCGAGTTCAGCCGCCACCTGCTCTACAACAATCCGGACCTCGCCAGCCGCAATCTGCAACCGTCCTTCGAT
CCCTTCCCTTGGGTTCAGGACGATGCTGCACTCGCCGCCTGGCAGCGCGGGCGGACCGGCTATCCGATCGTCGACGCCGG
ACTGCGCGAGCTATGGCACACCGGCAGCATGCACAACCGCGTCCGCATGGTGGCTGCTTCGCTGCTGGTGAAGCACCTGC
TGATCGACTGGCGGCAGGGCGAACAATGGTTCTGGGACACGCTGGTGGACGCCGACCCGGGCAGCAACCCGGCGAGCTGG
CAATGGGTGGCCGGCTCCGGGGCGGATGCGGCGCCCTACTTCCGCGTCTTCAACCCTGTGCTGCAGGGCGAGAAGTTCGA
TGCCAACGGCAGCTATGTGCGGCGCTGGGTTCCGGAGCTTGCGCGACTTCCTGCCGGGGTGATCCATCAGCCGTGGGCGG
CCAAGCCGCTTGAGCTCGCCGAGGCCGGTGTCACGCTCGGACGCTCCTACCCCACGCCGATCATCGATCACAAGCAGGGG
CGCGAGCGTGCGCTGGCGGCTTATGCGAGCTTGCGCACAAGTGATTAG

Upstream 100 bases:

>100_bases
TTGTAGTTACGTGTTCGATCAGGAGAGTCCGGGGCTTCGGCAACTCGGAGGAGCGACGCGATGGTGGCTTGCACAATCGC
TGCGTGCGCTGCGCACTGAG

Downstream 100 bases:

>100_bases
TTGCGCTCGCTTTGACAGCCGGGAGAATCCAGCTATCGTCGCAAGGTTTCCAACACATCGGGGGACCGATATGGACGACA
CCACTCTGACCGACCCGACC

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQSLGSDLVIRRGPAAQVLGQLARETNASAVYWNDVAQAGPRRVAASVEADLDHIGVASRVFPDDLLVDPATMSGKDGRG
PRVFTPFWKRVLALGDPPKPLPTPARLPMVPDVTGLTVDDLRLEPTKPDWAGGLRATWQAGERAAQQRLRSFLESTVSGY
AADRDRPDIDATSRLSPHLRFGEITPRQIWHAARFAAEERPAQAKGIDKFLSEIGWREFSRHLLYNNPDLASRNLQPSFD
PFPWVQDDAALAAWQRGRTGYPIVDAGLRELWHTGSMHNRVRMVAASLLVKHLLIDWRQGEQWFWDTLVDADPGSNPASW
QWVAGSGADAAPYFRVFNPVLQGEKFDANGSYVRRWVPELARLPAGVIHQPWAAKPLELAEAGVTLGRSYPTPIIDHKQG
RERALAAYASLRTSD

Sequences:

