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The map label for this gene is adhA [H]

Identifier: 146339864

GI number: 146339864

Start: 3065832

End: 3066857

Strand: Direct

Name: adhA [H]

Synonym: BRADO2866

Alternate gene names: 146339864

Gene position: 3065832-3066857 (Clockwise)

Preceding gene: 146339863

Following gene: 146339865

Centisome position: 41.12

GC content: 67.06

Gene sequence:

>1026_bases
ATGCAGACCATGAAAGCCGCCGTCGTCAAAGCCTTTGGCAAGCCGCTCGTCATCGAGGACGTGCCTGTTCCGGTGCCTGG
TCCGGGCGAGCTTCTCGTCAAGCTGAAGGCCTGCGGCGTCTGTCATACTGATCTCCACGCGGCTTCGGGCGATTGGCCGG
TCAAGCCGACGCCGCCCTTCATCCCAGGCCACGAAGCGGCCGGCGTGGTCGCCGCGCTCGGTGCTGGCGTGACCGACTTC
AAGGTCGGCGATGCCGTCGGTGTGGCTTGGCTGCACGACGCGTGCTTGCGTTGCGAATATTGCGAGACCGGCTGGGAAAC
GCTGTGCGAGCACCAGCACAATACGGGCTACAGCGTGAATGGCGGCTTCGCCGAGTACGTCATCGCCGCGGCCGCATTCG
CGGCGCGCCTGCCGGCCAACGTCGACTTCGCCAGAGTCGCGCCGATCCTGTGCGCCGGCGTCACGACCTACAAGGGCTTG
AAGGAGACGGACACCCGTCCGGGCGAGTGGGTGGTGATCTCTGGCGTGGGCGGCCTCGGTCACGTCGCGATCCAATACGC
CAAGGCGATGGGGCTGAAGGCGATCGGTCTCGACATCGCCGAGGACAAGCTCAAGCTGGCGCTGGAGGCGGGTGCCGCGC
ACGCCGTCAACGCGCTCGACAACGACGCCGTGGACCGCGTTCTCCAGATCACGGGGGGAGGGGCGCAGGGCGTGCTCGTG
ACGGCGGTCTCGACCCCGGCGTTCGCGCAGGCCTTGAAGATGGTCAGACGCAAGGGCACCGTCAGCCTGGTCGGCCTGCC
TCCCGGCGAATTCCCGACGCCGATCTTCGACGTCGTGCTCAAGCGCATCACCGTGCGCGGCTCGATCGTTGGCACGCGGC
GTGACCTCGACGAGGCCATCGCCTTTGCCGCCGAGGGCAAGGTGAAGGCGGAGGTCACCACGGCGCCGCTGTCGGAGATC
AACACCATCTTCGACCGCATGAAGGCCGGCAAGATCGACGGCCGCGTGGTGCTGGATTTCACCTGA

Upstream 100 bases:

>100_bases
TGTTACGCGTTGCGCAGCAAAGCGGCAGCGTATTTTGACACCGATCAAGACTGTCCTGGTTTCGCGTCATTAGTTTGCTC
CTTAACTAAGGAGCAAACCG

Downstream 100 bases:

>100_bases
TCATCGAAGGCACGTGTTCAAGGCGGCCGCCTCGCATCGGCGTGGCGGCCGTCTTGATCTGGATCAGGATGACGGCGCAG
CGTCATGGCACAGATGTCGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQTMKAAVVKAFGKPLVIEDVPVPVPGPGELLVKLKACGVCHTDLHAASGDWPVKPTPPFIPGHEAAGVVAALGAGVTDF
KVGDAVGVAWLHDACLRCEYCETGWETLCEHQHNTGYSVNGGFAEYVIAAAAFAARLPANVDFARVAPILCAGVTTYKGL
KETDTRPGEWVVISGVGGLGHVAIQYAKAMGLKAIGLDIAEDKLKLALEAGAAHAVNALDNDAVDRVLQITGGGAQGVLV
TAVSTPAFAQALKMVRRKGTVSLVGLPPGEFPTPIFDVVLKRITVRGSIVGTRRDLDEAIAFAAEGKVKAEVTTAPLSEI
NTIFDRMKAGKIDGRVVLDFT

Sequences:

