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The map label for this gene is hlyU [H]

Identifier: 146340186

GI number: 146340186

Start: 3403323

End: 3403625

Strand: Reverse

Name: hlyU [H]

Synonym: BRADO3202

Alternate gene names: 146340186

Gene position: 3403625-3403323 (Counterclockwise)

Preceding gene: 146340193

Following gene: 146340185

Centisome position: 45.65

GC content: 66.67

Gene sequence:

>303_bases
GTGGCGGCCGACCAGGCCCGTGACCTGTTGAAGGCGCTGTCGAACCGGCACCGGCTCCTGATCGTCTGCCAGCTGGTCGA
CGATGAACGGTCGGTCGGCGAGTTGGCGGCATTCCTCGGCCTGCGCGACTCGACCGTCTCGCAGCACTTGGCGTTGCTAC
GCAGAGACGGCCTAGTCACCGCCCGGCGCGACGGGCAGACCATCCACTACTCGATCGCCAGCGAGCCGGCCCGCGAGGTT
CTGAAGACGCTCTATCAGGTCTATTGCGCGACGCCGCCGCAGAAACCCGTCCCGAGACTATGA

Upstream 100 bases:

>100_bases
TTCTTGTCTCGCTCAGCCGCGACCTTCCGGGCCGGCCTTGACTATATATTTGAATATCTGTATATATGCAACTATGAAAT
TTAATGCTGACATCATGGAA

Downstream 100 bases:

>100_bases
CGGCGTCCAGCCGCCGACTTGACCGGTATCAAGCGGGAACCCGTATCCCGGTGGGATGTCTGGACCGCCCGTTTCGCCCG
ACCACACGATTTGATTCAAG

Product: Ars family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 100; Mature: 99

Protein sequence:

>100_residues
MAADQARDLLKALSNRHRLLIVCQLVDDERSVGELAAFLGLRDSTVSQHLALLRRDGLVTARRDGQTIHYSIASEPAREV
LKTLYQVYCATPPQKPVPRL

Sequences:

>Translated_100_residues
MAADQARDLLKALSNRHRLLIVCQLVDDERSVGELAAFLGLRDSTVSQHLALLRRDGLVTARRDGQTIHYSIASEPAREV
LKTLYQVYCATPPQKPVPRL
>Mature_99_residues
AADQARDLLKALSNRHRLLIVCQLVDDERSVGELAAFLGLRDSTVSQHLALLRRDGLVTARRDGQTIHYSIASEPAREVL
KTLYQVYCATPPQKPVPRL

Specific function: Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=89, Percent_Identity=47.1910112359551, Blast_Score=77, Evalue=3e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 11178; Mature: 11047

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADQARDLLKALSNRHRLLIVCQLVDDERSVGELAAFLGLRDSTVSQHLALLRRDGLVT
CCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEE
ARRDGQTIHYSIASEPAREVLKTLYQVYCATPPQKPVPRL
ECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AADQARDLLKALSNRHRLLIVCQLVDDERSVGELAAFLGLRDSTVSQHLALLRRDGLVT
CCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEE
ARRDGQTIHYSIASEPAREVLKTLYQVYCATPPQKPVPRL
ECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]