>Translated_415_residues
MQSLGSDLVIRRGPAAQVLGQLARETNASAVYWNDVAQAGPRRVAASVEADLDHIGVASRVFPDDLLVDPATMSGKDGRG
PRVFTPFWKRVLALGDPPKPLPTPARLPMVPDVTGLTVDDLRLEPTKPDWAGGLRATWQAGERAAQQRLRSFLESTVSGY
AADRDRPDIDATSRLSPHLRFGEITPRQIWHAARFAAEERPAQAKGIDKFLSEIGWREFSRHLLYNNPDLASRNLQPSFD
PFPWVQDDAALAAWQRGRTGYPIVDAGLRELWHTGSMHNRVRMVAASLLVKHLLIDWRQGEQWFWDTLVDADPGSNPASW
QWVAGSGADAAPYFRVFNPVLQGEKFDANGSYVRRWVPELARLPAGVIHQPWAAKPLELAEAGVTLGRSYPTPIIDHKQG
RERALAAYASLRTSD
>Mature_415_residues
MQSLGSDLVIRRGPAAQVLGQLARETNASAVYWNDVAQAGPRRVAASVEADLDHIGVASRVFPDDLLVDPATMSGKDGRG
PRVFTPFWKRVLALGDPPKPLPTPARLPMVPDVTGLTVDDLRLEPTKPDWAGGLRATWQAGERAAQQRLRSFLESTVSGY
AADRDRPDIDATSRLSPHLRFGEITPRQIWHAARFAAEERPAQAKGIDKFLSEIGWREFSRHLLYNNPDLASRNLQPSFD
PFPWVQDDAALAAWQRGRTGYPIVDAGLRELWHTGSMHNRVRMVAASLLVKHLLIDWRQGEQWFWDTLVDADPGSNPASW
QWVAGSGADAAPYFRVFNPVLQGEKFDANGSYVRRWVPELARLPAGVIHQPWAAKPLELAEAGVTLGRSYPTPIIDHKQG
RERALAAYASLRTSD

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=432, Percent_Identity=28.2407407407407, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI188536100, Length=271, Percent_Identity=31.7343173431734, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI188536103, Length=271, Percent_Identity=31.7343173431734, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786926, Length=408, Percent_Identity=38.2352941176471, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324962, Length=364, Percent_Identity=32.6923076923077, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17137248, Length=434, Percent_Identity=26.9585253456221, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585455, Length=434, Percent_Identity=26.9585253456221, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648152, Length=397, Percent_Identity=27.455919395466, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 46029; Mature: 46029

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLGSDLVIRRGPAAQVLGQLARETNASAVYWNDVAQAGPRRVAASVEADLDHIGVASR
CCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECHHHHCCHHHHHHHHHHHHHHHCCHHH
VFPDDLLVDPATMSGKDGRGPRVFTPFWKRVLALGDPPKPLPTPARLPMVPDVTGLTVDD
CCCHHHEECCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
LRLEPTKPDWAGGLRATWQAGERAAQQRLRSFLESTVSGYAADRDRPDIDATSRLSPHLR
CEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
FGEITPRQIWHAARFAAEERPAQAKGIDKFLSEIGWREFSRHLLYNNPDLASRNLQPSFD
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PFPWVQDDAALAAWQRGRTGYPIVDAGLRELWHTGSMHNRVRMVAASLLVKHLLIDWRQG
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
EQWFWDTLVDADPGSNPASWQWVAGSGADAAPYFRVFNPVLQGEKFDANGSYVRRWVPEL
CHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ARLPAGVIHQPWAAKPLELAEAGVTLGRSYPTPIIDHKQGRERALAAYASLRTSD
HHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSLGSDLVIRRGPAAQVLGQLARETNASAVYWNDVAQAGPRRVAASVEADLDHIGVASR
CCCCCCCCEEECCCHHHHHHHHHHHCCCCEEEECHHHHCCHHHHHHHHHHHHHHHCCHHH
VFPDDLLVDPATMSGKDGRGPRVFTPFWKRVLALGDPPKPLPTPARLPMVPDVTGLTVDD
CCCHHHEECCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
LRLEPTKPDWAGGLRATWQAGERAAQQRLRSFLESTVSGYAADRDRPDIDATSRLSPHLR
CEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCC
FGEITPRQIWHAARFAAEERPAQAKGIDKFLSEIGWREFSRHLLYNNPDLASRNLQPSFD
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PFPWVQDDAALAAWQRGRTGYPIVDAGLRELWHTGSMHNRVRMVAASLLVKHLLIDWRQG
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
EQWFWDTLVDADPGSNPASWQWVAGSGADAAPYFRVFNPVLQGEKFDANGSYVRRWVPEL
CHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ARLPAGVIHQPWAAKPLELAEAGVTLGRSYPTPIIDHKQGRERALAAYASLRTSD
HHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]