>Translated_341_residues
MQTMKAAVVKAFGKPLVIEDVPVPVPGPGELLVKLKACGVCHTDLHAASGDWPVKPTPPFIPGHEAAGVVAALGAGVTDF
KVGDAVGVAWLHDACLRCEYCETGWETLCEHQHNTGYSVNGGFAEYVIAAAAFAARLPANVDFARVAPILCAGVTTYKGL
KETDTRPGEWVVISGVGGLGHVAIQYAKAMGLKAIGLDIAEDKLKLALEAGAAHAVNALDNDAVDRVLQITGGGAQGVLV
TAVSTPAFAQALKMVRRKGTVSLVGLPPGEFPTPIFDVVLKRITVRGSIVGTRRDLDEAIAFAAEGKVKAEVTTAPLSEI
NTIFDRMKAGKIDGRVVLDFT
>Mature_341_residues
MQTMKAAVVKAFGKPLVIEDVPVPVPGPGELLVKLKACGVCHTDLHAASGDWPVKPTPPFIPGHEAAGVVAALGAGVTDF
KVGDAVGVAWLHDACLRCEYCETGWETLCEHQHNTGYSVNGGFAEYVIAAAAFAARLPANVDFARVAPILCAGVTTYKGL
KETDTRPGEWVVISGVGGLGHVAIQYAKAMGLKAIGLDIAEDKLKLALEAGAAHAVNALDNDAVDRVLQITGGGAQGVLV
TAVSTPAFAQALKMVRRKGTVSLVGLPPGEFPTPIFDVVLKRITVRGSIVGTRRDLDEAIAFAAEGKVKAEVTTAPLSEI
NTIFDRMKAGKIDGRVVLDFT

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=270, Percent_Identity=29.2592592592593, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI13236495, Length=270, Percent_Identity=29.2592592592593, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=30.3763440860215, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI194239676, Length=232, Percent_Identity=31.4655172413793, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=29.8387096774194, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=27.5401069518717, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI71565154, Length=361, Percent_Identity=29.9168975069252, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=29.8387096774194, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=27.3712737127371, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=27.3712737127371, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI156627571, Length=292, Percent_Identity=27.0547945205479, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=26.4623955431755, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=26.4623955431755, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=50.1597444089457, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=32.4712643678161, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=29.9418604651163, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=29.3768545994065, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788073, Length=255, Percent_Identity=32.156862745098, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=29.971181556196, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=30.3834808259587, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=28.169014084507, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=32.0441988950276, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790485, Length=312, Percent_Identity=29.4871794871795, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=31.25, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787863, Length=220, Percent_Identity=31.8181818181818, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=24.4514106583072, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=40.9883720930233, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=37.1345029239766, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=40, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17562876, Length=331, Percent_Identity=30.2114803625378, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=213, Percent_Identity=31.924882629108, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=237, Percent_Identity=32.0675105485232, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=238, Percent_Identity=31.5126050420168, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=201, Percent_Identity=29.3532338308458, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=43.9882697947214, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=44.574780058651, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=43.6950146627566, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=43.108504398827, Blast_Score=281, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6319949, Length=352, Percent_Identity=28.9772727272727, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323980, Length=327, Percent_Identity=27.82874617737, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=29.5081967213115, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=25.1412429378531, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=27.6073619631902, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=27.6073619631902, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=343, Percent_Identity=25.3644314868805, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=324, Percent_Identity=26.2345679012346, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=366, Percent_Identity=29.2349726775956, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17137530, Length=308, Percent_Identity=29.5454545454545, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737897, Length=308, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35566; Mature: 35566

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTMKAAVVKAFGKPLVIEDVPVPVPGPGELLVKLKACGVCHTDLHAASGDWPVKPTPPF
CCHHHHHHHHHCCCCEEEECCCCCCCCCHHHEEEEECCCCEECCCCCCCCCCCCCCCCCC
IPGHEAAGVVAALGAGVTDFKVGDAVGVAWLHDACLRCEYCETGWETLCEHQHNTGYSVN
CCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
GGFAEYVIAAAAFAARLPANVDFARVAPILCAGVTTYKGLKETDTRPGEWVVISGVGGLG
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHCCCHHCCCCCCCEEEEECCCCHH
HVAIQYAKAMGLKAIGLDIAEDKLKLALEAGAAHAVNALDNDAVDRVLQITGGGAQGVLV
HHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHEEEECCCCCCCEEE
TAVSTPAFAQALKMVRRKGTVSLVGLPPGEFPTPIFDVVLKRITVRGSIVGTRRDLDEAI
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECHHHHHHHH
AFAAEGKVKAEVTTAPLSEINTIFDRMKAGKIDGRVVLDFT
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MQTMKAAVVKAFGKPLVIEDVPVPVPGPGELLVKLKACGVCHTDLHAASGDWPVKPTPPF
CCHHHHHHHHHCCCCEEEECCCCCCCCCHHHEEEEECCCCEECCCCCCCCCCCCCCCCCC
IPGHEAAGVVAALGAGVTDFKVGDAVGVAWLHDACLRCEYCETGWETLCEHQHNTGYSVN
CCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
GGFAEYVIAAAAFAARLPANVDFARVAPILCAGVTTYKGLKETDTRPGEWVVISGVGGLG
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHCCCHHCCCCCCCEEEEECCCCHH
HVAIQYAKAMGLKAIGLDIAEDKLKLALEAGAAHAVNALDNDAVDRVLQITGGGAQGVLV
HHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCHHHHHHCCHHHHHHEEEECCCCCCCEEE
TAVSTPAFAQALKMVRRKGTVSLVGLPPGEFPTPIFDVVLKRITVRGSIVGTRRDLDEAI
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECHHHHHHHH
AFAAEGKVKAEVTTAPLSEINTIFDRMKAGKIDGRVVLDFT
HHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]